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SciProfiles: 214263

Keywords

Pharmacology, Toxicology, Fatty liver disease, Liver cancer, Lung cancer, Pharmacogenomics, Toxicogenomics, Biomarkers of disease, Adverse drug reactions, Drug-induced liver injury

Countries

Germany

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Works (19)

Comprehensive transcriptome, miRNA and kinome profiling identifies new treatment options for personalized lung cancer therapy

Clinical and Translational Medicine
2025-03 | Journal article
DOI: 10.1002/ctm2.70177
Contributors: Shen Zhong; Yvonne Börgeling; Patrick Zardo; Danny Jonigk; Jürgen Borlak
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Crossref

ATT-Myc Transgenic Mouse Model and Gene Expression Identify Genotoxic and Non-Genotoxic Chemicals That Accelerating Liver Tumor Growth in Short-Term Toxicity

Biomedicines
2025-03-18 | Journal article
DOI: 10.3390/biomedicines13030743
Contributors: Mahmoud Elalfy; Jürgen Borlak; Ahmed Jaafar Aljazzar; Mona G. Elhadidy
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Crossref

A comparative genomic study across 396 liver biopsies provides deep insight into FGF21 mode of action as a therapeutic agent in metabolic dysfunction‐associated steatotic liver disease

Clinical and Translational Medicine
2025-02 | Journal article
DOI: 10.1002/ctm2.70218
Contributors: Shifang Tang; Jürgen Borlak
Source: check_circle
Crossref

Genomics of human NAFLD: Lack of data reproducibility and high interpatient variability in drug target expression as major causes of drug failures

Hepatology
2024-10 | Journal article
DOI: 10.1097/HEP.0000000000000780
Contributors: Shifang Tang; Jürgen Borlak
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Crossref

The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes

Journal of Translational Medicine
2024-09-16 | Journal article
DOI: 10.1186/s12967-024-05623-8
Contributors: Jürgen Borlak; Yari Ciribilli; Alessandra Bisio; Saravanakumar Selvaraj; Alberto Inga; Jung-Hwa Oh; Reinhard Spanel
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Crossref

The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes

2024-07-10 | Preprint
DOI: 10.21203/rs.3.rs-4571548/v1
Contributors: Jürgen Borlak; Yari Ciribilli; Alessandra Bisio; Saravanakumar Selvaraj; Alberto Inga; Jung-Hwa Oh; Reinhard Spanel
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Crossref

Sex differences in the tumor promoting effects of tobacco smoke in a cRaf transgenic lung cancer disease model

Archives of Toxicology
2024-03 | Journal article
DOI: 10.1007/s00204-023-03671-5
Contributors: Shen Zhong; Jürgen Borlak
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Crossref

Dysfunctional Cori and Krebs cycle and inhibition of lactate transporters constitute a mechanism of primary nonfunction of fatty liver allografts

Translational Research
2023-09 | Journal article
DOI: 10.1016/j.trsl.2023.09.006
Contributors: Ulf Kulik; Caroline Moesta; Reinhard Spanel; Jürgen Borlak
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Crossref

Sex disparities in non-small cell lung cancer: mechanistic insights from a cRaf transgenic disease model

eBioMedicine
2023-09 | Journal article
DOI: 10.1016/j.ebiom.2023.104763
Contributors: Shen Zhong; Jürgen Borlak
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Crossref

Diclofenac Disrupts the Circadian Clock and through Complex Cross-Talks Aggravates Immune-Mediated Liver Injury—A Repeated Dose Study in Minipigs for 28 Days

International Journal of Molecular Sciences
2023-01-11 | Journal article
DOI: 10.3390/ijms24021445
Contributors: Saravanakumar Selvaraj; Jung-Hwa Oh; Seokjoo Yoon; Jürgen Borlak
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Crossref
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Advances in Liver Cancer Stem Cell Isolation and their Characterization

Stem Cell Reviews and Reports
2021-08 | Journal article
DOI: 10.1007/s12015-020-10114-6
Contributors: Lu Liu; Jürgen Borlak
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An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac

Archives of Toxicology
2020-08 | Journal article
DOI: 10.1007/s00204-020-02767-6
Contributors: Saravanakumar Selvaraj; Jung-Hwa Oh; Jürgen Borlak
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Crossref

The landscape of hepatobiliary adverse reactions across 53 herbal and dietary supplements reveals immune-mediated injury as a common cause of hepatitis

Archives of Toxicology
2020-01 | Journal article
DOI: 10.1007/s00204-019-02621-4
Contributors: Jieqiang Zhu; Minjun Chen; Jürgen Borlak; Weida Tong
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Crossref

Hepatobiliary Events in Migraine Therapy with Herbs—The Case of Petadolex, A Petasites Hybridus Extract

Journal of Clinical Medicine
2019-05-10 | Journal article
DOI: 10.3390/jcm8050652
Contributors: Nora Anderson; Jürgen Borlak
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Crossref

Genomics of lipid-laden human hepatocyte cultures enables drug target screening for the treatment of non-alcoholic fatty liver disease

BMC Medical Genomics
2018-12 | Journal article
DOI: 10.1186/s12920-018-0438-7
Contributors: Stephanie Breher-Esch; Nishika Sahini; Anna Trincone; Christin Wallstab; Jürgen Borlak
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Crossref

The Development of a Database for Herbal and Dietary Supplement Induced Liver Toxicity

International Journal of Molecular Sciences
2018-09 | Journal article | Author
DOI: 10.3390/ijms19102955
Contributors: Jieqiang Zhu; Ji-Eun Seo; Sanlong Wang; Kristin Ashby; Rodney Ballard; Dianke Yu; Baitang Ning; Rajiv Agarwal; Juergen Borlak; Weida Tong et al.
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Multidisciplinary Digital Publishing Institute
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N‐acetylcysteine and prednisolone treatment improved serum biochemistries in suspected flupirtine cases of severe idiosyncratic liver injury

Liver International
2018-02 | Journal article
DOI: 10.1111/liv.13538
Contributors: Jürgen Borlak; Florian van Bömmel; Thomas Berg
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Crossref

Primary non‐function is frequently associated with fatty liver allografts and high mortality after re‐transplantation

Liver International
2017-08 | Journal article
DOI: 10.1111/liv.13404
Contributors: Ulf Kulik; Frank Lehner; Jürgen Klempnauer; Jürgen Borlak
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Crossref

Associations of Drug Lipophilicity and Extent of Metabolism with Drug-Induced Liver Injury

International Journal of Molecular Sciences
2017-06 | Journal article
DOI: 10.3390/ijms18071335
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Multidisciplinary Digital Publishing Institute
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Preferred source (of 2)‎
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