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arbovirus, dengue virus, Zika virus, mosquito, Aedes aegypti, innate immunity, transposon, proteomics, flavivirus
United Kingdom

Biography

Kevin is a molecular virologist and immunologist interested in how virus-host interactions in mosquito vectors and vertebrate hosts drive arbovirus transmission, pathogenesis and emergence. Their work focusses on the Orthoflavivirus genus, taking a comparative virology approach to dissect the molecular determinants of species tropism and the maintenance of a dual-host lifecycle involving vertebrate hosts and invertebrate vectors. Kevin has made contributions to our understanding of how flaviviruses cause disease in humans by altering microvascular function, immune and cellular stress responses. They also developed new bioinformatics and molecular tools to study how flaviviruses modify the biology of their vertebrate vectors to enable disease transmission. On a technical level, their work combines molecular virology, mosquito transgenesis, systems biology and machine learning approaches, with a focus on the use of high consequence pathogens up to biocontainment level 3.

Kevin graduated with a degree in Medical Microbiology and Virology from the University of Warwick in 2007. They completed their PhD in the lab of Professor Gill Elliott at Imperial College London, where they studied herpes simplex virus particle assembly. After graduating from their PhD in 2011, Kevin secured a Sir Henry Wellcome Postdoctoral Fellowship from the Wellcome Trust to develop their dengue virus research programme in the labs of Professor Ana Fernandez-Sesma (Icahn School of Medicine at Mount Sinai, New York) and Dr Andrew Davidson (University of Bristol). Kevin established their own research group at the University of Surrey in 2016 and joined The Pirbright Institute as a group leader in 2020.

Kevin is passionate about making science accessible to the public and has contributed to program development at the BBC, and engaged with industry and policy makers through the Microbiology Society and Wellcome Trust. They have championed diversity and worked towards a more inclusive research environment in the life sciences by Co-Chairing the Microbiology Society Members Panel, developing networking opportunities for disabled and neurodivergent microbiologists, raising the visibility of LGBTQ+ scientists through blogs and workshops, and increasing university attainment for minoritised ethnic groups in New York City and England.

Activities

Employment (7)

Pirbright Institute: Pirbright, Surrey, GB

2020-10 to present | Group Leader
Employment
Source: Self-asserted source
Kevin Maringer

University of Surrey: Guildford, Surrey, GB

2016-10 to 2020-08 | Lecturer in Microbiology (Microbial Sciences)
Employment
Source: Self-asserted source
Kevin Maringer

University of Bristol: Bristol, Bristol, GB

2012-03 to 2016-09 | Sir Henry Wellcome Postdoctoral Fellow (Cellular and Molecular Medicine)
Employment
Source: Self-asserted source
Kevin Maringer

Icahn School of Medicine at Mount Sinai: New York, NY, US

2012-03 to 2016-09 | Sir Henry Wellcome Postdoctoral Fellow (Department of Microbiology)
Employment
Source: Self-asserted source
Kevin Maringer

Imperial College London: London, London, GB

2011-10 to 2012-02 | Research Assistant (Section of Virology)
Employment
Source: Self-asserted source
Kevin Maringer

AstraZeneca Alderley Park: Macclesfield, Cheshire, GB

2005-09 to 2006-09 | Undergraduate Research Scientist (Molecular Toxicology)
Employment
Source: Self-asserted source
Kevin Maringer

Pfizer Global Research and Development Europe: Sandwich, Kent, GB

2002-06 to 2002-08 | Summer Student Placement
Employment
Source: Self-asserted source
Kevin Maringer

Education and qualifications (3)

University of Surrey: Guildford, Surrey, GB

2017-01 to 2018-07 | Graduate Certificate in Learning and Teaching in Higher Education
Qualification
Source: Self-asserted source
Kevin Maringer

Imperial College London: London, London, GB

2008-01 to 2011-11 | PhD (Section of Virology)
Education
Source: Self-asserted source
Kevin Maringer

University of Warwick: Coventry, Coventry, GB

2003-10 to 2007-07 | BSc (Hons) (Medical Microbiology and Virology)
Education
Source: Self-asserted source
Kevin Maringer

Professional activities (10)

Public Library of Science: San Francisco, California, US

2023 to present | Guest Editor (PLOS Pathogens)
Service
Source: Self-asserted source
Kevin Maringer

Flaviviridae UK Meeting: Ambleside, GB

2023 to present | Co-Organiser
Service
Source: Self-asserted source
Kevin Maringer

International Society for Neglected Tropical Diseases: London, GB

2020 to present | Member of the Dengue Advisory Group
Service
Source: Self-asserted source
Kevin Maringer

Federation Of European Microbiological Societies: Wrexham, Wrexham, GB

2019 to present | Handling Editor (FEMS Microbiology Letters)
Service
Source: Self-asserted source
Kevin Maringer

Microbiology Society: London, London, GB

2009 to present | Member
Membership
Source: Self-asserted source
Kevin Maringer

Microbiology Society: London, GB

2022 to 2025 | Co-Chair (Members Panel)
Service
Source: Self-asserted source
Kevin Maringer

Wellcome Trust: London, GB

2023 to 2023 | Member of Consultation Group: Defining Zika R&D Priorities and Integrated Mosquito-borne Arbovirus Strategy
Service
Source: Self-asserted source
Kevin Maringer

Recently Independent Virology Researchers: London, GB

2018 to 2020 | Network Coordinator and Annual Conference Organiser
Service
Source: Self-asserted source
Kevin Maringer

Microbiology Society: London, London, GB

2018 to 2020 | Elected Member of Policy Committee (Policy Committee)
Service
Source: Self-asserted source
Kevin Maringer

Higher Education Academy: York, North Yorkshire, GB

2018 | Fellow of the Higher Education Academy
Distinction
Source: Self-asserted source
Kevin Maringer

Funding (9)

THE ROLE OF PERIVASCULAR CELL (PERICYTE) DYSFUNCTION IN HEPATIC COMPLICATIONS OF SEVERE DENGUE

2024-01-02 to 2027-01-01 | Grant
Medical Research Council (London, GB)
GRANT_NUMBER: MR/X009203/1
Source: Self-asserted source
Kevin Maringer via DimensionsWizard

Application of molecular xenomonitoring in a lateral flow test format for multiplexed monitoring of vector-borne viruses and their animal reservoirs and insect vectors in low-income settings

2024 to 2025 | Grant
Medical Research Council (Swindon, GB)
GRANT_NUMBER:

IAA2149

Source: Self-asserted source
Kevin Maringer

Application of a field-deployable surveillance tool to enhance molecular xenomonitoring of multiple vector-borne diseases

2023 to 2024 | Grant
Medical Research Council (Swindon, GB)
GRANT_NUMBER:

IAA2143

Source: Self-asserted source
Kevin Maringer

Conserved molecular mechanisms of replication for mosquito-borne flaviviruses

2022 to 2024 | Grant
National Institutes of Health (Bethesda, US)
GRANT_NUMBER:

R21AI168716

Source: Self-asserted source
Kevin Maringer

The battle for the 5' end: dissecting a novel virus-specific translation mechanism driven by eIF3

2019-03-31 to 2022-03-30 | Grant
Biotechnology and Biological Sciences Research Council (Swindon, GB)
GRANT_NUMBER: BB/S006931/1
Source: Self-asserted source
Kevin Maringer via DimensionsWizard

A new paradigm for arbovirus emergence: how transposons modulate mosquito vector competence

2019 to 2020 | Grant
Royal Society (London, GB)
GRANT_NUMBER:

RGS\R1\191486

Source: Self-asserted source
Kevin Maringer

Molecular mechanism of IMD (NF-kB) inhibition by dengue virus in the mosquito Aedes aegypti, and implications for transmission and emergence

2018-11 to 2021-11 | Grant
Medical Research Council (Swindon, GB)
GRANT_NUMBER:

MR/R010315/1

Source: Self-asserted source
Kevin Maringer

Promoting healthy lives for the rural poor in Southeast Asia – pre-empting emerging infections through capacity-strengthening zoonotic disease research

2017-11 to 2018-05 | Grant
Global Challenges Research Fund (Swindon, GB)
Source: Self-asserted source
Kevin Maringer

Unravelling the interplay between dengue virus and the host unfolded protein response and interferon pathways.

2011-10-01 to 2015-09-30 | Grant
Wellcome Trust (London, GB)
GRANT_NUMBER:

096062/Z/11/Z

GRANT_NUMBER: 096062/Z/11/Z
Source: Self-asserted source
Kevin Maringer via DimensionsWizard

Works (27)

Multi-omics analysis reveals key immunogenic signatures induced by oncolytic Zika virus infection of paediatric brain tumour cells

2024-11-29 | Preprint
Contributors: Matt Sherwood; Thiago G. Mitsugi; Carolini Kaid; Brandon Coke; Mayana Zatz; Kevin Maringer; Oswaldo K. Okamoto; Rob M. Ewing
Source: check_circle
Crossref

A genotyping array for the globally invasive vector mosquito, Aedes albopictus.

Parasites & vectors
2024-03 | Journal article
Contributors: Cosme LV; Corley M; Johnson T; Severson DW; Yan G; Wang X; Beebe N; Maynard A; Bonizzoni M; Khorramnejad A et al.
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central

Aalbo1200: global genetic differentiation and variability of the mosquito<i>Aedes albopictus</i>

2023-11 | Preprint
Contributors: Crawford JE; Beebe N; Bonizzoni M; Caputo B; Carter BH; Chen C; Cosme LV; De Marco CM; Torre Ad; Estallo E et al.
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central

Re-evaluating the mosquito RNAi pathway’s influence on arbovirus transmission

Trends in Parasitology
2023-11 | Journal article
Contributors: Kevin Maringer
Source: check_circle
Crossref

The antiviral role of NF-κB-mediated immune responses and their antagonism by viruses in insects

Journal of General Virology
2022-05-31 | Journal article
Contributors: Yin P. Cheung; Sohyun Park; Justine Pagtalunan; Kevin Maringer
Source: check_circle
Crossref

Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif

Viruses
2022-01-27 | Journal article
Contributors: Mafalda A. Farelo; Despoina Korrou-Karava; Katrina F. Brooks; Tiffany A. Russell; Kevin Maringer; Peter U. Mayerhofer
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes

Viruses
2021-10-20 | Journal article
Contributors: Ahmed M. E. Elrefaey; Philippa Hollinghurst; Christine M. Reitmayer; Luke Alphey; Kevin Maringer
Source: check_circle
Crossref

The emerging role of perivascular cells (pericytes) in viral pathogenesis

Journal of General Virology
2021-08-26 | Journal article
Contributors: Teemapron Butsabong; Mariana Felippe; Paola Campagnolo; Kevin Maringer
Source: check_circle
Crossref

CyTOF Profiling of Zika and Dengue Virus-Infected Human Peripheral Blood Mononuclear Cells Identifies Phenotypic Signatures of Monotype Subsets and Upregulation of the Interferon-Inducible Protein CD169.

mSphere
2021-06 | Journal article
Contributors: Fenutria R; Maringer K; Potla U; Bernal-Rubio D; Evans MJ; Harris E; Rahman AH; Fernandez-Sesma A; Ramos I
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central

An Aedes aegypti-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections

Viruses
2021-06-03 | Journal article
Contributors: Christina Scherer; Jack Knowles; Vattipally B. Sreenu; Anthony C. Fredericks; Janina Fuss; Kevin Maringer; Ana Fernandez-Sesma; Andres Merits; Margus Varjak; Alain Kohl et al.
Source: check_circle
Crossref
grade
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Imd pathway-specific immune assays reveal NF-κB stimulation by viral RNA PAMPs in Aedes aegypti Aag2 cells

PLOS Neglected Tropical Diseases
2021-02-16 | Journal article
Contributors: Tiffany A. Russell; Sujatha Sunil; Andalus Ayaz; Andrew D. Davidson; Ana Fernandez-Sesma; Kevin Maringer
Source: check_circle
Crossref

A Critical Role for Perivascular Cells in Amplifying Vascular Leakage Induced by Dengue Virus Nonstructural Protein 1

mSphere
2020-08-26 | Journal article
Contributors: Yin P. Cheung; Valeria Mastrullo; Davide Maselli; Teemapron Butsabong; Paolo Madeddu; Kevin Maringer; Paola Campagnolo; John Schoggins
Source: check_circle
Crossref

Imd pathway-specific immune assays reveal NF-κB stimulation by viral RNA PAMPs inAedes aegyptiAag2 cells

2020-06-30 | Preprint
Contributors: Tiffany A. Russell; Andalus Ayaz; Andrew D. Davidson; Ana Fernandez-Sesma; Kevin Maringer
Source: check_circle
Crossref

A Critical Role for Perivascular Cells in Amplifying Viral Haemorrhage Induced by Dengue Virus Non-Structural Protein 1

2020-02-14 | Preprint
Contributors: Yin P. Cheung; Valeria Mastrullo; Davide Maselli; Teemapron Butsabong; Paolo Madeddu; Kevin Maringer; Paola Campagnolo
Source: check_circle
Crossref

Aedes aegypti (Aag2)-derived clonal mosquito cell lines reveal the effects of pre-existing persistent infection with the insect-specific bunyavirus Phasi Charoen-like virus on arbovirus replication

PLOS Neglected Tropical Diseases
2019-11-06 | Journal article
Contributors: Anthony C. Fredericks; José M. C. Ribeiro; Tiffany A. Russell; Louisa E. Wallace; Andrew D. Davidson; Ana Fernandez-Sesma; Kevin Maringer
Source: check_circle
Crossref

Aedes aegypti Piwi4 Is a Noncanonical PIWI Protein Involved in Antiviral Responses.

2017 | Journal article
Contributors: Varjak M; Maringer K; Watson M; Sreenu VB; Fredericks AC; Pondeville E; Donald CL; Sterk J; Kean J; Vazeille M et al.
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central

Characterization of the Zika virus induced small RNA response in Aedes aegypti cells.

PLoS neglected tropical diseases
2017-10 | Journal article
Contributors: Varjak M; Donald CL; Mottram TJ; Sreenu VB; Merits A; Maringer K; Schnettler E; Kohl A
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central

High-dimensional CyTOF analysis of dengue virus-infected human DCs reveals distinct viral signatures.

2017-07 | Journal article
Contributors: Hamlin RE; Rahman A; Pak TR; Maringer K; Mena I; Bernal-Rubio D; Potla U; Maestre AM; Fredericks AC; Amir ED et al.
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central
grade
Preferred source (of 2)‎

Proteomics technique opens new frontiers in mobilome research

Mobile Genetic Elements
2017-07-04 | Journal article
Contributors: Andrew D. Davidson; David A. Matthews; Kevin Maringer
Source: check_circle
Crossref

A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses.

2017-03 | Journal article
Contributors: Tripathi S; Balasubramaniam VR; Brown JA; Mena I; Grant A; Bardina SV; Maringer K; Schwarz MC; Maestre AM; Sourisseau M et al.
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central
grade
Preferred source (of 2)‎

Proteomics informed by transcriptomics for characterising active transposable elements and genome annotation in Aedes aegypti.

2017-01 | Journal article
Contributors: Maringer K; Yousuf A; Heesom KJ; Fan J; Lee D; Fernandez-Sesma A; Bessant C; Matthews DA; Davidson AD
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection.

2015-11 | Journal article
Contributors: Taguwa S; Maringer K; Li X; Bernal-Rubio D; Rauch JN; Gestwicki JE; Andino R; Fernandez-Sesma A; Frydman J
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central

Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection.

2014-12 | Journal article
Contributors: Maringer K; Fernandez-Sesma A
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central

DENV inhibits type I IFN production in infected cells by cleaving human STING.

2012 | Journal article
Contributors: Aguirre S; Maestre AM; Pagni S; Patel JR; Savage T; Gutman D; Maringer K; Bernal-Rubio D; Shabman RS; Simon V et al.
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central

A network of protein interactions around the herpes simplex virus tegument protein VP22.

2012-12 | Journal article
Contributors: Maringer K; Stylianou J; Elliott G
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central

Recruitment of herpes simplex virus type 1 immediate-early protein ICP0 to the virus particle.

2010-05 | Journal article
Contributors: Maringer K; Elliott G
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central

Virion incorporation of the herpes simplex virus type 1 tegument protein VP22 occurs via glycoprotein E-specific recruitment to the late secretory pathway.

2009-05 | Journal article
Contributors: Stylianou J; Maringer K; Cook R; Bernard E; Elliott G
Source: Self-asserted source
Kevin Maringer via Europe PubMed Central

Peer review (14 reviews for 6 publications/grants)

Review activity for Journal of general virology. (3)
Review activity for Microbiology. (1)
Review activity for Nature communications (2)
Review activity for PLoS neglected tropical diseases (1)
Review activity for PLOS pathogens : (4)
Review activity for UK Research and Innovation (3)