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Mycobacterium, Molecular Biology, Tuberculosis
United Kingdom

Activities

Employment (4)

Newcastle University: Newcastle upon Tyne, Tyne and Wear, GB

2017-09-01 to present | Lecturer (Bioscience Institute)
Employment
Source: Self-asserted source
Alistair Brown

Durham University: Durham, Durham, GB

2015-09-01 to 2017-08-31 | Lecturer (Pharmacy)
Employment
Source: Self-asserted source
Alistair Brown

Northumbria University: Newcastle upon Tyne, Tyne and Wear, GB

2009-03-01 to 2015-08-31 | Lecturer (Applied Sciences)
Employment
Source: Self-asserted source
Alistair Brown

University of Birmingham: Birmingham, West Midlands, GB

2005-01-01 to 2009-02-28 | PDRA (Applied Sciences)
Employment
Source: Self-asserted source
Alistair Brown

Education and qualifications (1)

Newcastle University: Newcastle upon Tyne, Tyne and Wear, GB

2000-10-01 to 2004-09-30 | PhD in molecular biology and biochemistry (ICaMB)
Education
Source: Self-asserted source
Alistair Brown

Works (36)

A stereodivergent multicomponent approach for the synthesis of C–N atropisomeric peptide analogues

Chemical Science
2024 | Journal article
Contributors: Natalie J. Roper; Aaron D. G. Campbell; Paul G. Waddell; Alistair K. Brown; Kristaps Ermanis; Roly J. Armstrong
Source: check_circle
Crossref

Cryo-electron microscopy structure of the di-domain core of Mycobacterium tuberculosis polyketide synthase 13, essential for mycobacterial mycolic acid synthesis

Microbiology
2024-10-16 | Journal article
Contributors: Hannah E. Johnston; Sarah M. Batt; Alistair K. Brown; Christos G. Savva; Gurdyal S. Besra; Klaus Fütterer
Source: check_circle
Crossref

CryoEM structure of the di-domain core ofMycobacterium tuberculosispolyketide synthase 13, essential for mycobacterial mycolic acid synthesis

2024-04-28 | Preprint
Contributors: Hannah E Johnston; Sarah M Batt; Alistair K Brown; Christos G Savva; Gurdyal S Besra; Klaus Fütterer
Source: check_circle
Crossref

Identification of Substituted Amino Acid Hydrazides as Novel Anti-Tubercular Agents, Using a Scaffold Hopping Approach

Molecules
2020-05-21 | Journal article
Contributors: Alistair K. Brown; Ahmed K. B. Aljohani; Fatimah M. A. Alsalem; Joseph L. Broadhead; Jason H. Gill; Yucheng Lu; Jonathan D. Sellars
Source: check_circle
Crossref

Identification of Novel Benzoxa-[2,1,3]-diazole Substituted Amino Acid Hydrazides as Potential Anti-Tubercular Agents

Molecules
2019-02 | Journal article | Author
Contributors: Alistair Brown; Ahmed K. B. Aljohani; Jason Gill; Patrick Steel; Jonathan Sellars
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Crystal structure of Mycobacterium tuberculosis FadB2 implicated in mycobacterial β-oxidation

Acta Crystallographica Section D Structural Biology
2019-01-01 | Journal article
Contributors: Jonathan A. G. Cox; Rebecca C. Taylor; Alistair K. Brown; Samuel Attoe; Gurdyal S. Besra; Klaus Fütterer
Source: check_circle
Crossref

Shigatoxin encoding Bacteriophage ϕ24B modulates bacterial metabolism to raise antimicrobial tolerance.

2017 | Journal article
Source: Self-asserted source
Alistair Brown

Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis.

2017 | Journal article
Source: Self-asserted source
Alistair Brown

Design and synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N'-((E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) pyrrole hybrid derivatives : discovery of potent antitubercular agents effective against multidrug-resistant mycobacteria.

2016 | Journal article
Source: Self-asserted source
Alistair Brown

VapC20 of Mycobacterium tuberculosis cleaves the Sarcin--Ricin loop of 23S rRNA

Nature communications
2013 | Journal article
Source: Self-asserted source
Alistair Brown

Characterization of a $β$-hydroxybutyryl-CoA dehydrogenase from Mycobacterium tuberculosis

Microbiology
2010 | Journal article
Source: Self-asserted source
Alistair Brown

The rhodococcal cell envelope: composition, organisation and biosynthesis

Biology of Rhodococcus
2010 | Book chapter
Source: Self-asserted source
Alistair Brown

Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H 37 R v and the $β$-Ketoacyl-ACP Synthase mtFabH

PLoS One
2009 | Journal article
Source: Self-asserted source
Alistair Brown

Platensimycin activity against mycobacterial $β$-ketoacyl-ACP synthases

PLoS One
2009 | Journal article
Source: Self-asserted source
Alistair Brown

The Mycobacterium tuberculosis $β$-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue

Journal of Biological Chemistry
2009 | Journal article
Source: Self-asserted source
Alistair Brown

7 Antibiotics and New Inhibitors of the Cell Wall

2008 | Journal article
Source: Self-asserted source
Alistair Brown

Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY

Infection and immunity
2008 | Journal article
Source: Self-asserted source
Alistair Brown

Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing $β$-oxo-mycolic acid analogs and accumulation of ketones

Chemistry & biology
2008 | Journal article
Source: Self-asserted source
Alistair Brown

Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636

Microbiology
2008 | Journal article
Source: Self-asserted source
Alistair Brown

Tuberculosis: a balanced diet of lipids and carbohydrates

Biochemical Society Transactions
2008 | Journal article
Source: Self-asserted source
Alistair Brown

Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme

Bioorg Med Chem Letts
2007 | Journal article
Source: Self-asserted source
Alistair Brown

Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg 2+

BMC structural biology
2007 | Journal article
Source: Self-asserted source
Alistair Brown

Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II

Microbiology
2007 | Journal article
Source: Self-asserted source
Alistair Brown

Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex

Microbiology
2007 | Journal article
Source: Self-asserted source
Alistair Brown

Regulation of cell wall synthesis and growth

Current molecular medicine
2007 | Journal article
Source: Self-asserted source
Alistair Brown

Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA: acyl carrier protein transacylase (MCAT)

Acta Crystallographica Section F: Structural Biology and Crystallization Communications
2007 | Journal article
Source: Self-asserted source
Alistair Brown

Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library

Bioorganic & medicinal chemistry letters
2007 | Journal article
Source: Self-asserted source
Alistair Brown

The Mycobacterium tuberculosis triacylglycerol hydrolase LipY: functional role of the PE domain and immunogenicity

Infection and Immunity
2007 | Journal article
Source: Self-asserted source
Alistair Brown

X-ray crystal structure of Mycobacterium tuberculosis $β$-ketoacyl acyl carrier protein synthase II (mtKasB)

Journal of molecular biology
2007 | Journal article
Source: Self-asserted source
Alistair Brown

Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis

Bioorganic & medicinal chemistry letters
2006 | Journal article
Source: Self-asserted source
Alistair Brown

The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation

Journal of Biological Chemistry
2006 | Journal article
Source: Self-asserted source
Alistair Brown

Probing the Mechanism of the Mycobacterium tuberculosis $β$-Ketoacyl-Acyl Carrier Protein Synthase III mtFabH FACTORS INFLUENCING CATALYSIS AND SUBSTRATE SPECIFICITY

Journal of Biological Chemistry
2005 | Journal article
Source: Self-asserted source
Alistair Brown

Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum

Microbiology
2005 | Journal article
Source: Self-asserted source
Alistair Brown

Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis

Journal of Biological Chemistry
2004 | Journal article
Source: Self-asserted source
Alistair Brown

Molecular and biochemical characterisation of key enzymes involved in mycolic acid biosynthesis from Mycobacterium tuberculosis

2004 | Journal article
Source: Self-asserted source
Alistair Brown

Mycolic acid biosynthesis and enzymic characterization of the $β$-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis

Biochemical Journal
2002 | Journal article
Source: Self-asserted source
Alistair Brown

Peer review (1 review for 1 publication/grant)

Review activity for Microbiology. (1)