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Internatinal Institute for Zoonosis Control, Hokkaido University: Sapporo, Hokkaido, JP

2021-04-01 to present (Division of Molecular Pathobiology)
Employment
Source: Self-asserted source
Michihito Sasaki

Research Center for Zoonosis Control, Hokkaido University: Sapporo, Hokkaido, JP

2011-04-01 to 2021-03-31 (Division of Molecular Pathobilogy)
Employment
Source: Self-asserted source
Michihito Sasaki

Works (50 of 68)

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Molecular convergence of neutralizing antibodies in human revealed by repeated rabies vaccination

npj Vaccines
2025-02-23 | Journal article
DOI: 10.1038/s41541-025-01073-5
Contributors: Mizuki Fujisawa; Taishi Onodera; Daisuke Kuroda; Chidchamai Kewcharoenwong; Michihito Sasaki; Yukari Itakura; Kohei Yumoto; Arnone Nithichanon; Naoto Ito; Shinji Takeoka et al.
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Crossref

Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in a COVID-19 hamster model

eBioMedicine
2024-01 | Journal article
DOI: 10.1016/j.ebiom.2023.104950
Contributors: Michihito Sasaki; Tatsuki Sugi; Shun Iida; Yuichiro Hirata; Shinji Kusakabe; Kei Konishi; Yukari Itakura; Koshiro Tabata; Mai Kishimoto; Hiroko Kobayashi et al.
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Crossref

2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses

Proceedings of the National Academy of Sciences
2023-10-17 | Journal article
DOI: 10.1073/pnas.2304139120
Contributors: Kentaro Uemura; Haruaki Nobori; Akihiko Sato; Shinsuke Toba; Shinji Kusakabe; Michihito Sasaki; Koshiro Tabata; Keita Matsuno; Naoyoshi Maeda; Shiori Ito et al.
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Unprecedented spike flexibility revealed by BSL3 Cryo-ET of active SARS-CoV-2 virions

2023-10-11 | Preprint
DOI: 10.1101/2023.10.10.561643
Contributors: Hideo Fukuhara; Hisham M. Dokainish; Shunsuke Kita; Koshiro Tabata; Akira Takasu; Juha T. Huiskonen; Yuki Anraku; Toshiya Senda; David I. Stuart; Michihito Sasaki et al.
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Prevalence and Genomic Characterization of Rotavirus A from Domestic Pigs in Zambia: Evidence for Possible Porcine–Human Interspecies Transmission

Pathogens
2023-09-27 | Journal article
DOI: 10.3390/pathogens12101199
Contributors: Joseph Ndebe; Hayato Harima; Herman Moses Chambaro; Michihito Sasaki; Junya Yamagishi; Annie Kalonda; Misheck Shawa; Yongjin Qiu; Masahiro Kajihara; Ayato Takada et al.
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Prevalence and Genomic Characterization of Rotavirus A from Domestic Pigs in Zambia: Evidence for Porcine-Human Interspecies Transmission

2023-08-16 | Preprint
DOI: 10.20944/preprints202308.1137.v1
Contributors: Joseph Ndebe; Hayato Harima; Herman CHAMBARO; Michihito Sasaki; Junya Yamagishi; Annie Kalonda; Misheck Shawa; Yongjin Qiu; Masahiro Kajihara; Ayato Takada et al.
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Generation and characterization of a genetically modified live rabies vaccine strain with attenuating mutations in multiple viral proteins and evaluation of its potency in dogs

Vaccine
2023-07 | Journal article
DOI: 10.1016/j.vaccine.2023.06.076
Contributors: Fumiki Izumi; Shoya Miyamoto; Tatsunori Masatani; Michihito Sasaki; Kazuo Kawakami; Tatsuki Takahashi; Takuro Fujiwara; Yuji Fujii; Misuzu Okajima; Shoko Nishiyama et al.
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Surveillance, Isolation, and Genetic Characterization of Bat Herpesviruses in Zambia

Viruses
2023-06 | Journal article | Author
DOI: 10.3390/v15061369
Contributors: Hayato Harima; Yongjin Qiu; Junya Yamagishi; Masahiro Kajihara; Katendi Changula; Kosuke Okuya; Mao Isono; Tomoyuki Yamaguchi; Hirohito Ogawa; Naganori Nao et al.
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Multidisciplinary Digital Publishing Institute

Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in severe COVID-19

2023-06-21 | Preprint
DOI: 10.1101/2023.06.20.545832
Contributors: Michihito Sasaki; Tatsuki Sugi; Shun Iida; Yuichiro Hirata; Shinji Kusakabe; Kei Konishi; Yukari Itakura; Koshiro Tabata; Mai Kishimoto; Hiroko Kobayashi et al.
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Crossref

Structure-activity relationship studies of anti-bunyaviral cap-dependent endonuclease inhibitors

Bioorganic & Medicinal Chemistry Letters
2023-03 | Journal article
DOI: 10.1016/j.bmcl.2023.129175
Contributors: Yoshiyuki Taoda; Akihiko Sato; Shinsuke Toba; Yuto Unoh; Makoto Kawai; Michihito Sasaki; Yasuko Orba; Hirofumi Sawa
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Crossref

S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters

Science Translational Medicine
2023-01-18 | Journal article
DOI: 10.1126/scitranslmed.abq4064
Contributors: Michihito Sasaki; Koshiro Tabata; Mai Kishimoto; Yukari Itakura; Hiroko Kobayashi; Takuma Ariizumi; Kentaro Uemura; Shinsuke Toba; Shinji Kusakabe; Yuki Maruyama et al.
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2-Thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses

2022-12-14 | Preprint
DOI: 10.1101/2022.12.14.520006
Contributors: Kentaro Uemura; Haruaki Nobori; Akihiko Sato; Shinsuke Toba; Shinji Kusakabe; Michihito Sasaki; Koshiro Tabata; Keita Matsuno; Naoyoshi Maeda; Shiori Ito et al.
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LIGHTHOUSE illuminates therapeutics for a variety of diseases including COVID-19

iScience
2022-11 | Journal article
DOI: 10.1016/j.isci.2022.105314
Contributors: Hideyuki Shimizu; Manabu Kodama; Masaki Matsumoto; Yasuko Orba; Michihito Sasaki; Akihiko Sato; Hirofumi Sawa; Keiichi I. Nakayama
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Serological characterization of lineage II insect-specific flaviviruses compared with pathogenic mosquito-borne flaviviruses

Biochemical and Biophysical Research Communications
2022-08 | Journal article
DOI: 10.1016/j.bbrc.2022.05.080
Contributors: Koshiro Tabata; Yukari Itakura; Shinsuke Toba; Kentaro Uemura; Mai Kishimoto; Michihito Sasaki; Jessica J. Harrison; Akihiko Sato; William W. Hall; Roy A. Hall et al.
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A high-affinity aptamer with base-appended base-modified DNA bound to isolated authentic SARS-CoV-2 strains wild-type and B.1.617.2 (delta variant)

Biochemical and Biophysical Research Communications
2022-07 | Journal article
DOI: 10.1016/j.bbrc.2022.04.071
Contributors: Hirotaka Minagawa; Hirofumi Sawa; Tomoko Fujita; Shintaro Kato; Asumi Inaguma; Miwako Hirose; Yasuko Orba; Michihito Sasaki; Koshiro Tabata; Naoki Nomura et al.
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An unusually long Rift valley fever inter-epizootic period in Zambia: Evidence for enzootic virus circulation and risk for disease outbreak

PLOS Neglected Tropical Diseases
2022-06-02 | Journal article
DOI: 10.1371/journal.pntd.0010420
Contributors: Herman M. Chambaro; Daniel M. Parker; Kazuyo Hirose; Michihito Sasaki; Brigadier Libanda; Yona Sinkala; Paul Fandamu; Walter Muleya; Fredrick Banda; Joseph Chizimu et al.
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Crossref

Multiple Routes of Antibody-Dependent Enhancement of SARS-CoV-2 Infection

Microbiology Spectrum
2022-04-27 | Journal article
DOI: 10.1128/spectrum.01553-21
Contributors: Kosuke Okuya; Takanari Hattori; Takeshi Saito; Yoshihiro Takadate; Michihito Sasaki; Wakako Furuyama; Andrea Marzi; Yoichi Ohiro; Satoshi Konno; Takeshi Hattori et al.
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Crossref

Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells

Biochemical and Biophysical Research Communications
2021-11 | Journal article
DOI: 10.1016/j.bbrc.2021.09.015
Contributors: Michihito Sasaki; Mai Kishimoto; Yukari Itakura; Koshiro Tabata; Kittiya Intaruck; Kentaro Uemura; Shinsuke Toba; Takao Sanaki; Akihiko Sato; William W. Hall et al.
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Crossref

SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis

Nature Communications
2021-11-15 | Journal article
DOI: 10.1038/s41467-021-26910-8
Contributors: Ji-Seung Yoo; Michihito Sasaki; Steven X. Cho; Yusuke Kasuga; Baohui Zhu; Ryota Ouda; Yasuko Orba; Paul de Figueiredo; Hirofumi Sawa; Koichi S. Kobayashi
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Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2

Viruses
2021-10-22 | Journal article
DOI: 10.3390/v13112137
Contributors: Marumi Ohno; Michihito Sasaki; Yasuko Orba; Toshiki Sekiya; Md. Abdul Masum; Osamu Ichii; Tatsuya Sawamura; Akemi Kakino; Yasuhiko Suzuki; Hiroshi Kida et al.
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Novel Virulent Bacteriophage ØSG005, Which Infects <i>Streptococcus gordonii</i>, Forms a Distinct Clade among Streptococcus Viruses

Viruses
2021-09 | Journal article | Author
DOI: 10.3390/v13101964
Contributors: Jumpei Fujiki; Shin-ichi Yoshida; Tomohiro Nakamura; Keisuke Nakamura; Yurika Amano; Keita Nishida; Keitaro Nishi; Michihito Sasaki; Tomohito Iwasaki; Hirofumi Sawa et al.
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Multidisciplinary Digital Publishing Institute
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LIGHTHOUSE illuminates therapeutics for a variety of diseases including COVID-19

2021-09-25 | Preprint
DOI: 10.1101/2021.09.25.461785
Contributors: Hideyuki Shimizu; Manabu Kodama; Masaki Matsumoto; Yasuko Orba; Michihito Sasaki; Akihiko Sato; Hirofumi Sawa; Keiichi I. Nakayama
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Crossref

Attenuated infection by a Pteropine orthoreovirus isolated from an Egyptian fruit bat in Zambia

PLOS Neglected Tropical Diseases
2021-09-07 | Journal article
DOI: 10.1371/journal.pntd.0009768
Contributors: Hayato Harima; Tony Schountz; Michihito Sasaki; Yasuko Orba; Kosuke Okuya; Yongjin Qiu; Christida E. Wastika; Katendi Changula; Masahiro Kajihara; Edgar Simulundu et al.
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Dual Effect of Organogermanium Compound THGP on RIG-I-Mediated Viral Sensing and Viral Replication during Influenza a Virus Infection

Viruses
2021-08 | Journal article | Author
DOI: 10.3390/v13091674
Contributors: Sunanda Baidya; Yoko Nishimoto; Seiichi Sato; Yasuhiro Shimada; Nozomi Sakurai; Hirotaka Nonaka; Koki Noguchi; Mizuki Kido; Satoshi Tadano; Kozo Ishikawa et al.
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Multidisciplinary Digital Publishing Institute

SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective Immunity

mBio
2021-08-31 | Journal article
DOI: 10.1128/mBio.01415-21
Contributors: Michihito Sasaki; Shinsuke Toba; Yukari Itakura; Herman M. Chambaro; Mai Kishimoto; Koshiro Tabata; Kittiya Intaruck; Kentaro Uemura; Takao Sanaki; Akihiko Sato et al.
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Crossref

Complete Genome Sequence of a Veterinary Pseudomonas aeruginosa Isolate, Pa12

Microbiology Resource Announcements
2021-07 | Journal article
DOI: 10.1128/MRA.00398-21
Contributors: Keisuke Nakamura; Jumpei Fujiki; Takaaki Furusawa; Tomohiro Nakamura; Satoshi Gondaira; Michihito Sasaki; Masaru Usui; Hidetoshi Higuchi; Hirofumi Sawa; Yutaka Tamura et al.
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Crossref

RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells

Nature Immunology
2021-07 | Journal article
DOI: 10.1038/s41590-021-00942-0
Contributors: Taisho Yamada; Seiichi Sato; Yuki Sotoyama; Yasuko Orba; Hirofumi Sawa; Hajime Yamauchi; Michihito Sasaki; Akinori Takaoka
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Crossref

Immunization Coverage and Antibody Retention against Rabies in Domestic Dogs in Lusaka District, Zambia

Pathogens
2021-06-11 | Journal article
DOI: 10.3390/pathogens10060738
Contributors: Chiho Kaneko; Michihito Sasaki; Ryosuke Omori; Ryo Nakao; Chikako Kataoka-Nakamura; Ladslav Moonga; Joseph Ndebe; Walter Muleya; Edgar Simulundu; Bernard M. Hang’ombe et al.
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Host Serine Proteases TMPRSS2 and TMPRSS11D Mediate Proteolytic Activation and Trypsin-Independent Infection in Group A Rotaviruses

Journal of Virology
2021-05-10 | Journal article
DOI: 10.1128/JVI.00398-21
Contributors: Michihito Sasaki; Yukari Itakura; Mai Kishimoto; Koshiro Tabata; Kentaro Uemura; Naoto Ito; Makoto Sugiyama; Christida E. Wastika; Yasuko Orba; Hirofumi Sawa et al.
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Crossref

SARS-CoV-2 bearing a mutation at the S1/S2 cleavage site exhibits attenuated virulence and confers protective immunity

2021-04-30 | Other
DOI: 10.1101/2021.04.29.442060
Contributors: Michihito Sasaki; Shinsuke Toba; Yukari Itakura; Herman M. Chambaro; Mai Kishimoto; Koshiro Tabata; Kittiya Intaruck; Kentaro Uemura; Takao Sanaki; Akihiko Sato et al.
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Crossref

Domestic dog demographics and estimates of canine vaccination coverage in a rural area of Zambia for the elimination of rabies

PLOS Neglected Tropical Diseases
2021-04-28 | Journal article
DOI: 10.1371/journal.pntd.0009222
Contributors: Chiho Kaneko; Daniel Leo Horton; Ryosuke Omori; Michihito Sasaki; Chikako Kataoka-Nakamura; Edgar Simulundu; Walter Muleya; Ladslav Moonga; Joseph Ndebe; Bernard M. Hang’ombe et al.
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Crossref

Combinatorial approach with mass spectrometry and lectin microarray dissected glycoproteomic features of virion-derived spike protein of SARS-CoV-2

2021-04-12 | Preprint
DOI: 10.1101/2021.04.10.439300
Contributors: Takahiro Hiono; Azusa Tomioka; Hiroyuki Kaji; Michihito Sasaki; Yasuko Orba; Hirofumi Sawa; Atsushi Kuno
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Crossref

Diverse mosquito-specific flaviviruses in the Bolivian Amazon basin

Journal of General Virology
2021-03-01 | Journal article
DOI: 10.1099/jgv.0.001518
Contributors: Yasuko Orba; Keita Matsuno; Ryo Nakao; Kirill Kryukov; Yumi Saito; Fumihiko Kawamori; Ariel Loza Vega; Tokiko Watanabe; Tadashi Maemura; Michihito Sasaki et al.
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Crossref

Mastomys natalensis is a possible natural rodent reservoir for encephalomyocarditis virus

Journal of General Virology
2021-03-01 | Journal article
DOI: 10.1099/jgv.0.001564
Contributors: Mai Kishimoto; Bernard M. Hang’ombe; William W. Hall; Yasuko Orba; Hirofumi Sawa; Michihito Sasaki
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Crossref

TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein

Viruses
2021-02-28 | Journal article
DOI: 10.3390/v13030384
Contributors: Mai Kishimoto; Kentaro Uemura; Takao Sanaki; Akihiko Sato; William W. Hall; Hiroaki Kariwa; Yasuko Orba; Hirofumi Sawa; Michihito Sasaki
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SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells

PLOS Pathogens
2021-01-21 | Journal article
DOI: 10.1371/journal.ppat.1009233
Contributors: Michihito Sasaki; Andrew Pekosz; Kentaro Uemura; Akihiko Sato; Shinsuke Toba; Takao Sanaki; Katsumi Maenaka; William W. Hall; Yasuko Orba; Hirofumi Sawa
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Crossref

Whole-Genome Sequence of Fluoroquinolone-Resistant Escherichia coli HUE1, Isolated in Hokkaido, Japan

Microbiology Resource Announcements
2020-11-12 | Journal article
DOI: 10.1128/MRA.01135-20
Contributors: Montgomery Munby; Jumpei Fujiki; Kotaro Aoki; Chika Kawaguchi; Keisuke Nakamura; Tomohiro Nakamura; Michihito Sasaki; Toyotaka Sato; Masaru Usui; Hirofumi Sawa et al.
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Crossref

Evidence for exposure of asymptomatic domestic pigs to African swine fever virus during an inter‐epidemic period in Zambia

Transboundary and Emerging Diseases
2020-11-02 | Journal article
DOI: 10.1111/tbed.13630
Contributors: Herman M. Chambaro; Michihito Sasaki; Yona Sinkala; Gabriel Gonzalez; David Squarre; Paul Fandamu; Caesar Lubaba; Liywalii Mataa; Misheck Shawa; Kabemba E. Mwape et al.
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Crossref

The Lethal(2)-Essential-for-Life [L(2)EFL] Gene Family Modulates Dengue Virus Infection in Aedes aegypti

International Journal of Molecular Sciences
2020-10-12 | Journal article
DOI: 10.3390/ijms21207520
Contributors: Lucky R. Runtuwene; Shuichi Kawashima; Victor D. Pijoh; Josef S. B. Tuda; Kyoko Hayashida; Junya Yamagishi; Chihiro Sugimoto; Shoko Nishiyama; Michihito Sasaki; Yasuko Orba et al.
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Characterization of mammalian orthoreoviruses isolated from faeces of pigs in Zambia

Journal of General Virology
2020-10-01 | Journal article
DOI: 10.1099/jgv.0.001476
Contributors: Hayato Harima; Michihito Sasaki; Masahiro Kajihara; Gabriel Gonzalez; Edgar Simulundu; Eugene C. Bwalya; Yongjin Qiu; Kosuke Okuya; Mao Isono; Yasuko Orba et al.
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Crossref

Discoveries of Exoribonuclease-Resistant Structures of Insect-Specific Flaviviruses Isolated in Zambia

Viruses
2020-09-11 | Journal article
DOI: 10.3390/v12091017
Contributors: Christida E. Wastika; Hayato Harima; Michihito Sasaki; Bernard M. Hang’ombe; Yuki Eshita; Yongjin Qiu; William W. Hall; Michael T. Wolfinger; Hirofumi Sawa; Yasuko Orba
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Co-Circulation of Multiple Serotypes of Bluetongue Virus in Zambia

Viruses
2020-08-31 | Journal article
DOI: 10.3390/v12090963
Contributors: Herman M. Chambaro; Michihito Sasaki; Edgar Simulundu; Isaac Silwamba; Yona Sinkala; Gabriel Gonzalez; David Squarre; Paul Fandamu; Caesar H. Lubaba; Musso Munyeme et al.
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Genetic and Phenotypic Characterization of a Rabies Virus Strain Isolated from a Dog in Tokyo, Japan in the 1940s

Viruses
2020-08-20 | Journal article
DOI: 10.3390/v12090914
Contributors: Tatsuki Takahashi; Maho Inukai; Michihito Sasaki; Madlin Potratz; Supasiri Jarusombuti; Yuji Fujii; Shoko Nishiyama; Stefan Finke; Kentaro Yamada; Hiroki Sakai et al.
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Comparative Analyses of the Antiviral Activities of IgG and IgA Antibodies to Influenza A Virus M2 Protein

Viruses
2020-07-20 | Journal article
DOI: 10.3390/v12070780
Contributors: Kosuke Okuya; Nao Eguchi; Rashid Manzoor; Reiko Yoshida; Shinji Saito; Tadaki Suzuki; Michihito Sasaki; Takeshi Saito; Yurie Kida; Akina Mori-Kajihara et al.
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Identification of group A rotaviruses from Zambian fruit bats provides evidence for long-distance dispersal events in Africa

Infection, Genetics and Evolution
2018-09 | Journal article
DOI: 10.1016/j.meegid.2018.05.016
Contributors: Michihito Sasaki; Masahiro Kajihara; Katendi Changula; Akina Mori-Kajihara; Hirohito Ogawa; Bernard M. Hang'ombe; Aaron S. Mweene; Martin Simuunza; Reiko Yoshida; Michael Carr et al.
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Crossref

Ribavirin-related compounds exert in vitro inhibitory effects toward rabies virus

Antiviral Research
2018-06 | Journal article
DOI: 10.1016/j.antiviral.2018.03.011
Contributors: Paulina D. Anindita; Michihito Sasaki; Kazuma Okada; Naoto Ito; Makoto Sugiyama; Noriko Saito-Tarashima; Noriaki Minakawa; Satoshi Shuto; Satoko Otsuguro; Satoshi Ichikawa et al.
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Divergent bufavirus harboured in megabats represents a new lineage of parvoviruses.

2016 | Journal article
PMID: 27113297
PMC: PMC4845017
Contributors: Sasaki M; Gonzalez G; Wada Y; Setiyono A; Handharyani E; Rahmadani I; Taha S; Adiani S; Latief M; Kholilullah ZA et al.
Source: Self-asserted source
Michihito Sasaki via Europe PubMed Central

Generation of recombinant rabies viruses encoding NanoLuc luciferase for antiviral activity assays.

2016-04 | Journal article
PMID: 26869397
Contributors: Anindita PD; Sasaki M; Nobori H; Sato A; Carr M; Ito N; Sugiyama M; Orba Y; Sawa H
Source: Self-asserted source
Michihito Sasaki via Europe PubMed Central

Distinct Lineages of Bufavirus in Wild Shrews and Nonhuman Primates.

2015-07 | Journal article
PMID: 26079728
PMC: PMC4480391
Contributors: Sasaki M; Orba Y; Anindita PD; Ishii A; Ueno K; Hang'ombe BM; Mweene AS; Ito K; Sawa H
Source: Self-asserted source
Michihito Sasaki via Europe PubMed Central

Detection of coronavirus genomes in Moluccan naked-backed fruit bats in Indonesia.

2015-04 | Journal article
PMID: 25643817
Contributors: Anindita PD; Sasaki M; Setiyono A; Handharyani E; Orba Y; Kobayashi S; Rahmadani I; Taha S; Adiani S; Subangkit M et al.
Source: Self-asserted source
Michihito Sasaki via Europe PubMed Central
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Peer review (7 reviews for 5 publications/grants)

Review activity for Emerging microbes & infections. (2)
Review activity for Heliyon. (1)
Review activity for Microbiology and immunology. (1)
Review activity for PLoS neglected tropical diseases (1)
Review activity for Viruses. (2)
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