Personal information

Other IDs

Loop profile: 408875

Keywords

lncRNA, circRNA, radiation, neurobiology, exercise, diabetes

Countries

Germany

Activities

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Employment (6)

Helmholtz Zentrum München Deutsches Forschungszentrum für Umwelt und Gesundheit: Neuherberg, Bayern, DE

2015-10-01 to present | Group Leader (Institute of Radiation Biology)
Employment
Source: Self-asserted source
Valerie O'Leary

Helmholtz Zentrum München Deutsches Forschungszentrum für Umwelt und Gesundheit: Neuherberg, Bayern, DE

2013-04-14 to 2015-09-31 | Scientist (Institute of Radiation Biology)
Employment
Source: Self-asserted source
Valerie O'Leary

Columbia University: New York, NY, US

2006-02-01 to 2007-12-31 | Senior Research Officer (Molecular Virology Division)
Employment
Source: Self-asserted source
Valerie O'Leary

Cleveland Clinic Lerner Research Institute: Cleveland, OH, US

2005-07-01 to 2006-12-01 | Research Scholar (Pathobiology)
Employment
Source: Self-asserted source
Valerie O'Leary

Trinity College Dublin: Dublin, IE

1999-08-01 to 2004-12-31 | Senior Research Fellow (Biochemistry)
Employment
Source: Self-asserted source
Valerie O'Leary

University of Manchester: Manchester, Manchester, GB

1996-08-01 to 1999-06-01 | Post-doctoral Research Fellow (Pharmacology)
Employment
Source: Self-asserted source
Valerie O'Leary

Education and qualifications (4)

University of Cambridge: Cambridge, Cambridgeshire, GB

2003-07-08 to 2003-07-31 | Diploma on Genome Sequence and Variation (Genetics)
Education
Source: Self-asserted source
Valerie O'Leary

National Institute of Mental Health: Bethesda, MD, US

2002-05-01 to 2002-06-01 | Diploma in DNA sequencing (Genetics)
Education
Source: Self-asserted source
Valerie O'Leary

University College Dublin: Dublin, IE

1991-08-01 to 1996-06-15 | PhD (Botany)
Education
Source: Self-asserted source
Valerie O'Leary

University College Dublin: Dublin, IE

1987-10-04 to 1991-05-31 | Bachelor of Science Hon. Degree (Botany)
Education
Source: Self-asserted source
Valerie O'Leary

Funding (2)

Birth Defects Study

2001 to 2006 | Contract
NIH Clinical Center (MD, MD, US)
Source: Self-asserted source
Valerie O'Leary

Funding application for a ABI 377 DNA sequencer

2000-06 to present | Grant
Health Research Board (Dublin, IE)
Source: Self-asserted source
Valerie O'Leary

Works (40)

lncRNA Biomarkers of Glioblastoma Multiforme

Biomedicines
2024-04 | Journal article | Author
DOI: 10.3390/biomedicines12050932
Contributors: Markéta Pokorná; Marie Cerna; Stergios Boussios; Saak Ovsepian; Valerie O'Leary
Source: check_circle
Multidisciplinary Digital Publishing Institute

Biomolecules to Biomarkers? U87MG Marker Evaluation on the Path towards Glioblastoma Multiforme Pathogenesis

Pharmaceutics
2024-01 | Journal article | Author
DOI: 10.3390/pharmaceutics16010123
Contributors: Markéta Pokorná; Viera Kútna; Saak Ovsepian; Radoslav Matej; Marie Cerna; Valerie O'Leary
Source: check_circle
Multidisciplinary Digital Publishing Institute

The Immunological Epigenetic Landscape of the Human Life Trajectory

Biomedicines
2022-11 | Journal article | Author
DOI: 10.3390/biomedicines10112894
Contributors: Iva Juříčková; Michael Hudec; Felix Votava; Jan Vosáhlo; Saak Victor Ovsepian; Marie Cerna; Valerie O'Leary
Source: check_circle
Multidisciplinary Digital Publishing Institute

Enhanced Extracellular Transfer of HLA-DQ Activates CD3<sup>+</sup> Lymphocytes towards Compromised Treg Induction in Celiac Disease

International Journal of Molecular Sciences
2022-05 | Journal article | Author
DOI: 10.3390/ijms23116102
Contributors: Michael Hudec; Iva Juříčková; Kamila Riegerová; Saak Ovsepian; Marie Cerna; Valerie O'Leary
Source: check_circle
Multidisciplinary Digital Publishing Institute

All-Trans Retinoic Acid Fosters the Multifarious U87MG Cell Line as a Model of Glioblastoma

Brain Sciences
2021-06 | Journal article | Author
DOI: 10.3390/brainsci11060812
Contributors: Markéta Pokorná; Michael Hudec; Iva Juříčková; Michael Vácha; Zdeňka Polívková; Viera Kútna; Jan Pala; Saak V. Ovsepian; Marie Cerna; Valerie O'Leary
Source: check_circle
Multidisciplinary Digital Publishing Institute

Unpacking Pandora From Its Box: Deciphering the Molecular Basis of the SARS-CoV-2 Coronavirus

International Journal of Molecular Sciences
2020-12 | Journal article | Author
DOI: 10.3390/ijms22010386
Contributors: Valerie O'Leary; Oliver James Dolly; Cyril Höschl; Marie Cerna; Saak Victor Ovsepian
Source: check_circle
Multidisciplinary Digital Publishing Institute

Distinctive role of KV1.1 subunit in the biology and functions of low threshold K(+) channels with implications for neurological disease.

2016-03 | Journal article
DOI: 10.1016/j.pharmthera.2016.01.005
PMID: 26825872
Contributors: Ovsepian SV; LeBerre M; Steuber V; O'Leary VB; Leibold C; Oliver Dolly J
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Internalization and retrograde axonal trafficking of tetanus toxin in motor neurons and trans-synaptic propagation at central synapses exceed those of its C-terminal-binding fragments.

2015 | Journal article
DOI: 10.1007/s00429-015-1004-0
PMID: 25665801
Contributors: Ovsepian SV; Bodeker M; O'Leary VB; Lawrence GW; Oliver Dolly J
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Neuronal activity and amyloid plaque pathology: an update.

2015 | Journal article
DOI: 10.3233/JAD-150544
PMID: 26444792
Contributors: Ovsepian SV; O'Leary VB
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Cholinergic Mechanisms in the Cerebral Cortex: Beyond Synaptic Transmission.

2015-05 | Journal article
DOI: 10.1177/1073858415588264
PMID: 26002948
Contributors: Ovsepian SV; O'Leary VB; Zaborszky L
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

PARTICLE, a Triplex-Forming Long ncRNA, Regulates Locus-Specific Methylation in Response to Low-Dose Irradiation.

2015-04 | Journal article
PMID: 25900080
Contributors: O'Leary VB; Ovsepian SV; Carrascosa LG; Buske FA; Radulovic V; Niyazi M; Moertl S; Trau M; Atkinson MJ; Anastasov N
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Disruption of myelin leads to ectopic expression of K(V)1.1 channels with abnormal conductivity of optic nerve axons in a cuprizone-induced model of demyelination.

2014 | Journal article
DOI: 10.1371/journal.pone.0087736
PMID: 24498366
PMC: PMC3912067
Contributors: Bagchi B; Al-Sabi A; Kaza S; Scholz D; O'Leary VB; Dolly JO; Ovsepian SV
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons.

2014-09 | Journal article
DOI: 10.1007/s00429-013-0583-x
PMID: 23716278
PMC: PMC4675333
Contributors: Ovsepian SV; Antyborzec I; O'Leary VB; Zaborszky L; Herms J; Oliver Dolly J
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Glucose and lipopolysaccharide regulate proatherogenic cytokine release from mononuclear cells in polycystic ovary syndrome.

2014-06 | Journal article
DOI: 10.1016/j.jri.2014.01.001
PMID: 24576416
PMC: PMC4020957
Contributors: González F; Kirwan JP; Rote NS; Minium J; O'Leary VB
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Improved lentiviral transduction of ALS motoneurons in vivo via dual targeting.

2013-11 | Journal article
DOI: 10.1021/mp400247t
PMID: 24066863
Contributors: O'Leary VB; Ovsepian SV; Bodeker M; Dolly JO
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.

2013-04 | Journal article
DOI: 10.1113/jphysiol.2012.249706
PMID: 23318870
Contributors: Ovsepian SV; Steuber V; Le Berre M; O'Hara L; O'Leary VB; Dolly JO
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects.

2012 | Journal article
DOI: 10.1186/1471-2350-13-62
PMID: 22856873
PMC: PMC3458983
Contributors: Pangilinan F; Molloy AM; Mills JL; Troendle JF; Parle-McDermott A; Signore C; O'Leary VB; Chines P; Seay JM; Geiler-Samerotte K et al.
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Innocuous full-length botulinum neurotoxin targets and promotes the expression of lentiviral vectors in central and autonomic neurons.

2011-07 | Journal article
DOI: 10.1038/gt.2011.8
PMID: 21368902
Contributors: O'Leary VB; Ovsepian SV; Raghunath A; Huo Q; Lawrence GW; Smith L; Dolly JO
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Retinol-binding protein 4 (RBP4) protein expression is increased in omental adipose tissue of severely obese patients.

2010-04 | Journal article
DOI: 10.1038/oby.2009.328
PMID: 19816414
PMC: PMC2919818
Contributors: Kelly KR; Kashyap SR; O'Leary VB; Major J; Schauer PR; Kirwan JP
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Decreased visfatin after exercise training correlates with improved glucose tolerance.

2009-06 | Journal article
DOI: 10.1249/MSS.0b013e318195bad5
PMID: 19461540
Contributors: Haus JM; Solomon TP; Marchetti CM; O'Leary VB; Brooks LM; Gonzalez F; Kirwan JP
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity.

2009-06 | Journal article
DOI: 10.1152/ajpendo.00112.2009
PMID: 19351807
PMC: PMC2692394
Contributors: Kelly KR; Brooks LM; Solomon TP; Kashyap SR; O'Leary VB; Kirwan JP
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults.

2008-05 | Journal article
DOI: 10.1152/japplphysiol.00890.2007
PMID: 18323464
PMC: PMC3860368
Contributors: Solomon TP; Sistrun SN; Krishnan RK; Del Aguila LF; Marchetti CM; O'Carroll SM; O'Leary VB; Kirwan JP
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Obese reproductive-age women exhibit a proatherogenic inflammatory response during hyperglycemia.

2007-10 | Journal article
DOI: 10.1038/oby.2007.289
PMID: 17925469
PMC: PMC3000558
Contributors: González F; Rote NS; Minium J; O'leary VB; Kirwan JP
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Enhanced adiponectin multimer ratio and skeletal muscle adiponectin receptor expression following exercise training and diet in older insulin-resistant adults.

2007-07 | Journal article
DOI: 10.1152/ajpendo.00123.2007
PMID: 17488807
Contributors: O'Leary VB; Jorett AE; Marchetti CM; Gonzalez F; Phillips SA; Ciaraldi TP; Kirwan JP
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

The 19-bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR) may decrease rather than increase risk for spina bifida in the Irish population.

2007-06 | Journal article
DOI: 10.1002/ajmg.a.31725
PMID: 17486595
Contributors: Parle-McDermott A; Pangilinan F; Mills JL; Kirke PN; Gibney ER; Troendle J; O'Leary VB; Molloy AM; Conley M; Scott JM et al.
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population.

2006-06 | Journal article
DOI: 10.1038/sj.ejhg.5201603
PMID: 16552426
Contributors: Parle-McDermott A; Kirke PN; Mills JL; Molloy AM; Cox C; O'Leary VB; Pangilinan F; Conley M; Cleary L; Brody LC et al.
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat.

2006-05 | Journal article
DOI: 10.1152/japplphysiol.01336.2005
PMID: 16373444
Contributors: O'Leary VB; Marchetti CM; Krishnan RK; Stetzer BP; Gonzalez F; Kirwan JP
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Reduced folate carrier polymorphisms and neural tube defect risk.

2006-04 | Journal article
DOI: 10.1016/j.ymgme.2005.09.024
PMID: 16343969
Contributors: O'leary VB; Pangilinan F; Cox C; Parle-McDermott A; Conley M; Molloy AM; Kirke PN; Mills JL; Brody LC; Scott JM et al.
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Screening for new MTHFR polymorphisms and NTD risk.

2005-10 | Journal article
DOI: 10.1002/ajmg.a.30846
PMID: 16145688
Contributors: O'Leary VB; Mills JL; Parle-McDermott A; Pangilinan F; Molloy AM; Cox C; Weiler A; Conley M; Kirke PN; Scott JM et al.
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association.

2005-07 | Journal article
DOI: 10.1016/j.ymgme.2005.02.003
PMID: 15979034
Contributors: O'Leary VB; Mills JL; Pangilinan F; Kirke PN; Cox C; Conley M; Weiler A; Peng K; Shane B; Scott JM et al.
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population.

2005-04 | Journal article
DOI: 10.1002/bdra.20122
PMID: 15782407
Contributors: Swanson DA; Pangilinan F; Mills JL; Kirke PN; Conley M; Weiler A; Frey T; Parle-McDermott A; O'Leary VB; Seltzer RR et al.
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae.

2005-02 | Journal article
DOI: 10.1002/ajmg.a.30354
PMID: 15633187
Contributors: Parle-McDermott A; Mills JL; Kirke PN; Cox C; Signore CC; Kirke S; Molloy AM; O'Leary VB; Pangilinan FJ; O'Herlihy C et al.
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study.

2004-06 | Journal article
DOI: 10.1136/bmj.38036.646030.EE
PMID: 15155469
PMC: PMC437144
Contributors: Kirke PN; Mills JL; Molloy AM; Brody LC; O'Leary VB; Daly L; Murray S; Conley M; Mayne PD; Smith O et al.
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects.

2003 | Journal article
DOI: 10.1007/s10038-003-0008-4
PMID: 12730722
Contributors: Parle-McDermott A; Mills JL; Kirke PN; O'Leary VB; Swanson DA; Pangilinan F; Conley M; Molloy AM; Cox C; Scott JM et al.
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Polymorphisms within the vitamin B12 dependent methylmalonyl-coA mutase are not risk factors for neural tube defects.

2003-12 | Journal article
DOI: 10.1016/j.ymgme.2003.09.009
PMID: 14654360
Contributors: Parle-McDermott A; McManus EJ; Mills JL; O'Leary VB; Pangilinan F; Cox C; Weiler A; Molloy AM; Conley M; Watson D et al.
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Analysis of the human folate receptor beta gene for an association with neural tube defects.

2003-06 | Journal article
DOI: 10.1016/S1096-7192(03)00075-1
PMID: 12809644
Contributors: O'Leary VB; Mills JL; Kirke PN; Parle-McDermott A; Swanson DA; Weiler A; Pangilinan F; Conley M; Molloy AM; Lynch M et al.
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group.

2002-11 | Journal article
DOI: 10.1086/344213
PMID: 12384833
PMC: PMC385099
Contributors: Brody LC; Conley M; Cox C; Kirke PN; McKeever MP; Mills JL; Molloy AM; O'Leary VB; Parle-McDermott A; Scott JM et al.
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

MTRR and MTHFR polymorphism: link to Down syndrome?

2002-01 | Journal article
DOI: 10.1002/ajmg.10121
PMID: 11807890
Contributors: O'Leary VB; Parle-McDermott A; Molloy AM; Kirke PN; Johnson Z; Conley M; Scott JM; Mills JL
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern.

2001-05 | Journal article
DOI: 10.1007/s004270100146
PMID: 11455443
Contributors: Hicks MS; O'Leary V; Wilkin M; Bee SE; Humphries MJ; Baron M
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Multiple roles of the Dcdc42 GTPase during wing development in Drosophila melanogaster.

2000-09 | Journal article
DOI: 10.1007/s004380000287
PMID: 11016838
Contributors: Baron M; O'Leary V; Evans DA; Hicks M; Hudson K
Source: Self-asserted source
Valerie O'Leary via Europe PubMed Central

Peer review (1 review for 1 publication/grant)

Review activity for PLoS computational biology. (1)
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