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Employment (3)

Rheinische Friedrich-Wilhelms-Universität Bonn: Bonn, DE

2020-06-01 to present | Assistant Professor (Clinical Chemistry and Clinical Pharmacology)
Employment
Source: Self-asserted source
Jonathan Schmid-Burgk

Broad Institute: Cambridge, MA, US

2016-09-12 to 2020-06-01
Employment
Source: Self-asserted source
Jonathan Schmid-Burgk

Rheinische Friedrich Wilhelms Universität Bonn: Bonn, Nordrhein-Westfalen, DE

2011 to 2016 | PhD student (Institute of Molecular Medicine)
Employment
Source: Self-asserted source
Jonathan Schmid-Burgk

Education and qualifications (1)

Rheinische Friedrich-Wilhelms-Universität Bonn: Bonn, NRW, DE

2016-09-05 | PhD (Molecular Biomedicine)
Qualification
Source: Self-asserted source
Jonathan Schmid-Burgk

Works (38)

Sensing endogenous RNA in living human cells using a CRISPR-activated protease

2024-07-18 | Preprint
DOI: 10.1101/2024.07.17.603943
Contributors: Katja Blumenstock; Alexander Hoch; Leo D. Hinterlang; Caroline I. Fandrey; Niels Schneberger; Gregor Hagelueken; Jonathan L. Schmid-Burgk
Source: check_circle
Crossref

Diverse enzymatic activities mediate antiviral immunity in prokaryotes

Science
2020-08-28 | Journal article
DOI: 10.1126/science.aba0372
Contributors: Linyi Gao; Han Altae-Tran; Francisca Böhning; Kira S. Makarova; Michael Segel; Jonathan L. Schmid-Burgk; Jeremy Koob; Yuri I. Wolf; Eugene V. Koonin; Feng Zhang
Source: check_circle
Crossref

LAMP-Seq: Population-Scale COVID-19 Diagnostics Using Combinatorial Barcoding

2020-04-08 | Preprint
DOI: 10.1101/2020.04.06.025635
Contributors: Jonathan L. Schmid-Burgk; Ricarda M. Schmithausen; David Li; Ronja Hollstein; Amir Ben-Shmuel; Ofir Israeli; Shay Weiss; Nir Paran; Gero Wilbring; Jana Liebing et al.
Source: check_circle
Crossref

Highly Parallel Profiling of Cas9 Variant Specificity.

Molecular cell
2020-03 | Journal article
PMID: 32187529
Contributors: Schmid-Burgk JL; Gao L; Li D; Gardner Z; Strecker J; Lash B; Zhang F
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Experimental and stochastic models of melanoma T-cell therapy define impact of subclone fitness on selection of antigen loss variants

2019-11 | Other
OTHER-ID:

PPR104094
Contributors: Glodde N; Kraut A; van den Boorn-Konijnenberg D; Vadder S; Kreten F; Schmid-Burgk JL; Aymans P; Echelmeyer K; Rumpf M; Landsberg J et al.
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Optical Pooled Screens in Human Cells.

Cell
2019-10 | Journal article
PMID: 31626775
Contributors: Feldman D; Singh A; Schmid-Burgk JL; Carlson RJ; Mezger A; Garrity AJ; Zhang F; Blainey PC
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Priming enables a NEK7-independent route of NLRP3 activation

2019-10 | Other
OTHER-ID:

PPR95498
Contributors: Schmacke NA; Gaidt MM; Szymanska I; O’Duill F; Stafford CA; Chauhan D; Fröhlich AL; Nagl D; Pinci F; Schmid-Burgk JL et al.
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

RNA-guided DNA insertion with CRISPR-associated transposases.

Science (New York, N.Y.)
2019-06 | Journal article
DOI: 10.1126/science.aax9181
PMID: 31171706
Contributors: Strecker J; Ladha A; Gardner Z; Schmid-Burgk JL; Makarova KS; Koonin EV; Zhang F
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central
grade
Preferred source (of 2)‎

Engineering of CRISPR-Cas12b for human genome editing.

Nature communications
2019-01 | Journal article
DOI: 10.1038/s41467-018-08224-4
PMID: 30670702
PMC: PMC6342934
Contributors: Strecker J; Jones S; Koopal B; Schmid-Burgk J; Zetsche B; Gao L; Makarova KS; Koonin EV; Zhang F
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Pooled optical screens in human cells

2018-08 | Other
DOI: 10.1101/383943
OTHER-ID:

PPR46472
Contributors: Feldman D; Singh A; Schmid-Burgk JL; Mezger A; Garrity AJ; Carlson RJ; Zhang F; Blainey PC
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells.

Cell reports
2017-10 | Journal article
DOI: 10.1016/j.celrep.2017.09.082
PMID: 29045828
Contributors: Heuser C; Gotot J; Piotrowski EC; Philipp MS; Courrèges CJF; Otte MS; Guo L; Schmid-Burgk JL; Hornung V; Heine A et al.
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

Cell
2017-10 | Journal article
DOI: 10.1016/j.cell.2017.09.039
PMID: 29033128
PMC: PMC5901709
Contributors: Gaidt MM; Ebert TS; Chauhan D; Ramshorn K; Pinci F; Zuber S; O'Duill F; Schmid-Burgk JL; Hoss F; Buhmann R et al.
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Disruptive non-disruptive applications of CRISPR/Cas9.

Current opinion in biotechnology
2017-06 | Journal article
DOI: 10.1016/j.copbio.2017.06.001
PMID: 28633080
Contributors: Schmid-Burgk JL
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy.

Cancer research
2017-06 | Journal article
DOI: 10.1158/0008-5472.can-17-0395
PMID: 28652246
Contributors: Reinhardt J; Landsberg J; Schmid-Burgk JL; Ramis BB; Bald T; Glodde N; Lopez-Ramos D; Young A; Ngiow SF; Nettersheim D et al.
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism.

2016 | Journal article
DOI: 10.1038/ncomms12338
PMID: 27465542
PMC: PMC4974478
Contributors: Schmid-Burgk JL; Höning K; Ebert TS; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Designer Nuclease-Mediated Generation of Knockout THP1 Cells.

2016 | Journal article
DOI: 10.1007/978-1-4939-2932-0_19
PMID: 26443227
Contributors: Schmidt T; Schmid-Burgk JL; Ebert TS; Gaidt MM; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia.

2016-10 | Journal article
PMID: 27780859
Contributors: Vercruysse T; De Bie J; Neggers J; Jacquemyn M; Vanstreels E; Schmid-Burgk JL; Hornung V; Baloglu E; Landesman Y; Senapedis W et al.
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Human Monocytes Engage an Alternative Inflammasome Pathway.

2016-04 | Journal article
DOI: 10.1016/j.immuni.2016.01.012
PMID: 27037191
Contributors: Gaidt MM; Ebert TS; Chauhan D; Schmidt T; Schmid-Burgk JL; Rapino F; Robertson AA; Cooper MA; Graf T; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation.

2016-01 | Journal article
DOI: 10.1074/jbc.C115.700492
PMID: 26553871
Contributors: Schmid-Burgk JL; Chauhan D; Schmidt T; Ebert TS; Reinhardt J; Endl E; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Ligation-independent cloning (LIC) assembly of TALEN genes.

2015 | Journal article
DOI: 10.1007/978-1-4939-1862-1_8
PMID: 25408405
Contributors: Schmid-Burgk JL; Schmidt T; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Synthesis of an arrayed sgRNA library targeting the human genome.

2015 | Journal article
DOI: 10.1038/srep14987
PMID: 26446710
PMC: PMC4597219
Contributors: Schmidt T; Schmid-Burgk JL; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

BrowserGenome.org: web-based RNA-seq data analysis and visualization.

2015-11 | Journal article
DOI: 10.1038/nmeth.3615
PMID: 26513548
Contributors: Schmid-Burgk JL; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.

2015-10 | Journal article
DOI: 10.1002/eji.201545523
PMID: 26174085
Contributors: Schmid-Burgk JL; Gaidt MM; Schmidt T; Ebert TS; Bartok E; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

2015-07 | Journal article
DOI: 10.1016/j.immuni.2015.06.015
PMID: 26187414
Contributors: Schuberth-Wagner C; Ludwig J; Bruder AK; Herzner AM; Zillinger T; Goldeck M; Schmidt T; Schmid-Burgk JL; Kerber R; Wolter S et al.
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.

2015-06 | Journal article
DOI: 10.1016/j.chom.2015.05.003
PMID: 26048138
Contributors: Wassermann R; Gulen MF; Sala C; Perin SG; Lou Y; Rybniker J; Schmid-Burgk JL; Schmidt T; Hornung V; Cole ST et al.
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

ATP-dependent effector-like functions of RIG-I-like receptors.

2015-05 | Journal article
DOI: 10.1016/j.molcel.2015.03.014
PMID: 25891073
Contributors: Yao H; Dittmann M; Peisley A; Hoffmann HH; Gilmore RH; Schmidt T; Schmid-Burgk JL; Hornung V; Rice CM; Hur S
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Control of hepatitis C virus replication in mouse liver-derived cells by MAVS-dependent production of type I and type III interferons.

2015-04 | Journal article
DOI: 10.1128/JVI.03129-14
PMID: 25609814
PMC: PMC4403415
Contributors: Anggakusuma; Frentzen A; Gürlevik E; Yuan Q; Steinmann E; Ott M; Staeheli P; Schmid-Burgk J; Schmidt T; Hornung V et al.
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I.

2015-03 | Journal article
DOI: 10.1016/j.chom.2015.01.005
PMID: 25704008
Contributors: Weber M; Sediri H; Felgenhauer U; Binzen I; Bänfer S; Jacob R; Brunotte L; García-Sastre A; Schmid-Burgk JL; Schmidt T et al.
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Hierarchical ligation-independent assembly of PCR fragments.

2014 | Journal article
DOI: 10.1007/978-1-62703-764-8_4
PMID: 24395356
Contributors: Schmid-Burgk JL; Xie Z; Benenson Y
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms.

2014-10 | Journal article
DOI: 10.4049/jimmunol.1301886
PMID: 25187660
PMC: PMC4170058
Contributors: Pelka K; Phulphagar K; Zimmermann J; Stahl R; Schmid-Burgk JL; Schmidt T; Spille JH; Labzin LI; Agrawal S; Kandimalla ER et al.
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines.

2014-10 | Journal article
DOI: 10.1101/gr.176701.114
PMID: 25186908
PMC: PMC4199374
Contributors: Schmid-Burgk JL; Schmidt T; Gaidt MM; Pelka K; Latz E; Ebert TS; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.

2014-06 | Journal article
DOI: 10.1016/j.immuni.2014.05.007
PMID: 24931123
PMC: PMC4101812
Contributors: Zhu J; Zhang Y; Ghosh A; Cuevas RA; Forero A; Dhar J; Ibsen MS; Schmid-Burgk JL; Schmidt T; Ganapathiraju MK et al.
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

2014-06 | Journal article
DOI: 10.4049/jimmunol.1400737
PMID: 24813208
Contributors: Ablasser A; Hemmerling I; Schmid-Burgk JL; Behrendt R; Roers A; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

2013-11 | Journal article
DOI: 10.1038/nature12640
PMID: 24077100
PMC: PMC4142317
Contributors: Ablasser A; Schmid-Burgk JL; Hemmerling I; Horvath GL; Schmidt T; Latz E; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes.

2013-01 | Journal article
DOI: 10.1038/nbt.2460
PMID: 23242165
PMC: PMC4142318
Contributors: Schmid-Burgk JL; Schmidt T; Kaiser V; Höning K; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

NLRP3 inflammasome activity is negatively controlled by miR-223.

2012-10 | Journal article
DOI: 10.4049/jimmunol.1201516
PMID: 22984082
Contributors: Bauernfeind F; Rieger A; Schildberg FA; Knolle PA; Schmid-Burgk JL; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Rapid hierarchical assembly of medium-size DNA cassettes.

2012-07 | Journal article
DOI: 10.1093/nar/gks236
PMID: 22422837
PMC: PMC3384347
Contributors: Schmid-Burgk JL; Xie Z; Frank S; Virreira Winter S; Mitschka S; Kolanus W; Murray A; Benenson Y
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central

Inflammasomes: current understanding and open questions.

2011-03 | Journal article
DOI: 10.1007/s00018-010-0567-4
PMID: 21072676
Contributors: Bauernfeind F; Ablasser A; Bartok E; Kim S; Schmid-Burgk J; Cavlar T; Hornung V
Source: Self-asserted source
Jonathan Schmid-Burgk via Europe PubMed Central
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