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Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers

Nature Communications
2024-03-19 | Journal article
Contributors: R. Sumanth Iyer; Sarah R. Needham; Ioannis Galdadas; Benjamin M. Davis; Selene K. Roberts; Rico C. H. Man; Laura C. Zanetti-Domingues; David T. Clarke; Gilbert O. Fruhwirth; Peter J. Parker et al.
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Crossref

Drug-resistant EGFR lung cancer mutations promote tumor growth by stabilizing interfaces in ligand-free signaling-competent EGFR oligomers

2023-07-19 | Preprint
Contributors: Marisa Martin-Fernandez; Francesco Gervasio; Daniel Rolfe; R. Sumanth Iyer; Sarah Needham; Selene Roberts; Laura Zanetti-Domingues; Benjamin Davis; David Clarke; Gilbert Fruhwirth et al.
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Crossref

Cooperation and Interplay between EGFR Signalling and Extracellular Vesicle Biogenesis in Cancer

Cells
2020-12 | Journal article | Author
Contributors: Laura Carolina Zanetti-Domingues; Scott Bonner; R. Sumanth Iyer; marisa martin-fernandez; Veronica Huber
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Multidisciplinary Digital Publishing Institute
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A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity.

Scientific reports
2017-06-15 | Journal article
Contributors: Iyer RS; Chatham L; Sleigh R; Meek DW
Source: Self-asserted source
R. Sumanth Iyer

The RNA helicase/transcriptional co-regulator, p68 (DDX5), stimulates expression of oncogenic protein kinase, Polo-like kinase-1 (PLK1), and is associated with elevated PLK1 levels in human breast cancers.

Cell cycle (Georgetown, Tex.)
2014-03-06 | Journal article
Contributors: Iyer RS; Nicol SM; Philip Quinlan; Thompson AM; Meek DW; Fuller-Pace FV
Source: Self-asserted source
R. Sumanth Iyer