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Employment (5)

Masarykova univerzita: Brno, CZ

2013-03-01 to present | Assitant professor, Lab leader (Faculty of Medicine)
Employment
Source: Self-asserted source
Pavel Krejci

University of California Los Angeles: Los Angeles, CA, US

2009-10-31 to 2013-04-20 | Assistant Professor (David Geffen School of Medicine)
Employment
Source: Self-asserted source
Pavel Krejci

Cedars-Sinai Medical Center Medical Genetics Institute: Los Angeles, CA, US

2003-06-01 to 2013-04-20 | Research Scientist
Employment
Source: Self-asserted source
Pavel Krejci

Université Paul Sabatier - Complexe Scientifique de Rangueil: Toulouse, Midi-Pyrénées, FR

2003-07-01 to 2004-05-31 | Post-doctoral Researcher (INSERM U589)
Employment
Source: Self-asserted source
Pavel Krejci

Cedars-Sinai Medical Center Medical Genetics Institute: Los Angeles, CA, US

2001-02-20 to 2003-05-30 | Post-doctoral Researcher
Employment
Source: Self-asserted source
Pavel Krejci

Education and qualifications (1)

Mendel University: Brno, CZ

1997-06-01 to 2000-12-20 | PhD
Education
Source: Self-asserted source
Pavel Krejci

Works (50 of 94)

Items per page:
Page 1 of 2

Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer

Molecular Therapy - Nucleic Acids
2025-03 | Journal article | Author
DOI: 10.1016/j.omtn.2024.102405
Part of ISSN: 2162-2531
Contributors: Vladimira Zlinska; Zuzana Feketova; Aleksandra Czyrek; Julia Chudzian; Martina Lenarcic Zivkovic; Vlad-Constantin Ursachi; Pooja Dudeja; Bohumil Fafilek; Jan Rynes; Gustavo Rico-Llanos et al.
Source: Self-asserted source
Pavel Krejci

eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations

Proceedings of the National Academy of Sciences
2024-10-29 | Journal article
DOI: 10.1073/pnas.2321305121
Contributors: Barbora Valcikova; Natalia Vadovicova; Karolina Smolkova; Magdalena Zacpalova; Pavel Krejci; Shannon Lee; Jens Rauch; Walter Kolch; Alexander von Kriegsheim; Anna Dorotikova et al.
Source: check_circle
Crossref

Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy

Journal of Bone and Mineral Research
2024-10-18 | Journal article | Author
DOI: 10.1093/jbmr/zjae173
Part of ISSN: 0884-0431
Part of ISSN: 1523-4681
Contributors: Gustavo Rico-Llanos; Frantisek Spoutil; Eva Blahova; Adolf Koudelka; Michaela Prochazkova; Aleksandra Czyrek; Bohumil Fafilek; Jan Prochazka; Marcos Gonzalez Lopez; Jan Krivanek et al.
Source: Self-asserted source
Pavel Krejci

Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands

Cytokine & Growth Factor Reviews
2024-08 | Journal article
DOI: 10.1016/j.cytogfr.2024.07.002
Part of ISSN: 1359-6101
Contributors: Mateusz A. Krzyscik; Kelly Karl; Pooja Dudeja; Pavel Krejci; Kalina Hristova
Source: Self-asserted source
Pavel Krejci

Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2

Journal of Medicinal Chemistry
2024-08-08 | Journal article
DOI: 10.1021/acs.jmedchem.4c00629
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Václav Němec; Marek Remeš; Petr Beňovský; Michael C. Böck; Eliška Šranková; Jong Fu Wong; Julien Cros; Eleanor Williams; Tse, Lap Hang; David Smil et al.
Source: Self-asserted source
Pavel Krejci

Ligand bias underlies differential signaling of multiple FGFs via FGFR1

eLife
2024-04-03 | Journal article
DOI: 10.7554/eLife.88144.4
Contributors: Kelly Karl; Nuala Del Piccolo; Taylor Light; Tanaya Roy; Pooja Dudeja; Vlad-Constantin Ursachi; Bohumil Fafilek; Pavel Krejci; Kalina Hristova
Source: check_circle
Crossref

Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR

Frontiers in Cell and Developmental Biology
2023-01-16 | Journal article
DOI: 10.3389/fcell.2022.963389
Part of ISSN: 2296-634X
Contributors: Fabiana Csukasi; Michaela Bosakova; Tomas Barta; Jorge H. Martin; Jesus Arcedo; Maya Barad; Gustavo A. Rico-Llanos; Jennifer Zieba; Jose Becerra; Pavel Krejci et al.
Source: Self-asserted source
Pavel Krejci

A registry of achondroplasia: a 6-year experience from the Czechia and Slovak Republic

Orphanet Journal of Rare Diseases
2022-12 | Journal article
DOI: 10.1186/s13023-022-02374-x
Contributors: Martin Pesl; Hana Verescakova; Linda Skutkova; Jana Strenkova; Pavel Krejci
Source: check_circle
Crossref

Intervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo filamin B mouse model.

Bone research
2022-04-26 | Journal article
DOI: 10.1038/s41413-022-00200-5
PMID: 35474298
PMC: PMC9042866
Source: Self-asserted source
Pavel Krejci

LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters.

Life science alliance
2022-04-19 | Journal article
DOI: 10.26508/lsa.202201421
PMID: 35440493
PMC: PMC9018015
Source: Self-asserted source
Pavel Krejci

4-PBA Treatment Improves Bone Phenotypes in the Aga2 Mouse Model of Osteogenesis Imperfecta.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
2022-01-28 | Journal article
DOI: 10.1002/jbmr.4501
PMID: 34997935
Source: Self-asserted source
Pavel Krejci

Expanding horizons of achondroplasia treatment: current options and future developments.

Osteoarthritis and cartilage
2021-12-02 | Journal article
DOI: 10.1016/j.joca.2021.11.017
PMID: 34864168
Source: Self-asserted source
Pavel Krejci

Cilia kinases in skeletal development and homeostasis.

Developmental dynamics : an official publication of the American Association of Anatomists
2021-10-18 | Journal article
DOI: 10.1002/dvdy.426
PMID: 34582081
Source: Self-asserted source
Pavel Krejci

Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
2021-09-20 | Journal article
DOI: 10.1002/jbmr.4427
PMID: 34423857
Source: Self-asserted source
Pavel Krejci

Oncogenic FGFR Fusions Produce Centrosome and Cilia Defects by Ectopic Signaling.

Cells
2021-06-09 | Journal article
DOI: 10.3390/cells10061445
PMID: 34207779
PMC: PMC8227969
Source: Self-asserted source
Pavel Krejci

An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice.

Science translational medicine
2021-05-01 | Journal article
DOI: 10.1126/scitranslmed.aba4226
PMID: 33952673
Source: Self-asserted source
Pavel Krejci

Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia.

EBioMedicine
2020-11-23 | Journal article
DOI: 10.1016/j.ebiom.2020.103075
PMID: 33242826
PMC: PMC7695969
Source: Self-asserted source
Pavel Krejci

Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling.

EMBO molecular medicine
2020-10-14 | Journal article
DOI: 10.15252/emmm.201911739
PMID: 33200460
PMC: PMC7645380
Source: Self-asserted source
Pavel Krejci

Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signaling complex.

Cellular and molecular life sciences : CMLS
2019-12-09 | Journal article
DOI: 10.1007/s00018-019-03397-7
PMID: 31820037
Source: Self-asserted source
Pavel Krejci

Phosphoinositide 5-phosphatases SKIP and SHIP2 in ruffles, the endoplasmic reticulum and the nucleus: An update.

Advances in biological regulation
2019-10-07 | Journal article
DOI: 10.1016/j.jbior.2019.100660
PMID: 31628071
Source: Self-asserted source
Pavel Krejci

C-Type Natriuretic Peptide Analogue Therapy in Children with Achondroplasia.

The New England journal of medicine
2019-09-01 | Journal article
DOI: 10.1056/nejmc1910394
PMID: 31553847
Source: Self-asserted source
Pavel Krejci

Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase.

Proceedings of the National Academy of Sciences of the United States of America
2019-02 | Journal article
DOI: 10.1073/pnas.1800338116
PMID: 30782830
PMC: PMC6410813
Contributors: Kunova Bosakova M; Nita A; Gregor T; Varecha M; Gudernova I; Fafilek B; Barta T; Basheer N; Abraham SP; Balek L et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases.

Science signaling
2018-09 | Journal article
DOI: 10.1126/scisignal.aap8608
PMID: 30228226
Contributors: Fafilek B; Balek L; Bosakova MK; Varecha M; Nita A; Gregor T; Gudernova I; Krenova J; Ghosh S; Piskacek M et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling.

Science translational medicine
2018-09 | Journal article
DOI: 10.1126/scitranslmed.aat9356
PMID: 30232230
Contributors: Csukasi F; Duran I; Barad M; Barta T; Gudernova I; Trantirek L; Martin JH; Kuo CY; Woods J; Lee H et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Colicin FY inhibits pathogenic Yersinia enterocolitica in mice.

Scientific reports
2018-08 | Journal article
DOI: 10.1038/s41598-018-30729-7
PMID: 30115964
PMC: PMC6095899
Contributors: Bosák J; Micenková L; Hrala M; Pomorská K; Kunova Bosakova M; Krejci P; Göpfert E; Faldyna M; Šmajs D
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells.

Journal of cell science
2018-08 | Journal article
DOI: 10.1242/jcs.216408
PMID: 30012834
Contributors: Ghosh S; Scozzaro S; Ramos AR; Delcambre S; Chevalier C; Krejci P; Erneux C
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Nanodiamonds as "artificial proteins": Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals.

Biomaterials
2018-05 | Journal article
DOI: 10.1016/j.biomaterials.2018.05.030
PMID: 29879652
Contributors: Balek L; Buchtova M; Kunova Bosakova M; Varecha M; Foldynova-Trantirkova S; Gudernova I; Vesela I; Havlik J; Neburkova J; Turner S et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies.

Human molecular genetics
2018-03 | Journal article
DOI: 10.1093/hmg/ddy031
PMID: 29360984
PMC: PMC5886260
Contributors: Kunova Bosakova M; Varecha M; Hampl M; Duran I; Nita A; Buchtova M; Dosedelova H; Machat R; Xie Y; Ni Z et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Computer-assisted engineering of hyperstable fibroblast growth factor 2.

Biotechnology and bioengineering
2018-01 | Journal article
DOI: 10.1002/bit.26531
PMID: 29278409
Contributors: Dvorak P; Bednar D; Vanacek P; Balek L; Eiselleova L; Stepankova V; Sebestova E; Kunova Bosakova M; Konecna Z; Mazurenko S et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480.

Oncotarget
2017-11 | Journal article
DOI: 10.18632/oncotarget.22674
PMID: 29312610
PMC: PMC5752523
Contributors: Gudernova I; Balek L; Varecha M; Kucerova JF; Kunova Bosakova M; Fafilek B; Palusova V; Uldrijan S; Trantirek L; Krejci P
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Proteomic analyses of signalling complexes associated with receptor tyrosine kinase identify novel members of fibroblast growth factor receptor 3 interactome.

Cellular signalling
2017-10 | Journal article
DOI: 10.1016/j.cellsig.2017.10.003
PMID: 29030113
Contributors: Balek L; Nemec P; Konik P; Kunova Bosakova M; Varecha M; Gudernova I; Medalova J; Krakow D; Krejci P
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central
grade
Preferred source (of 2)‎

ARQ 087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3.

Bone
2017-08 | Journal article
DOI: 10.1016/j.bone.2017.08.016
PMID: 28826843
Contributors: Balek L; Gudernova I; Vesela I; Hampl M; Oralova V; Kunova Bosakova M; Varecha M; Nemec P; Hall T; Abbadessa G et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion.

Stem cells (Dayton, Ohio)
2017-07 | Journal article
DOI: 10.1002/stem.2660
PMID: 28631381
Contributors: Vanova T; Konecna Z; Zbonakova Z; La Venuta G; Zoufalova K; Jelinkova S; Varecha M; Rotrekl V; Krejci P; Nickel W et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Role of Primary Cilia in Odontogenesis.

Journal of dental research
2017-06 | Journal article
DOI: 10.1177/0022034517713688
PMID: 28605602
PMC: PMC5524235
Contributors: Hampl M; Cela P; Szabo-Rogers HL; Kunova Bosakova M; Dosedelova H; Krejci P; Buchtova M
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Statins do not inhibit the FGFR signaling in chondrocytes.

Osteoarthritis and cartilage
2017-06 | Journal article
DOI: 10.1016/j.joca.2017.05.014
PMID: 28583899
Contributors: Fafilek B; Hampl M; Ricankova N; Vesela I; Balek L; Kunova Bosakova M; Gudernova I; Varecha M; Buchtova M; Krejci P
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central
grade
Preferred source (of 2)‎

A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation.

Frontiers in cell and developmental biology
2017-05 | Journal article
DOI: 10.3389/fcell.2017.00047
PMID: 28523267
PMC: PMC5415574
Contributors: Bernatik O; Radaszkiewicz T; Behal M; Dave Z; Witte F; Mahl A; Cernohorsky NH; Krejci P; Stricker S; Bryja V
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

A Chaperone Complex Formed by HSP47, FKBP65, and BiP Modulates Telopeptide Lysyl Hydroxylation of Type I Procollagen.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
2017-04 | Journal article
DOI: 10.1002/jbmr.3095
PMID: 28177155
PMC: PMC5466459
Contributors: Duran I; Martin JH; Weis MA; Krejci P; Konik P; Li B; Alanay Y; Lietman C; Lee B; Eyre D et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

One reporter for in-cell activity profiling of majority of protein kinase oncogenes.

eLife
2017-02 | Journal article
DOI: 10.7554/eLife.21536
PMID: 28199182
PMC: PMC5310841
Contributors: Gudernova I; Foldynova-Trantirkova S; Ghannamova BE; Fafilek B; Varecha M; Balek L; Hruba E; Jonatova L; Jelinkova I; Kunova Bosakova M et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central
grade
Preferred source (of 2)‎

Computer-Assisted Engineering of Hyperstable Fibroblast Growth Factor 2

2017-01 | Other
DOI: 10.1101/100636
OTHER-ID:

PPR20311
Contributors: Dvorak P; Bednar D; Vanacek P; Balek L; Eiselleova L; Stepankova V; Sebestova E; Kunova Bosakova M; Konecna Z; Mazurenko S et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Proximity Labeling Reveals Molecular Determinants of FGFR4 Endosomal Transport.

Journal of proteome research
2016-09 | Journal article
DOI: 10.1021/acs.jproteome.6b00652
PMID: 27615514
Contributors: Haugsten EM; Sørensen V; Kunova Bosakova M; de Souza GA; Krejci P; Wiedlocha A; Wesche J
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

MORN5 Expression during Craniofacial Development and Its Interaction with the BMP and TGFβ Pathways.

Frontiers in physiology
2016-08 | Journal article
DOI: 10.3389/fphys.2016.00378
PMID: 27630576
PMC: PMC5005375
Contributors: Cela P; Hampl M; Fu KK; Kunova Bosakova M; Krejci P; Richman JM; Buchtova M
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome.

Human molecular genetics
2016-07 | Journal article
DOI: 10.1093/hmg/ddw240
PMID: 27466187
PMC: PMC5291234
Contributors: Paige Taylor S; Kunova Bosakova M; Varecha M; Balek L; Barta T; Trantirek L; Jelinkova I; Duran I; Vesela I; Forlenza KN et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Multikinase activity of fibroblast growth factor receptor (FGFR) inhibitors SU5402, PD173074, AZD1480, AZD4547 and BGJ398 compromises the use of small chemicals targeting FGFR catalytic activity for therapy of short-stature syndromes.

2016-01 | Journal article
DOI: 10.1093/hmg/ddv441
PMID: 26494904
Contributors: Gudernova I; Vesela I; Balek L; Buchtova M; Dosedelova H; Kunova M; Pivnicka J; Jelinkova I; Roubalova L; Kozubik A et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Fate of the molar dental lamina in the monophyodont mouse.

2015 | Journal article
DOI: 10.1371/journal.pone.0127543
PMID: 26010446
PMC: PMC4444311
Contributors: Dosedělová H; Dumková J; Lesot H; Glocová K; Kunová M; Tucker AS; Veselá I; Krejčí P; Tichý F; Hampl A et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Putting the brakes on chondrosarcoma.

2015-09 | Journal article
DOI: 10.18632/oncotarget.5242
PMID: 26309085
PMC: PMC4694780
Contributors: Krejci P
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

A novel variant of FGFR3 causes proportionate short stature.

2015-06 | Journal article
DOI: 10.1530/EJE-14-0945
PMID: 25777271
Contributors: Kant SG; Cervenkova I; Balek L; Trantirek L; Santen GW; de Vries MC; van Duyvenvoorde HA; van der Wielen MJ; Verkerk AJ; Uitterlinden AG et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Instability restricts signaling of multiple fibroblast growth factors.

2015-06 | Journal article
DOI: 10.1007/s00018-015-1856-8
PMID: 25854632
Contributors: Buchtova M; Chaloupkova R; Zakrzewska M; Vesela I; Cela P; Barathova J; Gudernova I; Zajickova R; Trantirek L; Martin J et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage.

2015-05 | Journal article
DOI: 10.1016/j.bbadis.2014.12.020
PMID: 25558817
Contributors: Buchtova M; Oralova V; Aklian A; Masek J; Vesela I; Ouyang Z; Obadalova T; Konecna Z; Spoustova T; Pospisilova T et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

HSP47 and FKBP65 cooperate in the synthesis of type I procollagen.

2015-04 | Journal article
DOI: 10.1093/hmg/ddu608
PMID: 25510505
Contributors: Duran I; Nevarez L; Sarukhanov A; Wu S; Lee K; Krejci P; Weis M; Eyre D; Krakow D; Cohn DH
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central

Neutral endopeptidase-resistant C-type natriuretic peptide variant represents a new therapeutic approach for treatment of fibroblast growth factor receptor 3-related dwarfism.

2015-04 | Journal article
DOI: 10.1124/jpet.114.218560
PMID: 25650377
Contributors: Wendt DJ; Dvorak-Ewell M; Bullens S; Lorget F; Bell SM; Peng J; Castillo S; Aoyagi-Scharber M; O'Neill CA; Krejci P et al.
Source: Self-asserted source
Pavel Krejci via Europe PubMed Central
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