Personal information

Czech Republic

Activities

Employment (3)

University of Ostrava: Ostrava, CZ

2017-02-07 to present (Medical Faculty)
Employment
Source: Self-asserted source
Michal Simicek

University Hospital Ostrava: Ostrava, CZ

2017-02-01 to present | Principal Investigator (Hematooncology)
Employment
Source: Self-asserted source
Michal Simicek

MRC Laboratory of Molecular Biology: Cambridge, Cambridgeshire, GB

2014-02-01 to 2016-12-31 | postdoctoral fellow
Employment
Source: Self-asserted source
Michal Simicek

Education and qualifications (2)

KU Leuven: Leuven, Vlaanderen, BE

2010-09-01 to 2014-01-15 | PhD (VIB Center for Biology of Disease)
Education
Source: Self-asserted source
Michal Simicek

Charles University: Prague, CZ

2005-10-01 to 2010-06-15 | MSc. (Life Science Faculty)
Education
Source: Self-asserted source
Michal Simicek

Funding (2)

Deubiquitinase OTUD1 in regulation of protein turnover, metastatic progression and drug resistance in multiple myeloma

2019-01 to 2021-12 | Grant
Czech Science Foundation (Prague, CZ)
GRANT_NUMBER:

19-25354Y

Source: Self-asserted source
Michal Simicek

Identification and functional validation of mutations in multiple myeloma patients resistant to therapy with proteasomal inhibitors

2018-01 to 2020-12 | Grant
Ministerstvo Školství, Mládeže a Tělovýchovy (Prague, CZ)
GRANT_NUMBER:

8E18B035

Source: Self-asserted source
Michal Simicek

Works (39)

Length-Dependent Translation Efficiency of ER-Destined Proteins

Current Issues in Molecular Biology
2023-08-14 | Journal article
Contributors: Hana Sahinbegovic; Alexander Vdovin; Renata Snaurova; Michal Durech; Jakub Nezval; Jiri Sobotka; Roman Hajek; Tomas Jelinek; Michal Simicek
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Data from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Data from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Figure 1 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Figure 1 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Figure 2 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Figure 2 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Figure 3 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Figure 3 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Figure 4 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Figure 4 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Table 1 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Table 1 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Table 2 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Table 2 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Table 3 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Table 3 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Table 4 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Supplementary Table 4 from Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

2023-04-01 | Preprint
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Length-dependent translation efficiency of ER-destined proteins

2023-03-16 | Preprint
Contributors: Hana Sahinbegovic; Alexander Vdovin; Renata Snaurova; Michal Durech; Jakub Nezval; Jiri Sobotka; Roman Hajek; Tomas Jelinek; Michal Simicek
Source: check_circle
Crossref

Genetic Alterations in Members of the Proteasome 26S Subunit, AAA-ATPase (PSMC) Gene Family in the Light of Proteasome Inhibitor Resistance in Multiple Myeloma

Cancers
2023-01-15 | Journal article
Contributors: Larissa Haertle; Natalia Buenache; Hipólito Nicolás Cuesta Hernández; Michal Simicek; Renata Snaurova; Inmaculada Rapado; Nerea Martinez; Nieves López-Muñoz; José María Sánchez-Pina; Umair Munawar et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

Clinical Cancer Research
2023-01-04 | Journal article
Contributors: Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt et al.
Source: check_circle
Crossref

Deubiquitinase OTUD1 Resolves Stalled Translation on polyA and Rare Codon Rich mRNAs

Molecular and Cellular Biology
2022-12 | Journal article
Contributors: Renata Snaurova; Alexander Vdovin; Michal Durech; Jakub Nezval; David Zihala; Tomas Jelinek; Roman Hajek; Michal Simicek
Source: check_circle
Crossref

Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment

Cells
2021-04-21 | Journal article
Contributors: Benjamin Motais; Sandra Charvátová; Zuzana Walek; Matouš Hrdinka; Ryszard Smolarczyk; Tomasz Cichoń; Justyna Czapla; Sebastian Giebel; Michal Šimíček; Tomáš Jelínek et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Intercellular Mitochondrial Transfer in the Tumor Microenvironment

Cancers
2020-07 | Journal article | Author
Contributors: Hana Sahinbegovic; Tomas Jelinek; Matous Hrdinka; Juli R. Bago; Marcello Turi; Tereza Sevcikova; Kurtovic-Kozaric; Roman Hajek; Michal Simicek
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Single-agent venetoclax induces MRD-negative response in relapsed primary plasma cell leukemia with t(11;14)

American Journal of Hematology
2019 | Journal article
WOSUID:

WOS:000453909800019

Contributors: Jelinek, Tomas; Mihalyova, Jana; Kascak, Michal; Duras, Juraj; Popkova, Tereza; Benkova, Katerina; Richterova, Petra; Plonkova, Hana; Zuchnicka, Jana; Broskevicova, Lucie et al.
Source: Self-asserted source
Michal Simicek via ResearcherID

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins

Embo Reports
2018 | Journal article
WOSUID:

WOS:000446430400008

Contributors: Morrow, Marie E.; Morgan, Michael T.; Clerici, Marcello; Growkova, Katerina; Yan, Ming; Komander, David; Sixma, Titia K.; Simicek, Michal; Wolberger, Cynthia
Source: Self-asserted source
Michal Simicek via ResearcherID

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

Science
2018 | Journal article
WOSUID:

WOS:000452506300060

Contributors: Steklov, M.; Pandolf, S.; Baietti, M. F.; Batiuk, A.; Carai, P.; Najm, P.; Zhang, M.; Jang, H.; Renzi, F.; Cai, Y. et al.
Source: Self-asserted source
Michal Simicek via ResearcherID

Venetoclax: A new wave in hematooncology

Experimental Hematology
2018 | Journal article
WOSUID:

WOS:000430637200002

Contributors: Mihalyova, Jana; Jelinek, Tomas; Growkova, Katerina; Hrdinka, Matous; Simicek, Michal; Hajek, Roman
Source: Self-asserted source
Michal Simicek via ResearcherID

Current applications of multiparameter flow cytometry in plasma cell disorders

Blood Cancer Journal
2017 | Journal article
WOSUID:

WOS:000413469800001

Contributors: Jelinek, T.; Bezdekova, R.; Zatopkova, M.; Burgos, L.; Simicek, M.; Sevcikova, T.; Paiva, B.; Hajek, R.
Source: Self-asserted source
Michal Simicek via ResearcherID

Whole Exome Sequencing of Plasma Cells Precancerosis MGUS and Malignant AL Amyloidosis Reveals Small Number of Shared Mutated Genes

Blood
2017 | Journal article
WOSUID:

WOS:000432419703374

Contributors: Kufova, Zuzana; Growkova, Katerina; Vojta, Petr; Filipova, Jana; Simicek, Michal; Jelinek, Tomas; Zatopkova, Martina; Grosicki, Sebastian; Mikulasova, Aneta; Hajduch, Marian et al.
Source: Self-asserted source
Michal Simicek via ResearcherID

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination

Embo Molecular Medicine
2016 | Journal article
WOSUID:

WOS:000372151100008

Contributors: Baietti, Maria Francesca; Simicek, Michal; Asbagh, Layka Abbasi; Radaelli, Enrico; Lievens, Sam; Crowther, Jonathan; Steklov, Mikhail; Aushev, Vasily N.; Garcia, David Martinez; Tavernier, Jan et al.
Source: Self-asserted source
Michal Simicek via ResearcherID

Assembly and Specific Recognition of K29-and K33-Linked Polyubiquitin

Molecular Cell
2015 | Journal article
WOSUID:

WOS:000352232000011

Contributors: Michel, Martin A.; Elliott, Paul R.; Swatek, Kirby N.; Simicek, Michal; Pruneda, Jonathan N.; Wagstaff, Jane L.; Freund, Stefan M. V.; Komander, David
Source: Self-asserted source
Michal Simicek via ResearcherID

Mechanism of phospho-ubiquitin-induced PARKIN activation

Nature
2015 | Journal article
WOSUID:

WOS:000359714000040

Contributors: Wauer, Tobias; Simicek, Michal; Schubert, Alexander; Komander, David
Source: Self-asserted source
Michal Simicek via ResearcherID

OTUB1 promotes KRAS wild-type lung cancers development by inhibiting RAS mono- and diubiquitination

Molecular Biology of the Cell
2015 | Journal article
WOSUID:

WOS:000209928500310

Contributors: Baietti, M. F.; Simicek, M.; Abbasi, L.; Radaelli, E.; Lievens, S.; Crowther, J.; Steklov, M.; Aushev, V. N.; Garcia, D. Martinez; Tavernier, J. et al.
Source: Self-asserted source
Michal Simicek via ResearcherID

Multiple Regulatory Roles of the Mouse Transmembrane Adaptor Protein NTAL in Gene Transcription and Mast Cell Physiology

Plos One
2014 | Journal article
WOSUID:

WOS:000340952200059

Contributors: Polakovicova, Iva; Draberova, Lubica; Simicek, Michal; Draber, Petr
Source: Self-asserted source
Michal Simicek via ResearcherID

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response

Nature Cell Biology
2013 | Journal article
WOSUID:

WOS:000325200300013

Contributors: Simicek, Michal; Lievens, Sam; Laga, Mathias; Guzenko, Dmytro; Aushev, Vasily N.; Kalev, Peter; Baietti, Maria Francesca; Strelkov, Sergei V.; Gevaert, Kris; Tavernier, Jan et al.
Source: Self-asserted source
Michal Simicek via ResearcherID

Loss of PPP2R2A Inhibits Homologous Recombination DNA Repair and Predicts Tumor Sensitivity to PARP Inhibition

Cancer Research
2012 | Journal article
WOSUID:

WOS:000312591900012

Contributors: Kalev, Peter; Simicek, Michal; Vazquez, Iria; Munck, Sebastian; Chen, Liping; Soin, Thomas; Danda, Natasha; Chen, Wen; Sablina, Anna
Source: Self-asserted source
Michal Simicek via ResearcherID

The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho

European Journal of Immunology
2010 | Journal article
WOSUID:

WOS:000284059000028

Contributors: Tumova, Magda; Koffer, Anna; Simicek, Michal; Draberova, Lubica; Draber, Petr
Source: Self-asserted source
Michal Simicek via ResearcherID

Peer review (2 reviews for 2 publications/grants)

Review activity for Cell death and differentiation. (1)
Review activity for Cell death and disease. (1)