Personal information

Other IDs

Loop profile: 1058750
Scopus Author ID: 26641617900

Keywords

Cancer biology, cell signaling, kinases, genetic screening, mouse models

Countries

Spain

Activities

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Employment (7)

Lewis Katz School of Medicine at Temple University: Philadelphia, PA, US

2022-09-01 to present | Assistant Professor (Cancer and Cellular Biology)
Employment
Source: Self-asserted source
Pedro Torres-Ayuso

National Cancer Institute: Frederick, MD, US

2022-01-01 to 2022-08-31 | Research Fellow (Laboratory of Cell and Developmental Signaling)
Employment
Source: Self-asserted source
Pedro Torres-Ayuso

National Cancer Institute: Frederick, MD, US

2017-01-09 to 2021-12-31 | Postdoctoral fellow (Laboratory of Cell and Developmental Signaling)
Employment
Source: Self-asserted source
Pedro Torres-Ayuso

Cancer Reseach UK Manchester Institute: Manchester, GB

2014-10-01 to 2016-12-31 | Postdoctoral scientist (Signalling Networks in Cancer)
Employment
Source: Self-asserted source
Pedro Torres-Ayuso

Centro Nacional de Biotecnología: Madrid, Madrid, ES

2012-09-21 to 2014-07-31 (Department of Immunology and Oncology)
Employment
Source: Self-asserted source
Pedro Torres-Ayuso

Centro Nacional de Biotecnología: Madrid, Madrid, ES

2008-01 to 2012-09 | PhD Student (Dept. of Immunology and Oncology)
Employment
Source: Self-asserted source
Pedro Torres-Ayuso

Universidad Complutense de Madrid: Madrid, Comunidad de Madrid, ES

2004-09 to 2007-09 | Undergraduate student research collaborator (Department of Biochemistry and Molecular Biology I)
Employment
Source: Self-asserted source
Pedro Torres-Ayuso

Education and qualifications (2)

Centro Nacional de Biotecnología: Madrid, Madrid, ES

2008-01-01 to 2012-09-21 | PhD in Molecular Biology (Dept. of Immunology and Oncology)
Education
Source: Self-asserted source
Pedro Torres-Ayuso

Universidad Complutense de Madrid: Madrid, Comunidad de Madrid, ES

2002-10 to 2007-09 | BSc in Biology
Education
Source: Self-asserted source
Pedro Torres-Ayuso

Professional activities (3)

Federation of European Biochemical Societies: Cambridge, GB

Membership
Source: Self-asserted source
Pedro Torres-Ayuso

European Association For Cancer Research: Nottingham, Nottingham, GB

Membership
Source: Self-asserted source
Pedro Torres-Ayuso

American Association for Cancer Research: Philadelphia, PA, US

Membership
Source: Self-asserted source
Pedro Torres-Ayuso

Funding (3)

Identification of druggable drivers in lung squamous cell carcinoma

2016-11 to 2018-10 | Grant
European Commission (Brussels, BE)
Source: Self-asserted source
Pedro Torres-Ayuso

New druggable drivers in lung squamous cell carcinoma

2014-10 to 2016-10 | Grant
Fundacion Ramon Areces (Madrid, ES)
Source: Self-asserted source
Pedro Torres-Ayuso

Role of diacylglycerol kinases in cancer progression

2008-01 to 2011-12 | Contract
Spanish Ministry of Education (FPU program) (Madrid, ES)
Source: Self-asserted source
Pedro Torres-Ayuso

Works (32)

Data from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.c.6549481
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Data from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.c.6549481.v1
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Supplementary Figure S8.1 from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.22540825
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Supplementary Figure S8.1 from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.22540825.v1
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Supplementary Figure S8.2 from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.22540822
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Supplementary Figure S8.2 from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.22540822.v1
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Supplementary Figures from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.22540819
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Supplementary Figures from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.22540819.v1
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Supplementary Methods from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.22540816
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Supplementary Methods from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.22540816.v1
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Supplementary Movie 1 from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.22540810
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Supplementary Movie 1 from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.22540810.v1
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Supplementary Tables from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.22540807
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Supplementary Tables from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2023-04-03 | Preprint
DOI: 10.1158/2159-8290.22540807.v1
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Degraders: The Ultimate Weapon Against Amplified Driver Kinases in Cancer

Molecular Pharmacology
2022-02-03 | Journal article
DOI: 10.1124/molpharm.121.000306
Contributors: Pedro Torres-Ayuso; John Brognard
Source: check_circle
Crossref

TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Cancer Discovery
2021-06-01 | Journal article
DOI: 10.1158/2159-8290.CD-20-0797
Contributors: Pedro Torres-Ayuso; Elvira An; Katherine M. Nyswaner; Ryan C. Bensen; Daniel A. Ritt; Suzanne I. Specht; Sudipto Das; Thorkell Andresson; Raul E. Cachau; Roger J. Liang et al.
Source: check_circle
Crossref

Diacylglycerol kinase malfunction in human disease and the search for specific inhibitors

Handbook of Experimental Pharmacology
2020 | Book chapter
DOI: 10.1007/164_2019_221
EID:

2-s2.0-85084104847

Part of ISBN:

18650325 01712004
Contributors: Merida, I.; Arranz-Nicolás, J.; Torres-Ayuso, P.; Ávila-Flores, A.
Source: Self-asserted source
Pedro Torres-Ayuso via Scopus - Elsevier

Penicillin acylase from streptomyces lavendulae and aculeacin a acylase from actinoplanes utahensis: Two versatile enzymes as useful tools for quorum quenching processes

Catalysts
2020 | Journal article
DOI: 10.3390/catal10070730
EID:

2-s2.0-85087387705

Part of ISBN:

20734344
Contributors: Velasco-Bucheli, R.; Hormigo, D.; Fernández-Lucas, J.; Torres-Ayuso, P.; Alfaro-Ureña, Y.; Saborido, A.I.; Serrano-Aguirre, L.; García, J.L.; Ramón, F.; Acebal, C. et al.
Source: Self-asserted source
Pedro Torres-Ayuso via Scopus - Elsevier

The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells

Journal of Biological Chemistry
2020 | Journal article
DOI: 10.1074/jbc.RA119.012365
EID:

2-s2.0-85086780172

Part of ISBN:

1083351X 00219258
Contributors: Hoang, V.T.; Nyswaner, K.; Torres-Ayuso, P.; Brognard, J.
Source: Self-asserted source
Pedro Torres-Ayuso via Scopus - Elsevier

Combing the Cancer Genome for Novel Kinase Drivers and New Therapeutic Targets

Cancers
2019-12-07 | Journal article
DOI: 10.3390/cancers11121972
Contributors: Pedro Torres-Ayuso; John Brognard
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Shipping Out MEK Inhibitor Resistance with SHP2 Inhibitors

Cancer Discovery
2018-10-01 | Journal article
DOI: 10.1158/2159-8290.CD-18-0915
Contributors: Pedro Torres-Ayuso; John Brognard
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin

npj Genomic Medicine
2018-06-20 | Journal article
DOI: 10.1038/s41525-018-0055-6
Contributors: Pedro Torres-Ayuso; Sudhakar Sahoo; Garry Ashton; Elvira An; Nicole Simms; Melanie Galvin; Hui Sun Leong; Kristopher K Frese; Kathryn Simpson; Natalie Cook et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Survival of Head and Neck Cancer Cells Relies upon LZK Kinase-Mediated Stabilization of Mutant p53.

Cancer research
2017-09 | Journal article
DOI: 10.1158/0008-5472.can-17-0267
PMID: 28760853
Contributors: Edwards ZC; Trotter EW; Torres-Ayuso P; Chapman P; Wood HM; Nyswaner K; Brognard J
Source: Self-asserted source
Pedro Torres-Ayuso via Europe PubMed Central
grade
Preferred source (of 2)‎

Diacylglycerol kinases in cancer.

Advances in biological regulation
2017-01 | Journal article
DOI: 10.1016/j.jbior.2016.09.005
PMID: 27697466
Contributors: Mérida I; Torres-Ayuso P; Ávila-Flores A; Arranz-Nicolás J; Andrada E; Tello-Lafoz M; Liébana R; Arcos R
Source: Self-asserted source
Pedro Torres-Ayuso via Europe PubMed Central
grade
Preferred source (of 2)‎

Somatically mutated ABL1 is an actionable and essential NSCLC survival gene.

EMBO molecular medicine
2016-02 | Journal article
DOI: 10.15252/emmm.201505456
PMID: 26758680
PMC: PMC4734836
Contributors: Testoni E; Stephenson NL; Torres-Ayuso P; Marusiak AA; Trotter EW; Hudson A; Hodgkinson CL; Morrow CJ; Dive C; Brognard J
Source: Self-asserted source
Pedro Torres-Ayuso via Europe PubMed Central
grade
Preferred source (of 2)‎

Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1.

Oncogenesis
2015 | Journal article
DOI: 10.1038/oncsis.2015.22
PMID: 26302180
PMC: PMC4632073
Contributors: Torres-Ayuso P; Tello-Lafoz M; Mérida I; Ávila-Flores A
Source: Self-asserted source
Pedro Torres-Ayuso via Europe PubMed Central
grade
Preferred source (of 2)‎

A Blk-p190RhoGAP signaling module downstream of activated Gα13 functionally opposes CXCL12-stimulated RhoA activation and cell invasion.

Cellular signalling
2014-11 | Journal article
DOI: 10.1016/j.cellsig.2014.07.008
PMID: 25025568
Contributors: Bartolomé RA; Díaz-Martínez M; Coló GP; Arellano-Sánchez N; Torres-Ayuso P; Kleinovink JW; Mérida I; Teixidó J
Source: Self-asserted source
Pedro Torres-Ayuso via Europe PubMed Central
grade
Preferred source (of 2)‎

Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.

Oncotarget
2014-10 | Journal article
DOI: 10.18632/oncotarget.2344
PMID: 25339152
PMC: PMC4259432
Contributors: Torres-Ayuso P; Daza-Martín M; Martín-Pérez J; Ávila-Flores A; Mérida I
Source: Self-asserted source
Pedro Torres-Ayuso via Europe PubMed Central
grade
Preferred source (of 2)‎

FoxO-dependent regulation of diacylglycerol kinase α gene expression.

Molecular and cellular biology
2012-10 | Journal article
DOI: 10.1128/mcb.00654-12
PMID: 22890845
PMC: PMC3457341
Contributors: Martínez-Moreno M; García-Liévana J; Soutar D; Torres-Ayuso P; Andrada E; Zhong XP; Koretzky GA; Mérida I; Ávila-Flores A
Source: Self-asserted source
Pedro Torres-Ayuso via Europe PubMed Central
grade
Preferred source (of 2)‎

Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse.

Molecular biology of the cell
2011-11 | Journal article
DOI: 10.1091/mbc.e11-03-0247
PMID: 21937721
PMC: PMC3216665
Contributors: Gharbi SI; Rincón E; Avila-Flores A; Torres-Ayuso P; Almena M; Cobos MA; Albar JP; Mérida I
Source: Self-asserted source
Pedro Torres-Ayuso via Europe PubMed Central
grade
Preferred source (of 2)‎

Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression.

Advances in enzyme regulation
2009 | Journal article
DOI: 10.1016/j.advenzreg.2009.01.003
PMID: 19534031
Contributors: Mérida I; Avila-Flores A; García J; Merino E; Almena M; Torres-Ayuso P
Source: Self-asserted source
Pedro Torres-Ayuso via Europe PubMed Central
grade
Preferred source (of 2)‎

Newly discovered penicillin acylase activity of aculeacin A acylase from Actinoplanes utahensis.

Applied and environmental microbiology
2007-08 | Journal article
DOI: 10.1128/aem.00452-07
PMID: 17586674
PMC: PMC1950969
Contributors: Torres-Bacete J; Hormigo D; Stuart M; Arroyo M; Torres P; Castillón MP; Acebal C; García JL; de la Mata I
Source: Self-asserted source
Pedro Torres-Ayuso via Europe PubMed Central

Peer review (14 reviews for 7 publications/grants)

Review activity for Cancers. (2)
Review activity for Communications biology. (1)
Review activity for Faculty Opinions (2)
Review activity for Gene. (6)
Review activity for International journal of molecular sciences. (1)
Review activity for Medicines. (1)
Review activity for Oncogene. (1)
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