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Employment (8)

University of Oxford: Oxford, Oxfordshire, GB

(Division of Structural Biology)
Employment
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ORCID Integration at the University of Oxford

Rosalind Franklin Institute: Harwell, GB

2021-06-01 to 2024-04-08 (Structural Biology)
Employment
Source: Self-asserted source
Philip Ward

University of Oxford: Oxford, Oxfordshire, GB

2011 to 2016 | Post-Doctoral Scientist (The Sir William Dunn School of Pathology)
Employment
Source: Self-asserted source
Philip Ward

University of Oxford: Oxford, Oxfordshire, GB

2006 to 2011 | Post Doctoral Scientist (Nuffield Dept. of Clinical and Infectious Diseases)
Employment
Source: Self-asserted source
Philip Ward

Institute for Animal Health - Compton: Compton, Berkshire, GB

2003 to 2005 | Senior Post-Doctoral scientist (Streptococcal Research Group)
Employment
Source: Self-asserted source
Philip Ward

Institute for Animal Health, Compton: Compton, Berkshire, GB

1996 to 2003 | Post-Doctoral scientist (Streptococcal Research Group)
Employment
Source: Self-asserted source
Philip Ward

Institute for Animal Health, Compton: Compton, Berkshire, GB

1990 to 1996 | Higher Scientific Officer (Toxins Research Group)
Employment
Source: Self-asserted source
Philip Ward

MRC Clinical Research Centre : Harrow, London, GB

1987 to 1990 | Scientific Officer (Dermatology Research Group)
Employment
Source: Self-asserted source
Philip Ward

Works (47)

The lipid linked oligosaccharide polymerase Wzy and its regulating co-polymerase, Wzz, from enterobacterial common antigen biosynthesis form a complex

Open Biology
2023-03 | Journal article
DOI: 10.1098/rsob.220373
Contributors: Miriam Weckener; Laura S. Woodward; Bradley R. Clarke; Huanting Liu; Philip N. Ward; Audrey Le Bas; David Bhella; Chris Whitfield; James H. Naismith
Source: check_circle
Crossref

Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes

Proceedings of the National Academy of Sciences
2022-08-02 | Journal article
DOI: 10.1073/pnas.2205412119
Contributors: Halina Mikolajek; Miriam Weckener; Z. Faidon Brotzakis; Jiandong Huo; Evmorfia V. Dalietou; Audrey Le Bas; Pietro Sormanni; Peter J. Harrison; Philip N. Ward; Steven Truong et al.
Source: check_circle
Crossref

Pathogen-sugar interactions revealed by universal saturation transfer analysis

Science
2022-07-22 | Journal article
DOI: 10.1126/science.abm3125
Contributors: Charles J. Buchanan; Ben Gaunt; Peter J. Harrison; Yun Yang; Jiwei Liu; Aziz Khan; Andrew M. Giltrap; Audrey Le Bas; Philip N. Ward; Kapil Gupta et al.
Source: check_circle
Crossref

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

Nature Communications
2021-09 | Journal article
DOI: 10.1038/s41467-021-25480-z
Part of ISSN: 2041-1723
Contributors: Jiandong Huo; Halina Mikolajek; Audrey Le Bas; Jordan J. Clark; Parul Sharma; Anja Kipar; Joshua Dormon; Chelsea Norman; Miriam Weckener; Daniel K. Clare et al.
Source: Self-asserted source
Philip Ward via Crossref Metadata Search

The molecular basis of regulation of bacterial capsule assembly by Wzc

Nature Communications
2021-07-16 | Journal article
DOI: 10.1038/s41467-021-24652-1
Contributors: Yun Yang; Jiwei Liu; Bradley R. Clarke; Laura Seidel; Jani R. Bolla; Philip N. Ward; Peijun Zhang; Carol V. Robinson; Chris Whitfield; James H. Naismith
Source: check_circle
Crossref

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Nature Structural & Molecular Biology
2021-03-03 | Journal article
DOI: 10.1038/s41594-021-00566-w
Contributors: Jiandong Huo; Audrey Le Bas; Reinis R. Ruza; Helen M. E. Duyvesteyn; Halina Mikolajek; Tomas Malinauskas; Tiong Kit Tan; Pramila Rijal; Maud Dumoux; Philip N. Ward et al.
Source: check_circle
Crossref

Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM

Nature Methods
2021-01 | Journal article
DOI: 10.1038/s41592-020-01001-6
Contributors: Tomasz Uchański; Simonas Masiulis; Baptiste Fischer; Valentina Kalichuk; Uriel López-Sánchez; Eleftherios Zarkadas; Miriam Weckener; Andrija Sente; Philip Ward; Alexandre Wohlkönig et al.
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Crossref

A Paradox in Bacterial Pathogenesis: Activation of the Local Macrophage Inflammasome Is Required for Virulence of Streptococcus uberis

Pathogens
2020-11-28 | Journal article
DOI: 10.3390/pathogens9120997
Contributors: Nathan Archer; Sharon A. Egan; Tracey J. Coffey; Richard D. Emes; M. Filippa Addis; Philip N. Ward; Adam M. Blanchard; James A. Leigh
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Nature Structural & Molecular Biology
2020-11-15 | Journal article
DOI: 10.1038/s41594-020-00527-9
Contributors: Jiangdong Huo; Audrey Le Bas; Reinis R. Ruza; Helen M. E. Duyvesteyn; Halina Mikolajek; Tomas Malinauskas; Tiong Kit Tan; Pramila Rijal; Maud Dumoux; Philip N. Ward et al.
Source: check_circle
Crossref

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Nature Structural & Molecular Biology
2020-09 | Journal article
DOI: 10.1038/s41594-020-0469-6
Contributors: Jiandong Huo; Audrey Le Bas; Reinis R. Ruza; Helen M. E. Duyvesteyn; Halina Mikolajek; Tomas Malinauskas; Tiong Kit Tan; Pramila Rijal; Maud Dumoux; Philip N. Ward et al.
Source: check_circle
Crossref

Identification of Novel Neisseria gonorrhoeae Lineages Harboring Resistance Plasmids in Coastal Kenya.

The Journal of infectious diseases
2018-07-01 | Journal article
DOI: 10.1093/infdis/jiy240
PMID: 29701830
PMC: PMC6057544
Source: Self-asserted source
Philip Ward
grade
Preferred source (of 2)‎

A Comparative Structure/Function Analysis of Two Type IV Pilin DNA Receptors Defines a Novel Mode of DNA Binding

2016 | Other
DOI: 10.1016/j.str.2016.04.001
SOURCE-WORK-ID: BASE:8a1efbdf92860b72aeadfc81d4ba558db84ae05ecca23cd5208e76e5d537bab7
Contributors: Berry, Jamie-Lee; Xu, Yingqi; Ward, Philip N.; Lea, Susan M.; Matthews, Stephen J.; Pelicic, Vladimir
Source: Self-asserted source
Philip Ward via BASE - Bielefeld Academic Search Engine
grade
Preferred source (of 2)‎

Virulence related sequences; insights provided by comparative genomics of Streptococcus uberis of differing virulence.

BMC genomics
2015-04-23 | Journal article
DOI: 10.1186/s12864-015-1512-6
PMID: 25898893
PMC: PMC4427978
Source: Self-asserted source
Philip Ward

Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility.

eLife
2014-12-23 | Journal article
DOI: 10.7554/elife.04008
PMID: 25534642
PMC: PMC4273445
Source: Self-asserted source
Philip Ward

Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules

2012 | Journal article
DOI: 10.1371/journal.ppat.1002981
SOURCE-WORK-ID: BASE:fb0eafc6631ffdbbdead1d4c502efb2918ce28eb580655e3cba00cea52fff840
Contributors: Johnson, Steven; Tan, Lionel; van der Veen, Stijn; Caesar, Joseph; Goicoechea De Jorge, Elena; Harding, Rachel J.; Bai, Xilian; Exley, Rachel M.; Ward, Philip N.; Ruivo, Nicola et al.
Source: Self-asserted source
Philip Ward via BASE - Bielefeld Academic Search Engine
grade
Preferred source (of 2)‎

Vru (Sub0144) controls expression of proven and putative virulence determinants and alters the ability of Streptococcus uberis to cause disease in dairy cattle.

Microbiology (Reading, England)
2012-03-01 | Journal article
DOI: 10.1099/mic.0.055863-0
PMID: 22383474
PMC: PMC3541772
Source: Self-asserted source
Philip Ward

Differential protein expression in Streptococcus uberis under planktonic and biofilm growth conditions.

Applied and environmental microbiology
2010-11-12 | Journal article
DOI: 10.1128/aem.01099-10
PMID: 21075893
PMC: PMC3019713
Source: Self-asserted source
Philip Ward

Sortase anchored proteins of Streptococcus uberis play major roles in the pathogenesis of bovine mastitis in dairy cattle.

Veterinary research
2010-06-04 | Journal article
DOI: 10.1051/vetres/2010036
PMID: 20519112
PMC: PMC2898060
Source: Self-asserted source
Philip Ward

Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif.

Journal of proteome research
2010-02-01 | Journal article
DOI: 10.1021/pr901025w
PMID: 20038184
Source: Self-asserted source
Philip Ward

Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis.

PloS one
2009-07-15 | Journal article
DOI: 10.1371/journal.pone.0006072
PMID: 19603075
PMC: PMC2705793
Source: Self-asserted source
Philip Ward

Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis.

BMC genomics
2009-01-28 | Journal article
DOI: 10.1186/1471-2164-10-54
PMID: 19175920
PMC: PMC2657157
Source: Self-asserted source
Philip Ward

In the absence of Lgt, lipoproteins are shed from Streptococcus uberis independently of Lsp

2008 | Other
SOURCE-WORK-ID: BASE:06bc097ee65ff3b671e1850fe16b6a761109410ca81b5863ff8b70bb525b7fe6
Contributors: E. L. Denham; P. N. Ward; J. A. Leigh
Source: Self-asserted source
Philip Ward via BASE - Bielefeld Academic Search Engine

Structural consideration of the formation of the activation complex between the staphylokinase-like streptococcal plasminogen activator PadA and bovine plasminogen.

Journal of molecular biology
2008-06-17 | Journal article
DOI: 10.1016/j.jmb.2008.06.027
PMID: 18588895
Source: Self-asserted source
Philip Ward

Lipoprotein signal peptides are processed by Lsp and Eep of Streptococcus uberis.

Journal of bacteriology
2008-05-09 | Journal article
DOI: 10.1128/jb.00287-08
PMID: 18469106
PMC: PMC2446809
Source: Self-asserted source
Philip Ward

Identification of multiple linear epitopes of the plasminogen activator A (PauA) of Streptococcus uberis with murine monoclonal antibodies.

Veterinary immunology and immunopathology
2005-04-01 | Journal article
DOI: 10.1016/j.vetimm.2004.11.005
PMID: 15734536
Source: Self-asserted source
Philip Ward

Complex interactions between bovine plasminogen and streptococcal plasminogen activator PauA.

Journal of molecular biology
2004-09-01 | Journal article
DOI: 10.1016/j.jmb.2004.07.079
PMID: 15351638
Source: Self-asserted source
Philip Ward

The exploitation of the genome in the search for determinants of virulence in Streptococcus uberis.

Veterinary immunology and immunopathology
2004-08-01 | Journal article
DOI: 10.1016/j.vetimm.2004.04.004
PMID: 15207452
Source: Self-asserted source
Philip Ward

Genetic analysis of Streptococcus uberis plasminogen activators.

The Indian journal of medical research
2004-05-01 | Journal article
PMID: 15232179
Source: Self-asserted source
Philip Ward

Hyperinvasive neonatal group B streptococcus has arisen from a bovine ancestor.

Journal of clinical microbiology
2004-05-01 | Journal article
DOI: 10.1128/jcm.42.5.2161-2167.2004
PMID: 15131184
PMC: PMC404684
Source: Self-asserted source
Philip Ward

Streptococcus agalactiae infection in dairy cows.

The Veterinary record
2004-05-01 | Journal article
PMID: 15198320
Source: Self-asserted source
Philip Ward

Localization of MtuA, an LraI homologue in Streptococcus uberis.

Journal of applied microbiology
2004-01-01 | Journal article
DOI: 10.1111/j.1365-2672.2004.02284.x
PMID: 15186452
Source: Self-asserted source
Philip Ward

The activation of bovine plasminogen by PauA is not required for virulence of Streptococcus uberis.

Infection and immunity
2003-12-01 | Journal article
DOI: 10.1128/iai.71.12.7193-7196.2003
PMID: 14638815
PMC: PMC308948
Source: Self-asserted source
Philip Ward

Identification of a differentially expressed oligopeptide binding protein (OppA2) in Streptococcus uberis by representational difference analysis of cDNA.

Journal of bacteriology
2003-09-01 | Journal article
DOI: 10.1128/jb.185.17.5210-5219.2003
PMID: 12923094
PMC: PMC181005
Source: Self-asserted source
Philip Ward

MtuA, a lipoprotein receptor antigen from Streptococcus uberis, is responsible for acquisition of manganese during growth in milk and is essential for infection of the lactating bovine mammary gland.

Infection and immunity
2003-09-01 | Journal article
DOI: 10.1128/iai.71.9.4842-4849.2003
PMID: 12933824
PMC: PMC187302
Source: Self-asserted source
Philip Ward

The hyaluronic acid capsule of Streptococcus uberis is not required for the development of infection and clinical mastitis.

Infection and immunity
2003-01-01 | Journal article
DOI: 10.1128/iai.71.1.132-139.2003
PMID: 12496158
PMC: PMC143150
Source: Self-asserted source
Philip Ward
grade
Preferred source (of 2)‎

Characterization of PauB, a novel broad-spectrum plasminogen activator from Streptococcus uberis.

Journal of bacteriology
2002-01-01 | Journal article
DOI: 10.1128/jb.184.1.119-125.2002
PMID: 11741851
PMC: PMC134755
Source: Self-asserted source
Philip Ward

Isolation and characterization of a mutant strain of Streptococcus uberis, which fails to utilize a plasmin derived beta-casein peptide for the acquisition of methionine.

Journal of applied microbiology
2002-01-01 | Journal article
DOI: 10.1046/j.1365-2672.2002.01723.x
PMID: 12234346
Source: Self-asserted source
Philip Ward

Generation and characterization of a defined mutant of Streptococcus suis lacking suilysin.

Infection and immunity
2001-04-01 | Journal article
DOI: 10.1128/iai.69.4.2732-2735.2001
PMID: 11254643
PMC: PMC98215
Source: Self-asserted source
Philip Ward

Identification and disruption of two discrete loci encoding hyaluronic acid capsule biosynthesis genes hasA, hasB, and hasC in Streptococcus uberis.

Infection and immunity
2001-01-01 | Journal article
DOI: 10.1128/iai.69.1.392-399.2001
PMID: 11119529
PMC: PMC97895
Source: Self-asserted source
Philip Ward

Epithelial invasion and cell lysis by virulent strains of Streptococcus suis is enhanced by the presence of suilysin.

FEMS immunology and medical microbiology
1999-10-01 | Journal article
DOI: 10.1111/j.1574-695x.1999.tb01369.x
PMID: 10518040
Source: Self-asserted source
Philip Ward

PauA: a novel plasminogen activator from Streptococcus uberis.

FEMS microbiology letters
1999-09-01 | Journal article
DOI: 10.1111/j.1574-6968.1999.tb13755.x
PMID: 10483719
Source: Self-asserted source
Philip Ward

Activity of the mitogenic Pasteurella multocida toxin requires an essential C-terminal residue.

Infection and immunity
1998-12-01 | Journal article
PMID: 9826336
PMC: PMC108712
Source: Self-asserted source
Philip Ward
grade
Preferred source (of 2)‎

Mutation of a putative ADP-ribosylation motif in the Pasteurella multocida toxin does not affect mitogenic activity.

FEBS letters
1994-03-01 | Journal article
DOI: 10.1016/0014-5793(94)80589-x
PMID: 8143855
Source: Self-asserted source
Philip Ward
grade
Preferred source (of 2)‎

A single base mutation in the gene for type III collagen (COL3A1) converts glycine 847 to glutamic acid in a family with Ehlers-Danlos syndrome type IV. An unaffected family member is mosaic for the mutation.

Human genetics
1992-06-01 | Journal article
DOI: 10.1007/bf00194313
PMID: 1352273
Source: Self-asserted source
Philip Ward

A 27-bp deletion from one allele of the type III collagen gene (COL3A1) in a large family with Ehlers-Danlos syndrome type IV.

Human genetics
1992-01-01 | Journal article
DOI: 10.1007/bf00197268
PMID: 1370809
Source: Self-asserted source
Philip Ward

Characterisation of a glycine to valine substitution at amino acid position 910 of the triple helical region of type III collagen in a patient with Ehlers-Danlos syndrome type IV.

Journal of medical genetics
1991-07-01 | Journal article
DOI: 10.1136/jmg.28.7.458
PMID: 1895316
PMC: PMC1016955
Source: Self-asserted source
Philip Ward

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

Other
DOI: 10.21203/rs.3.rs-548968/v1
Contributors: Jiandong Huo; Halina Mikolajek; Audrey Le Bas; Jordan Clark; Parul Sharma; Anja Kipar; Joshua Dormon; Chelsea Norman; Miriam Weckener; Daniel Clare et al.
Source: Self-asserted source
Philip Ward via Crossref Metadata Search
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