Personal information

Keywords

Proteomics, Biomarkers, Mass Spectrometry

Countries

United Kingdom

Activities

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Employment (1)

Proteome Sciences plc: Cobham, Surrey, GB

2001-05-01 to 2017-04-30 | Head of Facility (Proteomics)
Employment
Source: Self-asserted source
Malcolm Ward

Education and qualifications (1)

Kings College London: London, UK, GB

2003-10-01 to 2009-06-01 | PhD (Old Age Psychiatry)
Education
Source: Self-asserted source
Malcolm Ward

Funding (2)

Evaluation of a plasma protein panel as a compound biomarker for Alzheimers disease

Source: Self-asserted source
Malcolm Ward via DimensionsWizard

Differential display proteomics for drug discovery and diagnostics for Alzheimer s disease (DIPAD)

Source: Self-asserted source
Malcolm Ward via DimensionsWizard

Works (50 of 52)

Items per page:
Page 1 of 2

Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidates.

2017 | Journal article
PMID: 27636850
Contributors: Russell CL; Mitra V; Hansson K; Blennow K; Gobom J; Zetterberg H; Hiltunen M; Ward M; Pike I
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative proteomics.

2017-04 | Journal article
DOI: 10.1016/j.parkreldis.2017.01.016
PMID: 28214264
Contributors: Magdalinou NK; Noyce AJ; Pinto R; Lindstrom E; Holmén-Larsson J; Holtta M; Blennow K; Morris HR; Skillbäck T; Warner TT et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Combined tissue and fluid proteomics with Tandem Mass Tags to identify low-abundance protein biomarkers of disease in peripheral body fluid: An Alzheimer's Disease case study.

2017-01 | Journal article
DOI: 10.1002/rcm.7777
PMID: 27813239
Contributors: Russell CL; Heslegrave A; Mitra V; Zetterberg H; Pocock JM; Ward MA; Pike I
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide.

2017-01 | Journal article
DOI: 10.1038/srep39328
PMID: 28067231
PMC: PMC5220358
Contributors: Mesnage R; Renney G; Séralini GE; Ward M; Antoniou MN
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process.

2016-12 | Journal article
DOI: 10.1038/srep37855
PMID: 27991589
PMC: PMC5171704
Contributors: Mesnage R; Agapito-Tenfen SZ; Vilperte V; Renney G; Ward M; Séralini GE; Nodari RO; Antoniou MN
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Comparative analysis of phenol-soluble modulin production and Galleria mellonella killing by community-associated and healthcare-associated meticillin-resistant Staphylococcusaureus strains.

2016-12 | Journal article
DOI: 10.1099/jmm.0.000379
PMID: 27902400
Contributors: Boakes E; Marbach H; Lynham S; Ward M; Edgeworth JD; Otter JA
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

N-terminally truncated FOXP1 protein expression and alternate internal FOXP1 promoter usage in normal and malignant B cells.

2016-07 | Journal article
DOI: 10.3324/haematol.2016.142141
PMID: 27056922
PMC: PMC5004466
Contributors: Brown PJ; Gascoyne DM; Lyne L; Spearman H; Felce SL; McFadden N; Chakravarty P; Barrans S; Lynham S; Calado DP et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly.

2016-03 | Journal article
DOI: 10.3233/jad-151155
PMID: 27031486
Contributors: Westwood S; Leoni E; Hye A; Lynham S; Khondoker MR; Ashton NJ; Kiddle SJ; Baird AL; Sainz-Fuertes R; Leung R et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Correction to "Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer's Disease".

2016-03 | Journal article
DOI: 10.1021/acs.jproteome.6b00080
PMID: 26828705
Contributors: Liang HC; Russell C; Mitra V; Chung R; Hye A; Bazenet C; Lovestone S; Pike I; Ward M
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins.

2016-01 | Journal article
DOI: 10.1038/tp.2015.205
PMID: 26812040
PMC: PMC5068879
Contributors: Voyle N; Kim M; Proitsi P; Ashton NJ; Baird AL; Bazenet C; Hye A; Westwood S; Chung R; Ward M et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Quantitation of protein post-translational modifications using isobaric tandem mass tags.

2015 | Journal article
DOI: 10.4155/bio.14.296
PMID: 25697195
Contributors: Liang HC; Lahert E; Pike I; Ward M
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer's Disease.

2015-12 | Journal article
DOI: 10.1021/acs.jproteome.5b00892
PMID: 26488311
Contributors: Liang HC; Russell C; Mitra V; Chung R; Hye A; Bazenet C; Lovestone S; Pike I; Ward M
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Blood protein predictors of brain amyloid for enrichment in clinical trials?

2015-03 | Journal article
DOI: 10.1016/j.dadm.2014.11.005
PMID: 27239491
PMC: PMC4876903
Contributors: Ashton NJ; Kiddle SJ; Graf J; Ward M; Baird AL; Hye A; Westwood S; Wong KV; Dobson RJ; Rabinovici GD et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Proteomics links the redox state to calcium signaling during bleaching of the scleractinian coral Acropora microphthalma on exposure to high solar irradiance and thermal stress.

2015-03 | Journal article
DOI: 10.1074/mcp.m114.043125
PMID: 25561505
PMC: PMC4349979
Contributors: Weston AJ; Dunlap WC; Beltran VH; Starcevic A; Hranueli D; Ward M; Long PF
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

An integrated workflow for multiplex CSF proteomics and peptidomics-identification of candidate cerebrospinal fluid biomarkers of Alzheimer's disease.

2015-02 | Journal article
DOI: 10.1021/pr501076j
PMID: 25490617
Contributors: Hölttä M; Minthon L; Hansson O; Holmén-Larsson J; Pike I; Ward M; Kuhn K; Rüetschi U; Zetterberg H; Blennow K et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Post-translational modifications in Alzheimer's disease and the potential for new biomarkers.

2014 | Journal article
DOI: 10.3233/jad-132312
PMID: 24662105
Contributors: Russell CL; Koncarevic S; Ward MA
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets.

2014 | Journal article
DOI: 10.1371/journal.pone.0090948
PMID: 24670416
PMC: PMC3966770
Contributors: Britton D; Zen Y; Quaglia A; Selzer S; Mitra V; Löβner C; Jung S; Böhm G; Schmid P; Prefot P et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Plasma proteins predict conversion to dementia from prodromal disease.

2014-11 | Journal article
DOI: 10.1016/j.jalz.2014.05.1749
PMID: 25012867
PMC: PMC4240530
Contributors: Hye A; Riddoch-Contreras J; Baird AL; Ashton NJ; Bazenet C; Leung R; Westman E; Simmons A; Dobson R; Sattlecker M et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects.

2014-08 | Journal article
DOI: 10.1111/bcp.12335
PMID: 25099258
PMC: PMC4137824
Contributors: Floyd CN; Goodman T; Becker S; Chen N; Mustafa A; Schofield E; Campbell J; Ward M; Sharma P; Ferro A
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

A new derivative for oxosteroid analysis by mass spectrometry.

2014-04 | Journal article
DOI: 10.1016/j.bbrc.2014.01.190
PMID: 24525129
PMC: PMC4000438
Contributors: Rigdova K; Wang Y; Ward M; Griffiths WJ
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Developing novel blood-based biomarkers for Alzheimer's disease.

2014-01 | Journal article
DOI: 10.1016/j.jalz.2013.10.007
PMID: 24365657
PMC: PMC4769619
Contributors: Snyder HM; Carrillo MC; Grodstein F; Henriksen K; Jeromin A; Lovestone S; Mielke MM; O'Bryant S; Sarasa M; Sjøgren M et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Urine protein concentration estimation for biomarker discovery.

2013-10 | Journal article
DOI: 10.1016/j.preghy.2013.07.001
PMID: 26103798
Contributors: Mistry HD; Bramham K; Weston AJ; Ward MA; Thompson AJ; Chappell LC
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Proteomic characterisation of toxins isolated from nematocysts of the South Atlantic jellyfish Olindias sambaquiensis.

2013-09 | Journal article
DOI: 10.1016/j.toxicon.2013.05.002
PMID: 23688393
Contributors: Weston AJ; Chung R; Dunlap WC; Morandini AC; Marques AC; Moura-da-Silva AM; Ward M; Padilla G; da Silva LF; Andreakis N et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Plasma based markers of [11C] PiB-PET brain amyloid burden.

2012 | Journal article
DOI: 10.1371/journal.pone.0044260
PMID: 23028511
PMC: PMC3454385
Contributors: Kiddle SJ; Thambisetty M; Simmons A; Riddoch-Contreras J; Hye A; Westman E; Pike I; Ward M; Johnston C; Lupton MK et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Plasma transthyretin as a candidate marker for Alzheimer's disease.

2012 | Journal article
DOI: 10.3233/jad-2011-110611
PMID: 22002789
Contributors: Velayudhan L; Killick R; Hye A; Kinsey A; Güntert A; Lynham S; Ward M; Leung R; Lourdusamy A; To AW et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Pharmacoproteomic investigation into antidepressant response in two mouse inbred strains.

2012-08 | Journal article
DOI: 10.1002/pmic.201100306
PMID: 22696452
Contributors: Malki K; Campbell J; Davies M; Keers R; Uher R; Ward M; Paya-Cano J; Aitchinson KJ; Binder E; Sluyter F et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.

2012-05 | Journal article
DOI: 10.1007/s12031-012-9716-6
PMID: 22351109
PMC: PMC3323815
Contributors: Löffler T; Flunkert S; Taub N; Schofield EL; Ward MA; Windisch M; Hutter-Paier B
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn.

2011 | Journal article
DOI: 10.1186/1750-1326-6-12
PMID: 21269457
PMC: PMC3037338
Contributors: Scales TM; Derkinderen P; Leung KY; Byers HL; Ward MA; Price C; Bird IN; Perera T; Kellie S; Williamson R et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Plasma gelsolin is decreased and correlates with rate of decline in Alzheimer's disease.

2010 | Journal article
DOI: 10.3233/jad-2010-100279
PMID: 20571216
Contributors: Güntert A; Campbell J; Saleem M; O'Brien DP; Thompson AJ; Byers HL; Ward MA; Lovestone S
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.

2010-07 | Journal article
DOI: 10.1001/archgenpsychiatry.2010.78
PMID: 20603455
PMC: PMC3111021
Contributors: Thambisetty M; Simmons A; Velayudhan L; Hye A; Campbell J; Zhang Y; Wahlund LO; Westman E; Kinsey A; Güntert A et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Candidate verification of iron-regulated Neisseria meningitidis proteins using isotopic versions of tandem mass tags (TMT) and single reaction monitoring.

2009-12 | Journal article
DOI: 10.1016/j.jprot.2009.09.002
PMID: 19778646
Contributors: Byers HL; Campbell J; van Ulsen P; Tommassen J; Ward MA; Schulz-Knappe P; Prinz T; Kuhn K
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

AddNeuroMed--the European collaboration for the discovery of novel biomarkers for Alzheimer's disease.

2009-10 | Journal article
DOI: 10.1111/j.1749-6632.2009.05064.x
PMID: 19906259
Contributors: Lovestone S; Francis P; Kloszewska I; Mecocci P; Simmons A; Soininen H; Spenger C; Tsolaki M; Vellas B; Wahlund LO et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Proteomics for brain disorders--the promise for biomarkers.

2009-10 | Journal article
DOI: 10.1111/j.1749-6632.2009.05018.x
PMID: 19906262
Contributors: Ward M; Güntert A; Campbell J; Pike I
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin.

2008-09 | Journal article
DOI: 10.1096/fj.08-109181
PMID: 18511549
Contributors: Cuchillo-Ibanez I; Seereeram A; Byers HL; Leung KY; Ward MA; Anderton BH; Hanger DP
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Comparison of cellular ribonucleoprotein complexes associated with the APOBEC3F and APOBEC3G antiviral proteins.

2008-06 | Journal article
DOI: 10.1128/jvi.00287-08
PMID: 18367521
PMC: PMC2395208
Contributors: Gallois-Montbrun S; Holmes RK; Swanson CM; Fernández-Ocaña M; Byers HL; Ward MA; Malim MH
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Biomarkers for Alzheimer's disease.

2007-09 | Journal article
DOI: 10.1586/14737159.7.5.635
PMID: 17892369
Contributors: Ward M
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.

2007-08 | Journal article
DOI: 10.1074/jbc.m703269200
PMID: 17562708
Contributors: Hanger DP; Byers HL; Wray S; Leung KY; Saxton MJ; Seereeram A; Reynolds CH; Ward MA; Anderton BH
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.

2007-07 | Journal article
DOI: 10.1021/pr0700753
PMID: 17552550
Contributors: Dalrymple A; Wild EJ; Joubert R; Sathasivam K; Björkqvist M; Petersén A; Jackson GS; Isaacs JD; Kristiansen M; Bates GP et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Purification and identification of the STAT5 protease in myeloid cells.

2007-05 | Journal article
DOI: 10.1042/bj20061877
PMID: 17300217
Contributors: Schuster B; Hendry L; Byers H; Lynham SF; Ward MA; John S
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Proteomics of Alzheimer's disease: understanding mechanisms and seeking biomarkers.

2007-04 | Journal article
DOI: 10.1586/14789450.4.2.227
PMID: 17425458
Contributors: Lovestone S; Güntert A; Hye A; Lynham S; Thambisetty M; Ward M
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Antiviral protein APOBEC3G localizes to ribonucleoprotein complexes found in P bodies and stress granules.

2007-03 | Journal article
DOI: 10.1128/jvi.02287-06
PMID: 17166910
PMC: PMC1865933
Contributors: Gallois-Montbrun S; Kramer B; Swanson CM; Byers H; Lynham S; Ward M; Malim MH
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Proteome-based plasma biomarkers for Alzheimer's disease.

2006-11 | Journal article
DOI: 10.1093/brain/awl279
PMID: 17071923
Contributors: Hye A; Lynham S; Thambisetty M; Causevic M; Campbell J; Byers HL; Hooper C; Rijsdijk F; Tabrizi SJ; Banner S et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.

2005-10 | Journal article
DOI: 10.1074/jbc.m506216200
PMID: 16049005
Contributors: Tudor EL; Perkinton MS; Schmidt A; Ackerley S; Brownlees J; Jacobsen NJ; Byers HL; Ward M; Hall A; Leigh PN et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

A novel strategy using MASCOT Distiller for analysis of cleavable isotope-coded affinity tag data to quantify protein changes in plasma.

2005-08 | Journal article
DOI: 10.1002/pmic.200402101
PMID: 16041675
Contributors: Leung KY; Lescuyer P; Campbell J; Byers HL; Allard L; Sanchez JC; Ward MA
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

2005-07 | Journal article
DOI: 10.1523/jneurosci.1487-05.2005
PMID: 16014719
Contributors: Derkinderen P; Scales TM; Hanger DP; Leung KY; Byers HL; Ward MA; Lenz C; Price C; Bird IN; Perera T et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

ApoC-I and ApoC-III as potential plasmatic markers to distinguish between ischemic and hemorrhagic stroke.

2004-08 | Journal article
DOI: 10.1002/pmic.200300809
PMID: 15274118
Contributors: Allard L; Lescuyer P; Burgess J; Leung KY; Ward M; Walter N; Burkhard PR; Corthals G; Hochstrasser DF; Sanchez JC
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

Effect of high-fat diet on the expression of proteins in muscle, adipose tissues, and liver of C57BL/6 mice.

2004-08 | Journal article
DOI: 10.1002/pmic.200300810
PMID: 15274121
Contributors: Schmid GM; Converset V; Walter N; Sennitt MV; Leung KY; Byers H; Ward M; Hochstrasser DF; Cawthorne MA; Sanchez JC
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.

2004-06 | Journal article
DOI: 10.1016/j.mcn.2004.02.009
PMID: 15207859
Contributors: Ackerley S; Grierson AJ; Banner S; Perkinton MS; Brownlees J; Byers HL; Ward M; Thornhill P; Hussain K; Waby JS et al.
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.

2004-05 | Journal article
DOI: 10.1074/jbc.m311479200
PMID: 15031292
Contributors: Perkinton MS; Standen CL; Lau KF; Kesavapany S; Byers HL; Ward M; McLoughlin DM; Miller CC
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central

The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).

2003-12 | Journal article
DOI: 10.1016/j.mcn.2003.07.002
PMID: 14697653
Contributors: Standen CL; Perkinton MS; Byers HL; Kesavapany S; Lau KF; Ward M; McLoughlin D; Miller CC
Source: Self-asserted source
Malcolm Ward via Europe PubMed Central
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