Georges E. Janssens (0000-0003-2104-8145)

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Georges Janssens is Assistant Professor in the Laboratory Genetic Metabolic Diseases, at the Amsterdam UMC, location AMC in The Netherlands. His work is focused on multi-omics data integration studying the molecular determinants of healthy aging. His research education has taken place in California, the UK, Sweden, and the Netherlands. During his postdoctoral work at the Karolinska institute in Stockholm, he pioneered transcriptome-based machine-learning enabled drug screening, an approach he continues to expand upon today in his independent research line. Dr. Janssens has been awarded several prestigious fellowships including the FEBS (2017) and the VENI (2019). He has authored over 30 publications, with recent first authorships in journals including Cell Metabolism and Cell Reports, and recent corresponding authorships in journals including EMBO Molecular Medicine and Biogerontology. He writes a popular-science blog that distills myths on aging (AgingIsBeautiful.com) and is passionate to develop healthy aging diagnostics and interventions that are accessible to the public.

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Low-dose naltrexone extends healthspan and lifespan in C. elegans via SKN-1 activation

iScience

2024-06 | Journal article | Author

DOI: 10.1016/j.isci.2024.109949

Part of ISSN: 2589-0042

Contributors: Weisha Li; Rebecca L. McIntyre; Bauke V. Schomakers; Rashmi Kamble; Anne H.G. Luesink; Michel van Weeghel; Riekelt H. Houtkooper; Arwen W. Gao; Georges E. Janssens

Georges E. Janssens

https://orcid.org/0000-0003-2104-8145

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Works (50 of 53)

Low-dose naltrexone extends healthspan and lifespan in C. elegans via SKN-1 activation

A conserved complex lipid signature marks human muscle aging and responds to short-term exercise

HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice

Ophthalmic acid is a glutathione regulating tripeptide

Repurposing nucleoside reverse transcriptase inhibitors (NRTIs) to slow aging

Human ovarian aging is characterized by oxidative damage and mitochondrial dysfunction

Fungi as a source of bioactive molecules for the development of longevity medicines

Age prediction from human blood plasma using proteomic and small RNA data: a comparative analysis

A metabolomic signature of decelerated physiological aging in human plasma

Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice

Remote monitoring technologies for measuring cardiovascular functions in community-dwelling adults: a systematic review

Anti-retroviral treatment with zidovudine alters pyrimidine metabolism, reduces translation, and extends healthy longevity via ATF-4

Divergent remodeling of the skeletal muscle metabolome over 24 h between young, healthy men and older, metabolically compromised men

Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans

NAD+ to assess health in aging humans

Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity

Considerations Regarding Public Use of Longevity Interventions

Healthy aging and muscle function are positively associated with NAD+ abundance in humans

Meeting Report: Aging Research and Drug Discovery

Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women

Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF‐16‐induced longevity

Biological Age Prediction From Wearable Device Movement Data Identifies Nutritional and Pharmacological Interventions for Healthy Aging

Longevity pathways are associated with human ovarian ageing

Metabolomics and lipidomics in Caenorhabditis elegans using a single-sample preparation

Identification of longevity compounds with minimized probabilities of side effects

Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction

Mitochondrial cross-compartmental signalling to maintain proteostasis and longevity

Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

A genome‐wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells

Disease progression in women with X-linked adrenoleukodystrophy is slow

From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs

HNRNPR Variants that Impair Homeobox Gene Expression Drive Developmental Disorders in Humans

Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging

Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative lifespan

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity

Identification of key pathways and metabolic fingerprints of longevity in C. elegans

Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation

Increased genome instability is not accompanied by sensitivity to DNA damaging agents in aged yeast cells.

The Natural Variation in Lifespans of Single Yeast Cells Is Related to Variation in Cell Size, Ribosomal Protein, and Division Time

Evidence for the hallmarks of human aging in replicatively aging yeast.

Protein biogenesis machinery is a driver of replicative aging in yeast.

The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource.

An analysis and validation pipeline for large-scale RNAi-based screens

In Silico Approaches and the Role of Ontologies in Aging Research

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast