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Biography

Biochemist
Neurobiologist
Group Leader of "LAFINEM" (Laboratory of Neuromuscular Pathophysiology)
Director of CItNe, Centro para la Investigacion Traslacional en Neurofarmacología
Research Line: focused in the understanding of the molecular mechanisms implicated in Congenital Myopathies and Alzheimer´s Disease synaptopathy

Activities

Employment (3)

Universidad de Valparaíso: Valparaiso, Valparaiso, CL

2021-03-01 to present | Associate Professor
Employment
Source: Self-asserted source
Arlek Gonzalez-Jamett

Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso: Valparaiso, Valparaiso, CL

2018-11-01 to 2021-02-28 | Young Researcher
Employment
Source: Self-asserted source
Arlek Gonzalez-Jamett

Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso: Valparaiso, Valparaiso, CL

2013-03-01 to 2018-10-31 | Investigadora Postdoctoral
Employment
Source: Self-asserted source
Arlek Gonzalez-Jamett

Education and qualifications (5)

University of Chile: Santiago, CL

2024-10-01 to 2024-12-31 | Certificate for teaching through EMI: English as a medium of Instruction (Estudios de Postgrado)
Education
Source: Self-asserted source
Arlek Gonzalez-Jamett

Universidad de Valparaíso: Valparaiso, CL

2022 to 2023 | Diplomado en Docencia Universitaria
Education
Source: Self-asserted source
Arlek Gonzalez-Jamett

Universidad Andrés Bello: Santiago, CL

2021 to 2022 | Diplomado en Bioestadística y Metodología de la Investigación
Education
Source: Self-asserted source
Arlek Gonzalez-Jamett

Universidad de Valparaíso: Valparaiso, Valparaiso, CL

2008-03-01 to 2013-02-28 | Doctor en Ciencias, mencion Neurociencia
Education
Source: Self-asserted source
Arlek Gonzalez-Jamett

Pontificia Universidad Católica de Valparaíso: Valparaiso, Valparaiso, CL

2000-03-01 to 2007-04-01 | Bioquimico
Education
Source: Self-asserted source
Arlek Gonzalez-Jamett

Professional activities (5)

Sociedad de Farmacologia de Chile: VALPARAISO, Chile, CL

2024 to present | Socia Titular (SOFARCHI)
Membership
Source: Self-asserted source
Arlek Gonzalez-Jamett

Sociedad Chilena de Neurociencia: Valparaiso, Valparaiso, CL

2013 to present | Socio
Membership
Source: Self-asserted source
Arlek Gonzalez-Jamett

IBRO FALAN: BUENOS AIRES, AR

2016 | TRAVEL AWARD
Distinction
Source: Self-asserted source
Arlek Gonzalez-Jamett

ANID/CONICYT: Valparaiso, CL

2010 | BECA DE APOYO A LA REALIZACION DE TESIS DOCTORAL
Distinction
Source: Self-asserted source
Arlek Gonzalez-Jamett

CONICYT-ANID: Valparaiso, CL

2008 | BECA PARA EL ESTUDIO DE DOCTORADO EN CHILE
Distinction
Source: Self-asserted source
Arlek Gonzalez-Jamett

Funding (8)

Sistema de adquisición y análisis de imágenes de alto contenido para el monitoreo simultáneo y semiautomatizado de múltiples muestras biológicas in vivo e in vitro: Potenciando la investigación y docencia en la Universidad de Valparaíso

2024 to 2027 | Award
ANID (Santiago, CL)
GRANT_NUMBER:

ANID-GRANT NUMBER : FONDEQUIP EQM240137

Source: Self-asserted source
Arlek Gonzalez-Jamett

IR- Contribution of dynamin superfamily to the neuronal cuytoskeleton-dependent synaptopathy in Alzheimer Disease

2023-04 to 2027-03 | Award
ANID (Valparaiso, Valparaiso, CL)
GRANT_NUMBER:

1231511

Source: Self-asserted source
Arlek Gonzalez-Jamett

IR- Adquisición de una plataforma de procesamiento, documentación y análisis de western blots para el apoyo a la investigación básica y aplicada en la Universidad de Valparaíso, Polo Playa Ancha

2022-10 to 2026-10 | Award
ANID (Valparaiso, CL)
GRANT_NUMBER:

EQM220100

Source: Self-asserted source
Arlek Gonzalez-Jamett

Dyn-actin: un nuevo mecanismos patologico en la Enfermedad de Alzheimer"

2022 to 2023 | Award
Universidad de Valparaiso (Valparaiso, CL)
Source: Self-asserted source
Arlek Gonzalez-Jamett

IR-Dyn2-Test: un potencial biomarcador sanguineo para la Enfermedad de Alzheimer"

2022 to 2023 | Award
Universidad de Valparaiso (Valparaiso, CL)
Source: Self-asserted source
Arlek Gonzalez-Jamett

Co-I- Overactivation of Panx1 in neurons leads to intracellular Ca2+ overload and subsequent defects in neuronal cytoskeleton and signaling

2020-04 to 2024-03 | Award
ANID (Valparaiso, Valparaiso, CL)
GRANT_NUMBER:

1201342

Source: Self-asserted source
Arlek Gonzalez-Jamett

IR-Role of dynamin-2 in central nervous system synapses: potential impact of centronuclear myopathy-causing mutations on AMPA-receptor trafficking and excitatory synaptic transmission

2018-11 to 2021-10 | Award
ANID (Valparaiso, Valparaiso, CL)
GRANT_NUMBER:

11180731

Source: Self-asserted source
Arlek Gonzalez-Jamett

IR-Impact of Centronuclear Myopathy associated dynamin-2 mutations on actin cytoskeleton dynamics and membrane trafficking in muscle cells”

2015-11 to 2018-10 | Award
ANID (Valparaiso, CL)
GRANT_NUMBER:

3160311

Source: Self-asserted source
Arlek Gonzalez-Jamett

Works (29)

Dynamin‐2 mutations linked to neonatal‐onset centronuclear myopathy impair exocytosis and endocytosis in adrenal chromaffin cells

Journal of Neurochemistry
2024-09 | Journal article
Part of ISSN: 0022-3042
Part of ISSN: 1471-4159
Contributors: Lucas Bayonés; María José Guerra‐Fernández; Cindel Figueroa‐Cares; Luciana I. Gallo; Samuel Alfonso‐Bueno; Octavio Caspe; María Pilar Canal; Ximena Báez‐Matus; Arlek González‐Jamett; Ana M. Cardenas et al.
Source: Self-asserted source
Arlek Gonzalez-Jamett

A centronuclear myopathy-causing mutation in dynamin-2 disrupts neuronal morphology and excitatory synaptic transmission in a murine model of the disease

Neuropathology and Applied Neurobiology
2023 | Journal article
EID:

2-s2.0-85165493126

Part of ISSN: 13652990 03051846
Contributors: Arriagada-Diaz, J.; Flores-Muñoz, C.; Gómez-Soto, B.; Labraña-Allende, M.; Mattar-Araos, M.; Prado-Vega, L.; Hinostroza, F.; Gajardo, I.; Guerra-Fernández, M.J.; Bevilacqua, J.A. et al.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Isolation and Purification of Chromaffin Granules from Adrenal Glands and Cultured Neuroendocrine Cells

Methods in Molecular Biology
2023 | Book chapter
EID:

2-s2.0-85139571343

Part of ISSN: 19406029 10643745
Contributors: González-Jamett, A.; Maldifassi, M.C.; Cárdenas, A.M.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Probenecid, an Old Drug with Potential New Uses for Central Nervous System Disorders and Neuroinflammation

Biomedicines
2023-05 | Journal article | Author
Contributors: Claudia García-Rodríguez; Paula Mujica; Javiera Illanes-González; Araceli López; Camilo Vargas; Juan Sáez; Arlek Gonzalez-Jamett; Alvaro O. Ardiles
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Dynamin Superfamily at Pre- and Postsynapses: Master Regulators of Synaptic Transmission and Plasticity in Health and Disease

Neuroscientist
2022 | Journal article
EID:

2-s2.0-85097448740

Part of ISSN: 10894098 10738584
Contributors: Arriagada-Diaz, J.; Prado-Vega, L.; Cárdenas, A.M.; Ardiles, A.O.; Gonzalez-Jamett, A.M.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Gain-of-function dynamin-2 mutations linked to centronuclear myopathy impair Ca<sup>2+</sup>-induced exocytosis in human myoblasts

bioRxiv
2022 | Other
EID:

2-s2.0-85141149955

Part of ISSN: 26928205
Contributors: Bayonés, L.; Guerra-Fernández, M.J.; Hinostroza, F.; Báez-Matus, X.; Vásquez-Navarrete, J.; Gallo, L.I.; Parra, S.; Martínez, A.D.; González-Jamett, A.; Marengo, F.D. et al.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Long-term Pannexin 1 Ablation Produces an Imbalance Between Small Rho-GTPases Activity and Actin Polymerization Leading to Structural and Functional Modifications in Hippocampal Neurons

Research Square
2022 | Other
EID:

2-s2.0-85163254674

Contributors: Flores-Muñoz, C.; García-Rojas, F.; Perez, M.A.; Santander, O.; Mery, E.; Lopez-Espíndola, D.; Gonzalez-Jamett, A.M.; Fuenzalida, M.; Martinez, A.D.; Ardiles, A.O.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

The Long-Term Pannexin 1 Ablation Produces Structural and Functional Modifications in Hippocampal Neurons

Cells
2022-11 | Journal article | Author
Contributors: Carolina Flores-Muñoz; Francisca García-Rojas; Miguel A. Pérez; Odra Santander; Elena Mery; Stefany Ordenes; Javiera Illanes-González; Daniela López-Espíndola; Arlek Gonzalez-Jamett; Marco Fuenzalida et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Gain-of-Function Dynamin-2 Mutations Linked to Centronuclear Myopathy Impair Ca<sup>2+</sup>-Induced Exocytosis in Human Myoblasts

International Journal of Molecular Sciences
2022-09 | Journal article | Author
Contributors: Lucas Bayonés; María José Guerra-Fernández; Fernando Hinostroza; Ximena Báez-Matus; Jacqueline Vásquez-Navarrete; Luciana I. Gallo; Sergio Parra; Agustín D. Martínez; Arlek Gonzalez-Jamett; Fernando D. Marengo et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Oxidative Stress, Inflammation and Connexin Hemichannels in Muscular Dystrophies

Biomedicines
2022-02 | Journal article | Author
Contributors: Arlek Gonzalez-Jamett; Walter Vásquez; Gabriela Cifuentes-Riveros; Rafaela Martínez-Pando; Juan C. Sáez; Ana M. Cardenas
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

A centronuclear myopathy-causing mutation in dynamin-2 perturbs the actin-dependent structure of dendritic spines leading to excitatory synaptic defects in a murine model of the disease

bioRxiv
2021 | Other
EID:

2-s2.0-85111543027

Part of ISSN: 26928205
Contributors: Arriagada-Diaz, J.; Gómez, B.; Prado-Vega, L.; Mattar-Araos, M.; Labraña-Allende, M.; Hinostroza, F.; Gajardo, I.; Guerra-Fernández, M.J.; Bevilacqua, J.A.; Cárdenas, A.M. et al.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Long-term Pannexin 1 ablation promotes structural and functional modifications in hippocampal neurons through the regulation of actin cytoskeleton and Rho GTPases activity.

bioRxiv
2021 | Other
EID:

2-s2.0-85121509935

Part of ISSN: 26928205
Contributors: Flores-Muñoz, C.; García-Rojas, F.; Perez, M.A.; Santander, O.; Mery, E.; Lopez-Espíndola, D.; Gonzalez-Jamett, A.M.; Fuenzalida, M.; Martinez, A.D.; Ardiles, Á.O.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease

Frontiers in Cellular Neuroscience
2020 | Journal article
EID:

2-s2.0-85082647373

Part of ISSN: 16625102
Contributors: Flores-Muñoz, C.; Gómez, B.; Mery, E.; Mujica, P.; Gajardo, I.; Córdova, C.; Lopez-Espíndola, D.; Durán-Aniotz, C.; Hetz, C.; Muñoz, P. et al.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Defects in g-actin incorporation into filaments in myoblasts derived from dysferlinopathy patients are restored by dysferlin C2 domains

International Journal of Molecular Sciences
2020 | Journal article
EID:

2-s2.0-85077016051

Part of ISSN: 14220067 16616596
Contributors: Cárdenas, A.M.; Báez-Matus, X.; Figueroa-Cares, C.; Gónzalez-Jamett, A.M.; Almarza-Salazar, H.; Arriagada, C.; Maldifassi, M.C.; Guerra, M.J.; Mouly, V.; Bigot, A. et al.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

The Ca<sup>2+</sup> channel subunit Ca<sub>V</sub>β2a-subunit down-regulates voltage-activated ion current densities by disrupting actin-dependent traffic in chromaffin cells

Journal of Neurochemistry
2019 | Journal article
EID:

2-s2.0-85076532096

Part of ISSN: 14714159 00223042
Contributors: Guerra, M.J.; González-Jamett, A.M.; Báez-Matus, X.; Navarro-Quezada, N.; Martínez, A.D.; Neely, A.; Cárdenas, A.M.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Lack of pannexin 1 alters synaptic GluN2 subunit composition and spatial reversal learning in mice

Frontiers in Molecular Neuroscience
2018 | Journal article
EID:

2-s2.0-85046892973

Part of ISSN: 16625099
Contributors: Gajardo, I.; Salazar, C.S.; Lopez-Espíndola, D.; Estay, C.; Flores-Muñoz, C.; Elgueta, C.; Gonzalez-Jamett, A.M.; Martínez, A.D.; Muñoz, P.; Ardiles, Á.O.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

RCAN1 knockdown reverts defects in the number of calcium-induced exocytotic events in a cellular model of down syndrome

Frontiers in Cellular Neuroscience
2018 | Journal article
EID:

2-s2.0-85053437000

Part of ISSN: 16625102
Contributors: Vásquez-Navarrete, J.; Martínez, A.D.; Ory, S.; Baéz-Matus, X.; González-Jamett, A.M.; Brauchi, S.; Caviedes, P.; Cárdenas, A.M.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells

Scientific Reports
2017 | Journal article
EID:

2-s2.0-85021742106

Part of ISSN: 20452322
Contributors: González-Jamett, A.M.; Baez-Matus, X.; Olivares, M.J.; Hinostroza, F.; Guerra-Fernández, M.J.; Vasquez-Navarrete, J.; Bui, M.T.; Guicheney, P.; Romero, N.B.; Bevilacqua, J.A. et al.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome)

Neurotoxicity Research
2017 | Journal article
EID:

2-s2.0-85022220067

Part of ISSN: 14763524 10298428
Contributors: Cárdenas, A.M.; Fernández-Olivares, P.; Díaz-Franulic, I.; González-Jamett, A.M.; Shimahara, T.; Segura-Aguilar, J.; Caviedes, R.; Caviedes, P.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

The F-actin binding protein cortactin regulates the dynamics of the exocytotic fusion pore through its SH3 domain

Frontiers in Cellular Neuroscience
2017 | Journal article
EID:

2-s2.0-85019184575

Part of ISSN: 16625102
Contributors: González-Jamett, A.M.; Guerra, M.J.; Olivares, M.J.; Haro-Acuña, V.; Baéz-Matus, X.; Vásquez-Navarrete, J.; Momboisse, F.; Martinez-Quiles, N.; Cárdenas, A.M.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Dysferlin function in skeletal muscle: Possible pathological mechanisms and therapeutical targets in dysferlinopathies

Experimental Neurology
2016 | Journal article
EID:

2-s2.0-84976543763

Part of ISSN: 10902430 00144886
Contributors: Cárdenas, A.M.; González-Jamett, A.M.; Cea, L.A.; Bevilacqua, J.A.; Caviedes, P.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension

Neurotoxicity Research
2016 | Journal article
EID:

2-s2.0-84960439369

Part of ISSN: 14763524 10298428
Contributors: Pérez-Núñez, R.; Barraza, N.; Gonzalez-Jamett, A.; Cárdenas, A.M.; Barnier, J.-V.; Caviedes, P.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Sustained exocytosis after action potential-like stimulation at low frequencies in mouse chromaffin cells depends on a dynamin-dependent fast endocytotic process

Frontiers in Cellular Neuroscience
2016 | Journal article
EID:

2-s2.0-84983750689

Part of ISSN: 16625102
Contributors: Moya-Díaz, J.; Álvarez, Y.D.; Montenegro, M.; Bayonés, L.; Belingheri, A.V.; González-Jamett, A.M.; Cárdenas, A.M.; Marengo, F.D.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Dynamin-2 in nervous system disorders

Journal of Neurochemistry
2014 | Journal article
EID:

2-s2.0-84891832660

Part of ISSN: 00223042 14714159
Contributors: González-Jamett, A.M.; Haro-Acuña, V.; Momboisse, F.; Caviedes, P.; Bevilacqua, J.A.; Cárdenas, A.M.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Src kinases regulate de novo actin polymerization during exocytosis in neuroendocrine chromaffin cells

PLoS ONE
2014 | Journal article
EID:

2-s2.0-84902455450

Part of ISSN: 19326203
Contributors: Olivares, M.J.; González-Jamett, A.M.; Guerra, M.J.; Baez-Matus, X.; Haro-Acuña, V.; Martínez-Quiles, N.; Cárdenas, A.M.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Dynamin-2 function and dysfunction along the secretory pathway

Frontiers in Endocrinology
2013 | Journal article
EID:

2-s2.0-84886065082

Part of ISSN: 16642392
Contributors: González-Jamett, A.M.; Momboisse, F.; Haro-Acuña, V.; Bevilacqua, J.A.; Caviedes, P.; Cárdenas, A.M.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Dynamin-2 Regulates Fusion Pore Expansion and Quantal Release through a Mechanism that Involves Actin Dynamics in Neuroendocrine Chromaffin Cells

PLoS ONE
2013 | Journal article
EID:

2-s2.0-84881089731

Part of ISSN: 19326203
Contributors: González-Jamett, A.M.; Momboisse, F.; Guerra, M.J.; Ory, S.; Báez-Matus, X.; Barraza, N.; Calco, V.; Houy, S.; Couve, E.; Neely, A. et al.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

The association of dynamin with synaptophysin regulates quantal size and duration of exocytotic events in chromaffin cells

Journal of Neuroscience
2010 | Journal article
EID:

2-s2.0-77956198113

Part of ISSN: 02706474 15292401
Contributors: González-Jamett, A.M.; Báez-Matus, X.; Hevia, M.A.; Guerra, M.J.; Olivares, M.J.; Martínez, A.D.; Neely, A.; Cárdenas, A.M.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier

Calcium channel subtypes differentially regulate fusion pore stability and expansion

Journal of Neurochemistry
2007 | Journal article
EID:

2-s2.0-35448983425

Part of ISSN: 00223042 14714159
Contributors: Ardiles, A.O.; González-Jamett, A.M.; Maripillán, J.; Naranjo, D.; Caviedes, P.; Cárdenas, A.M.
Source: Self-asserted source
Arlek Gonzalez-Jamett via Scopus - Elsevier