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Keywords

Expert in Animal Experimentation, Experimental Neuroscience Coordinator for INSERM's national “Aging” plan, Neuroscience, Endocrinology, Integrative Physiology, Metabolism, Animal Behavior, Autophagy, Platform design for animal experimentation, Human, technical and financial management of the platforms department

Biography

Specialist in Endocrinology and Neurophysiology, I obtained my PhD in the field of “Life and Health Sciences”.

My career path spans 26 years of varied professional experiences in the fields of scientific research (2 Post-Docs : 6 years) and the design and management of experimental platforms (Engineer position at INSERM since 2009).

During my various professional experiences, my research activities were firstly realized with a 10 years of Pharmaceutical Industry collaborations (PhD - Postdocs). In my Ingeneer fposition at INSERM, I designed and managed Animal Experimentation (AE) platforms for 9 years. All my professional experiences have led me to focus on the importance of AE in the use of animal models in Biomedical Research, and have enabled me to develop recognized expertise in Integrative Neurobiology. I am interesting by the cross-talk between the brain and peripheral organs in the neuro-Metabolism regulation (Endocrinology).

Today, my engineering role is being put to good use in the technical and experimental coordination of the Neurosciences part of INSERM's major international cross-disciplinary “Aging” plan.

Activities

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Employment (5)

INSERM: Paris, 75, FR

2018 to present | Neuroscience Experimental Coordinator for INSERM's national “Aging” plan (AgeMed) (U1151 - INEM - Cell Biology Department)
Employment
Source: Self-asserted source
Francois MAILLIET

INSERM: Paris, Île-de-France, FR

2009 to 2018 | Technical Director and Design Manager of an Experimental Platform (U1266 - Institut de Psychiatrie et Neurosciences de Paris)
Employment
Source: Self-asserted source
Francois MAILLIET

INSERM: Paris, 75, FR

2005 to 2009 | Post Doc (CDD IR2) (U894 - Physiopathologies des maladies Psychiatriques)
Employment
Source: Self-asserted source
Francois MAILLIET

Laboratoires Phamaceutiques Servier: Croissy sur Seine, 78, FR

2003 to 2004 | CDD Cadre de Laboratoire (Post-Doc) (Pharmacologie Moléculaire et Cellulaire)
Employment
Source: Self-asserted source
Francois MAILLIET

INRA: Nouzilly, Indre et loire, FR

2002 | CDD Ingénieur de laboratoire (Physiologie de la Reproduction et du Comportement)
Employment
Source: Self-asserted source
Francois MAILLIET

Education and qualifications (8)

Université Pierre et Marie Curie: Paris, 75, FR

2010 (Habilitation à la Chirurgie Animale)
Education
Source: Self-asserted source
Francois MAILLIET

Université Pierre et Marie Curie: PARIS, 75, FR

2008 (Habilitation à l'Expérimentation Animale niveau I)
Education
Source: Self-asserted source
Francois MAILLIET

Université Francois Rabelais de Tours: Tours, 37, FR

2003 | Niveau I >= BAC + 4 ou 5 - Doctorat 3ème cycle (Sciences de la Vie et de la Santé)
Education
Source: Self-asserted source
Francois MAILLIET

Université Victor Segalen de Bordeaux: Bordeaux, Bordeaux Nouvelle Aquitaine, FR

1997 | - Niveau I >= BAC + 4 ou 5 - Diplôme d'études approfondies (Neurosciences et Neuropharmacologie)
Education
Source: Self-asserted source
Francois MAILLIET

Université Francois Rabelais de Tours: Tours, 37, FR

1996 | - Niveau II BAC + 3 ou 4 - Maîtrise (Maîtrise Biologie Cellulaire et Physiologie Animale)
Education
Source: Self-asserted source
Francois MAILLIET

Université Francois Rabelais de Tours: Tours, 37, FR

1995 | Niveau II BAC + 3 ou 4 - Licence (Licence Biologie Cellulaire et Physiologie Animale)
Education
Source: Self-asserted source
Francois MAILLIET

Université Francois Rabelais de Tours: Tours, 37, FR

1994 | Niveau III BAC + 2 - Diplôme d'études universitaires générales (DEUG Biologie (option Physiologie))
Education
Source: Self-asserted source
Francois MAILLIET

Académie française: Tours, 37, FR

1992 | - Niveau IV BAC - Baccalauréat (BAC D Mathématiques et Sciences Naturelles)
Education
Source: Self-asserted source
Francois MAILLIET

Professional activities (2)

INSERM: Paris, Île-de-France, FR

2022-01-01 | Ingénieur d'Etude Hors Classe
Distinction
Source: Self-asserted source
Francois MAILLIET

INSERM: Paris, Île-de-France, FR

2019 | Coordinateur Expérimental en Neuroscience du plan national "Vieillissement" de l'INSERM (AgeMed)
Distinction
Source: Self-asserted source
Francois MAILLIET

Funding (1)

Université de Tours

1999 to 2002 | Award
Université de Tours (Tours, FR)
Source: Self-asserted source
Francois MAILLIET

Works (16)

Acyl-CoA binding protein for the experimental treatment of anorexia

Science Translational Medicine
2024-08-14 | Journal article
DOI: 10.1126/scitranslmed.adl0715
Contributors: Hui Chen; Stéphanie Moriceau; Adrien Joseph; Francois Mailliet; Sijing Li; Virginie Tolle; Philibert Duriez; Roland Dardennes; Sylvère Durand; Vincent Carbonnier et al.
Source: check_circle
Crossref
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Preferred source (of 2)‎

Slc20a1 and Slc20a2 regulate neuronal plasticity and cognition independently of their phosphate transport ability

Cell Death & Disease
2024-01-09 | Journal article
DOI: 10.1038/s41419-023-06292-z
Part of ISSN: 2041-4889
Contributors: Mariana Ramos-Brossier; David Romeo-Guitart; Fabien Lanté; Valérie Boitez; François Mailliet; Soham Saha; Manon Rivagorda; Eleni Siopi; Ivan Nemazanyy; Christine Leroy et al.
Source: Self-asserted source
Francois MAILLIET

Acute tianeptine treatment selectively modulates neuronal activation in the central nucleus of the amygdala and attenuates fear extinction.

Molecular psychiatry
2015-01-06 | Journal article
DOI: 10.1038/mp.2014.169
PMID: 25560759
Contributors: Bill P. Godsil; Bontempi B; Mailliet F; Delagrange P; Michael Spedding; Thérèse Jay; Therese M Jay
Source: Self-asserted source
Francois MAILLIET

Acute stress induces contrasting changes in AMPA receptor subunit phosphorylation within the prefrontal cortex, amygdala and hippocampus.

PloS one
2010-12-08 | Journal article
DOI: 10.1371/journal.pone.0015282
PMID: 21170339
PMC: PMC2999558
Contributors: Dorian Caudal; Bill P. Godsil; Mailliet F; Bergerot D; Thérèse Jay; Therese M Jay
Source: Self-asserted source
Francois MAILLIET

Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation.

Neuropharmacology
2008-07-09 | Journal article
DOI: 10.1016/j.neuropharm.2008.06.068
PMID: 18657555
Contributors: Qi H; Mailliet F; Michael Spedding; Rocher C; Zhang X; Delagrange P; McEwen B; Therese M Jay; Svenningsson P
Source: Self-asserted source
Francois MAILLIET

Protection of stress-induced impairment of hippocampal/prefrontal LTP through blockade of glucocorticoid receptors: implication of MEK signaling.

Experimental neurology
2008-03-16 | Journal article
DOI: 10.1016/j.expneurol.2008.02.030
PMID: 18436212
Contributors: Mailliet F; Qi H; Rocher C; Michael Spedding; Svenningsson P; Thérèse Jay; Therese M Jay
Source: Self-asserted source
Francois MAILLIET

Cellular knock-down of quinone reductase 2: a laborious road to successful inhibition by RNA interference.

Biochimie
2007-07-15 | Journal article
DOI: 10.1016/j.biochi.2007.07.004
PMID: 17714848
Contributors: Chomarat P; Cogé F; Guénin SP; Mailliet F; Vella F; Mallet C; Giraudet S; Nagel N; Leonce S; Ferry G et al.
Source: Self-asserted source
Francois MAILLIET

The prefrontal cortex as a key target of the maladaptive response to stress.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2007-03-01 | Journal article
DOI: 10.1523/jneurosci.4372-06.2007
PMID: 17360899
PMC: PMC6672565
Contributors: Joao Cerqueira; Mailliet F; Osborne F.X. Almeida; Thérèse Jay; Therese M Jay; Sousa, N
Source: Self-asserted source
Francois MAILLIET

Common efficacy of psychotropic drugs in restoring stress-induced impairment of prefrontal plasticity.

Neurotoxicity research
2006-12-01 | Journal article
DOI: 10.1007/bf03033356
PMID: 17197369
Contributors: Nicolas Dupin; Mailliet F; Rocher C; Kessal K; Michael Spedding; Therese M Jay; Thérèse Jay
Source: Self-asserted source
Francois MAILLIET

Characterization of the melatoninergic MT3 binding site on the NRH:quinone oxidoreductase 2 enzyme.

Biochemical pharmacology
2005-11-15 | Journal article
DOI: 10.1016/j.bcp.2005.09.030
PMID: 16293234
Contributors: Mailliet F; Ferry G; Vella F; Berger S; Cogé F; Chomarat P; Mallet C; Guénin SP; Guillaumet G; Viaud-Massuard MC et al.
Source: Self-asserted source
Francois MAILLIET

Organs from mice deleted for NRH:quinone oxidoreductase 2 are deprived of the melatonin binding site MT3.

FEBS letters
2004-12-01 | Journal article
DOI: 10.1016/j.febslet.2004.10.083
PMID: 15581627
Contributors: Mailliet F; Ferry G; Vella F; Thiam K; Delagrange P; Jean Albert Boutin
Source: Self-asserted source
Francois MAILLIET

Molecular pharmacology of the ovine melatonin receptor: comparison with recombinant human MT1 and MT2 receptors.

Biochemical pharmacology
2004-02-01 | Journal article
DOI: 10.1016/j.bcp.2003.09.037
PMID: 14757166
Contributors: Mailliet F; Audinot V; Malpaux B; Bonnaud A; Delagrange P; Martine Migaud; Perry Barrett; Viaud-Massuard MC; Lesieur D; Lefoulon F et al.
Source: Self-asserted source
Francois MAILLIET

New selective ligands of human cloned melatonin MT1 and MT2 receptors.

Naunyn-Schmiedeberg's archives of pharmacology
2003-05-23 | Journal article
DOI: 10.1007/s00210-003-0751-2
PMID: 12764576
Contributors: Audinot V; Mailliet F; Lahaye-Brasseur C; Bonnaud A; Le Gall A; Amossé C; Dromaint S; Rodriguez M; Nagel N; Galizzi JP et al.
Source: Self-asserted source
Francois MAILLIET

Melatonin and seasonal reproduction: understanding the neuroendocrine mechanisms using the sheep as a model.

Reproduction (Cambridge, England). Supplement
2002-01-01 | Journal article
PMID: 12698980
Contributors: Malpaux B; Tricoire H; Mailliet F; Daveau A; Migaud M; Skinner DC; Pelletier J; Chemineau P
Source: Self-asserted source
Francois MAILLIET

Comparative effects of melatonin, zolpidem and diazepam on sleep, body temperature, blood pressure and heart rate measured by radiotelemetry in Wistar rats.

Psychopharmacology
2001-08-01 | Journal article
DOI: 10.1007/s002130100769
PMID: 11498719
Contributors: Mailliet F; Galloux P; Poisson D
Source: Self-asserted source
Francois MAILLIET

Effects of neonatal focal cerebral hypoxia-ischemia on sleep-waking pattern, ECoG power spectra and locomotor activity in the adult rat.

Brain research
1998-10-01 | Journal article
DOI: 10.1016/s0006-8993(98)00703-3
PMID: 9756989
Contributors: Antier D; Zhang BL; Mailliet F; Akoka S; Pourcelot L; Sannajust F
Source: Self-asserted source
Francois MAILLIET
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