Personal information

immunity, cancer, Innate lymphoid cells, Lymphocytes, NLRP3
France

Activities

Employment (3)

INSERM U1231: Dijon, FR

2016-09-01 to present | post-doctoral fellow (lipide nutrition cancer)
Employment
Source: Self-asserted source
melanie Bruchard

Amsterdam UMC Locatie AMC: Amsterdam, North Holland, NL

2014-02-01 to 2016-03-31 | post-doctoral fellow (cellular biology and histology)
Employment
Source: Self-asserted source
melanie Bruchard

INSERM U866: Dijon, FR

2009-09-01 to 2013-12-31
Employment
Source: Self-asserted source
melanie Bruchard

Education and qualifications (1)

Université de Bourgogne: Dijon, Bourgogne, FR

2009-09-01 to 2013-10-17 | PhD
Education
Source: Self-asserted source
melanie Bruchard

Professional activities (2)

Ligue Contre le Cancer: Dijon, Bourgogne, FR

2021-09 | Prix du centennaire
Distinction
Source: Self-asserted source
melanie Bruchard

Institut Necker Fondation Tourre : Paris, FR

2021
Distinction
Source: Self-asserted source
melanie Bruchard

Funding (1)

study of ILC3 in gut cancer

2014-02 to 2016-02 | Salary award
EMBO (heidelberg, DE)
GRANT_NUMBER:

ALTF 786-2013

Source: Self-asserted source
melanie Bruchard

Works (29)

Role of Cytokines and Chemokines in Angiogenesis in a Tumor Context

Cancers
2022-05 | Journal article | Author
Contributors: Mannon GEINDREAU; melanie Bruchard; Frederique VEGRAN
Source: check_circle
Multidisciplinary Digital Publishing Institute

ILC2s in cancer: context matters

Nature Immunology
2021 | Journal article
EID:

2-s2.0-85107670925

Part of ISSN: 15292916 15292908
Contributors: Bruchard, M.; Ghiringhelli, F.
Source: Self-asserted source
melanie Bruchard via Scopus - Elsevier

Modulation of CD4 T cell response according to tumor cytokine microenvironment

Cancers
2021 | Journal article
EID:

2-s2.0-85099681937

Part of ISSN: 20726694
Contributors: Accogli, T.; Bruchard, M.; Végran, F.
Source: Self-asserted source
melanie Bruchard via Scopus - Elsevier

The tumor microenvironment impairs Th1 IFNg secretion through alternative splicing modifications of Irf1 Pre-mRNA

Cancer Immunology Research
2021 | Journal article
EID:

2-s2.0-85102184120

Part of ISSN: 23266074 23266066
Contributors: Bernard, A.; Hibos, C.; Richard, C.; Viltard, E.; Chevrier, S.; Lemoine, S.; Meliń, J.; Humblin, E.; Mary, R.; Accoglí, T. et al.
Source: Self-asserted source
melanie Bruchard via Scopus - Elsevier

Vascular Endothelial Growth Factor, a Key Modulator of the Anti-Tumor Immune Response

International Journal of Molecular Sciences
2021-05 | Journal article | Author
Contributors: Mannon GEINDREAU; François Ghiringhelli; melanie Bruchard
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs.

Nature communications
2020-04-27 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Deciphering the Roles of Innate Lymphoid Cells in Cancer.

Frontiers in Immunology
2019-04-03 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Regulation of T cell antitumor immune response by tumor induced metabolic stress.

Cell stress
2018-11-27 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens.

Frontiers in immunology
2018-01-01 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates.

Cell reports
2017-02-01 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs.

Nature immunology
2016-04-25 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Erratum : The receptor NLRP3 is a transcriptional regulator of T<inf>H</inf>2 differentiation (Nat. Immunol. (2015), 16, (859-870))

Nature Immunology
2015 | Journal article
EID:

2-s2.0-84947800817

Part of ISSN: 15292916 15292908
Contributors: Bruchard, M.; Rebé, C.; Derangère, V.; Togbé, D.; Ryffel, B.; Boidot, R.; Humblin, E.; Hamman, A.; Chalmin, F.; Berger, H. et al.
Source: Self-asserted source
melanie Bruchard via Scopus - Elsevier

Transcriptome analysis of TH2 CD4(+) T cells differentiated from wild-type and NLRP3KO mice.

Genomics data
2015-07-09 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.

Nature immunology
2015-06-22 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells.

Cell death and differentiation
2014-08-15 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells.

Nature immunology
2014-06-29 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

[Impact of chemotherapies on immunosuppression and discovery of new therapeutic targets].

Bulletin du cancer
2014-06-01 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

[Tumor microenvironment: regulatory cells and immunosuppressive cytokines].

Medecine sciences : M/S
2014-04-01 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Bleomycin exerts ambivalent antitumor immune effect by triggering both immunogenic cell death and proliferation of regulatory T cells.

PloS one
2013-06-07 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth.

Cancer research
2013-04-25 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Immune effects of 5-fluorouracil: Ambivalence matters.

Oncoimmunology
2013-03-01 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.

Nature medicine
2012-12-02 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Production of adenosine by ectonucleotidases: a key factor in tumor immunoescape.

Journal of biomedicine & biotechnology
2012-10-14 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth.

The Journal of investigative dermatology
2012-09-06 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression.

Immunity
2012-03-08 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Erratum: 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity (Cancer Research (2010) 70, (3052-3061) DOI:10.1158/0008-5472.CAN-09-3690)

Cancer Research
2010 | Journal article
EID:

2-s2.0-77953156048

Part of ISSN: 15387445 00085472
Contributors: Vincent, J.; Mignot, G.; Chalmin, F.; Ladoire, S.; Bruchard, M.; Chevriaux, A.; Martin, F.; Apetoh, L.; Rébé, C.; Ghiringhelli, F.
Source: Self-asserted source
melanie Bruchard via Scopus - Elsevier

5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity.

Cancer research
2010-04-13 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy.

Breast cancer research and treatment
2010-03-13 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells.

The Journal of clinical investigation
2010-01-19 | Journal article
Source: Self-asserted source
melanie Bruchard
grade
Preferred source (of 2)‎

Peer review (5 reviews for 4 publications/grants)

Review activity for Communications biology. (1)
Review activity for Journal for immunotherapy of cancer. (1)
Review activity for Journal of cancer research and clinical oncology. (1)
Review activity for npj precision oncology. (2)