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Biography

Dr. Díaz is postdoctoral researcher in the Faculty of Medicine of the University of Granada, Spain. She finished her studies in Biology at the University of Granada in 2007. Next, she studied a Master´s Degree in Agrarian Biology and Aquaculture at the University of Granada, which she finished in 2008. Parallel she intervened in a study in fish larvae Acipenser Naccarii, specializing in techniques of oxidative stress. From 2008 to 2010, she worked at the University of Granada in different research projects related to oxidative stress. During 2011, she worked at the Consejo Superior de Invesigaciones Científicas (CSIC) on issues related to oxidative stress and the response to biotic and abiotic stress in plants. From 2012 to 2016, she did her doctorate in Intercellular Communication group at the University of Granada (Sapin), where she worked in a new model of Parkinson´s disease in the zebrafish. As a part of her predoctoral training, she past three months in the laboratory of Dr. David Rubinsztein (University of Cambridge) to learn techniques related to zebrafish. In 2016, she defended her doctoral thesis titled “Zebrafish as a model of Parkinson´s disease, evaluation of mitochondrial dysfunction and therapeutic capacity of melatonin” at the University of Granada, obtaining the maximal qualification. Her thesis deals with the evaluation of mitochondrial dysfunction in the parkinsonian zebrafish embryo and the evaluation of the therapeutic capabilities of melatonin. Her work has led to the discovery of new molecular targets of the melatonin in the Parkinson´s disease, with great interest in clinical research for this disease. In 2017 she got a one-year postdoctoral grant to evaluating a chronic parkinsonian model and the molecular mechanisms by which melatonin carries out its neuroprotective functions.
After, she worked as a postdoc in the Laboratory of Audiomotor Disorders at the Institute of Neuroscience of Castilla y León (University of Salamanca), in the group leaded for the Dr. López. Her research was focused on the study of the genetic variants and differential gene expression in an audiogenic epilepsy model. Currently, she is working at University of Granada, in the Mito Lab, which is led by the Dr. L. López. Her research is focused on the study of therapeutic potential of different drugs in models deficient in CoQ. Her research adopts a multidisciplinary viewpoint, integrating data from genomics, transciptomic, proteomic, physiology and cell biology.

Activities

Employment (9)

Universidad de Granada: Granada, Andalucía, ES

2020-02-01 to present | Investigador postdoctoral (Departamento de Fisiología)
Employment
Source: Self-asserted source
María Elena Díaz Casado

University of Salamanca: Salamanca , ES

2018-05-01 to present | Postdoctoral (Cellular Biology and Phatology)
Employment
Source: Self-asserted source
María Elena Díaz Casado

Universidad de Granada: Granada, Andalucía, ES

2019-09-18 to 2020-01-31 | Profesor sustituto interino (Departamento de Fisiología)
Employment
Source: Self-asserted source
María Elena Díaz Casado

Universidad de Granada: Granada, Andalucía, ES

2019-03-17 to 2019-09-15 | Investigador postdoctoral (Departamento de Fisiología)
Employment
Source: Self-asserted source
María Elena Díaz Casado

University of Granada: Granada, Andalucía, ES

2017-04-01 to 2018-03-31 | Postdoctoral (Physilogy)
Employment
Source: Self-asserted source
María Elena Díaz Casado

University of Granada: Granada, Andalucía, ES

2012-02-01 to 2016-01-31 | Phd student (Physiology)
Employment
Source: Self-asserted source
María Elena Díaz Casado

Estación Experimental del Zaidín (CSIC): Granada, Andalucía, ES

2010 to 2012 | Research support staff
Employment
Source: Self-asserted source
María Elena Díaz Casado

University of Granada: Granada, ES

2009 to 2010 | Research Staff (Physiology)
Employment
Source: Self-asserted source
María Elena Díaz Casado

University of Granada: Granada, ES

2008 to 2009 | Research staff (Physiology)
Employment
Source: Self-asserted source
María Elena Díaz Casado

Education and qualifications (1)

University of Granada: Granada, ES

Degree in Biology
Education
Source: Self-asserted source
María Elena Díaz Casado

Works (22)

Daily Changes in the Expression of Clock Genes in Sepsis and Their Relation with Sepsis Outcome and Urinary Excretion of 6-Sulfatoximelatonin

Shock
2019 | Journal article
EID:

2-s2.0-85071249506

Contributors: Acuña-Fernández, C.; Marín, J.S.; Díaz-Casado, M.E.; Rusanova, I.; Darias-Delbey, B.; Pérez-Guillama, L.; Florido-Ruiz, J.; Acuña-Castroviejo, D.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin

Journals of Gerontology - Series A Biological Sciences and Medical Sciences
2019 | Journal article
EID:

2-s2.0-85065885712

Contributors: Sayed, R.K.A.; Fernández-Ortiz, M.; Diaz-Casado, M.E.; Aranda-Martínez, P.; Fernández-Martínez, J.; Guerra-Librero, A.; Escames, G.; López, L.C.; Alsaadawy, R.M.; Acuña-Castroviejo, D.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Molecular tools for the characterization of seizure susceptibility in genetic rodent models of epilepsy

Epilepsy and Behavior
2019 | Journal article
EID:

2-s2.0-85074510034

Contributors: Bosque, J.R.; Gómez-Nieto, R.; Hormigo, S.; Herrero-Turrión, M.J.; Díaz-Casado, E.; Sancho, C.; López, D.E.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

The paradox of coenzyme Q10 in aging

Nutrients
2019 | Journal article
EID:

2-s2.0-85072521522

Contributors: Elena Díaz-Casado, M.; Quiles, J.L.; Barriocanal-Casado, E.; González-García, P.; Battino, M.; López, L.C.; Varela-López, A.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 <sup>R239X</sup> mice

EMBO Molecular Medicine
2019 | Journal article
EID:

2-s2.0-85057238081

Contributors: Hidalgo-Gutiérrez, A.; Barriocanal-Casado, E.; Bakkali, M.; Díaz-Casado, M.E.; Sánchez-Maldonado, L.; Romero, M.; Sayed, R.K.; Prehn, C.; Escames, G.; Duarte, J. et al.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Analysis of plasma microRNAs as predictors and biomarkers of aging and frailty in humans. Oxidative Medicine and Cellular Longevity

Oxid Med Cell Longev
2018 | Journal article
Source: Self-asserted source
María Elena Díaz Casado
grade
Preferred source (of 2)‎

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation

Journal of Pineal Research
2018 | Journal article
EID:

2-s2.0-85040258557

Contributors: Shen, Y.-Q.; Guerra-Librero, A.; Fernandez-Gil, B.I.; Florido, J.; García-López, S.; Martinez-Ruiz, L.; Mendivil-Perez, M.; Soto-Mercado, V.; Acuña-Castroviejo, D.; Ortega-Arellano, H. et al.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy

Zebrafish
2018 | Journal article
EID:

2-s2.0-85041323315

Contributors: Díaz-Casado, M.E.; Rusanova, I.; Aranda, P.; Fernández-Ortiz, M.; Sayed, R.K.A.; Fernández-Gil, B.I.; Hidalgo-Gutiérrez, A.; Escames, G.; López, L.C.; Acuña-Castroviejo, D.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes

Journals of Gerontology - Series A Biological Sciences and Medical Sciences
2018 | Journal article
EID:

2-s2.0-85054069608

Contributors: Sayed, R.K.A.; Fernández-Ortiz, M.; Diaz-Casado, M.E.; Rusanova, I.; Rahim, I.; Escames, G.; López, L.C.; Mokhtar, D.M.; Acuña-Castroviejo, D.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Melatonin, clock genes and mitochondria in sepsis

Cellular and Molecular Life Sciences
2017 | Journal article
EID:

2-s2.0-85026907993

Contributors: Acuña-Castroviejo, D.; Rahim, I.; Acuña-Fernández, C.; Fernández-Ortiz, M.; Solera-Marín, J.; Sayed, R.K.A.; Díaz-Casado, M.E.; Rusanova, I.; López, L.C.; Escames, G.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases

PLoS ONE
2017 | Journal article
EID:

2-s2.0-85027399274

Contributors: López, A.; Ortiz, F.; Doerrier, C.; Venegas, C.; Fernández-Ortiz, M.; Aranda, P.; Díaz-Casado, M.E.; Fernández-Gil, B.; Barriocanal-Casado, E.; Escames, G. et al.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network

Journal of Pineal Research
2016 | Journal article
EID:

2-s2.0-84978116690

Contributors: Díaz-Casado, M.E.; Lima, E.; García, J.A.; Doerrier, C.; Aranda, P.; Sayed, R.K.A.; Guerra-Librero, A.; Escames, G.; López, L.C.; Acuña-Castroviejo, D.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network

Mitochondrion
2016 | Journal article
EID:

2-s2.0-84959510818

Contributors: Doerrier, C.; García, J.A.; Volt, H.; Díaz-Casado, M.E.; Luna-Sánchez, M.; Fernández-Gil, B.; Escames, G.; López, L.C.; Acuña-Castroviejo, D.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Same molecule but different expression: Aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin

Journal of Pineal Research
2016 | Journal article
EID:

2-s2.0-84956884053

Contributors: Volt, H.; García, J.A.; Doerrier, C.; Díaz-Casado, M.E.; Guerra-Librero, A.; Lõpez, L.C.; Escames, G.; Tresguerres, J.A.; Acuña-Castroviejo, D.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry

Life Sciences
2015 | Journal article
EID:

2-s2.0-84920680700

Contributors: Doerrier, C.; García, J.A.; Volt, H.; Díaz-Casado, M.E.; Lima-Cabello, E.; Ortiz, F.; Luna-Sánchez, M.; Escames, G.; López, L.C.; Acuña-Castroviejo, D.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Spatial and temporal dynamics of primary and secondary metabolism in Phaseolus vulgaris challenged by Pseudomonas syringae

Physiologia Plantarum
2015 | Journal article
EID:

2-s2.0-84939419204

Contributors: Pérez-Bueno, M.L.; Pineda, M.; Díaz-Casado, E.; Barón, M.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene

EMBO Molecular Medicine
2015 | Journal article
Source: Self-asserted source
María Elena Díaz Casado
grade
Preferred source (of 2)‎

A review of the melatonin functions in zebrafish physiology

Journal of Pineal Research
2014 | Journal article
EID:

2-s2.0-84925883255

Contributors: Lima-Cabello, E.; Díaz-Casado, M.E.; Guerrero, J.A.; Otalora, B.B.; Escames, G.; Lõpez, L.C.; Reiter, R.J.; Acuña-Castroviejo, D.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Extrapineal melatonin: Sources, regulation, and potential functions

Cellular and Molecular Life Sciences
2014 | Journal article
EID:

2-s2.0-84905089096

Contributors: Acuña-Castroviejo, D.; Escames, G.; Venegas, C.; Díaz-Casado, M.E.; Lima-Cabello, E.; López, L.C.; Rosales-Corral, S.; Tan, D.-X.; Reiter, R.J.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Early gender differences in the redox status of the brain mitochondria with age: Effects of melatonin therapy

Hormone Molecular Biology and Clinical Investigation
2013 | Journal article
EID:

2-s2.0-84928650381

Contributors: Escames, G.; Díaz-Casado, M.E.; Doerrier, C.; Luna-Sánchez, M.; López, L.C.; Acuña-Castroviejo, D.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Study of the enzymatic digestive profile in three species of Mediterranean sea urchins

Aquaculture
2012 | Journal article
EID:

2-s2.0-84860446695

Contributors: Trenzado, C.E.; Hidalgo, F.; Villanueva, D.; Furné, M.; Díaz-Casado, M.E.; Merino, R.; Sanz, A.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier

Antioxidant defences in the first life phases of the sturgeon Acipenser naccarii

Aquaculture
2010 | Journal article
EID:

2-s2.0-77955771118

Contributors: Díaz, M.E.; Furné, M.; Trenzado, C.E.; García-Gallego, M.; Domezain, A.; Sanz, A.
Source: Self-asserted source
María Elena Díaz Casado via Scopus - Elsevier