Personal information

Antisense therapy, Muscular dystrophy, Animal models, Muscle biology
Japan

Activities

Employment (3)

Nihon University: Fujisawa, Kanagawa, JP

2017-04 to present | Associate Professor (Veterinary Medicine)
Employment
Source: Self-asserted source
Yusuke Echigoya

University of Alberta: Edmonton, AB, CA

2012-04 to 2017-03 | Postdoctoral Fellow (Medical Genetics)
Employment
Source: Self-asserted source
Yusuke Echigoya

National Center for Geriatrics and Gerontology: Oobu, Aichi, JP

2011-04 to 2012-03 | Postdoctoral Researcher (Regenerative Medicine)
Employment
Source: Self-asserted source
Yusuke Echigoya

Funding (2)

Development of therapeutic oligonucleotides as antiviral compounds

2017 to 2021 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
Source: Self-asserted source
Yusuke Echigoya

Multiple exon skipping therapy in a transgenic pig model of muscular dystrophy

2015 to 2017 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
Source: Self-asserted source
Yusuke Echigoya

Works (29)

Antiviral Efficacy of RNase H-Dependent Gapmer Antisense Oligonucleotides against Japanese Encephalitis Virus

International Journal of Molecular Sciences
2023-10-02 | Journal article
Contributors: Shunsuke Okamoto; Yusuke Echigoya; Ayaka Tago; Takao Segawa; Yukita Sato; Takuya Itou
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Development of DG9 peptide-conjugated single- and multi-exon skipping therapies for the treatment of Duchenne muscular dystrophy

Proceedings of the National Academy of Sciences
2022-03 | Journal article
Contributors: Kenji Rowel Q. Lim; Stanley Woo; Dyanna Melo; Yiqing Huang; Kasia Dzierlega; Md Nur Ahad Shah; Tejal Aslesh; Rohini Roy Roshmi; Yusuke Echigoya; Rika Maruyama et al.
Source: check_circle
Crossref

A Dystrophin Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping

International Journal of Molecular Sciences
2021-12-02 | Journal article
Contributors: Yusuke Echigoya; Nhu Trieu; William Duddy; Hong M. Moulton; HaiFang Yin; Terence A. Partridge; Eric P. Hoffman; Joe N. Kornegay; Frank A. Rohret; Christopher S. Rogers et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Inhibition of DUX4 expression with antisense LNA gapmers as a therapy for facioscapulohumeral muscular dystrophy

Proceedings of the National Academy of Sciences
2020-07-14 | Journal article
Contributors: Kenji Rowel Q. Lim; Rika Maruyama; Yusuke Echigoya; Quynh Nguyen; Aiping Zhang; Hunain Khawaja; Sreetama Sen Chandra; Takako Jones; Peter Jones; Yi-Wen Chen et al.
Source: check_circle
Crossref

Efficacy of Multi-exon Skipping Treatment in Duchenne Muscular Dystrophy Dog Model Neonates

Molecular therapy : the journal of the American Society of Gene Therapy
2019 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes

Biochemical and Biophysical Research Communications
2019-11 | Journal article
Part of ISSN: 0006-291X
Source: Self-asserted source
Yusuke Echigoya

Exons 45–55 Skipping Using Mutation-Tailored Cocktails of Antisense Morpholinos in the DMD Gene

Molecular Therapy
2019-07 | Journal article
Part of ISSN: 1525-0016
Source: Self-asserted source
Yusuke Echigoya

Antisense PMO cocktails effectively skip dystrophin exons 45-55 in myotubes transdifferentiated from DMD patient fibroblasts

PloS one
2018 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Multiple Exon Skipping in the Duchenne Muscular Dystrophy Hot Spots: Prospects and Challenges

Journal of Personalized Medicine
2018-12 | Journal article | Author
Contributors: Yusuke Echigoya; Kenji Rowel Q. Lim; Akinori Nakamura; Given Names Deactivated Family Name Deactivated
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Comparison of the phenotypes of patients harboring in-frame deletions starting at exon 45 in the Duchenne muscular dystrophy gene indicates potential for the development of exon skipping therapy

Journal of human genetics
2017 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy

Proceedings of the National Academy of Sciences of the United States of America
2017 | Journal article
Source: Self-asserted source
Yusuke Echigoya

LNA/DNA mixmer-based antisense oligonucleotides correct alternative splicing of the SMN2 gene and restore SMN protein expression in type 1 SMA fibroblasts

Scientific reports
2017 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Quantitative Antisense Screening and Optimization for Exon 51 Skipping in Duchenne Muscular Dystrophy

Molecular therapy : the journal of the American Society of Gene Therapy
2017 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy

Methods in molecular biology (Clifton, N.J.)
2017 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Current Translational Research and Murine Models For Duchenne Muscular Dystrophy

Journal of neuromuscular diseases
2016 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Deletion of exons 3-9 encompassing a mutational hot spot in the DMD gene presents an asymptomatic phenotype, indicating a target region for multiexon skipping therapy

Journal of human genetics
2016 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Impaired regenerative capacity and lower revertant fibre expansion in dystrophin-deficient mdx muscles on DBA/2 background

Scientific reports
2016 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Dystrophin-deficient large animal models: translational research and exon skipping

American journal of translational research
2015 | Journal article
Source: Self-asserted source
Yusuke Echigoya

In silico screening based on predictive algorithms as a design tool for exon skipping oligonucleotides in Duchenne muscular dystrophy

PloS one
2015 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Long-term efficacy of systemic multiexon skipping targeting dystrophin exons 45-55 with a cocktail of vivo-morpholinos in mdx52 mice

Molecular therapy. Nucleic acids
2015 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Skipping multiple exons of dystrophin transcripts using cocktail antisense oligonucleotides

Nucleic acid therapeutics
2014 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Mutation types and aging differently affect revertant fiber expansion in dystrophic mdx and mdx52 mice

PloS one
2013 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Effects of extracellular lactate on production of reactive oxygen species by equine polymorphonuclear leukocytes in vitro

American journal of veterinary research
2012 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Exon skipping for nonsense mutations in Duchenne muscular dystrophy: too many mutations, too few patients?

Expert opinion on biological therapy
2012 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Extensive and prolonged restoration of dystrophin expression with vivo-morpholino-mediated multiple exon skipping in dystrophic dogs

Nucleic acid therapeutics
2012 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Molecular characterization of glycogen synthase 1 and its tissue expression profile with type II hexokinase and muscle-type phosphofructokinase in horses

Molecular biology reports
2011 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Molecular cloning and expression of bottlenose dolphin CD34

Veterinary immunology and immunopathology
2011 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Molecular characterization and expression pattern of the equine lactate dehydrogenase A and B genes

Gene
2009 | Journal article
Source: Self-asserted source
Yusuke Echigoya

Molecular characterization and expression of the equine M(1) and M(2)-pyruvate kinase gene

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
2008 | Journal article
Source: Self-asserted source
Yusuke Echigoya