Personal information

Alcohol use disorders, delta opioid receptor, drug development, psychiatric disorders, psychostimulant use, behavioral neuropharmacology, g protein-coupled receptors

Activities

Employment (8)

Purdue University West Lafayette: West Lafayette, Indiana, US

2021-09-01 to present | Adjunct Associate Professor (Medicinal Chemistry and Molecular Pharmacology)
Employment
Source: Self-asserted source
Richard van Rijn

Septerna Inc: South San Francisco, CA, US

2021-08-15 to present | Principal Scientist (Disease Biology)
Employment
Source: Self-asserted source
Richard van Rijn

Purdue University: West Lafayette, IN, US

2019-08-12 to 2021-09-01 | Associate Professor (Medicinal Chemistry and Molecular Pharmacology)
Employment
Source: Self-asserted source
Richard van Rijn

Purdue University: West Lafayette, IN, US

2013-09-15 to 2019-08-11 | Assistant Professor (Medicinal Chemistry and Molecular Pharmacology)
Employment
Source: Self-asserted source
Richard van Rijn

Ernest Gallo Clinic and Research Center: Emeryville, CA, US

2011-09-01 to 2013-09-14 | Associate Research Scientist (Neurology)
Employment
Source: Self-asserted source
Richard van Rijn

Ernest Gallo Clinic and Research Center: Emeryville, CA, US

2011-01-01 to 2011-08-31 | Assistant Research Scientist (Neurology)
Employment
Source: Self-asserted source
Richard van Rijn

Ernest Gallo Clinic and Research Center: Emeryville, CA, US

2007-01-09 to 2010-12-31 | Postdoctoral fellow (Neurology)
Employment
Source: Self-asserted source
Richard van Rijn

BioFocus DPI BV: Leiden, Zuid-Holland, NL

2006-06-01 to 2006-12-31 | Research associate
Employment
Source: Self-asserted source
Richard van Rijn

Education and qualifications (2)

VU University Amsterdam: Amsterdam, NL

2002-05-01 to 2006-05-31 | PhD (Chemistry and Pharmaceutical Sciences)
Education
Source: Self-asserted source
Richard van Rijn

Universiteit Leiden: Leiden, Zuid-Holland, NL

1997-09-01 to 2002-04-15 | BS/MS (Biopharmaceutical Sciences)
Education
Source: Self-asserted source
Richard van Rijn

Professional activities (3)

Indiana University School of Medicine: West Lafayette, IN, US

2019-09-01 to 2021-09-01 | Adjunct Associate Professor (Pharmacology and Toxicology)
Invited position
Source: Self-asserted source
Richard van Rijn

University of California, San Francisco: San Francisco, California, US

2020-01-24 to 2020-08-21 | Visiting Professor (sabbatical) (Pharmaceutical Chemistry)
Invited position
Source: Self-asserted source
Richard van Rijn

Indiana University School of Medicine: West Lafayette, IN, US

2014-09-01 to 2019-08-31 | Adjunct Assistant Professor (Pharmacology & Toxicology)
Invited position
Source: Self-asserted source
Richard van Rijn

Funding (10)

Accelerating Molecular Innovation in Pain through a Human-Guided, AI-Driven, and Automated Open Drug Discovery Platform

2021-04 to 2022-04 | Award
National Institutes of Health (Md., Md., US)
Source: Self-asserted source
Richard van Rijn

The influence of alcohol on the metastatic dormancy of breast cancer

2018-09 to 2020-08 | Grant
National Institute on Alcohol Abuse and Alcoholism (MD, MD, US)
GRANT_NUMBER:

AA026675

Source: Self-asserted source
Richard van Rijn

Opioidergic alkaloids from Mitragynia Speciosa (kratom) as novel treatment for alcohol use disorder

2018-08 to 2020-07 | Grant
National Institute on Alcohol Abuse and Alcoholism (Baltimore, US)
GRANT_NUMBER:

AA026949

Source: Self-asserted source
Richard van Rijn

Development of G-protein biased delta opioid receptor agonist for inflammatory pain

2018-04 to 2020-03 | Award
National Institute on Drug Abuse (Baltimore, US)
GRANT_NUMBER:

DA045897

Source: Self-asserted source
Richard van Rijn

G-protein-, beta-arrestin- and ERK-signaling in alcohol use- and anxiety-disorders

2017-09-10 to 2022-08-31 | Grant
National Institute On Alcohol Abuse and Alcoholism (n/a, US)
GRANT_NUMBER: grant.R01AA025368
Source: Self-asserted source
Richard van Rijn via DimensionsWizard

Development of novel designer G-protein coupled receptors to study the role of β-arrestin2 biased signal transduction in anxiety disorders.

2016-07 to 2018-07 | Grant
Brain and Behavior Research Foundation (NY, US)
GRANT_NUMBER:

23603

Source: Self-asserted source
Richard van Rijn

New mechanism for modulating opioid receptor mediated analgesia

2014-09 to 2015-08 | Grant
Ralph W. and Grace M. Showalter Research Trust Fund (IL, IL, US)
GRANT_NUMBER:

207655

Source: Self-asserted source
Richard van Rijn

Development of a preclinical candidate for the treatment of alcoholism

2013-09-05 to 2016-08-31 | Grant
National Institute on Alcohol Abuse and Alcoholism (Bethesda, US)
GRANT_NUMBER: 5R00AA020539-05
GRANT_NUMBER: 5R00AA020539-05
Source: Self-asserted source
Richard van Rijn via DimensionsWizard

Development of a preclinical candidate for the treatment of alcoholism

2011-08-20 to 2013-07-31 | Grant
National Institute on Alcohol Abuse and Alcoholism (Bethesda, US)
GRANT_NUMBER: 5K99AA020539-02
GRANT_NUMBER: 5K99AA020539-02
Source: Self-asserted source
Richard van Rijn via DimensionsWizard

Identification of delta opioid receptor subtypes as novel targets to treat alcoholism

2011-01 to 2012-12 | Grant
ABMRF/The Foundation for Alcohol Research (MD, MD, US)
Source: Self-asserted source
Richard van Rijn

Works (50 of 61)

Items per page:
Page 1 of 2

Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine

Journal of Medicinal Chemistry
2024-12-12 | Journal article
Contributors: Madeline R. Hennessy; Simone M. Creed; Anna M. Gutridge; Lisa E. Rusali; Dan Luo; Bakhtyar Sepehri; Elizabeth S. Rhoda; José A. Villegas; Richard M. van Rijn; Andrew P. Riley
Source: check_circle
Crossref

Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine

2024-03-29 | Preprint
Contributors: Madeline R. Hennessy; Simone M. Creed; Anna M. Gutridge; Elizabeth S. Rhoda; Richard M. van Rijn; Andrew P. Riley
Source: check_circle
Crossref

Receptor expression and signaling properties in the brain, and structural ligand motifs that contribute to delta opioid receptor agonist-induced seizures

Neuropharmacology
2023-07 | Journal article
Contributors: Arryn T. Blaine; Richard M. van Rijn
Source: check_circle
Crossref

ClickArr: a novel, high throughput assay for evaluating β-arrestin isoform recruitment

2022-09-30 | Preprint
Contributors: Alexander R. French; Yazan J. Meqbil; Richard M. van Rijn
Source: check_circle
Crossref

Copper Modulates Adult Neurogenesis in Brain Subventricular Zone

International Journal of Molecular Sciences
2022-08-31 | Journal article
Contributors: Luke L. Liu; Richard M. van Rijn; Wei Zheng
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Opportunities and Challenges for In Silico Drug Discovery at Delta Opioid Receptors

Pharmaceuticals
2022-07-15 | Journal article
Contributors: Yazan Meqbil; Richard van Rijn
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery II

Molecules
2022-05-13 | Journal article
Contributors: Richard M. Van Rijn; Mariana Spetea
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

An updated assessment of the translational promise of G-protein-biased kappa opioid receptor agonists to treat pain and other indications without debilitating adverse effects

Pharmacological Research
2022-03 | Journal article
Part of ISSN: 1043-6618
Source: Self-asserted source
Richard van Rijn

Modulating β-arrestin 2 recruitment at the δ- and μ-opioid receptors using peptidomimetic ligands

RSC Medicinal Chemistry
2021 | Journal article
Contributors: Krishna K. Sharma; Robert J. Cassell; Yazan J. Meqbil; Hongyu Su; Arryn T. Blaine; Benjamin R. Cummins; Kendall L. Mores; David K. Johnson; Richard M. van Rijn; Ryan A. Altman
Source: check_circle
Crossref

Identification of a Novel Delta Opioid Receptor Agonist Chemotype with Potential Negative Allosteric Modulator Capabilities

Molecules
2021-11-29 | Journal article
Contributors: Yazan J. Meqbil; Hongyu Su; Robert J. Cassell; Kendall L. Mores; Anna M. Gutridge; Benjamin R. Cummins; Lan Chen; Richard M. van Rijn
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder

Frontiers in Pharmacology
2021-11-03 | Journal article
Part of ISSN: 1663-9812
Source: Self-asserted source
Richard van Rijn

A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects

Journal of Medicinal Chemistry
2021-09-23 | Journal article
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Richard van Rijn

β-Arrestin–dependent ERK signaling reduces anxiety-like and conditioned fear–related behaviors in mice

Science Signaling
2021-08-03 | Journal article
Contributors: Mee Jung Ko; Terrance Chiang; Arbaaz A. Mukadam; Grace E. Mulia; Anna M. Gutridge; Angel Lin; Julia A. Chester; Richard M. van Rijn
Source: check_circle
Crossref

Engineering Quick- and Long-acting Naloxone Delivery Systems for Treating Opioid Overdose.

Pharmaceutical research
2021-06-10 | Journal article
Source: Self-asserted source
Richard van Rijn

Drug screening with zebrafish visual behavior identifies carvedilol as a potential treatment for an autosomal dominant form of retinitis pigmentosa

Scientific Reports
2021-06-02 | Journal article
Part of ISSN: 2045-2322
Source: Self-asserted source
Richard van Rijn

A non‐convulsant delta‐opioid receptor agonist, KNT‐127, reduces cortical spreading depression and nitroglycerin‐induced allodynia

Headache: The Journal of Head and Face Pain
2021-01 | Journal article
Contributors: Zachariah Bertels; Wiktor D. Witkowski; Sarah Asif; Kendra Siegersma; Richard M. van Rijn; Amynah A. Pradhan
Source: check_circle
Crossref

Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids

Journal of Natural Products
2021-01-22 | Journal article
Contributors: Simone M. Creed; Anna M. Gutridge; Malaika D. Argade; Madeline R. Hennessy; J. Brent Friesen; Guido F. Pauli; Richard M. van Rijn; Andrew P. Riley
Source: check_circle
Crossref

The CUL3/neddylation inhibitor MLN4924 reduces ethanol-induced locomotor sensitization and inflammatory pain allodynia in mice.

Behavioural brain research
2020-12-03 | Journal article
Source: Self-asserted source
Richard van Rijn

Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids

2020-09-28 | Preprint
Contributors: Simone Creed; Anna Gutridge; Malaika Argade; Madeline Hennessy; J. Brent Friesen; Guido Pauli; Richard van Rijn; Andrew Riley
Source: check_circle
Crossref

Drug Screening with Zebrafish Visual Behavior Identifies Carvedilol as a Potential Treatment for Retinitis Pigmentosa

2020-07-29 | Preprint
Contributors: Logan Ganzen; MeeJung Ko; Mengrui Zhang; Rui Xie; Yongkai Chen; Liyun Zhang; Rebecca James; Jeff Mumm; Richard van Rijn; Wenxuan Zhong et al.
Source: check_circle
Crossref

Modulating β Arrestin-2 Recruitment at the δ- and μ-Opioid Receptors

2020-07-23 | Preprint
Contributors: Krishna Sharma; Robert Cassell; HongYu Su; Arryn Blaine; Benjamin Cummins; Kendall Mores; David Johnson; Richard van Rijn; Ryan Altman
Source: check_circle
Crossref

G protein‐biased kratom‐alkaloids and synthetic carfentanil‐amide opioids as potential treatments for alcohol use disorder

British Journal of Pharmacology
2020-04 | Journal article
Contributors: Anna M. Gutridge; Meridith T. Robins; Robert J. Cassell; Rajendra Uprety; Kendall L. Mores; Mee Jung Ko; Gavril W. Pasternak; Susruta Majumdar; Richard M. van Rijn
Source: check_circle
Crossref

The Meta-Position of Phe4 in Leu-Enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors

Molecules
2019-12-12 | Journal article
Contributors: Robert J. Cassell; Krishna K. Sharma; Hongyu Su; Benjamin R. Cummins; Haoyue Cui; Kendall L. Mores; Arryn T. Blaine; Ryan A. Altman; Richard M. van Rijn
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells

Journal of the American Chemical Society
2019-10-30 | Journal article
Contributors: Bo Cai; Dongwook Kim; Saeed Akhand; Yixing Sun; Robert J. Cassell; Aktan Alpsoy; Emily C. Dykhuizen; Richard M. Van Rijn; Michael K. Wendt; Casey J. Krusemark
Source: check_circle
Crossref

Arrestin recruitment and signaling by G protein-coupled receptor heteromers

Neuropharmacology
2019-07 | Journal article
Contributors: Kendall L. Mores; Robert J. Cassell; Richard M. van Rijn
Source: check_circle
Crossref

A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists.

Frontiers in pharmacology
2019-04-17 | Journal article
Source: Self-asserted source
Richard van Rijn

Rubiscolins are naturally occurring G protein-biased delta opioid receptor peptides

European Neuropsychopharmacology
2019-03 | Journal article
Contributors: Robert J. Cassell; Kendall L. Mores; Breanna L. Zerfas; Amr H. Mahmoud; Markus A. Lill; Darci J. Trader; Richard M. van Rijn
Source: check_circle
Crossref

Commonly Used Anesthesia/Euthanasia Methods for Brain Collection Differentially Impact MAPK Activity in Male and Female C57BL/6 Mice.

Frontiers in cellular neuroscience
2019-03-28 | Journal article
Source: Self-asserted source
Richard van Rijn

Repeated Use of the Psychoactive Substance Ethylphenidate Impacts Neurochemistry and Reward Learning in Adolescent Male and Female Mice.

Frontiers in neuroscience
2019-02 | Journal article
Contributors: Robins MT; Blaine AT; Ha JE; Brewster AL; van Rijn RM
Source: Self-asserted source
Richard van Rijn via Europe PubMed Central

A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery

Scientific Reports
2019-02-20 | Journal article
Contributors: Mee Jung Ko; Logan C. Ganzen; Emre Coskun; Arbaaz A. Mukadam; Yuk Fai Leung; Richard M. van Rijn
Source: check_circle
Crossref

Optimization of a 1,3,4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain

European Journal of Medicinal Chemistry
2019-01 | Journal article
Contributors: Jatinder Kaur; Monica Soto-Velasquez; Zhong Ding; Ahmadreza Ghanbarpour; Markus A. Lill; Richard M. van Rijn; Val J. Watts; Daniel P. Flaherty
Source: check_circle
Crossref

Behavioral Characterization of β-Arrestin 1 Knockout Mice in Anxiety-Like and Alcohol Behaviors.

Frontiers in behavioral neuroscience
2018 | Journal article
Contributors: Robins MT; Chiang T; Berry JN; Ko MJ; Ha JE; van Rijn RM
Source: Self-asserted source
Richard van Rijn via Europe PubMed Central

Critical Role for Gi/o-Protein Activity in the Dorsal Striatum in the Reduction of Voluntary Alcohol Intake in C57Bl/6 Mice.

Frontiers in psychiatry
2018 | Journal article
Contributors: Robins MT; Chiang T; Mores KL; Alongkronrusmee D; van Rijn RM
Source: Self-asserted source
Richard van Rijn via Europe PubMed Central

An integrated perspective on diabetic, alcoholic, and drug-induced neuropathy, etiology, and treatment in the US.

2017 | Journal article
Contributors: Zeng L; Alongkronrusmee D; van Rijn RM
Source: Self-asserted source
Richard van Rijn via Europe PubMed Central

Functional histamine H3 and adenosine A2A receptor heteromers in recombinant cells and rat striatum.

Pharmacological research
2017-12 | Journal article
Contributors: Márquez-Gómez R; Robins MT; Gutiérrez-Rodelo C; Arias JM; Olivares-Reyes JA; van Rijn RM; Arias-Montaño JA
Source: Self-asserted source
Richard van Rijn via Europe PubMed Central

Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties

Science Signaling
2017-02-21 | Journal article
Contributors: Tarsis F. Brust; Doungkamol Alongkronrusmee; Monica Soto-Velasquez; Tanya A. Baldwin; Zhishi Ye; Mingji Dai; Carmen W. Dessauer; Richard M. van Rijn; Val J. Watts
Source: check_circle
Crossref

β-Arrestin 2 dependence of δ opioid receptor agonists is correlated with alcohol intake

British Journal of Pharmacology
2016 | Journal article
EID:

2-s2.0-84953350870

Contributors: Chiang, T.; Sansuk, K.; Van Rijn, R.M.
Source: Self-asserted source
Richard van Rijn via Scopus - Elsevier

Adolescent intake of caffeinated energy drinks does not affect adult alcohol consumption in C57BL/6 and BALB/c mice

Alcohol
2016-08 | Journal article
Contributors: Meridith T. Robins; Julia N. DeFriel; Richard M. van Rijn
Source: check_circle
Crossref

Involvement of delta opioid receptors in alcohol withdrawal-induced mechanical allodynia in male C57BL/6 mice.

2016-08 | Journal article
Contributors: Alongkronrusmee D; Chiang T; van Rijn RM
Source: Self-asserted source
Richard van Rijn via Europe PubMed Central

β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment.

2016-07 | Journal article
Contributors: Yang S; Ben-Shalom R; Ahn M; Liptak AT; van Rijn RM; Whistler JL; Bender KJ
Source: Self-asserted source
Richard van Rijn via Europe PubMed Central

Unique Behavioral and Neurochemical Effects Induced by Repeated Adolescent Consumption of Caffeine-Mixed Alcohol in C57BL/6 Mice

PLOS ONE
2016-07-05 | Journal article
Contributors: Meridith T. Robins; James Edgar McCutcheon; Julie Lu; Richard M. van Rijn
Source: check_circle
Crossref

Delta Opioid Pharmacology in Relation to Alcohol Behaviors.

2016-06 | Journal article
Contributors: Alongkronrusmee D; Chiang T; van Rijn RM
Source: Self-asserted source
Richard van Rijn via Europe PubMed Central

A FLIPR assay for evaluating agonists and antagonists of GPCR heterodimers

Methods in Molecular Biology
2013 | Book
EID:

2-s2.0-84877043027

Contributors: Harvey, J.H.; Van Rijn, R.M.; Whistler, J.L.
Source: Self-asserted source
Richard van Rijn via Scopus - Elsevier

Anti-Analgesic Effect of the Mu/Delta Opioid Receptor Heteromer Revealed by Ligand-Biased Antagonism

PLoS ONE
2013 | Journal article
EID:

2-s2.0-84875009844

Contributors: Milan-Lobo, L.; Enquist, J.; van Rijn, R.M.; Whistler, J.L.
Source: Self-asserted source
Richard van Rijn via Scopus - Elsevier

Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling

Journal of Pharmacology and Experimental Therapeutics
2013 | Journal article
EID:

2-s2.0-84871686505

Contributors: Van Rijn, R.M.; Harvey, J.H.; Brissett, D.I.; DeFriel, J.N.; Whistler, J.L.
Source: Self-asserted source
Richard van Rijn via Scopus - Elsevier

Pharmacological traits of delta opioid receptors: Pitfalls or opportunities?

Psychopharmacology
2013 | Journal article
EID:

2-s2.0-84876918645

Contributors: Van Rijn, R.M.; Defriel, J.N.; Whistler, J.L.
Source: Self-asserted source
Richard van Rijn via Scopus - Elsevier

Contribution of mu and delta opioid receptors to the pharmacological profile of kappa opioid receptor subtypes.

European journal of pain (London, England)
2012 | Journal article
EID:

2-s2.0-84874970262

Contributors: Brissett, D.I.; Whistler, J.L.; van Rijn, R.M.
Source: Self-asserted source
Richard van Rijn via Scopus - Elsevier

Distinctive modulation of ethanol place preference by delta opioid receptor-selective agonists

Drug and Alcohol Dependence
2012 | Journal article
EID:

2-s2.0-84858446783

Contributors: van Rijn, R.M.; Brissett, D.I.; Whistler, J.L.
Source: Self-asserted source
Richard van Rijn via Scopus - Elsevier

Emergence of functional spinal delta opioid receptors after chronic ethanol exposure

Biological Psychiatry
2012 | Journal article
EID:

2-s2.0-84855433635

Contributors: Van Rijn, R.M.; Brissett, D.I.; Whistler, J.L.
Source: Self-asserted source
Richard van Rijn via Scopus - Elsevier

Dual efficacy of delta opioid receptor-selective ligands for ethanol drinking and anxiety

Journal of Pharmacology and Experimental Therapeutics
2010 | Journal article
EID:

2-s2.0-77957224441

Contributors: Van Rijn, R.M.; Brissett, D.I.; Whistler, J.L.
Source: Self-asserted source
Richard van Rijn via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (29 reviews for 14 publications/grants)

Review activity for Analytical chemistry. (1)
Review activity for Archives of pharmacal research. (1)
Review activity for Archives of toxicology. (1)
Review activity for Biochemistry. (1)
Review activity for CNS drugs. (1)
Review activity for Journal of medicinal chemistry. (9)
Review activity for Molecular pharmaceutics. (1)
Review activity for Molecular psychiatry. (1)
Review activity for Nature communications (3)
Review activity for Pharmacology, biochemistry and behavior. (2)
Review activity for PloS one. (2)
Review activity for Psychopharmacologia. (4)
Review activity for Signal transduction and targeted therapy. (1)
Review activity for UK Research and Innovation (1)