Personal information

Aging Obesity Lifespan epigenetics genetics, metabolism diabetes cancer
United States

Biography

David Sinclair, Ph.D. is a Professor at Harvard Medical School in the Department of Genetics. After a Ph.D. in Australia, he worked with Lenny Guarente at M.I.T. where he discovered a cause of aging in yeast controlled by genes called the sirtuins. In 1999, he moved to Harvard Medical School where his lab works primarily on understanding the role of sirtuins in diseases and aging in mammals, with interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. He has also contributed to the understanding of how sirtuins are modulated by endogenous molecules and pharmacological agents such as resveratrol. He has co-founded biotechnology companies and is co-founder and co-chief editor of the journal Aging. Dr. Sinclair has received awards including The Australian Commonwealth Prize, a Helen Hay Whitney Postdoctoral Award, a Leukemia Society Fellowship, a Ludwig Scholarship, a Harvard-Armenise Fellowship, an American Association for Aging Research Fellowship, The Nathan Shock Award from NIH, Scholarships from The Ellison Medical Foundation, The Merck Prize, the Genzyme Outstanding Achievement in Biomedical Science Award, a "Bio-Innovator award", the David Murdock-Dole Lectureship, the Fisher Honorary Lectureship at UCLA, a MERIT Award from the National Institute on Aging, the Denham Harman Award, and the ASRM Medal from the Australian Society for Medical Research, and listed by TIME magazine as one of the 100 most influential people in the world in 2014.

Activities

Employment (4)

Harvard Medical School: Boston, MA, US

2010 to present | Professor (Genetics)
Employment
Source: Self-asserted source
David Sinclair

Harvard Medical School: Boston, MA, US

2005 to 2010 | Associate Professor (Pathology)
Employment
Source: Self-asserted source
David Sinclair

Harvard Medical School: Boston, MA, US

1999 to 2004 | Assistant Professor (Pathology)
Employment
Source: Self-asserted source
David Sinclair

Massachusetts Institute of Technology: Cambridge, MA, US

1995 to 1999 | Postdoctoral Fellow (Biology)
Employment
Source: Self-asserted source
David Sinclair

Education and qualifications (2)

University of New South Wales: Sydney, NSW, AU

1992 to 1995 | Ph.D. (Biochemistry)
Education
Source: Self-asserted source
David Sinclair

University of New South Wales: Sydney, NSW, AU

1987 to 1991 | B.Sc. (1st class honors) (Biochemistry)
Education
Source: Self-asserted source
David Sinclair

Professional activities (1)

Australian Government: Canberra, Australian Capital Territory, AU

2018-04 | Officer of the Order of Australia
Distinction
Source: Self-asserted source
David Sinclair

Funding (1)

SIRT1 as a regulator of health and lifespan of mammals

2011-09 to 2017-10 | Grant
NIH Office of the Director (MD, MD, US)
GRANT_NUMBER:

RO1 AG028730

Source: Self-asserted source
David Sinclair

Peer review (10 reviews for 5 publications/grants)

Review activity for Cell research (1)
Review activity for Nature (4)
Review activity for Nature aging. (3)
Review activity for Nature communications (1)
Review activity for Nature reviews. (1)