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Loop profile: 1198945

Keywords

Bioinformatics, Protein sequence analysis, Protein evolution, Toxin-Antitotoxin, Host-pathogen

Activities

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Employment (2)

M.S. Ramaiah University of Applied Sciences: Bangalore, IN

2021-11-15 to 2023-12-31 | Associate Professor (School of Biotechnology)
Employment
Source: Self-asserted source
Sankaran Sandhya

Indian Institute of Science: Bengaluru, Karnataka, IN

2009-11-14 to 2021-11-12 | Post-doctoral fellow (Molecular Biophysics Unit)
Employment
Source: Self-asserted source
Sankaran Sandhya

Education and qualifications (4)

Indian Institute of Science: Bangalore, Karnataka, IN

2014-11-14 to 2021-11-12 | Post-doctoral fellow (Molecular Biophysics Unit)
Qualification
Source: Self-asserted source
Sankaran Sandhya

Indian Institute of Science: Bangalore, Karnataka, IN

2011-08 to 2014-08 | DST-Women Scientist A /Post-doctoral fellow (Department of Biochemistry)
Qualification
Source: Self-asserted source
Sankaran Sandhya

Indian Institute of Science: Bangalore, Karnataka, IN

2009-11 to 2011-08 | Post-doctoral fellow (Molecular Biophysics Unit)
Education
Source: Self-asserted source
Sankaran Sandhya

National Centre for Biological Sciences: Bangalore, Karnataka, IN

2003-08 to 2009-03 | Ph.D student
Qualification
Source: Self-asserted source
Sankaran Sandhya

Works (24)

Rewards of divergence in sequences, 3-D structures and dynamics of yeast and human spliceosome SF3b complexes

Current Research in Structural Biology
2021 | Journal article
DOI: 10.1016/j.crstbi.2021.05.003
Contributors: Arangasamy Yazhini; Sankaran Sandhya; Narayanaswamy Srinivasan
Source: check_circle
Crossref

Artificial protein sequences enable recognition of vicinal and distant protein functional relationships

Proteins: Structure, Function, and Bioinformatics
2020-12 | Journal article
DOI: 10.1002/prot.25986
Contributors: Gayatri Kumar; Narayanaswamy Srinivasan; Sankaran Sandhya
Source: check_circle
Crossref

Molecular and Structural Basis of Cross-Reactivity in <i>M. tuberculosis</i> Toxin–Antitoxin Systems

Toxins
2020-07 | Journal article | Author
DOI: 10.3390/toxins12080481
Contributors: Himani Tandon; Akhila MELARKODE VATTEKATTE; Narayanaswamy Srinivasan; Sankaran Sandhya
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Bioinformatic and mutational studies of related toxin-antitoxin pairs in Mycobacterium tuberculosis predict and identify key functional residues.

The Journal of biological chemistry
2019-04-24 | Journal article
DOI: 10.1074/jbc.ra118.006814
PMID: 31018964
PMC: PMC6556569
Source: Self-asserted source
Sankaran Sandhya
grade
Preferred source (of 2)‎

Mycobacterium tuberculosis Rv0366c-Rv0367c encodes a non-canonical PezAT-like toxin-antitoxin pair.

Scientific reports
2019-02-04 | Journal article
DOI: 10.1038/s41598-018-37473-y
PMID: 30718534
PMC: PMC6362051
Source: Self-asserted source
Sankaran Sandhya

Domain architecture of BAF250a reveals the ARID and ARM-repeat domains with implication in function and assembly of the BAF remodeling complex.

PloS one
2018-10-11 | Journal article
DOI: 10.1371/journal.pone.0205267
PMID: 30307988
PMC: PMC6181354
Source: Self-asserted source
Sankaran Sandhya

Use of designed sequences in protein structure recognition.

Biology direct
2018-05-09 | Journal article
DOI: 10.1186/s13062-018-0209-6
PMID: 29776380
PMC: PMC5960202
Source: Self-asserted source
Sankaran Sandhya

Protein sequence design and its applications.

Current opinion in structural biology
2016-01-08 | Journal article
DOI: 10.1016/j.sbi.2015.12.004
PMID: 26773478
Source: Self-asserted source
Sankaran Sandhya

De-DUFing the DUFs: Deciphering distant evolutionary relationships of Domains of Unknown Function using sensitive homology detection methods.

Biology direct
2015-07-31 | Journal article
DOI: 10.1186/s13062-015-0069-2
PMID: 26228684
PMC: PMC4520260
Source: Self-asserted source
Sankaran Sandhya

CHEXVIS: a tool for molecular channel extraction and visualization.

BMC bioinformatics
2015-04-16 | Journal article
DOI: 10.1186/s12859-015-0545-9
PMID: 25888118
PMC: PMC4411761
Source: Self-asserted source
Sankaran Sandhya

Mapping post-translational modifications of mammalian testicular specific histone variant TH2B in tetraploid and haploid germ cells and their implications on the dynamics of nucleosome structure.

Journal of proteome research
2014-10-06 | Journal article
DOI: 10.1021/pr500597a
PMID: 25252820
Source: Self-asserted source
Sankaran Sandhya

NrichD database: sequence databases enriched with computationally designed protein-like sequences aid in remote homology detection.

Nucleic acids research
2014-09-27 | Journal article
DOI: 10.1093/nar/gku888
PMID: 25262355
PMC: PMC4384005
Source: Self-asserted source
Sankaran Sandhya

Structural Annotation of the Mycobacterium tuberculosis Proteome.

Microbiology spectrum
2014-04-01 | Journal article
DOI: 10.1128/microbiolspec.mgm2-0027-2013
PMID: 26105824
Source: Self-asserted source
Sankaran Sandhya

Filling-in void and sparse regions in protein sequence space by protein-like artificial sequences enables remarkable enhancement in remote homology detection capability.

Journal of molecular biology
2013-12-04 | Journal article
DOI: 10.1016/j.jmb.2013.11.026
PMID: 24316367
Source: Self-asserted source
Sankaran Sandhya

Improved detection of remote homologues using cascade PSI-BLAST: influence of neighbouring protein families on sequence coverage.

PloS one
2013-02-20 | Journal article
DOI: 10.1371/journal.pone.0056449
PMID: 23437136
PMC: PMC3577913
Source: Self-asserted source
Sankaran Sandhya

Cascaded walks in protein sequence space: use of artificial sequences in remote homology detection between natural proteins.

Molecular bioSystems
2012-06-13 | Journal article
DOI: 10.1039/c2mb25113b
PMID: 22692068
Source: Self-asserted source
Sankaran Sandhya

Structural annotation of Mycobacterium tuberculosis proteome.

PloS one
2011-10-31 | Journal article
DOI: 10.1371/journal.pone.0027044
PMID: 22073123
PMC: PMC3205055
Source: Self-asserted source
Sankaran Sandhya

Length variations amongst protein domain superfamilies and consequences on structure and function.

PloS one
2009-03-31 | Journal article
DOI: 10.1371/journal.pone.0004981
PMID: 19333395
PMC: PMC2659687
Source: Self-asserted source
Sankaran Sandhya

CUSP: an algorithm to distinguish structurally conserved and unconserved regions in protein domain alignments and its application in the study of large length variations.

BMC structural biology
2008-05-31 | Journal article
DOI: 10.1186/1472-6807-8-28
PMID: 18513436
PMC: PMC2423364
Source: Self-asserted source
Sankaran Sandhya

The antigen binding sites of various hCG monoclonal antibodies show homology to different domains of LH receptor.

Molecular and cellular endocrinology
2006-10-11 | Journal article
DOI: 10.1016/j.mce.2006.07.006
PMID: 17045394
Source: Self-asserted source
Sankaran Sandhya

Cascade PSI-BLAST web server: a remote homology search tool for relating protein domains.

Nucleic acids research
2006-07-01 | Journal article
DOI: 10.1093/nar/gkl157
PMID: 16844978
PMC: PMC1538780
Source: Self-asserted source
Sankaran Sandhya

Recent trends in remote homology detection: an Indian Medley.

Bioinformation
2006-02-21 | Journal article
DOI: 10.6026/97320630001094
PMID: 17597865
PMC: PMC1891658
Source: Self-asserted source
Sankaran Sandhya

Assessment of a rigorous transitive profile based search method to detect remotely similar proteins.

Journal of biomolecular structure & dynamics
2005-12-01 | Journal article
DOI: 10.1080/07391102.2005.10507066
PMID: 16218755
Source: Self-asserted source
Sankaran Sandhya

Effective detection of remote homologues by searching in sequence dataset of a protein domain fold.

FEBS letters
2003-09-01 | Journal article
DOI: 10.1016/s0014-5793(03)00929-3
PMID: 14527691
Source: Self-asserted source
Sankaran Sandhya
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