Jing Wang

Biography

Dr. Wang was trained by a molecular dynamic imaging immunologist (Wanli Liu) at the Institute of Immunology of Tsinghua University. During the PhD training, Dr. Wang developed a photoactivable antigen system for the B cell activation study, and independently established the experimental technology of photo controllable antigen based high-resolution high-speed real-time living cell imaging system to explore the molecular events in early and late stage of immune synapses formation and B cell activation. By using this technique, a series of precise molecular events such as BCR microcluster formation, maturation and immune synapses formation triggered by antigen recognition were systematically analyzed.
During the research career at Shanghai University, Dr. Wang focused on explore the regulation mechanism of different signal molecules on the formation and maturation of BCR microclusters and the function of B cells. By using the genetically modified cell lines, the primary cells from mice with autoimmune diseases or cardiovascular diseases with the combination of molecular immunology, biochemistry, cell biology and experimental methods, such as high precision live cell imaging, the applicant detailed revealed the molecular mechanisms of PTEN, Dock2, PIP2 and PIP3 function in regulating the maturation of BCR microclusters and the function of B cells in autoimmune and cardiovascular diseases. These findings provide new research ideas for the immune recognition, activation, and regulation of B cells, and help people to further understand autoimmune diseases and immune cell function in cardiovascular diseases, thus providing a new theoretical basis for the exploration of the pathogenesis of related diseases, as well as drug and vaccine development and other important work. The results of these studies have been published in high-ranking peer review journals, including Proc Natl Acad Sci U S A, Cell Rep, Theranostics and others. Due to Dr. Wang’s research achievements in B cell activation and B cell function in cardiovascular diseases, she has been invited for oral talk in AAI meeting. In addition, she has served as an associate editor for the Front Cardiovasc Med.
From 2021, Dr. Wang joined Liwu Li’s group which is internationally known for the characterization of the programming dynamics of innate leukocytes including macrophages/monocytes and neutrophils during sepsis. In this remarkable laboratory, she will explore the interactions between adaptive and innate leukocytes and understand the role of these interactions in associated diseases such as sepsis under prof. Li’s guidance.