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Biography

Dr. Henry Levin is the head of the Section of Eukaryotic Transposable Elements. He received his PhD from University of California, Berkeley and then was a postdoctoral fellow at Johns Hopkins University with Jef Boeke. Dr. Levin’s studies on the LTR retrotransposons in fission yeast identified mechanistic details of particle formation, reverse transcription, and integration. This research led to innovative methods of DNA sequencing that revealed integration behavior of transposable elements. With these methods the laboratory demonstrated that transposable element integration in fission yeast occurs primarily at promoters resulting in altered gene expression. These sequencing methods were also applied to studies of HIV-1 and provided new insight into the integration behavior of HIV-1. In addition, Dr. Levin develops novel technologies that rely on transposable elements to characterize genetic function genome-wide. Dr. Levin has organized several conferences and symposia on transposon biology and retrovirus replication.

Activities

Employment (1)

NIH: Bethesda, MD, US

1992 to present (NICHD)
Employment
Source: Self-asserted source
Henry Levin

Education and qualifications (1)

University of California Berkeley: Berkeley, CA, US

1981 to 1987 | PhD (Molecular Biology)
Education
Source: Self-asserted source
Henry Levin

Works (50 of 63)

Items per page:
Page 1 of 2

Identification of an integrase-independent pathway of retrotransposition

Science advances
2022 | Journal article
Part of ISSN: 2375-2548
Source: Self-asserted source
Henry Levin

A protocol for transposon insertion sequencing in <i>Schizosaccharomyces pombe</i> to identify factors that maintain heterochromatin

STAR protocols
2021 | Journal article
Part of ISSN: 2666-1667
Source: Self-asserted source
Henry Levin

Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation

Cell reports
2020 | Journal article
Part of ISSN: 2211-1247
Source: Self-asserted source
Henry Levin

Transposon Insertion Sequencing, a Global Measure of Gene Function

Annual review of genetics
2020 | Journal article
Part of ISSN: 0066-4197
Source: Self-asserted source
Henry Levin

Fitness Landscape of the Fission Yeast Genome

Molecular biology and evolution
2019 | Journal article
Part of ISSN: 0737-4038
Source: Self-asserted source
Henry Levin

Transposable element insertions in fission yeast drive adaptation to environmental stress

Genome research
2019 | Journal article
Part of ISSN: 1088-9051
Source: Self-asserted source
Henry Levin

Duplication and Transformation of the Schizosaccharomyces pombe Collection of Deletion Strains

Methods in molecular biology (Clifton, N.J.)
2018 | Journal article
Part of ISSN: 1064-3745
Source: Self-asserted source
Henry Levin

High-Frequency Lithium Acetate Transformation of Schizosaccharomyces pombe

Methods in molecular biology (Clifton, N.J.)
2018 | Journal article
Part of ISSN: 1064-3745
Source: Self-asserted source
Henry Levin

Meeting report: mobile genetic elements and genome plasticity 2018

Mobile DNA
2018 | Journal article
Part of ISSN: 1759-8753
Source: Self-asserted source
Henry Levin

Ten things you should know about transposable elements

Genome biology
2018 | Journal article
Part of ISSN: 1474-7596
Source: Self-asserted source
Henry Levin

Host factors that promote retrotransposon integration are similar in distantly related eukaryotes

PLoS genetics
2017 | Journal article
Part of ISSN: 1553-7390
Source: Self-asserted source
Henry Levin

Qualitative and Quantitative Assays of Transposition and Homologous Recombination of the Retrotransposon Tf1 in Schizosaccharomyces pombe

Methods in molecular biology (Clifton, N.J.)
2016 | Journal article
Part of ISSN: 1064-3745
Source: Self-asserted source
Henry Levin

A long terminal repeat retrotransposon of Schizosaccharomyces japonicus integrates upstream of RNA pol III transcribed genes

Mobile DNA
2015 | Journal article
Part of ISSN: 1759-8753
Source: Self-asserted source
Henry Levin

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

Genes & development
2015 | Journal article
Part of ISSN: 0890-9369
Source: Self-asserted source
Henry Levin

Single-Nucleotide-Specific Targeting of the Tf1 Retrotransposon Promoted by the DNA-Binding Protein Sap1 of Schizosaccharomyces pombe

Genetics
2015 | Journal article
Part of ISSN: 0016-6731
Source: Self-asserted source
Henry Levin

The Long Terminal Repeat Retrotransposons Tf1 and Tf2 of Schizosaccharomyces pombe

Microbiology spectrum
2015 | Journal article
Part of ISSN: 2165-0497
Source: Self-asserted source
Henry Levin

Host and viral determinants for MxB restriction of HIV-1 infection

Retrovirology
2014 | Journal article
Part of ISSN: 1742-4690
Source: Self-asserted source
Henry Levin

Mobile genetic elements and genome evolution 2014

Mobile DNA
2014 | Journal article
Part of ISSN: 1759-8753
Source: Self-asserted source
Henry Levin

Serial number tagging reveals a prominent sequence preference of retrotransposon integration

Nucleic acids research
2014 | Journal article
Part of ISSN: 0305-1048
Source: Self-asserted source
Henry Levin

Integration profiling of gene function with dense maps of transposon integration

Genetics
2013 | Journal article
Part of ISSN: 0016-6731
Source: Self-asserted source
Henry Levin

Transposon integration enhances expression of stress response genes

Nucleic acids research
2013 | Journal article
Part of ISSN: 0305-1048
Source: Self-asserted source
Henry Levin

Epigenetic regulation of condensin-mediated genome organization during the cell cycle and upon DNA damage through histone H3 lysine 56 acetylation

Molecular cell
2012 | Journal article
Part of ISSN: 1097-2765
Source: Self-asserted source
Henry Levin

Determinants that specify the integration pattern of retrotransposon Tf1 in the fbp1 promoter of Schizosaccharomyces pombe

Journal of virology
2011 | Journal article
Part of ISSN: 0022-538X
Source: Self-asserted source
Henry Levin

Dynamic interactions between transposable elements and their hosts

Nature reviews. Genetics
2011 | Journal article
Part of ISSN: 1471-0056
Source: Self-asserted source
Henry Levin

High-throughput sequencing of retrotransposon integration provides a saturated profile of target activity in Schizosaccharomyces pombe

Genome research
2010 | Journal article
Part of ISSN: 1088-9051
Source: Self-asserted source
Henry Levin

The chromodomain of Tf1 integrase promotes binding to cDNA and mediates target site selection

Journal of virology
2009 | Journal article
Part of ISSN: 0022-538X
Source: Self-asserted source
Henry Levin

The Hermes transposon of Musca domestica and its use as a mutagen of Schizosaccharomyces pombe

Methods (San Diego, Calif.)
2009 | Journal article
Part of ISSN: 1046-2023
Source: Self-asserted source
Henry Levin

Transposon technology. Guest editor's introduction

Methods (San Diego, Calif.)
2009 | Journal article
Part of ISSN: 1046-2023
Source: Self-asserted source
Henry Levin

Host genome surveillance for retrotransposons by transposon-derived proteins

Nature
2008 | Journal article
Part of ISSN: 0028-0836
Source: Self-asserted source
Henry Levin

Retrotransposon Tf1 is targeted to Pol II promoters by transcription activators

Molecular cell
2008 | Journal article
Part of ISSN: 1097-2765
Source: Self-asserted source
Henry Levin

The GP(Y/F) domain of TF1 integrase multimerizes when present in a fragment, and substitutions in this domain reduce enzymatic activity of the full-length protein

The Journal of biological chemistry
2008 | Journal article
Part of ISSN: 0021-9258
Source: Self-asserted source
Henry Levin

Stress management: how cells take control of their transposons

Molecular cell
2007 | Journal article
Part of ISSN: 1097-2765
Source: Self-asserted source
Henry Levin

The hermes transposon of Musca domestica is an efficient tool for the mutagenesis of Schizosaccharomyces pombe

Genetics
2007 | Journal article
Part of ISSN: 0016-6731
Source: Self-asserted source
Henry Levin

The self primer of the long terminal repeat retrotransposon Tf1 is not removed during reverse transcription

Journal of virology
2006 | Journal article
Part of ISSN: 0022-538X
Source: Self-asserted source
Henry Levin

Specific recognition and cleavage of the plus-strand primer by reverse transcriptase

Journal of virology
2005 | Journal article
Part of ISSN: 0022-538X
Source: Self-asserted source
Henry Levin

The evolution of transposons in Schizosaccharomyces pombe

Cytogenetic and genome research
2005 | Journal article
Part of ISSN: 1424-8581
Source: Self-asserted source
Henry Levin

The integrase of the long terminal repeat-retrotransposon tf1 has a chromodomain that modulates integrase activities

The Journal of biological chemistry
2005 | Journal article
Part of ISSN: 0021-9258
Source: Self-asserted source
Henry Levin

The long terminal repeat-containing retrotransposon Tf1 possesses amino acids in gag that regulate nuclear localization and particle formation

Journal of virology
2005 | Journal article
Part of ISSN: 0022-538X
Source: Self-asserted source
Henry Levin

A long terminal repeat-containing retrotransposon of Schizosaccharomyces pombe expresses a Gag-like protein that assembles into virus-like particles which mediate reverse transcription

Journal of virology
2003 | Journal article
Part of ISSN: 0022-538X
Source: Self-asserted source
Henry Levin

Retrotransposons and their recognition of pol II promoters: a comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombe

Genome research
2003 | Journal article
Part of ISSN: 1088-9051
Source: Self-asserted source
Henry Levin

A long terminal repeat retrotransposon of fission yeast has strong preferences for specific sites of insertion

Eukaryotic cell
2002 | Journal article
Part of ISSN: 1535-9778
Source: Self-asserted source
Henry Levin

Evidence for the packaging of multiple copies of Tf1 mRNA into particles and the trans priming of reverse transcription

Journal of virology
2000 | Journal article
Part of ISSN: 0022-538X
Source: Self-asserted source
Henry Levin

Nuclear import of the retrotransposon Tf1 is governed by a nuclear localization signal that possesses a unique requirement for the FXFG nuclear pore factor Nup124p

Molecular and cellular biology
2000 | Journal article
Part of ISSN: 0270-7306
Source: Self-asserted source
Henry Levin

A new member of the Sin3 family of corepressors is essential for cell viability and required for retroelement propagation in fission yeast

Molecular and cellular biology
1999 | Journal article
Part of ISSN: 0270-7306
Source: Self-asserted source
Henry Levin

Nup124p is a nuclear pore factor of Schizosaccharomyces pombe that is important for nuclear import and activity of retrotransposon Tf1

Molecular and cellular biology
1999 | Journal article
Part of ISSN: 0270-7306
Source: Self-asserted source
Henry Levin

A map of interactions between the proteins of a retrotransposon

Journal of virology
1998 | Journal article
Part of ISSN: 0022-538X
Source: Self-asserted source
Henry Levin

Reverse transcription of a self-primed retrotransposon requires an RNA structure similar to the U5-IR stem-loop of retroviruses

Molecular and cellular biology
1998 | Journal article
Part of ISSN: 0270-7306
Source: Self-asserted source
Henry Levin

Schizosaccharomyces pombe retrotransposon Tf2 mobilizes primarily through homologous cDNA recombination

Molecular and cellular biology
1998 | Journal article
Part of ISSN: 0270-7306
Source: Self-asserted source
Henry Levin

The application of a homologous recombination assay revealed amino acid residues in an LTR-retrotransposon that were critical for integration

Journal of virology
1998 | Journal article
Part of ISSN: 0022-538X
Source: Self-asserted source
Henry Levin

A complex structure in the mRNA of Tf1 is recognized and cleaved to generate the primer of reverse transcription

Genes & development
1997 | Journal article
Part of ISSN: 0890-9369
Source: Self-asserted source
Henry Levin
Items per page:
Page 1 of 2

Peer review (1 review for 1 publication/grant)

Review activity for PLoS biology. (1)