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Biography

Bokai Zhu, Ph.D.
Assistant Professor of Medicine
Aging Institute of UPMC
Division of Endocrinology and Metabolism
Department of Medicine
University of Pittsburgh School of Medicine

Activities

Employment (1)

University of Pittsburgh: Pittsburgh, PA, US

2018-09-01 to present | Assistant Professor (Medicine)
Employment
Source: Self-asserted source
Bokai Zhu

Professional activities (3)

Society for Research on Biological Rhythms: Evanston, Illinois, US

Membership
Source: Self-asserted source
Bokai Zhu

American Society for Cell Biology: Bethesda, Maryland, US

Membership
Source: Self-asserted source
Bokai Zhu

American Diabetes Association: Alexandria, VA, US

Membership
Source: Self-asserted source
Bokai Zhu

Funding (4)

Ultradian to circadian transcriptome re-wiring underlies liver aging

2022-09-15 to 2024-05-31 | Grant
National Institute on Aging (Baltimore, US)
GRANT_NUMBER: R21AG071893
Source: Self-asserted source
Bokai Zhu via DimensionsWizard

Decoding the regulation and functions of mammalian 12h-clock

2020-09-30 to 2025-05-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: DP2GM140924
Source: Self-asserted source
Bokai Zhu via DimensionsWizard

Bolstering the hepatic 12h clock to protect against non-alcoholic fatty liver disease

2018-01-01 to 2021-12-31 | Grant
American Diabetes Association (Alexandria, US)
GRANT_NUMBER: 1-18-JDF-025
Source: Self-asserted source
Bokai Zhu via DimensionsWizard

EAGER: Collaborative Research: Data Science Applications In Cyberphysical Systems for Health

2017-09-15 to 2020-08-31 | Grant
Directorate for Computer & Information Science & Engineering (Alexandria, US)
GRANT_NUMBER: 1703170
Source: Self-asserted source
Bokai Zhu via DimensionsWizard

Works (50 of 71)

Items per page:
Page 1 of 2

Basic research and opportunities for translational advancement in the field of mammalian ∼12-hour ultradian chronobiology

Frontiers in Physiology
2024-11-20 | Journal article
Part of ISSN: 1664-042X
Contributors: William Dion; Bokai Zhu
Source: Self-asserted source
Bokai Zhu

A TBK1-independent primordial function of STING in lysosomal biogenesis

Molecular Cell
2024-09 | Journal article
Part of ISSN: 1097-2765
Contributors: Bo Lv; William A. Dion; Haoxiang Yang; Jinrui Xun; Do-Hyung Kim; Bokai Zhu; Jay Xiaojun Tan
Source: Self-asserted source
Bokai Zhu

Epigenetic regulation of global proteostasis dynamics by RBBP5 ensures mammalian organismal health

2024-09-13 | Preprint | Author
Contributors: Syeda Kubra; Michelle Sun; William Dion; Ahmet Catak; Hannah Luong; Haokun Wang; Yinghong Pan; Jia-Jun Liu; Aishwarya Ponna; Ian Sipula et al.
Source: Self-asserted source
Bokai Zhu

Evidence for ~12-h ultradian gene programs in humans

npj Biological Timing and Sleep
2024-08-09 | Journal article
Part of ISSN: 2948-281X
Contributors: Bokai Zhu; Silvia Liu; Natalie L. David; William Dion; Nandini K. Doshi; Lauren B. Siegel; Tânia Amorim; Rosemary E. Andrews; G. V. Naveen Kumar; Hanwen Li et al.
Source: Self-asserted source
Bokai Zhu

Methionine as a regulator of bone remodeling with fasting

JCI Insight
2024-06-24 | Journal article
Contributors: Tânia Amorim; Naveen G.V. Kumar; Natalie L. David; William Dion; Trishya Pagadala; Nandini K. Doshi; Bokai Zhu; Andrey Parkhitko; Matthew L. Steinhauser; Pouneh K. Fazeli
Source: check_circle
Crossref

Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids

Biomolecules
2024-05-21 | Journal article
Contributors: Bokai Zhu; Xiaoyang Zhu; Michael Borland; Douglas Ralph; Christopher Chiaro; Kristopher Krausz; James Ntambi; Adam Glick; Andrew Patterson; Gary Perdew et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Epigenetically active chromatin in neonatal iWAT reveals GABPα as a potential regulator of beige adipogenesis

Frontiers in Endocrinology
2024-05-03 | Journal article
Part of ISSN: 1664-2392
Contributors: Raja Gopal Reddy Mooli; Bokai Zhu; Saifur R. Khan; Veerababu Nagati; Kulandaimanuvel Antony Michealraj; Michael J. Jurczak; Sadeesh K. Ramakrishnan
Source: Self-asserted source
Bokai Zhu

Nuclear speckle rejuvenation alleviates proteinopathies at the expense of YAP1

2024-04-21 | Preprint | Author
Contributors: William Dion; Yuren Tao; Maci Chambers; Shanshan Zhao; Riley K Arbuckle; Michelle Sun; Syeda Kubra; Yuhang Nie; Megan Ye; Mads B Larsen et al.
Source: Self-asserted source
Bokai Zhu

LEF1 isoforms regulate cellular senescence and aging

Aging Cell
2023-11-13 | Journal article | Author
Part of ISSN: 1474-9718
Part of ISSN: 1474-9726
Contributors: Minxue Jia; Khaled Sayed; Maria G. Kapetanaki; William Dion; Lorena Rosas; Saad Irfan; Eleanor Valenzi; Ana L. Mora; Robert A. Lafyatis; Mauricio Rojas et al.
Source: Self-asserted source
Bokai Zhu

LEF1 isoforms regulate cellular senescence and aging

2023-07-21 | Preprint | Author
Contributors: Minxue Jia; Khaled Sayed; Maria G. Kapetanaki; William Dion; Lorena Rosas; Saad Irfan; Eleanor Valenzi; Ana L. Mora; Robert A. Lafyatis; Mauricio Rojas et al.
Source: Self-asserted source
Bokai Zhu

Preservation of ∼12-h ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock

Frontiers in Physiology
2023-05-30 | Journal article
Part of ISSN: 1664-042X
Contributors: Bokai Zhu; Silvia Liu
Source: Self-asserted source
Bokai Zhu

TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer

Proceedings of the National Academy of Sciences
2023-05-16 | Journal article
Contributors: Ramesh Singh; Huan Meng; Tao Shen; Lance Edward V. Lumahan; Steven Nguyen; Hong Shen; Subhamoy Dasgupta; Li Qin; Dileep Karri; Bokai Zhu et al.
Source: check_circle
Crossref

Evidence for conservation of primordial ∼12-hour ultradian gene programs in humans under free-living conditions

2023-05-02 | Preprint
Contributors: Bokai Zhu; Silvia Liu; Natalie L. David; William Dion; Nandini K Doshi; Lauren B. Siegel; Tânia Amorim; Rosemary E. Andrews; GV Naveen Kumar; Hanwen Li et al.
Source: check_circle
Crossref

Preservation of ∼12-hour ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock

2023-05-02 | Preprint
Contributors: Bokai Zhu; Silvia Liu
Source: check_circle
Crossref

Beyond circadian rhythms: emerging roles of ultradian rhythms in control of liver functions

Hepatology
2023-03 | Journal article
Contributors: Gad Asher; Bokai Zhu
Source: check_circle
Crossref

Data from Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone

2023-03-31 | Preprint
Contributors: Abhisha Sawant Dessai; Mayrel Palestino Dominguez; Uan-I Chen; John Hasper; Christian Prechtl; Cuijuan Yu; Eriko Katsuta; Tao Dai; Bokai Zhu; Sung Yun Jung et al.
Source: check_circle
Crossref

Data from Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone

2023-03-31 | Preprint
Contributors: Abhisha Sawant Dessai; Mayrel Palestino Dominguez; Uan-I Chen; John Hasper; Christian Prechtl; Cuijuan Yu; Eriko Katsuta; Tao Dai; Bokai Zhu; Sung Yun Jung et al.
Source: check_circle
Crossref

Supplementary Figures from Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone

2023-03-31 | Preprint
Contributors: Abhisha Sawant Dessai; Mayrel Palestino Dominguez; Uan-I Chen; John Hasper; Christian Prechtl; Cuijuan Yu; Eriko Katsuta; Tao Dai; Bokai Zhu; Sung Yun Jung et al.
Source: check_circle
Crossref

Supplementary Figures from Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone

2023-03-31 | Preprint
Contributors: Abhisha Sawant Dessai; Mayrel Palestino Dominguez; Uan-I Chen; John Hasper; Christian Prechtl; Cuijuan Yu; Eriko Katsuta; Tao Dai; Bokai Zhu; Sung Yun Jung et al.
Source: check_circle
Crossref

Supplementary Methods from Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone

2023-03-31 | Preprint
Contributors: Abhisha Sawant Dessai; Mayrel Palestino Dominguez; Uan-I Chen; John Hasper; Christian Prechtl; Cuijuan Yu; Eriko Katsuta; Tao Dai; Bokai Zhu; Sung Yun Jung et al.
Source: check_circle
Crossref

Supplementary Methods from Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone

2023-03-31 | Preprint
Contributors: Abhisha Sawant Dessai; Mayrel Palestino Dominguez; Uan-I Chen; John Hasper; Christian Prechtl; Cuijuan Yu; Eriko Katsuta; Tao Dai; Bokai Zhu; Sung Yun Jung et al.
Source: check_circle
Crossref

Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia

PLOS Biology
2023-01-24 | Journal article
Contributors: Madeline R. Scott; Gad Asher; Wei Zong; Kyle D. Ketchesin; Marianne L. Seney; George C. Tseng; Bokai Zhu; Colleen A. McClung
Source: check_circle
Crossref

Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence

Cell Reports
2022-12 | Journal article
Part of ISSN: 2211-1247
Contributors: Bokai Zhu; Tao Dai; Spencer R. Rosario; Eriko Katsuta; Abhisha Sawant Dessai; Emily J. Paterson; Aaron T. Novickis; Eduardo Cortes Gomez; Bokai Zhu; Song Liu et al.
Source: Self-asserted source
Bokai Zhu

Temporal gene expression patterns in the coral Euphyllia paradivisa reveal the complexity of biological clocks in the cnidarian-algal symbiosis

Science Advances
2022-09-16 | Journal article
Contributors: Mieka Rinsky; Eviatar Weizman; Hiba Waldman Ben-Asher; Gal Eyal; Bokai Zhu; Oren Levy
Source: check_circle
Crossref

Logic of the temporal compartmentalization of the hepatic metabolic cycle

Physiology
2022-06-06 | Journal article
Part of ISSN: 1548-9213
Part of ISSN: 1548-9221
Source: Self-asserted source
Bokai Zhu
grade
Preferred source (of 2)‎

The ultradian transcriptome of the human prefrontal cortex and abnormalities in schizophrenia

2022-05-26 | Preprint
Contributors: Madeline R. Scott; Wei Zong; Kyle D. Ketchesin; Marianne L. Seney; George C. Tseng; Bokai Zhu; Colleen A. McClung
Source: check_circle
Crossref

Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolism

Cell Reports
2022-03 | Journal article
Part of ISSN: 2211-1247
Source: Self-asserted source
Bokai Zhu
grade
Preferred source (of 2)‎

Four-dimensional nuclear speckle phase separation dynamics regulate proteostasis

Science Advances
2022-01-07 | Journal article
Part of ISSN: 2375-2548
Source: Self-asserted source
Bokai Zhu

Restoration of the molecular clock is tumor suppressive in neuroblastoma.

Nature communications
2021-06-28 | Journal article
Source: Self-asserted source
Bokai Zhu

Revealing the hidden reality of the mammalian 12-h ultradian rhythms

Cellular and Molecular Life Sciences
2021-04-15 | Journal article
Contributors: Heather Ballance; Bokai Zhu
Source: check_circle
Crossref

Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha

Communications Biology
2020-12 | Journal article
Part of ISSN: 2399-3642
Source: Self-asserted source
Bokai Zhu

XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis

Nature Communications
2020-12 | Journal article
Part of ISSN: 2041-1723
Source: Self-asserted source
Bokai Zhu

Transcriptional repression of SIRT3 potentiates mitochondrial aconitase activation to drive aggressive prostate cancer to the bone

Cancer Research
2020-10-28 | Journal article
Part of ISSN: 0008-5472
Part of ISSN: 1538-7445
Source: Self-asserted source
Bokai Zhu
grade
Preferred source (of 2)‎

Decoding the function and regulation of the mammalian 12h-clock

Journal of Molecular Cell Biology
2020-05-08 | Journal article
Part of ISSN: 1674-2788
Part of ISSN: 1759-4685
Source: Self-asserted source
Bokai Zhu
grade
Preferred source (of 2)‎

12-h clock regulation of genetic information flow by XBP1s

PLOS Biology
2020-01-14 | Journal article
Part of ISSN: 1545-7885
Source: Self-asserted source
Bokai Zhu

A novel mathematical method for disclosing oscillations in gene transcription: a comparative study

Plos One
2018-09-19 | Journal article
Source: Self-asserted source
Bokai Zhu

miR-30a remodels subcutaneous adipose tissue inflammation to improve insulin sensitivity in obesity

Diabetes
2018-07-12 | Journal article
Source: Self-asserted source
Bokai Zhu

Unveiling “Musica Universalis” of the Cell: A Brief History of biological 12h Rhythms

Journal of Endocrine Society
2018-06-06 | Journal article
Source: Self-asserted source
Bokai Zhu

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

Nature
2018-04-03 | Journal article
Source: Self-asserted source
Bokai Zhu

Peroxisome proliferator-activated receptor-β/δ inhibits human neuroblastoma cell tumorigenesis by inducing p53- and SOX2-mediated cell differentiation

Molecular Carcinogenesis
2017 | Journal article
EID:

2-s2.0-85017525371

Contributors: Yao, P.-L.; Chen, L.; Dobrzański, T.P.; Zhu, B.; Kang, B.-H.; Müller, R.; Gonzalez, F.J.; Peters, J.M.
Source: Self-asserted source
Bokai Zhu via Scopus - Elsevier

A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms.

Cell Metabolism
2017-06 | Journal article
Source: Self-asserted source
Bokai Zhu
grade
Preferred source (of 3)‎

A novel mathematical method for disclosing oscillations in gene transcription: a comparative study

2017-06-21 | Other
Contributors: Athanasios C. Antoulas; Bokai Zhu; Qiang Zhang; Brian York; Bert W. O'Malley; Clifford Dacso
Source: check_circle
Crossref

SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer

PLOS Genetics
2017-03-08 | Journal article
Contributors: Shruthy Suresh; David R. Beier; Deniz Durakoglugil; Xiaorong Zhou; Bokai Zhu; Sarah A. Comerford; Chao Xing; Xian-Jin Xie; Brian York; Kathryn A. O’Donnell
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Asprosin, a Fasting-Induced Glucogenic Protein Hormone

Cell
2016 | Journal article
EID:

2-s2.0-84963627618

Contributors: Romere, C.; Duerrschmid, C.; Bournat, J.; Constable, P.; Jain, M.; Xia, F.; Saha, P.K.; Del Solar, M.; Zhu, B.; York, B. et al.
Source: Self-asserted source
Bokai Zhu via Scopus - Elsevier

Genetic and environmental models of circa

Journal of Biological Rhythms
2016 | Journal article
EID:

2-s2.0-84988419088

Contributors: Fleet, T.; Stashi, E.; Zhu, B.; Rajapakshe, K.; Marcelo, K.L.; Kettner, N.M.; Gorman, B.K.; Coarfa, C.; Fu, L.; O'Malley, B.W. et al.
Source: Self-asserted source
Bokai Zhu via Scopus - Elsevier

Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology.

Journal of biological rhythm
2016-07 | Journal article
Source: Self-asserted source
Bokai Zhu
grade
Preferred source (of 2)‎

Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading

Molecular Cell
2015 | Journal article
EID:

2-s2.0-84952871218

Contributors: Zhu, B.; Gates, L.A.; Stashi, E.; Dasgupta, S.; Gonzales, N.; Dean, A.; Dacso, C.C.; York, B.; O'Malley, B.W.
Source: Self-asserted source
Bokai Zhu via Scopus - Elsevier

Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms

Oncotarget
2015 | Journal article
EID:

2-s2.0-84946866392

Contributors: Yao, P.-L.; Chen, L.P.; Dobrzanski, T.P.; Phillips, D.A.; Zhu, B.; Kang, B.-H.; Gonzalez, F.J.; Peters, J.M.
Source: Self-asserted source
Bokai Zhu via Scopus - Elsevier

SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis

Proceedings of the National Academy of Sciences of the United States of America
2015 | Journal article
EID:

2-s2.0-84946567245

Contributors: Fleet, T.; Zhang, B.; Lin, F.; Zhu, B.; Dasgupta, S.; Stashi, E.; Tackett, B.; Thevananther, S.; Rajapakshe, K.I.; Gonzales, N. et al.
Source: Self-asserted source
Bokai Zhu via Scopus - Elsevier

Activation of peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) inhibits human breast cancer cell line tumorigenicity

Molecular Cancer Therapeutics
2014 | Journal article
EID:

2-s2.0-84908143823

Contributors: Yao, P.-L.; Morales, J.L.; Zhu, B.; Kang, B.-H.; Gonzalez, F.J.; Peters, J.M.
Source: Self-asserted source
Bokai Zhu via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (2 reviews for 2 publications/grants)

Review activity for Communications biology. (1)
Review activity for eLife (1)