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Employment (3)

University of Oxford: Oxford, Oxfordshire, GB

(Nuffield Department of Clinical Neurosciences)
Employment
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ORCID Integration at the University of Oxford

University of Alberta: Edmonton, Alberta, CA

2017-10-23 to 2022-07 | Postdoctoral Fellow (Centre for Prions and Protein Folding Diseases)
Employment
Source: Self-asserted source
Andrew Castle

MedImmune: Cambridge, GB

2010-07 to 2011-09 | Industrial Placement Student (Neuroscience)
Employment
Source: Self-asserted source
Andrew Castle

Education and qualifications (2)

The Roslin Institute, The University of Edinburgh : Edinburgh, GB

2012-10 to 2017-07 | PhD (Neurobiology)
Education
Source: Self-asserted source
Andrew Castle

University of Bath: Bath, GB

2008-10 to 2012-07 | BSc Biology with Professional Placement
Education
Source: Self-asserted source
Andrew Castle

Professional activities (1)

British Neuroscience Association: Bristol, GB

2014 to present | Early Career
Membership
Source: Self-asserted source
Andrew Castle

Works (13)

Prion Protein Endoproteolysis: Cleavage Sites, Mechanisms and Connections to Prion Disease

Journal of Neurochemistry
2025-01 | Journal article
DOI: 10.1111/jnc.16310
Contributors: Andrew R. Castle; David Westaway
Source: check_circle
Crossref

Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation

Science Advances
2023-06-16 | Journal article
DOI: 10.1126/sciadv.add8910
Contributors: Dmitry Zenko; Jade Marsh; Andrew R. Castle; Rahel Lewin; Roman Fischer; George K. Tofaris
Source: check_circle
Crossref

Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein

Proceedings of the National Academy of Sciences
2023-01-03 | Journal article
DOI: 10.1073/pnas.2209815120
Contributors: Andrew R. Castle; Sang-Gyun Kang; Ghazaleh Eskandari-Sedighi; Serene Wohlgemuth; My-Anh Nguyen; Daniel J. Drucker; Erin E. Mulvihill; David Westaway
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Crossref

Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein

Prion 2022
2022-09-11 | Conference abstract
Part of DOI: 10.1080/19336896.2022.2091286
Source: Self-asserted source
Andrew Castle

Investigating CRISPR/Cas9 gene drive for production of disease-preventing prion gene alleles

PLOS ONE
2022-06-07 | Journal article
DOI: 10.1371/journal.pone.0269342
Contributors: Andrew R. Castle; Rodrigo Morales; Serene Wohlgemuth; Luis Arce; David Westaway
Source: check_circle
Crossref

Prion protein with a mutant N-terminal octarepeat region undergoes cobalamin-dependent assembly into high–molecular weight complexes

Journal of Biological Chemistry
2022-04 | Journal article
DOI: 10.1016/j.jbc.2022.101770
Contributors: Nathalie Daude; Agnes Lau; Ilaria Vanni; Sang-Gyun Kang; Andrew R. Castle; Serene Wohlgemuth; Lyudmyla Dorosh; Holger Wille; Maria Stepanova; David Westaway
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Crossref

Susceptibility of Beavers to Chronic Wasting Disease

Biology
2022-04-26 | Journal article
DOI: 10.3390/biology11050667
Contributors: Allen Herbst; Serene Wohlgemuth; Jing Yang; Andrew R. Castle; Diana Martinez Moreno; Alicia Otero; Judd M. Aiken; David Westaway; Debbie McKenzie
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Crossref
grade
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Application of high-throughput, capillary-based western immunoassays to modulated cleavage of PrPC

Prion 2019
2019-05-15 | Conference abstract
Part of DOI: 10.1080/19336896.2019.1615197
Part of ISSN: 1933-6896
Source: Self-asserted source
Andrew Castle

Application of high-throughput, capillary-based Western analysis to modulated cleavage of the cellular prion protein

Journal of Biological Chemistry
2019-02 | Journal article
DOI: 10.1074/jbc.ra118.006367
Part of ISSN: 0021-9258
Source: Self-asserted source
Andrew Castle

The cellular and pathologic prion protein

Human Prion Diseases
2018 | Book chapter
DOI: 10.1016/b978-0-444-63945-5.00002-7
Part of ISBN: 9780444639455
Part of ISSN: 0072-9752
Source: Self-asserted source
Andrew Castle

Investigating the cell biological mechanisms regulated by the cellular prion protein

2017-06-08 | Dissertation or Thesis
Source: Self-asserted source
Andrew Castle

Physiological Functions of the Cellular Prion Protein

Frontiers in Molecular Biosciences
2017-04-06 | Journal article
DOI: 10.3389/fmolb.2017.00019
Part of ISSN: 2296-889X
Source: Self-asserted source
Andrew Castle

Lack of stress protection by the cellular prion protein: An alternative role in regulating growth factor signaling

Prion 2016
2016 | Conference abstract
Part of DOI: 10.1080/19336896.2016.1162644
Part of ISSN: 1933-6896
Source: Self-asserted source
Andrew Castle

Peer review (2 reviews for 1 publication/grant)

Review activity for Neurobiology of disease. (2)
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