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Genetics, Epigenetics, Molecular Medicine, Osteoarthritis, Cartilage
United Kingdom

Biography

I did my PhD in developmental biology at Leeds University and then carried out postdoctoral studies in the Institute of Molecular Medicine at Oxford University. These involved a genetic study of common and rare diseases of the musculoskeletal system. I subsequently obtained a fellowship from the Arthritis Research Campaign and established my own research group, with a focus on the genetics of osteoarthritis (OA).

In 2002 I moved to the Botnar Research Centre in Oxford, where I took up the post of Lecturer in Musculoskeletal Biology, and in 2008 I moved to Newcastle as Professor of Musculoskeletal Research.

My group investigates how OA genetic risk acts on our joints. We use a number of different techniques, most involving molecular biology, molecular genetics and cell biology. We also use human tissues that have been donated by patients who have had their hips or knees surgically replaced due to severe OA. Our aim is to use the insights that we generate from our genetic studies to improve OA diagnosis and to develop new therapeutic avenues.

Activities

Employment (5)

Newcastle University: Newcastle upon Tyne, Tyne and Wear, GB

2008-02-01 to present | Prof of Musculoskeletal Research (Biosciences)
Employment
Source: check_circle
Newcastle University via ORCID Member Portal

University of Oxford: Oxford, Oxfordshire, GB

2002-05-01 to 2007-12-31 | University Lecturer (tenured post) (Nuffield Department of Orthopaedic Surgery)
Employment
Source: Self-asserted source
John Loughlin

University of Oxford: Oxford, Oxfordshire, GB

1997-05-01 to 2002-04-31 | Research Fellow and PI (Nuffield Department of Clinical Laboratory Science)
Employment
Source: Self-asserted source
John Loughlin

University of Oxford: Oxford, Oxfordshire, GB

1995-01-02 to 1997-04-31 | Postdoctoral Scientist (Wellcome Trust Centre for Human Genetics)
Employment
Source: Self-asserted source
John Loughlin

University of Oxford: Oxford, Oxfordshire, GB

1990-12-01 to 1995-01-01 | Postdoctoral Scientist (Institute of Molecular Medicine)
Employment
Source: Self-asserted source
John Loughlin

Education and qualifications (2)

University of Leeds: Leeds, Leeds, GB

1987-10-01 to 1990-11-15 | PhD Molecular and Developmental Biology
Education
Source: Self-asserted source
John Loughlin

Liverpool Polytechnic: Liverpool, Liverpool, GB

1983-10-01 to 1987-06-30 | BSc (Hon) Applied Biochemistry
Education
Source: Self-asserted source
John Loughlin

Funding (54)

Assessing the lifetime risk of osteoarthritis acquired during foetal development

2023-04 to 2024-03 | Grant
JGW Patterson Foundation (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

Investigating the epigenetics of osteoarthritis genetic risk

2021-03 to 2025-02 | Grant
The Ruth and Lionel Jacobson Charitable Trust (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

CRISPR/Cas9 Genome Editing for Investigating Musculoskeletal Genetics and Developing Personalised Arthritis Therapeutics

2020-08 to 2023-08 | Grant
Wellcome Trust (London, GB)
Source: Self-asserted source
John Loughlin

CRISPR/Cas9 human stem-cell modulation for personalised arthritis therapeutics

2020-08 to 2022-04 | Grant
Royal College of Surgeons of England (London, GB)
Source: Self-asserted source
John Loughlin

Molecular genetic and epigenetic analysis of the chromosome 4p16.3 osteoarthritis risk locus

2019-09 to 2020-09 | Grant
JGW Patterson Foundation (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

Functional genomic analysis of osteoarthritis tissue to underpin clinical academic training

2018-10 to 2020-09 | Grant
Newcastle upon Tyne Hospitals NHS Foundation Trust (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

Molecular genetics of osteoarthritis - enhancing cartilage integrity for future patient benefit – salary support for technician plus consumables

2018-07 to 2019-08 | Grant
JGW Patterson Foundation (Newcastle upon Tyne, Please Select, GB)
Source: Self-asserted source
John Loughlin

Molecular Genetics of Osteoarthritis – Enhancing Cartilage Integrity for Future Patient Benefit – salary support for fellow

2018-07 to 2019-08 | Grant
Royal College of Surgeons of Edinburgh (Edinburgh, GB)
Source: Self-asserted source
John Loughlin

CRACT IT Challenge 22: Osteo:chip. Full award

2017-10 to 2021-10 | Grant
NC3Rs (London, GB)
Source: Self-asserted source
John Loughlin

The MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA) - renewal

2017-06 to 2023-05 | Grant
Medical Research Council (London, GB)
Source: Self-asserted source
John Loughlin

Pyrosequencer and postdoctoral support

2017-01 to 2018-12 | Award
The Ruth and Lionel Jacobson Charitable Trust (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

Epigenetic and functional analysis of osteoarthritis susceptibility loci

2017-01 to 2017-12 | Grant
Newcastle upon Tyne Hospitals NHS Foundation Trust (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

CRACT IT Challenge 22: Osteo:chip. Pilot study

2017-01 to 2017-06 | Grant
NC3Rs (London, GB)
Source: Self-asserted source
John Loughlin

Postdoctoral support for the Approach study

2016-08 to 2021-11 | Grant
GlaxoSmithKline (Stevenage, GB)
Source: Self-asserted source
John Loughlin

Applied Public-Private Research enabling OsteoArthritis Clinical Headway – APPROACH

2015-10 to 2021-11 | Grant
European Commission (Brussels, BE)
Source: Self-asserted source
John Loughlin

The molecular basis of the inflammatory component of osteoarthritis - a functional stratification of the disease process

2015-09 to 2019-09 | Grant
Randerson Foundation (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

Epigenetic biomarkers of osteoarthritis in blood and cartilage

2015-06 to 2018-05 | Grant
JGW Patterson Foundation (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

Exploiting osteoarthritis genetics to enhance cartilage integrity

2015-05 to 2021-04 | Grant
Arthritis Research UK (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Functional analysis of the osteoarthritis susceptibility locus residing at the nuclear receptor coactivator 3 gene NCOA3

2015-05 to 2018-09 | Grant
Arthritis Research UK (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Functional analysis of the hip osteoarthritis susceptibility locus at chromosome 6q13-q14.1

2013-06 to 2016-05 | Grant
Arthritis Research UK (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Novel diagnostics and biomarkers for early identification of chronic inflammatory joint diseases: D-BOARD

2012-10 to 2017-09 | Grant
European Commission (Brussels, BE)
Source: Self-asserted source
John Loughlin

Functional analysis of the osteoarthritis association signal at chromosome 9q33.1

2012-09 to 2016-09 | Grant
Dr William Harker Foundation (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

Functional analysis of the osteoarthritis susceptibility locus located downstream of the parathyroid hormone-related protein gene PTHLH

2012-09 to 2015-09 | Grant
Arthritis Research UK (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Modulation of the effect of the osteoarthritis-associated GDF5 polymorphism rs143383 by rs143384 – a molecular genetic and functional study

2012-09 to 2013-06 | Grant
JGW Patterson Foundation (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

The MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA)

2012-06 to 2017-05 | Grant
Medical Research Council (London, GB)
Source: Self-asserted source
John Loughlin

Epigenetic analysis of osteoarthritis susceptibility loci

2012-06 to 2015-05 | Grant
Arthritis Research UK (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Functional analysis of the osteoarthritis susceptibility locus at chromosome 3p21.1

2012-06 to 2015-05 | Grant
Arthritis Research UK (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Bioinformatic and statistical support for Newcastle Biomedicine genomics platforms

2011-01 to 2013-12 | Grant
Newcastle upon Tyne Hospitals NHS Foundation Trust (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

Identification and control of the genes that cause osteoarthritis: massively parallel sequencing of the osteoarthritic transcriptome and methylome

2010-06 to 2012-05 | Grant
JGW Patterson Foundation (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

Validating risk factors for developmental dysplasia of the hip

2010-06 to 2012-05 | Grant
Arthritis Research UK (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Applied Biosystems 7900HT FAST real-time system

2010-01 to 2011-12 | Grant
Arthritis Research UK (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Exomic analysis of rare monogenic disorders to identify causal mutations: a pilot study

2010-01 to 2011-01 | Grant
Newcastle Healthcare Charity (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

Allelic expression imbalance in OA and ageing

2009-09 to 2012-09 | Grant
National Institute for Health Research (London, GB)
Source: Self-asserted source
John Loughlin

Genetic and functional analysis of polymorphism at the GDF5 locus

2009-09 to 2010-12 | Award
Arthritis Research UK (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Oliver Bird Rheumatism Programme, 4-year PhD Studentship Programme

2008-09 to 2013-09 | Grant
Nuffield Foundation (London, GB)
Source: Self-asserted source
John Loughlin

Osteoarthritis genetics and functional analysis

2008-09 to 2011-09 | Grant
Dr William Harker Foundation (Newcastle upon Tyne, GB)
Source: Self-asserted source
John Loughlin

Translational Research in Europe- Applied Technologies for Osteoarthritis: TREAT-OA

2008-01 to 2010-12 | Grant
European Commission (Brussels, BE)
Source: Self-asserted source
John Loughlin

Applied Biosystems 3130xl Genetic Analyzer

2008-01 to 2008-12 | Grant
Arthritis Research Campaign (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

arcOGEN – a genome wide association scan in osteoarthritis

2007-10 to 2011-05 | Grant
Arthritis Research UK (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Functional analysis of the SFRP3 arginine substitutions that are risk factors for osteoarthritis

2007-06 to 2011-05 | Grant
Arthritis Research UK (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Genetic markers for susceptibility of osteoarthritis of the knee and hip

2007-01 to 2008-12 | Grant
Arthritis Research Campaign (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Cellular, molecular and genetic studies of bone and joint diseases

2007-01 to 2007-12 | Grant
John Fell Fund, University of Oxford (Oxford, GB)
Source: Self-asserted source
John Loughlin

Molecular genetic and functional analysis of osteoarthritis susceptibility genes

2004-09 to 2007-09 | Grant
Research into Ageing (London, GB)
Source: Self-asserted source
John Loughlin

Molecular genetics of arthritis

2004-09 to 2007-09 | Award
Marshall Aid Commemoration Commission (Washington, US)
Source: Self-asserted source
John Loughlin

The wnt-signalling pathway and genetic susceptibility to osteoarthritis

2004-01 to 2006-12 | Grant
Arthritis Research Campaign (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Cellular, molecular and genetic studies of bone and joint diseases

2003-01 to 2007-01 | Grant
Wellcome Trust (London, GB)
Source: Self-asserted source
John Loughlin

Identification of the osteoarthritis susceptibility gene that resides on chromosome 4q12-q21.1

2003-01 to 2005-12 | Grant
Arthritis Research Campaign (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

The identification and characterisation of the primary osteoarthritis susceptibility gene that resides on chromosome 6p12.3-q13

2002-06 to 2008-01 | Grant
Research into Ageing (London, GB)
Source: Self-asserted source
John Loughlin

Joint proposal for the fine mapping of OA susceptibility loci

2002-01 to 2003-12 | Grant
Arthritis Research Campaign (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Identification and analysis of genes encoding for susceptibility to osteoarthritis

2000-09 to 2003-09 | Grant
Research into Ageing (London, GB)
Source: Self-asserted source
John Loughlin

A comprehensive analysis of pedigree data generated from a genome screen search for susceptible loci for osteoarthritis

2000-01 to 2002-12 | Grant
Wellcome Trust (London, GB)
Source: Self-asserted source
John Loughlin

Identification of osteoarthritis susceptibility genes using cDNA microarrays

2000-01 to 2002-12 | Grant
Nuffield Foundation (London, GB)
Source: Self-asserted source
John Loughlin

Fine mapping of three chromosomal regions which contain susceptibility genes for osteoarthritis

2000-01 to 2001-12 | Grant
Arthritis Research Campaign (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Identification of the loci responsible for genetic susceptibility in osteoarthritis

1997-05 to 2002-04 | Grant
Arthritis Research Campaign (Chesterfield, GB)
Source: Self-asserted source
John Loughlin

Works (50 of 164)

Items per page:
Page 1 of 4

Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence

Arthritis Research & Therapy
2024-04-03 | Journal article
Contributors: Jack B. Roberts; Olivia L.G. Boldvig; Guillaume Aubourg; S. Tanishq Kanchenapally; David J. Deehan; Sarah J. Rice; John Loughlin
Source: check_circle
Crossref

Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials: the IMI-APPROACH study

Osteoarthritis and Cartilage Open
2023-12 | Journal article
Part of ISSN: 2665-9131
Contributors: Paweł Widera; Paco M.J. Welsing; Samuel O. Danso; Sjaak Peelen; Margreet Kloppenburg; Marieke Loef; Anne C. Marijnissen; Eefje M. van Helvoort; Francisco J Blanco Garcia; Joana Magalhães et al.
Source: Self-asserted source
John Loughlin

Three decades of osteoarthritis molecular genetics research: from early discussions to impressive breakthroughs

Osteoarthritis and Cartilage
2023-11 | Journal article
Part of ISSN: 1063-4584
Contributors: J. Loughlin
Source: Self-asserted source
John Loughlin

Mediation of the Same Epigenetic and Transcriptional Effect by Independent Osteoarthritis Risk–Conferring Alleles on a Shared Target Gene, COLGALT2

Arthritis & Rheumatology
2023-06 | Journal article
Contributors: Yulia S. Kehayova; J. Mark Wilkinson; Sarah J. Rice; John Loughlin
Source: check_circle
Crossref

Genetic risk of osteoarthritis operates during human skeletogenesis

Human Molecular Genetics
2023-06-19 | Journal article
Contributors: Sarah J Rice; Abby Brumwell; Julia Falk; Yulia S Kehayova; John Casement; Eleanor Parker; Ines M J Hofer; Colin Shepherd; John Loughlin
Source: check_circle
Crossref

Osteoarthritis genetic risk acting on the galactosyltransferase gene COLGALT2 has opposing functional effects in articulating joint tissues

Arthritis Research & Therapy
2023-05-19 | Journal article
Part of ISSN: 1478-6362
Contributors: Yulia S. Kehayova; J. Mark Wilkinson; Sarah J. Rice; John Loughlin
Source: Self-asserted source
John Loughlin

Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk

Arthritis Research & Therapy
2022-08-08 | Journal article
Contributors: Abby Brumwell; Guillaume Aubourg; Juhel Hussain; Eleanor Parker; David J. Deehan; Sarah J. Rice; John Loughlin
Source: check_circle
Crossref

Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method

The Lancet Rheumatology
2022-07 | Journal article
Part of ISSN: 2665-9913
Contributors: John Loughlin
Source: Self-asserted source
John Loughlin

Predicted and actual 2-year structural and pain progression in the IMI-APPROACH knee osteoarthritis cohort

Rheumatology
2022-05-16 | Journal article
Part of ISSN: 1462-0324
Part of ISSN: 1462-0332
Source: Self-asserted source
John Loughlin

Towards precision medicine – is genetic risk prediction ready for prime time in osteoarthritis?

Arthritis & Rheumatology
2022-05-06 | Journal article
Part of ISSN: 2326-5191
Part of ISSN: 2326-5205
Source: Self-asserted source
John Loughlin

Translating osteoarthritis genetics research: challenging times ahead

Trends in Molecular Medicine
2022-03 | Journal article
Contributors: John Loughlin
Source: check_circle
Crossref

Neuropathic pain in the IMI-APPROACH knee osteoarthritis cohort: prevalence and phenotyping

RMD Open
2021-12 | Journal article
Part of ISSN: 2056-5933
Source: Self-asserted source
John Loughlin

Osteoarthritis Research Society International (OARSI): Past, present and future

Osteoarthritis and Cartilage Open
2021-06 | Journal article
Part of ISSN: 2665-9131
Source: Self-asserted source
John Loughlin

Genetic and epigenetic factors fine-tune TGFB1 expression within the osteoarthritic articular joint.

Arthritis & rheumatology (Hoboken, N.J.)
2021-03-24 | Journal article
Source: Self-asserted source
John Loughlin
grade
Preferred source (of 2)‎

Genetic and epigenetic interplay regulates COLGALT2, contributing to osteoarthritis genetic risk.

Arthritis & rheumatology (Hoboken, N.J.)
2021-03-24 | Journal article
Source: Self-asserted source
John Loughlin
grade
Preferred source (of 2)‎

Genetics of Osteoarthritis.

Osteoarthritis and cartilage
2021-03-12 | Journal article
Source: Self-asserted source
John Loughlin

Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene

Annals of the Rheumatic Diseases
2020-10-14 | Journal article
Part of ISSN: 0003-4967
Part of ISSN: 1468-2060
Source: Self-asserted source
John Loughlin

Multi‐tissue Epigenetic and Gene Expression Analysis Combined with Epigenome Modulation Identifies RWDD2B as a Target of Osteoarthritis Susceptibility

Arthritis & Rheumatology
2020-08-04 | Journal article
Part of ISSN: 2326-5191
Part of ISSN: 2326-5205
Source: Self-asserted source
John Loughlin

Cohort profile: The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers

BMJ Open
2020-07 | Journal article
Part of ISSN: 2044-6055
Part of ISSN: 2044-6055
Source: Self-asserted source
John Loughlin

The use of technology in the subcategorisation of osteoarthritis: A delphi study approach

Osteoarthritis and Cartilage Open
2020-06 | Journal article
Part of ISSN: 2665-9131
Source: Self-asserted source
John Loughlin

Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene PLEC.

Osteoarthritis and cartilage
2020-06-21 | Journal article
Source: Self-asserted source
John Loughlin

Multi-classifier prediction of knee osteoarthritis progression from incomplete imbalanced longitudinal data.

Scientific reports
2020-05-21 | Journal article
Source: Self-asserted source
John Loughlin

Interplay between genetics and epigenetics in osteoarthritis

Nature Reviews Rheumatology
2020-05-09 | Journal article
Contributors: Sarah J. Rice; Frank Beier; David A. Young; John Loughlin
Source: check_circle
Crossref

Functional testing of thousands of osteoarthritis-associated variants for regulatory activity

Nature Communications
2019-12 | Journal article
Part of ISSN: 2041-1723
Source: Self-asserted source
John Loughlin

Discovery and analysis of methylation quantitative trait loci (mQTLs) mapping to novel osteoarthritis genetic risk signals.

Osteoarthritis and cartilage
2019-06 | Journal article
Contributors: Rice SJ; Cheung K; Reynard LN; Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP

Arthritis Research & Therapy
2019-06-18 | Journal article
Part of ISSN: 1478-6362
Source: Self-asserted source
John Loughlin

GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures.

Nature communications
2019-05 | Journal article
Contributors: Styrkarsdottir U; Stefansson OA; Gunnarsdottir K; Thorleifsson G; Lund SH; Stefansdottir L; Juliusson K; Agustsdottir AB; Zink F; Halldorsson GH et al.
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Prioritization of PLEC and GRINA as osteoarthritis risk genes through the identification and characterization of novel methylation quantitative trait loci.

Arthritis & rheumatology (Hoboken, N.J.)
2019-02 | Journal article
Contributors: Rice SJ; Tselepi M; Sorial AK; Aubourg G; Shepherd C; Almarza D; Skelton AJ; Pangou I; Deehan D; Reynard LN et al.
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Identification of a novel, methylation-dependent, RUNX2 regulatory region associated with osteoarthritis risk.

Human molecular genetics
2018-10 | Journal article
Contributors: Rice SJ; Aubourg G; Sorial AK; Almarza D; Tselepi M; Deehan DJ; Reynard LN; Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant.

Arthritis & rheumatology (Hoboken, N.J.)
2018-08 | Journal article
Contributors: Shepherd C; Zhu D; Skelton AJ; Combe J; Threadgold H; Zhu L; Vincent TL; Stuart P; Reynard LN; Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5.

Communications biology
2018-05 | Journal article
Contributors: Hatzikotoulas K; Roposch A; DDH Case Control Consortium; Shah KM; Clark MJ; Bratherton S; Limbani V; Steinberg J; Zengini E; Warsame K et al.
Source: Self-asserted source
John Loughlin via Europe PubMed Central

A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5.

PloS one
2017-05 | Journal article
Contributors: Ratnayake M; Tselepi M; Bloxham R; Plöger F; Reynard LN; Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central
grade
Preferred source (of 2)‎

Genome editing for human osteoarthritis - a perspective.

Osteoarthritis and cartilage
2017-05 | Journal article
Contributors: Almarza D; Cucchiarini M; Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.

Nature genetics
2017-03 | Journal article
Contributors: Styrkarsdottir U; Helgason H; Sigurdsson A; Norddahl GL; Agustsdottir AB; Reynard LN; Villalvilla A; Halldorsson GH; Jonasdottir A; Magnusdottir A et al.
Source: Self-asserted source
John Loughlin via Europe PubMed Central

A proteomic analysis of chondrogenic, osteogenic and tenogenic constructs from ageing mesenchymal stem cells.

Stem cell research & therapy
2016-09 | Journal article
Contributors: Peffers MJ; Collins J; Loughlin J; Proctor C; Clegg PD
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Decoding the Regulatory Landscape of Ageing in Musculoskeletal Engineered Tissues Using Genome-Wide DNA Methylation and RNASeq.

PloS one
2016-08 | Journal article
Contributors: Peffers MJ; Goljanek-Whysall K; Collins J; Fang Y; Rushton M; Loughlin J; Proctor C; Clegg PD
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Functional Characterization of the Osteoarthritis Susceptibility Mapping to CHST11-A Bioinformatics and Molecular Study.

PloS one
2016-07 | Journal article
Contributors: Reynard LN; Ratnayake M; Santibanez-Koref M; Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central
grade
Preferred source (of 2)‎

Translation of clinical problems in osteoarthritis into pathophysiological research goals.

RMD open
2016-05 | Journal article
Contributors: van der Kraan PM; Berenbaum F; Blanco FJ; Cosimo de B; Lafeber F; Hauge E; Higginbottom A; Ioan-Facsinay A; Loughlin J; Meulenbelt I et al.
Source: Self-asserted source
John Loughlin via Europe PubMed Central

The first international workshop on the epigenetics of osteoarthritis.

Connective tissue research
2016-03 | Journal article
Contributors: Meulenbelt IM; Bhutani N; den Hollander W; Gay S; Oppermann U; Reynard LN; Skelton AJ; Young DA; Beier F; Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Age-related changes in mesenchymal stem cells identified using a multi-omics approach.

European cells & materials
2016-02 | Journal article
Contributors: Peffers MJ; Collins J; Fang Y; Goljanek-Whysall K; Rushton M; Loughlin J; Proctor C; Clegg PD
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Correlation of the osteoarthritis susceptibility variants that map to chromosome 20q13 with an expression quantitative trait locus operating on NCOA3 and with functional variation at the polymorphism rs116855380.

Arthritis & rheumatology (Hoboken, N.J.)
2015-11 | Journal article
Contributors: Gee F; Rushton MD; Loughlin J; Reynard LN
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874.

BMC medical genetics
2015-11 | Journal article
Contributors: Shepherd C; Skelton AJ; Rushton MD; Reynard LN; Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central

The role of inflammation-related genes in osteoarthritis.

Osteoarthritis and cartilage
2015-11 | Journal article
Contributors: Rogers EL; Reynard LN; Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk.

Human molecular genetics
2015-10 | Journal article
Contributors: Rushton MD; Reynard LN; Young DA; Shepherd C; Aubourg G; Gee F; Darlay R; Deehan D; Cordell HJ; Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591.

BMC medical genetics
2015-09 | Journal article
Contributors: Johnson K; Reynard LN; Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Genetic contribution to osteoarthritis development: current state of evidence.

Current opinion in rheumatology
2015-05 | Journal article
Contributors: Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients.

Annals of the rheumatic diseases
2015-04 | Journal article
Contributors: Rushton MD; Young DA; Loughlin J; Reynard LN
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA.

Nature reviews. Rheumatology
2014-11 | Journal article
Contributors: Loughlin J; Reynard LN
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Characterization of the cartilage DNA methylome in knee and hip osteoarthritis.

Arthritis & rheumatology (Hoboken, N.J.)
2014-09 | Journal article
Contributors: Rushton MD; Reynard LN; Barter MJ; Refaie R; Rankin KS; Young DA; Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central

Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1.

BMC medical genetics
2014-05 | Journal article
Contributors: Gee F; Clubbs CF; Raine EV; Reynard LN; Loughlin J
Source: Self-asserted source
John Loughlin via Europe PubMed Central
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