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Works (33)

Directed evolution of a highly efficient TNA polymerase achieved by homologous recombination

Nature Catalysis
2024-10-01 | Journal article
Contributors: Victoria A. Maola; Eric J. Yik; Mohammad Hajjar; Joy J. Lee; Manuel J. Holguin; Riley N. Quijano; Kalvin K. Nguyen; Katherine L. Ho; Jenny V. Medina; Nicholas Chim et al.
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Crossref

Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid

Nucleic Acids Research
2022-09-23 | Journal article
Contributors: Mohammad Hajjar; Nicholas Chim; Chao Liu; Piet Herdewijn; John C Chaput
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Crossref

Transliteration of synthetic genetic enzymes

Nucleic Acids Research
2021-11-18 | Journal article
Contributors: Yajun Wang; Xiaolin Liu; Mouhamad Shehabat; Nicholas Chim; John C Chaput
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Crossref

Evolution of Functionally Enhanced α-l-Threofuranosyl Nucleic Acid Aptamers.

ACS synthetic biology
2021-11-05 | Journal article
Contributors: McCloskey CM; Li Q; Yik EJ; Chim N; Ngor AK; Medina E; Grubisic I; Co Ting Keh L; Poplin R; John Chaput
Source: Self-asserted source
Nicholas Chim

Synthesis and Polymerase Recognition of Threose Nucleic Acid Triphosphates Equipped with Diverse Chemical Functionalities.

Journal of the American Chemical Society
2021-10-12 | Journal article
Contributors: Li Q; Maola VA; Chim N; Javeena Hussain; Adriana Lozoya-Colinas; John Chaput
Source: Self-asserted source
Nicholas Chim

Following replicative DNA synthesis by time-resolved X-ray crystallography

Nature Communications
2021-05-11 | Journal article
Contributors: Nicholas Chim; Roman A. Meza; Anh M. Trinh; Kefan Yang; John C. Chaput
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Crossref

Engineering polymerases for applications in synthetic biology

Quarterly Reviews of Biophysics
2020 | Journal article
Contributors: Ali Nikoomanzar; Nicholas Chim; Eric J. Yik; John C. Chaput
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Crossref

Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase

Nucleic Acids Research
2019-07-26 | Journal article
Contributors: Lynnette N Jackson; Nicholas Chim; Changhua Shi; John C Chaput
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Crossref

Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway

eLife
2018-10-19 | Journal article
Contributors: Nicholas Chim; Lynnette N Jackson; Anh M Trinh; John C Chaput
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Crossref

Synthesis of 2'-Deoxy-α-l-threofuranosyl Nucleoside Triphosphates.

The Journal of organic chemistry
2018-07-27 | Journal article
Contributors: Bala S; Liao JY; Li Zhang; Tran CN; Chim N; John Chaput
Source: Self-asserted source
Nicholas Chim

Structural basis for TNA synthesis by an engineered TNA polymerase

Nature Communications
2017-11-27 | Journal article
Contributors: Nicholas Chim; Changhua Shi; Sujay P. Sau; Ali Nikoomanzar; John C. Chaput
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Crossref

Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration.

Cell host & microbe
2016-06-01 | Journal article
Contributors: Diaz-Ochoa VE; Lam D; Lee CS; Klaus S; Judith Behnsen; Liu JZ; Chim N; Sean-Paul Nuccio; Rathi SG; Mastroianni JR et al.
Source: Self-asserted source
Nicholas Chim

The Structure and Interactions of Periplasmic Domains of Crucial MmpL Membrane Proteins from Mycobacterium tuberculosis.

Chemistry & biology
2015-08-13 | Journal article
Contributors: Chim N; Torres R; Liu Y; Capri J; Batot G; Whitelegge JP; Celia Goulding
Source: Self-asserted source
Nicholas Chim

Structural snapshots along the reaction pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase.

Acta crystallographica. Section D, Biological crystallography
2014-03-20 | Journal article
Contributors: Torres R; Lan B; Latif Y; Chim N; Celia Goulding
Source: Self-asserted source
Nicholas Chim

Heme uptake in bacterial pathogens.

Current opinion in chemical biology
2014-01-04 | Journal article
Contributors: Contreras H; Chim N; Credali A; Celia Goulding
Source: Self-asserted source
Nicholas Chim

Insights into redox sensing metalloproteins in Mycobacterium tuberculosis.

Journal of inorganic biochemistry
2013-11-15 | Journal article
Contributors: Chim N; Johnson PM; Celia Goulding
Source: Self-asserted source
Nicholas Chim

Structural and biochemical characterization of the essential DsbA-like disulfide bond forming protein from Mycobacterium tuberculosis.

BMC structural biology
2013-10-18 | Journal article
Contributors: Chim N; Harmston CA; Guzman DJ; Celia Goulding
Source: Self-asserted source
Nicholas Chim

Structures of oligomers of a peptide from β-amyloid.

Journal of the American Chemical Society
2013-08-08 | Journal article
Contributors: Pham JD; Chim N; Celia Goulding; Nowick JS
Source: Self-asserted source
Nicholas Chim

Insights on how the Mycobacterium tuberculosis heme uptake pathway can be used as a drug target.

Future medicinal chemistry
2013-08-01 | Journal article
Contributors: Cedric Owens; Chim N; Celia Goulding
Source: Self-asserted source
Nicholas Chim

The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11.

The Journal of biological chemistry
2013-06-11 | Journal article
Contributors: Cedric Owens; Chim N; Graves AB; Harmston CA; Iniguez A; Contreras H; Liptak MD; Celia Goulding
Source: Self-asserted source
Nicholas Chim

Structural insights into RipC, a putative citrate lyase β subunit from a Yersinia pestis virulence operon.

Acta crystallographica. Section F, Structural biology and crystallization communications
2011-12-24 | Journal article
Contributors: Torres R; Chim N; Sankaran B; Pujol C; Bliska JB; Celia Goulding
Source: Self-asserted source
Nicholas Chim

Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis.

PloS one
2011-09-26 | Journal article
Contributors: Torres R; Swift RV; Chim N; Wheatley N; Lan B; Atwood BR; Pujol C; Sankaran B; Bliska JB; Rommie E. Amaro et al.
Source: Self-asserted source
Nicholas Chim

Structure of H/ACA RNP protein Nhp2p reveals cis/trans isomerization of a conserved proline at the RNA and Nop10 binding interface.

Journal of molecular biology
2011-06-25 | Journal article
Contributors: Koo BK; Chin-Ju Park; Fernandez CF; Chim N; Ding Y; Chanfreau G; Feigon J
Source: Self-asserted source
Nicholas Chim

Discovery and characterization of a unique mycobacterial heme acquisition system.

Proceedings of the National Academy of Sciences of the United States of America
2011-03-07 | Journal article
Contributors: Tullius MV; Harmston CA; Cedric Owens; Chim N; Morse RP; McMath LM; Iniguez A; Jacqueline M Kimmey; Sawaya MR; Whitelegge JP et al.
Source: Self-asserted source
Nicholas Chim

The TB Structural Genomics Consortium: a decade of progress.

Tuberculosis (Edinburgh, Scotland)
2011-01-17 | Journal article
Contributors: Chim N; Habel JE; Johnston JM; Krieger I; Miallau L; Sankaranarayanan R; Morse RP; John Bruning; Swanson S; Kim H et al.
Source: Self-asserted source
Nicholas Chim

An extracellular disulfide bond forming protein (DsbF) from Mycobacterium tuberculosis: structural, biochemical, and gene expression analysis.

Journal of molecular biology
2010-01-11 | Journal article
Contributors: Chim N; Robert Riley; The J; Im S; Brent Segelke; Lekin T; Yu M; Li-Wei Hung; Thomas Terwilliger; Whitelegge JP et al.
Source: Self-asserted source
Nicholas Chim

Unusual diheme conformation of the heme-degrading protein from Mycobacterium tuberculosis.

Journal of molecular biology
2009-11-14 | Journal article
Contributors: Chim N; Iniguez A; Nguyen TQ; Celia Goulding
Source: Self-asserted source
Nicholas Chim

Advances in Mycobacterium tuberculosis structural genomics: investigating potential chinks in the armor of a deadly pathogen.

Infectious disorders drug targets
2009-11-01 | Journal article
Contributors: Chim N; McMath LM; Morgan Beeby; Celia Goulding
Source: Self-asserted source
Nicholas Chim

Structural and functional characterization of human telomerase RNA processing and cajal body localization signals.

Molecular cell
2007-09-01 | Journal article
Contributors: Theimer CA; Jády BE; Chim N; Patricia Richard; Breece KE; Tamas Kiss; Feigon J
Source: Self-asserted source
Nicholas Chim

Cross-polarization dynamics in polycrystalline samples

Journal of Molecular Structure
2007-03 | Journal article
Part of ISSN: 0022-2860
Contributors: R.E. Taylor; Nicholas Chim; C. Dybowski
Source: Self-asserted source
Nicholas Chim

NMR characterization of partially deuterated γ-glycine

Journal of Molecular Structure
2006-08 | Journal article
Part of ISSN: 0022-2860
Contributors: R.E. Taylor; Nicholas Chim; C. Dybowski
Source: Self-asserted source
Nicholas Chim

Solution structure of the ubiquitin-binding domain in Swa2p from Saccharomyces cerevisiae.

Proteins
2004-03-01 | Journal article
Contributors: Chim N; Gall WE; Xiao J; Harris MP; Graham TR; Krezel AM
Source: Self-asserted source
Nicholas Chim

1H, 13C, and 15N backbone assignments of the ligand binding domain of TGFbeta type II receptor.

Journal of biomolecular NMR
2000-08-01 | Journal article
Contributors: Marlow MS; Chim N; Brown CB; Barnett JV; Krezel AM
Source: Self-asserted source
Nicholas Chim