Personal information

Alzheimer' disease, amyloid beta, alpha-synuclein , dityrosine, tau
Iraq

Activities

Education and qualifications (1)

University of Sussex: Brighton, Brighton and Hove, GB

2010 to 2014 | PhD (Biochemsitry and Molecular Biology)
Education
Source: Self-asserted source
Dr Youssra Al-Hilaly

Professional activities (3)

Alzheimer’s Research UK: Cambridge , GB

Membership
Source: Self-asserted source
Dr Youssra Al-Hilaly

Royal Society of Biology: London, GB

2018-10 to present
Membership
Source: Self-asserted source
Dr Youssra Al-Hilaly

Biochemical Society: London, London, GB

2018 to present | Member
Membership
Source: Self-asserted source
Dr Youssra Al-Hilaly

Funding (1)

PHF formed by truncated tau as a seed for full length tau assembly

2019-07 to 2019-08 | Grant
Alzheimer’s Research UK (Cambridge, GB)
Source: Self-asserted source
Dr Youssra Al-Hilaly

Works (33)

Fluorine-based Zn salan complexes

Dalton Transactions
2023 | Journal article
Contributors: Nsikak B. Essien; Antal Galvácsi; Csilla Kállay; Youssra Al-Hilaly; Ramón González-Méndez; Geoffrey R. Akien; Graham J. Tizzard; Simon J. Coles; Maria Besora; George E. Kostakis
Source: check_circle
Crossref

Chiral Co3Y Propeller-Shaped Chemosensory Platforms Based on 19F-NMR

Inorganic Chemistry
2023-02-13 | Journal article
Contributors: Gabrielle Audsley; Harry Carpenter; Nsikak B. Essien; James Lai-Morrice; Youssra Al-Hilaly; Louise C. Serpell; Geoffrey R. Akien; Graham J. Tizzard; Simon J. Coles; Cristina Pubill Ulldemolins et al.
Source: check_circle
Crossref

Charge screening wormlike micelles affects extensional relaxation time and noodle formation

Chemical Communications
2022 | Journal article
Contributors: Rui Huang; Daniel McDowall; Henry Ng; Lisa Thomson; Youssra K. Al-Hilaly; James Doutch; Sam Burholt; Louise C. Serpell; Robert J. Poole; Dave J. Adams
Source: check_circle
Crossref

Shapeshifting tau: from intrinsically disordered to paired-helical filaments

Essays in Biochemistry
2022-12-16 | Journal article
Contributors: Samrat Mukhopadhyay; Kurtis Mengham; Youssra Al-Hilaly; Sebastian Oakley; Kamillia Kasbi; Mahmoud B. Maina; Louise C. Serpell
Source: check_circle
Crossref

Dityrosine Cross-links are Present in Alzheimer’s Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro

Journal of Molecular Biology
2022-10 | Journal article
Part of ISSN: 0022-2836
Contributors: Dr Youssra Al-Hilaly; Mahmoud B. Maina; Youssra K. Al-Hilaly; Sebastian Oakley; Gunasekhar Burra; Tahmida Khanom; Luca Biasetti; Kurtis Mengham; Karen Marshall; Charles R. Harrington et al.
Source: Self-asserted source
Dr Youssra Al-Hilaly

Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)

2022-06-10 | Preprint
Contributors: Youssra K. Al-Hilaly; Connor Hurt; Janet E. Rickard; Charles R. Harrington; John M.D. Storey; Claude M. Wischik; Louise C. Serpell; Ansgar B. Siemer
Source: check_circle
Crossref

Self-assembly and cellular effect of tau35, a disease-associated tau fragment

Alzheimer's & dementia : the journal of the Alzheimer's Association
2021 | Journal article
Source: Self-asserted source
Dr Youssra Al-Hilaly
grade
Preferred source (of 2)‎

The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau

Frontiers in Molecular Biosciences
2021 | Journal article
EID:

2-s2.0-85119069755

Part of ISSN: 2296889X
Contributors: Lyu, C.; Da Vela, S.; Al-Hilaly, Y.; Marshall, K.E.; Thorogate, R.; Svergun, D.; Serpell, L.C.; Pastore, A.; Hanger, D.P.
Source: Self-asserted source
Dr Youssra Al-Hilaly via Scopus - Elsevier

Structural identification of individual helical amyloid filaments by integration of cryo-electron microscopy-derived maps in comparative morphometric atomic force microscopy image analysis

2021-10-20 | Other
Contributors: Liisa Lutter; Youssra K. Al-Hilaly; Christopher J. Serpell; Mick F. Tuite; Claude M. Wischik; Louise C. Serpell; Wei-Feng Xue
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

The disease associated Tau35 fragment has an increased propensity to aggregate compared to full-length tau

2021-07-09 | Other
Contributors: Chen Lyu; Stefano Da Vela; Youssra Al-Hilaly; Karen E. Marshall; Richard Thorogate; Dmitri Svergun; Louise Serpell; Annalisa Pastore; Diane Hanger
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates

Cells
2021-03-22 | Journal article
Contributors: Mahmoud B. Maina; Youssra K. Al-Hilaly; Gunasekhar Burra; Janet E. Rickard; Charles R. Harrington; Claude M. Wischik; Louise C. Serpell
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Oxidative stress conditions result in trapping of PHF-core tau (297-391) intermediates

bioRxiv
2020 | Other
EID:

2-s2.0-85099895461

Part of ISSN: 26928205
Contributors: Maina, M.B.; Al-Hilaly, Y.K.; Burra, G.; Rickard, J.; Harrington, C.; Wischik, C.; Serpell, L.C.
Source: Self-asserted source
Dr Youssra Al-Hilaly via Scopus - Elsevier

Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target

Frontiers in Neurology
2020-11-12 | Journal article
Part of ISSN: 1664-2295
Source: Self-asserted source
Dr Youssra Al-Hilaly
grade
Preferred source (of 2)‎

Metal- and UV- Catalyzed Oxidation Results in Trapped Amyloid-β Intermediates Revealing that Self-Assembly Is Required for Aβ-Induced Cytotoxicity

iScience
2020-10 | Journal article
Part of ISSN: 2589-0042
Source: Self-asserted source
Dr Youssra Al-Hilaly
grade
Preferred source (of 2)‎

Dityrosine Crossed-linked Amyloid-like Fibrils as Bionanomaterials

Iraqi Journal of Nanotechnology
2020-10-29 | Journal article
Contributors: Youssra Kareem Al-Hilaly; Mahmoud Bukar Maina; Alaa Abdul-Sada; Louise Serpell
Source: check_circle
Crossref

Paired Helical Filament-Forming Region of Tau (297-391) Influences Endogenous Tau Protein and Accumulates in Acidic Compartments in Human Neuronal Cells.

Journal of molecular biology
2020-07 | Journal article
Contributors: Pollack SJ; Trigg J; Khanom T; Biasetti L; Marshall KE; Al-Hilaly YK; Rickard JE; Harrington CR; Wischik CM; Serpell LC
Source: Self-asserted source
Dr Youssra Al-Hilaly via Europe PubMed Central
grade
Preferred source (of 2)‎

Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer’s disease brain

FEBS Letters
2020-03 | Journal article
Contributors: Youssra K. Al‐Hilaly; Bronwen E. Foster; Luca Biasetti; Liisa Lutter; Saskia J. Pollack; Janet E. Rickard; John M. D. Storey; Charles R. Harrington; Wei‐Feng Xue; Claude M. Wischik et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Dityrosine cross-link trapping of amyloid-β intermediates reveals that self-assembly is required for Aβ-induced cytotoxicity

2020-03-26 | Preprint
Contributors: Mahmoud B. Maina; Kurtis Mengham; Gunasekhar K. Burra; Youssra A. Al-Hilaly; Louise C. Serpell
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Methods for Structural Analysis of Amyloid Fibrils in Misfolding Diseases

Methods in molecular biology (Clifton, N.J.)
2019 | Journal article
Source: Self-asserted source
Dr Youssra Al-Hilaly
grade
Preferred source (of 2)‎

The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

Acta Neuropathologica Communications
2019 | Journal article
Source: Self-asserted source
Dr Youssra Al-Hilaly
grade
Preferred source (of 2)‎

The molecular basis for Apolipoprotein E4 as the major risk factor for late onset Alzheimer’s disease

Journal of Molecular Biology
2019 | Journal article
Source: Self-asserted source
Dr Youssra Al-Hilaly
grade
Preferred source (of 2)‎

Using Chirality to Influence Supramolecular Gelation

Chem. Sci.
2019 | Journal article
Source: Self-asserted source
Dr Youssra Al-Hilaly
grade
Preferred source (of 3)‎

Zinc–dysprosium functionalized amyloid fibrils

Dalton Transactions
2019 | Journal article
Contributors: Stavroula I. Sampani; Youssra K. Al-Hilaly; Sharali Malik; Louise C. Serpell; George E. Kostakis
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

The involvement of dityrosine crosslinks in lipofuscin accumulation in Alzheimer’s disease

Journal of Physics: Conference Series
2019-09 | Journal article
Part of ISSN: 1742-6588
Part of ISSN: 1742-6596
Source: Self-asserted source
Dr Youssra Al-Hilaly
grade
Preferred source (of 2)‎

The CDR1 and Other Regions of Immunoglobulin Light Chains are Hot Spots for Amyloid Aggregation

Scientific Reports
2019-02-28 | Journal article
Contributors: Robin Axel Ruiz-Zamora; Simon Guillaumé; Youssra K. Al-Hilaly; Zahraa Al-Garawi; Francisco Javier Rodríguez-Alvarez; Guadalupe Zavala-Padilla; Julio I. Pérez-Carreón; Sandra L. Rodríguez-Ambriz; Guillermo A. Herrera; Baltazar Becerril-Luján et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Cysteine-Independent Inhibition of Alzheimer's Disease-like Paired Helical Filament Assembly by Leuco-Methylthioninium (LMT)

Journal of Molecular Biology
2018 | Journal article
EID:

2-s2.0-85053053674

Contributors: Al-Hilaly, Y.K.; Pollack, S.J.; Rickard, J.E.; Simpson, M.; Raulin, A.-C.; Baddeley, T.; Schellenberger, P.; Storey, J.M.D.; Harrington, C.R.; Wischik, C.M. et al.
Source: Self-asserted source
Dr Youssra Al-Hilaly via Scopus - Elsevier

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking

Journal of Molecular Biology
2017 | Journal article
EID:

2-s2.0-85030644788

Contributors: Al-Hilaly, Y.K.; Pollack, S.J.; Vadukul, D.M.; Citossi, F.; Rickard, J.E.; Simpson, M.; Storey, J.M.D.; Harrington, C.R.; Wischik, C.M.; Serpell, L.C.
Source: Self-asserted source
Dr Youssra Al-Hilaly via Scopus - Elsevier
grade
Preferred source (of 2)‎

A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration

Scientific Reports
2016 | Journal article
EID:

2-s2.0-84979257072

Contributors: Marshall, K.E.; Vadukul, D.M.; Dahal, L.; Theisen, A.; Fowler, M.W.; Al-Hilaly, Y.; Ford, L.; Kemenes, G.; Day, I.J.; Staras, K. et al.
Source: Self-asserted source
Dr Youssra Al-Hilaly via Scopus - Elsevier

Nuclear tau and its potential role in alzheimer’s disease

Biomolecules
2016 | Journal article
EID:

2-s2.0-85012065369

Contributors: Maina, M.B.; Al-Hilaly, Y.K.; Serpell, L.C.
Source: Self-asserted source
Dr Youssra Al-Hilaly via Scopus - Elsevier

The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson's disease

Scientific Reports
2016 | Journal article
EID:

2-s2.0-85020024761

Contributors: Al-Hilaly, Y.K.; Biasetti, L.; Blakeman, B.J.F.; Pollack, S.J.; Zibaee, S.; Abdul-Sada, A.; Thorpe, J.R.; Xue, W.-F.; Serpell, L.C.
Source: Self-asserted source
Dr Youssra Al-Hilaly via Scopus - Elsevier

Fructose, glucose and uric acid levels in sera of Iraqi women with diabetes mellitus

Research Journal of Pharmaceutical, Biological and Chemical Sciences
2014 | Journal article
EID:

2-s2.0-84901193707

Contributors: Zainal, I.G.; Al-Garawi, Z.S.; Al-Hilali, Y.K.
Source: Self-asserted source
Dr Youssra Al-Hilaly via Scopus - Elsevier

A central role for dityrosine crosslinking of Amyloid-$β$ in Alzheimer's disease

Acta Neuropathologica Communications
2013 | Journal article
Source: Self-asserted source
Dr Youssra Al-Hilaly
grade
Preferred source (of 2)‎

Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer’s disease brain

Journal article
Source: Self-asserted source
Dr Youssra Al-Hilaly

Peer review (163 reviews for 34 publications/grants)

Review activity for Advanced science. (5)
Review activity for Advances in therapy. (2)
Review activity for Advances in therapy. (3)
Review activity for Ageing and neurodegenerative diseases. (1)
Review activity for All Life (1)
Review activity for Analyst. (1)
Review activity for Antioxidants. (5)
Review activity for Arabian journal of chemistry. (2)
Review activity for Baghdad Journal of Biochemistry and Applied Biological Sciences (1)
Review activity for Biochemistry and biophysics reports. (10)
Review activity for Biology. (2)
Review activity for Biomedicines. (9)
Review activity for Biomolecules. (10)
Review activity for Brain sciences. (8)
Review activity for Cells. (15)
Review activity for FEBS letters. (2)
Review activity for Geriatrics. (3)
Review activity for International journal of environmental research and public health (9)
Review activity for International journal of molecular sciences. (41)
Review activity for Iraqi journal of nanotechnology. (4)
Review activity for Journal of clinical medicine. (4)
Review activity for Journal of food biochemistry. (4)
Review activity for Journal of Molecular Biology. (1)
Review activity for Journal of molecular biology. (1)
Review activity for Journal of molecular structure. (2)
Review activity for Journal of personalized medicine. (2)
Review activity for Life. (3)
Review activity for Materials today: proceedings. (2)
Review activity for Molecules. (2)
Review activity for Nature communications (3)
Review activity for Oxygen. (2)
Review activity for PloS one. (1)
Review activity for Scientific reports. (1)
Review activity for STAR protocols. (1)