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Oregon Health & Science University: Portland, OR, US

2003-01-15 to present | Professor (Neurology)
Employment
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Amala Soumyanath

Works (21)

Oral Asiatic Acid Improves Cognitive Function and Modulates Antioxidant and Mitochondrial Pathways in Female 5xFAD Mice

Nutrients
2025-02-19 | Journal article
DOI: 10.3390/nu17040729
Contributors: Samantha Varada; Stephen R. Chamberlin; Lillie Bui; Mikah S. Brandes; Noah Gladen-Kolarsky; Christopher J. Harris; Wyatt Hack; Cody J. Neff; Barbara H. Brumbach; Amala Soumyanath et al.
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Crossref
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Centella asiaticaimproves sleep quality and quantity in aged mice

2025-02-06 | Preprint
DOI: 10.1101/2025.02.01.636070
Contributors: Laura Dovek; Carolyn E. Tinsley; Katelyn Gutowsky; Kayla McDaniel; Zoe Potter; Matthias Ruffins; Noah E.P. Milman; Claire Wong; Amala Soumyanath; Nora E. Gray et al.
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Crossref

Peripheral Blood DNA Methylation Changes in Response to Centella asiatica Treatment in Aged Mice

Biology
2025-01-10 | Journal article
DOI: 10.3390/biology14010052
Contributors: Olivia Monestime; Brett A. Davis; Cora Layman; Kandace J. Wheeler; Wyatt Hack; Jonathan A. Zweig; Amala Soumyanath; Lucia Carbone; Nora E. Gray
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<i>Centella asiatica</i> Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis

Pharmaceuticals
2024-12 | Journal article | Author
DOI: 10.3390/ph17121681
Contributors: Payel Kundu; Kanon Yasuhara; Mikah S. Brandes; Jonathan A. Zweig; Cody J. Neff; Sarah Holden; Kat Kessler; Steven Matsumoto; Halina Offner; Carin Waslo et al.
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Multidisciplinary Digital Publishing Institute

Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds of Centella asiatica

Pharmaceuticals
2024-12-27 | Journal article
DOI: 10.3390/ph18010019
Contributors: Steven R. Chamberlin; Jonathan A. Zweig; Cody J. Neff; Luke Marney; Jaewoo Choi; Liping Yang; Claudia S. Maier; Amala Soumyanath; Shannon McWeeney; Nora E. Gray
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Crossref
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Quantifying Withanolides in Plasma: Pharmacokinetic Studies and Analytical Methods

Nutrients
2024-11-08 | Journal article
DOI: 10.3390/nu16223836
Contributors: Alex B Speers; Axel Lozano-Ortiz; Amala Soumyanath
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Withania somnifera (Ashwagandha) Improves Spatial Memory, Anxiety and Depressive-like Behavior in the 5xFAD Mouse Model of Alzheimer’s Disease

Antioxidants
2024-09-25 | Journal article
DOI: 10.3390/antiox13101164
Contributors: Noah Gladen-Kolarsky; Olivia Monestime; Melissa Bollen; Jaewoo Choi; Liping Yang; Armando Alcazar Magaña; Claudia S. Maier; Amala Soumyanath; Nora E. Gray
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Withania somnifera (Ashwagandha) Improves Spatial Memory, Anxiety and Depressive-Like Behavior in the 5xFAD Mouse Model of Alzheimer’s Disease

2024-08-19 | Preprint
DOI: 10.20944/preprints202408.1265.v1
Contributors: Noah Gladen-Kolarsky; Olivia Monestime; Melissa Bollen; Jae-woo Choi; Liping Yang; Armando Alcazar-Magana; Claudia S Maier; Amala Soumyanath; Nora E Gray
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Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of <i>C. asiatica</i> Extract Associates Dicaffeoylquinic Acids with Protection against Amyloid-β Toxicity

Molecules
2024-02 | Journal article | Author
DOI: 10.3390/molecules29040838
Contributors: Armando Alcazar Magaña; Ashish Vaswani; Kevin Brown; Yuan Jiang; Md Nure Alam; Maya Caruso; Parnian Lak; Paul Cheong; Nora E. Gray; Joseph Quinn et al.
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Multidisciplinary Digital Publishing Institute

Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice

Journal of Alzheimer's Disease Reports
2024-01 | Journal article
DOI: 10.1177/25424823241296740
Contributors: Donald G Matthews; Mona Khorani; Gerd Bobe; Maya Caruso; Armando Alcazar Magana; Nora E Gray; Joseph F Quinn; Jan F Stevens; Claudia S Maier; Amala Soumyanath
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Crossref

Quantification of caffeoylquinic acids and triterpenes as targeted bioactive compounds of Centella Asiatica in extracts and formulations by liquid chromatography mass spectrometry

Journal of Chromatography Open
2023-11 | Journal article
DOI: 10.1016/j.jcoa.2023.100091
Contributors: Liping Yang; Luke Marney; Armando Alcazar Magana; Jaewoo Choi; Kirsten Wright; Janis Mcferrin; Nora E. Gray; Amala Soumyanath; Jan F. Stevens; Claudia S. Maier
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Crossref

Chlorogenic Acids, Acting via Calcineurin, Are the Main Compounds in Centella asiatica Extracts That Mediate Resilience to Chronic Stress in Drosophila melanogaster

Nutrients
2023-09-16 | Journal article
DOI: 10.3390/nu15184016
Contributors: Helen Holvoet; Dani M. Long; Liping Yang; Jaewoo Choi; Luke Marney; Burkhard Poeck; Claudia S. Maier; Amala Soumyanath; Doris Kretzschmar; Roland Strauss
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<i>Withania somnifera</i> Extracts Promote Resilience against Age-Related and Stress-Induced Behavioral Phenotypes in <i>Drosophila melanogaster;</i> a Possible Role of Other Compounds besides Withanolides

Nutrients
2022-09 | Journal article | Author
DOI: 10.3390/nu14193923
Contributors: Helen Holvoet; Dani M. Long; Alexander Law; Christine McClure; Jaewoo Choi; Liping Yang; Luke Marney; Burkhard Poeck; Roland Strauss; Jan Frederik Stevens et al.
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Multidisciplinary Digital Publishing Institute

<i>Withania somnifera</i> and <i>Centella asiatica</i> Extracts Ameliorate Behavioral Deficits in an In Vivo <i>Drosophila melanogaster</i> Model of Oxidative Stress

Antioxidants
2022-01 | Journal article | Author
DOI: 10.3390/antiox11010121
Contributors: Kadine Cabey; Dani M. Long; Alexander Law; Nora E. Gray; Christine McClure; Maya Caruso; Parnian Lak; Kirsten M. Wright; Jan Frederik Stevens; Claudia S. Maier et al.
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Multidisciplinary Digital Publishing Institute

Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized <i>Centella asiatica</i> Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial

Antioxidants
2022-01 | Journal article | Author
DOI: 10.3390/antiox11020215
Contributors: Kirsten Wright; Melissa Bollen; Jason David; Alex Speers; Mikah S. Brandes; Nora E. Gray; Armando Alcazar Magaña; Christine McClure; Jan Frederik Stevens; Claudia S. Maier et al.
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Multidisciplinary Digital Publishing Institute

Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging

Neurobiology of Aging
2021-04 | Journal article
DOI: 10.1016/j.neurobiolaging.2020.11.019
Contributors: Jonathan A. Zweig; Mikah S. Brandes; Barbara H. Brumbach; Maya Caruso; Kirsten M. Wright; Joseph F. Quinn; Amala Soumyanath; Nora E. Gray
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Crossref

Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice

Nutrients
2020-11-13 | Journal article
DOI: 10.3390/nu12113488
Contributors: Donald G. Matthews; Maya Caruso; Armando Alcazar Magana; Kirsten M. Wright; Claudia S. Maier; Jan F. Stevens; Nora E. Gray; Joseph F. Quinn; Amala Soumyanath
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Centella asiatica Water Extract Shows Low Potential for Cytochrome P450–Mediated Drug Interactions

Drug Metabolism and Disposition
2020-10 | Journal article
DOI: 10.1124/dmd.120.090860
Contributors: Kirsten M. Wright; Armando Alcazar Magana; Ronald M. Laethem; Caroline L. Moseley; Troy T. Banks; Claudia S. Maier; Jan F. Stevens; Joseph F. Quinn; Amala Soumyanath
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Crossref

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

Antioxidants
2019-12-08 | Journal article
DOI: 10.3390/antiox8120630
Contributors: Donald G Matthews; Maya Caruso; Charles F Murchison; Jennifer Y Zhu; Kirsten M Wright; Christopher J Harris; Nora E Gray; Joseph F Quinn; Amala Soumyanath
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Crossref
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Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis

Source: check_circle
Multidisciplinary Digital Publishing Institute

Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study – Analysis of <em>Centella asiatica</em> Extract Associates Di-Caffeoylquinic Acids with Protection against Amyloid-β Toxicity in an MC65 cell model
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Multidisciplinary Digital Publishing Institute

Peer review (1 review for 1 publication/grant)

Review activity for The Journal of nutritional biochemistry. (1)
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