Personal information

King University, oxidative stress, neurotoxicology, mitochondrial inhibition, manzate, glyphosate, Parkinson's disease, C elegans

Biography

Vanessa A Fitsanakis is an Associate Professor and Chair of the Department of Biology at King University in Bristol, TN, USA. Following completion of an MSc in Science and Technology Studies at the University of Edinburgh in Scotland (UK), she received her PhD in Neuroscience from Vanderbilt University, with a focus on the neurotoxicity of organometallic compounds. She then completed a post-doctoral fellowship at Wake Forest University Medical School in Winston-Salem, NC. Using C elegans as a model organism, her current research focuses on the the ability of various pesticides to contribute to the etiology of neurodegenerative diseases, particularly Parkinson’s disease. She is interested in mechanisms of oxidative stress, mitochondrial inhibition, and toxicant transport in the central nervous system. She is a member of the Society of Toxicology, and the Science Group of the Appalachian College Association.

Activities

Works (19)

A Chronic Iron-Deficient/High-Manganese Diet in Rodents Results in Increased Brain Oxidative Stress and Behavioral Deficits in the Morris Water Maze

Journal article
DOI:

10.1007/s12640-009-9017-1

Source: Self-asserted source
VA Fitsanakis

A model for the analysis of competitive relaxation effects of manganese and ironin vivo

Journal article
DOI:

10.1002/nbm.1348

Source: Self-asserted source
VA Fitsanakis

Alterations of Oxidative Stress Biomarkers Due to In Utero and Neonatal Exposures of Airborne Manganese

Journal article
DOI:

10.1385/BTER:111:1:199

Source: Self-asserted source
VA Fitsanakis

Brain Accumulation of Depleted Uranium in Rats Following 3- or 6-Month Treatment With Implanted Depleted Uranium Pellets

Journal article
DOI:

10.1385/BTER:111:1:185

Source: Self-asserted source
VA Fitsanakis

Catalysis of catechol oxidation by metal-dithiocarbamate complexes in pesticides

Journal article
DOI:

10.1016/S0891-5849(02)01169-3

Source: Self-asserted source
VA Fitsanakis

Changes in Dietary Iron Exacerbate Regional Brain Manganese Accumulation as Determined by Magnetic Resonance Imaging

Journal article
DOI:

10.1093/toxsci/kfq376

Source: Self-asserted source
VA Fitsanakis

Characteristics of manganese (Mn) transport in rat brain endothelial (RBE4) cells, an in vitro model of the blood–brain barrier

Journal article
DOI:

10.1016/j.neuro.2005.06.004

Source: Self-asserted source
VA Fitsanakis

Effects of inhaled manganese on biomarkers of oxidative stress in the rat brain

Journal article
DOI:

10.1016/j.neuro.2006.05.006

Source: Self-asserted source
VA Fitsanakis

Exposure to Glyphosate- and/or Mn/Zn-Ethylene-bis-Dithiocarbamate-Containing Pesticides Leads to Degeneration of γ-Aminobutyric Acid and Dopamine Neurons in Caenorhabditis elegans

Journal article
DOI:

10.1007/s12640-011-9274-7

Source: Self-asserted source
VA Fitsanakis

Exposure to Mn/Zn ethylene-bis-dithiocarbamate and glyphosate pesticides leads to neurodegeneration in Caenorhabditis elegans

Journal article
DOI:

10.1016/j.neuro.2011.02.002

Source: Self-asserted source
VA Fitsanakis

Manganese (Mn) and Iron (Fe): Interdependency of Transport and Regulation

Journal article
DOI:

10.1007/s12640-009-9130-1

Source: Self-asserted source
VA Fitsanakis

Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction

Journal article
DOI:

10.1046/j.1471-4159.2003.01525.x

Source: Self-asserted source
VA Fitsanakis

Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia

Journal article
DOI:

10.1111/j.1471-4159.2009.06145.x

Source: Self-asserted source
VA Fitsanakis

Manganese transport by rat brain endothelial (RBE4) cell-based transwell model in the presence of astrocyte conditioned media

Journal article
DOI:

10.1002/jnr.20560

Source: Self-asserted source
VA Fitsanakis

Putative proteins involved in manganese transport across the blood-brain barr 1ier

Journal article
DOI:

10.1177/0960327107070496

Source: Self-asserted source
VA Fitsanakis

The effects of manganese on glutamate, dopamine and γ-aminobutyric acid regulation

Journal article
DOI:

10.1016/j.neuint.2005.10.012

Source: Self-asserted source
VA Fitsanakis

The importance of glutamate, glycine, and γ-aminobutyric acid transport and regulation in manganese, mercury and lead neurotoxicity

Journal article
DOI:

10.1016/j.taap.2004.11.013

Source: Self-asserted source
VA Fitsanakis

The In Vitro Uptake of Glutamate in GLAST and GLT-1 Transfected Mutant CHO-K1 Cells Is Inhibited by Manganese

Journal article
DOI:

10.1385/BTER:107:3:221

Source: Self-asserted source
VA Fitsanakis

The use of magnetic resonance imaging (MRI) in the study of manganese neurotoxicity

Journal article
DOI:

10.1016/j.neuro.2006.03.001

Source: Self-asserted source
VA Fitsanakis