Personal information

drosophila; apoptosis; debcl; Rbf1

Activities

Employment (2)

Université de Versailles Saint-Quentin-en-Yvelines: Versailles, FR

2017 to present | Professor
Employment
Source: Self-asserted source
Isabelle Guénal

Université de Versailles Saint-Quentin-en-Yvelines: Versailles, FR

1998 to 2017 | Assistant Professor
Employment
Source: Self-asserted source
Isabelle Guénal

Education and qualifications (2)

Université de Versailles Saint-Quentin-en-Yvelines: Versailles, FR

2013 to 2013 | Habilitation to supervise research (HDR)
Education
Source: Self-asserted source
Isabelle Guénal

Université Paris-Sud: Orsay, FR

1992 to 1996 | PhD in Molecular and Cellular Develomental Biology
Education
Source: Self-asserted source
Isabelle Guénal

Works (41)

DREAM a little dREAM of DRM: Model organisms and conservation of DREAM‐like complexes

BioEssays
2024-02 | Journal article
Contributors: Marion Hoareau; Aurore Rincheval‐Arnold; Sébastien Gaumer; Isabelle Guénal
Source: check_circle
Crossref

Differential adhesion during development establishes individual neural stem cell niches and shapes adult behaviour in <i>Drosophila</i>

PLoS Biology
2023 | Journal article
Contributors: Banach-Latapy, Agata; Rincheval, Vincent; Briand, David; Guenal, Isabelle; Speder, Pauline
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

Mycobacterium abscessus resists the innate cellular response by surviving cell lysis of infected phagocytes

PLoS Pathogens
2023 | Journal article
Contributors: Hamadoun Touré; Lee Ann Galindo; Marion Lagune; Simon Glatigny; Robert M Waterhouse; Isabelle Guénal; Jean-Louis Herrmann; Fabienne Girard-Misguich; Sébastien Szuplewski
Source: Self-asserted source
Isabelle Guénal via HAL
grade
Preferred source (of 2)‎

TGFβ signaling pathway is altered by HLA-B27 expression, resulting in pathogenic consequences relevant for spondyloarthritis.

2023-12-21 | Working paper
Contributors: Marc Lauraine; Maxence de Taffin de Tilques; Dganit Melamed-Kadosh; Bilade Cherqaoui; Vincent Rincheval; Erwann Prevost; Aurore Rincheval-Arnold; Eneida Cela; Arie Admon; Isabelle Guénal et al.
Source: Self-asserted source
Isabelle Guénal via HAL

PINK1 and BNIP3 mitophagy inducers have an antagonistic effect on Rbf1-induced apoptosis inDrosophila

2023-12-10 | Preprint
Contributors: Mélanie Fages; Vincent Ruby; Mégane Brusson; Aurore Arnold-Rincheval; Christine Wintz; Sylvina Bouleau; Isabelle Guénal
Source: check_circle
Crossref

Mycobacterium abscessus Opsonization Allows an Escape from the Defensin Bactericidal Action in Drosophila

Microbiology Spectrum
2023-06 | Journal article
Part of ISSN: 2165-0497
Contributors: Hamadoun Touré; Nicolas Durand; Isabelle Guénal; Jean-Louis Herrmann; Fabienne Girard-misguich; Sébastien Szuplewski
Source: Self-asserted source
Isabelle Guénal

Mass Purification Protocol for Drosophila melanogaster Wing Imaginal Discs: An Alternative to Dissection to Obtain Large Numbers of Disc Cells

Biology
2022-09-22 | Journal article
Contributors: Marion Hoareau; Juliette de Noiron; Jessie Colin; Isabelle Guénal
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

A High-Throughput Search for SFXN1 Physical Partners Led to the Identification of ATAD3, HSD10 and TIM50

Biology
2022-08 | Journal article | Author
Contributors: Nesrine Tifoun; Mourad Bekhouche; José M De las Heras; Arnaud Guillaume; Sylvina Bouleau; Isabelle Guénal; Bernard Mignotte; Nathalie LE FLOCH
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 7)‎

Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network

Biomolecules
2022-06 | Journal article | Author
Contributors: Gabriel Ichim; Benjamin GIBERT; Sahil ADRIOUCH; Catherine Brenner; Nathalie Davoust; Solange Desagher; David Devos; Svetlana Dokudovskaya; Dubrez Laurence; Jérôme Estaquier et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Apoptosis Quantification in Tissue: Development of a Semi-Automatic Protocol and Assessment of Critical Steps of Image Processing

Biomolecules
2021-10-15 | Journal article
Contributors: Juliette de Noiron; Marion Hoareau; Jessie Colin; Isabelle Guénal
Source: check_circle
Crossref
grade
Preferred source (of 5)‎

Lessons on SpA pathogenesis from animal models.

Seminars in immunopathology
2021-01-15 | Journal article
Source: Self-asserted source
Isabelle Guénal
grade
Preferred source (of 2)‎

MISREGULATION OF BMP/TGFB SHEDS LIGHT ON THE PATHOGENICITY OF HLA-B27 IN SPONDYLOARTHRITIS

Annals of the Rheumatic Diseases
2019 | Journal article
Contributors: Grandon, Benjamin; Rincheval, Auroe; Jah, Nadege; Corsi, Jean-Marc; Araujo, Luiza M.; Glatigny, Simon; Roche, Delphine; Chiocchia, Gilles; Guenal, Isabelle; Gaumer, Sebastein et al.
Source: check_circle
Web of Science Researcher Profile Sync

HLA-B27 alters BMP/TGFβ signalling in <i>Drosophila</i>, revealing putative pathogenic mechanism for spondyloarthritis.

Annals of the rheumatic diseases
2019-09-28 | Journal article
Source: Self-asserted source
Isabelle Guénal
grade
Preferred source (of 2)‎

IS FRUIT FLY RELEVANT TO SpA?

Clinical and Experimental Rheumatology
2018 | Journal article
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

Evolutionary conservation of Notch signaling inhibition by TMEM131L overexpression

Biochemical and Biophysical Research Communications
2017 | Journal article
EID:

2-s2.0-85016432584

Contributors: Szuplewski, S.; Maharzi, N.; Nelson, E.; Alhaj Hussen, K.; Mignotte, B.; Guénal, I.; Canque, B.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 3)‎

HLA-B27/Human beta 2-Microglobulin (beta 2m) Transgenic Drosophila Expresses Specific Cross-Vein Less (CVL) and Small-Eye Phenotypes Resulting from Disruption of the BMP/TGF beta Signaling Pathway

Arthritis & Rheumatology
2017 | Journal article
WOSUID:

WOS:000411824103104

Contributors: Grandon, Benjamin; Jah, Nadege; Rincheval-Arnold, Aurore; Guenal, Isabelle; Gaumer, Sebastien; Andre, Claudine; Breban, Maxime; Chiocchia, Gilles
Source: Self-asserted source
Isabelle Guénal via ResearcherID
grade
Preferred source (of 2)‎

Apoptosis in Drosophila: Which role for mitochondria?

Apoptosis
2016 | Journal article
EID:

2-s2.0-84957438144

Contributors: Clavier, A.; Rincheval-Arnold, A.; Colin, J.; Mignotte, B.; Guénal, I.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 4)‎

HLA-B27/hB2m DROSOPHILA A NEW MODEL TO STUDY HLA-B27 IMPLICATION IN SPONDYLOARTHRITIS

Clinical and Experimental Rheumatology
2016 | Journal article
WOSUID:

WOS:000383927800085

Contributors: Jah, N.; Grandon, B.; Rincheval-Arnold, A.; Guenal, I; Gaumer, S.; Andre, C.; Breban, M.; Chiocchia, G.
Source: Self-asserted source
Isabelle Guénal via ResearcherID
grade
Preferred source (of 2)‎

La drosophile comme outil de comprehension moléculaire du role de HLA-B27 dans la spondylarthrite

Revue du Rhumatisme (Edition Francaise)
2016 | Journal article
EID:

2-s2.0-85007536597

Contributors: Grandon, B.; Jah, N.; Rincheval-Arnold, A.; Guenal, I.; Gaumer, S.; Breban, M.; Chiocchia, G.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier

Le come-back de la mitochondrie dans l'apoptose chez la drosophile

Medecine/Sciences
2016 | Journal article
EID:

2-s2.0-84971578028

Contributors: Isabelle Guénal; Clavier, A.; Rincheval-Arnold, A.; Mignotte, B.; Guénal, I.
Source: Self-asserted source
Isabelle Guénal
grade
Preferred source (of 4)‎

Taking Fly for Understanding the Molecular Role of HLA-B27/hB2m in Spondyloarthritis

Arthritis & Rheumatology
2016 | Journal article
WOSUID:

WOS:000417143404331

Contributors: Jah, Nadege; Grandon, Benjamin; Rincheval-Arnold, Aurore; Guenal, Isabelle; Gaumer, Sebastien; Andre, Claudine; Breban, Maxime A.; Chiocchia, Gilles
Source: Self-asserted source
Isabelle Guénal via ResearcherID
grade
Preferred source (of 2)‎

Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila

Cell Cycle
2016 | Journal article
EID:

2-s2.0-84962829479

Contributors: Clavier, A.; Rincheval-Arnold, A.; Baillet, A.; Mignotte, B.; Guénal, I.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 3)‎

Screening of suppressors of bax-induced cell death identifies glycerophosphate oxidase-1 as a mediator of debcl-induced apoptosis in Drosophila

Genes and Cancer
2015 | Journal article
EID:

2-s2.0-84949543177

Contributors: Colin, J.; Garibal, J.; Clavier, A.; Szuplewski, S.; Risler, Y.; Milet, C.; Gaumer, S.; Guénal, I.; Mignotte, B.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 4)‎

The Drosophila retinoblastoma protein, Rbf1, induces a Debcl- and Drp1-dependent mitochondrial apoptosis

Journal of Cell Science
2015 | Journal article
EID:

2-s2.0-84946046423

Contributors: Clavier, A.; Ruby, V.; Rincheval-Arnold, A.; Mignotte, B.; Guénal, I.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 3)‎

Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis

2014 | Journal article
EID:

2-s2.0-84905457680

Contributors: Milet, C.; Rincheval-Arnold, A.; Moriéras, A.; Clavier, A.; Garrigue, A.; Mignotte, B.; Guénal, I.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 3)‎

The drosophila Bcl-2 family protein Debcl is targeted to the proteasome by the β-TrCP homologue slimb

2014 | Journal article
EID:

2-s2.0-84919625965

Contributors: Colin, J.; Garibal, J.; Clavier, A.; Rincheval-Arnold, A.; Gaumer, S.; Mignotte, B.; Guénal, I.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 3)‎

The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA.

2014 | Journal article
Contributors: Clavier A; Baillet A; Rincheval-Arnold A; Coléno-Costes A; Lasbleiz C; Mignotte B; Guénal I
Source: Self-asserted source
Isabelle Guénal via Europe PubMed Central
grade
Preferred source (of 4)‎

The Drosophila retinoblastoma protein induces apoptosis in proliferating but not in post-mitotic cells

2010 | Journal article
EID:

2-s2.0-74549187640

Contributors: Milet, C.; Rincheval-Arnold, A.; Mignotte, B.; Guénal, I.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 5)‎

Mitochondria, Bcl-2 family proteins and apoptosomes: Of worms, flies and men

2009 | Journal article
EID:

2-s2.0-63849086165

Contributors: Colin, J.; Gaumer, S.; Guenal, I.; Mignotte, B.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 5)‎

The mitochondrial TOM complex modulates bax-induced apoptosis in Drosophila

2009 | Journal article
EID:

2-s2.0-58949102766

Contributors: Colin, J.; Garibal, J.; Mignotte, B.; Guénal, I.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 3)‎

The myb-related gene stonewall induces both hyperplasia and cell death in Drosophila: Rescue of fly lethality by coexpression of apoptosis inducers

2006 | Journal article
EID:

2-s2.0-33748711625

Contributors: Brun, S.; Rincheval-Arnold, A.; Colin, J.; Risler, Y.; Mignotte, B.; Guénal, I.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 7)‎

Apoptosis: the fly point of view

2005 | Book chapter
Contributors: Bernard Mignotte; Jessie Colin; Sylvain Brun; Isabelle Guénal
Source: Self-asserted source
Isabelle Guénal via HAL

L'apoptose chez la drosophile : conservation et originalité

médecine/sciences
2002 | Journal article
EID:

2-s2.0-19244379963

Contributors: Sébastien Gaumer; Isabelle Guenal; Sylvain Brun; Bernard Mignotte
Source: Self-asserted source
Isabelle Guénal
grade
Preferred source (of 5)‎

reaper and bax initiate two different apoptotic pathways affecting mitochondria and antagonized by bcl-2 in Drosophila

2002 | Journal article
EID:

2-s2.0-0037136675

Contributors: Brun, S.; Rincheval, V.; Gaumer, S.; Mignotte, B.; Guenal, I.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 5)‎

Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila

Cell Death and Differentiation
2000 | Journal article
Contributors: S Gaumer; I Guenal; S Brun; L Theodore; Bernard Mignotte
Source: Self-asserted source
Isabelle Guénal via HAL
grade
Preferred source (of 4)‎

SV40 large T antigen expression driven by col2a1 regulatory sequences immortalizes articular chondrocytes but does not allow stabilization of type II collagen expression

1999 | Journal article
EID:

2-s2.0-0033563653

Contributors: Steimberg, N.; Viengchareun, S.; Biehlmann, F.; Guénal, I.; Mignotte, B.; Adolphe, M.; Thenet, S.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 7)‎

Bcl-2 and Hsp27 act at different levels to suppress programmed cell death

Oncogene
1997 | Journal article
WOSUID:

WOS:A1997XK99900011

Contributors: Guenal, I; SidotideFraisse, C; Gaumer, S; Mignotte, B
Source: Self-asserted source
Isabelle Guénal via ResearcherID
grade
Preferred source (of 2)‎

Down-regulation of actin genes precedes microfilament network disruption and actin cleavage during p53-mediated apoptosis

Journal of Cell Science
1997 | Journal article
WOSUID:

WOS:A1997WL46000009

Contributors: Guenal, I; Risler, Y; Mignotte, B
Source: Self-asserted source
Isabelle Guénal via ResearcherID
grade
Preferred source (of 8)‎

The three dominant female-sterile mutations of the Drosophila ovo gene are point mutations that create new translation-initiator AUG codons

Development
1996 | Journal article
WOSUID:

WOS:A1996WC55400043

Contributors: MevelNinio, M; Fouilloux, E; Guenal, I; Vincent, A
Source: Self-asserted source
Isabelle Guénal via ResearcherID
grade
Preferred source (of 4)‎

Studies of specific gene induction during apoptosis of cell lines conditionally immortalized by SV40

1995 | Journal article
EID:

2-s2.0-0028881217

Contributors: Guénal, I.; Mignotte, B.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 5)‎

Production of dominant female sterility in Drosophila melanogaster by insertion of the ovo<sup>D1</sup> allele on autosomes: use of transformed strains to generate germline mosaics

Mechanisms of Development
1994 | Journal article
EID:

2-s2.0-0028137714

Contributors: Mével-Ninio, M.; Guénal, I.; Limbourg-Bouchon, B.
Source: Self-asserted source
Isabelle Guénal via Scopus - Elsevier
grade
Preferred source (of 3)‎

Peer review (2 reviews for 2 publications/grants)

Review activity for EMBO journal. (1)
Review activity for PloS one. (1)