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heart regeneration, heart development, cell cycle, differentiation, cardiac tissue engineering, growth factors, cytokines, hypertrophy
Germany

Biography

I am a professor at the Friedrich-Alexander-University Erlangen-Nürnberg. My expertise is cardiac regeneration and development, cardiac tissue engineering/biofabrication, and cancer research. I’ve got interested in cardiac research while a doctoral student in Dr. von Harsdorf's laboratory at the Max Delbrück Center for Molecular Medicine (Berlin, Germany, 1997). At that time, I developed a novel cell-free system in which cardiomyocyte nuclear replication could be monitored in vitro. This work resulted in two first author publications (Circ Res, 1999; Mol Cell Biol, 2003). After earning my Ph.D. degree in Cell Biology, I joined Mark Keating's laboratory at Harvard Medical School in 2001 to examine proliferation-based regenerative growth in the mammalian heart. Here, I observed that p38 MAP kinase activity levels were inversely related to cardiomyocyte cell cycle activity in a number of models. In addition, inhibition of p38 MAP kinase promoted cardiomyocyte proliferation in vitro. These results were published in Genes and Development (2005) leading to the upsetting of scientific dogma, and promise for new therapeutic approaches to cardiac disease. For this work I was awarded with the Children’s Hospital (Boston) Research Day Award and the Charles H. Hood Foundation Child Health Research Award. I then proved in vivo that inhibition of p38 MAP kinase contributes to cardiac regeneration. These results were published in PNAS (2005). Subsequently, I became faculty member at Harvard Medical School and was awarded the prestigious Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation endowed with around 1.5 Million Dollars. I continued my career at the Max Planck Institute for Heart and Lung Research (Bad Nauheim, Germany) where Thomas Braun was my host. Here, I got involved in cardiac tissue engineering (focusing on silk) resulting in publications as last author in Biomaterials. Finally, I got appointed Professor and expanded once more my expertise working on cancer biology. This interest was initially based on the idea to learn from the heart how to suppress cancer, as primary tumors in the adult heart are extremely rare if they exist at all. I am previliged that a number of excellent PhD students and postdocs joined my lab resulting in publications as last author in world-leading Journals such as Cell Research, Advanced Functional Materials, PNAS, Biomaterials, and Development. In addition, I have contributed to publications in journals such as Cell, Developmental Cell, Molecular Cell, and European Heart Journal. Furthermore, I have edited a book entitled as “Heart Regeneration: Stem Cells and Beyond” and authored many book chapters. I have been frequently invited to different countries such as the United States of America, England, China, Taiwan and Germany to give lectures and seminars and served as nucleus member for the European Cardiac Society (ESC).

Activities

Employment (4)

Friedrich-Alexander-Universitat Erlangen-Nurnberg: Erlangen, Bayern, DE

2012-10-01 to present | W2-Professor for Renal and Cardiovascular Research (Nephropathologie)
Employment
Source: Self-asserted source
Felix B. Engel

Max-Planck-Institut für Herz- und Lungenforschung W G Kerckhoff-Institute: Bad Nauheim, Hessen, DE

2006-12-01 to 2012-09-31 | Research Group Leader (Cardiac Development and Remodelling)
Employment
Source: Self-asserted source
Felix B. Engel

Harvard Medical School: MA, MA, US

2001-11-01 to 2006-10-31 | Postdoctoral Fellow/Instructor (Heart Regeneration)
Employment
Source: Self-asserted source
Felix B. Engel

Max Delbrück Centrum für Molekulare Medizin Berlin Buch: Berlin-Buch, Berlin, DE

2001-03-30 to 2001-10-31 | Postdoctoral Fellow (Heart Regeneration)
Employment
Source: Self-asserted source
Felix B. Engel

Education and qualifications (3)

Goethe-Universitat Frankfurt am Main: Frankfurt am Main, Hessen, DE

2008 to 2013-05-27 | Habilitation (Biowissenschaften)
Education
Source: Self-asserted source
Felix B. Engel

Technische Universität Berlin: Berlin, Berlin, DE

1997-02-01 to 2001-03-29 | Dr. rer. nat. (Max Delbrück Center for Molecular Medicine)
Education
Source: Self-asserted source
Felix B. Engel

Technische Universität Berlin: Berlin, Berlin, DE

1990 to 1996 | Dipl. Ing. (Biotechnologie)
Education
Source: Self-asserted source
Felix B. Engel

Professional activities (1)

University of Konstanz: Konstanz, Baden-Württemberg, DE

2018 to present | Chair/W3 Professor (Developmental Biology)
Invited position
Source: Self-asserted source
Felix B. Engel

Peer review (357 reviews for 91 publications/grants)

Review activity for ACS applied materials & interfaces. (1)
Review activity for ACS applied polymer materials. (3)
Review activity for ACS biomaterials science & engineering. (1)
Review activity for Acta biomaterialia. (4)
Review activity for Advanced biology. (2)
Review activity for Advanced biosystems (1)
Review activity for Advanced functional materials. (15)
Review activity for Advanced healthcare materials (17)
Review activity for Advanced materials interfaces. (4)
Review activity for Advanced Materials Technologies (2)
Review activity for Advanced materials. (5)
Review activity for Advanced science. (13)
Review activity for Applied materials today. (1)
Review activity for Basic research in cardiology (7)
Review activity for Basic research in cardiology. (17)
Review activity for Biomaterials science. (2)
Review activity for Biomaterials. (1)
Review activity for Biomaterials. (7)
Review activity for BMC cardiovascular disorders (5)
Review activity for BMC genomics (1)
Review activity for British journal of pharmacology. (1)
Review activity for Cardiology. (1)
Review activity for Cardiovascular research (59)
Review activity for Cardiovascular research. (1)
Review activity for Cell cycle. (1)
Review activity for Cell death and disease. (1)
Review activity for Cell regeneration. (2)
Review activity for Cell reports medicine. (2)
Review activity for Cell reports. (2)
Review activity for Cell reports. (4)
Review activity for Cellular and molecular life sciences (1)
Review activity for Cellular signalling. (1)
Review activity for Chemical engineering journal. (2)
Review activity for Circulation : (14)
Review activity for Circulation research : (4)
Review activity for Clinical research in cardiology. (1)
Review activity for Clinical science. (1)
Review activity for Colloids and surfaces. (1)
Review activity for Communications biology. (2)
Review activity for Cytokine. (1)
Review activity for Development. (2)
Review activity for Developmental biology. (5)
Review activity for Developmental dynamics. (2)
Review activity for EBioMedicine. (3)
Review activity for eLife (3)
Review activity for EMBO journal. (1)
Review activity for EMBO molecular medicine. (2)
Review activity for EMBO molecular medicine. (1)
Review activity for European heart journal. (3)
Review activity for European journal of biochemistry. (2)
Review activity for Expert opinion on drug delivery (1)
Review activity for Expert review of clinical pharmacology (1)
Review activity for Frontiers in bioengineering and biotechnology. (4)
Review activity for Frontiers in cardiovascular medicine. (2)
Review activity for Frontiers in cell and developmental biology. (5)
Review activity for Frontiers in immunology. (1)
Review activity for International journal of biological sciences (1)
Review activity for iScience. (8)
Review activity for JACC. (1)
Review activity for Journal of cardiovascular development and disease. (12)
Review activity for Journal of cell science. (1)
Review activity for Journal of Cellular and Molecular Medicine. (2)
Review activity for Journal of cellular physiology. (1)
Review activity for Journal of Molecular and Cellular Cardiology. (1)
Review activity for Journal of molecular and cellular cardiology. (11)
Review activity for Journal of the American College of Cardiology (1)
Review activity for Journal of the American Heart Association. (5)
Review activity for Kidney360. (1)
Review activity for Materials today bio. (4)
Review activity for Nature cardiovascular research. (2)
Review activity for Nature cell biology (1)
Review activity for Nature communications (15)
Review activity for Nature medicine. (2)
Review activity for Nature reviews. (2)
Review activity for npj regenerative medicine. (6)
Review activity for Open biology. (1)
Review activity for PloS one. (1)
Review activity for PPAR research. (2)
Review activity for Regenerative medicine (1)
Review activity for Science. (1)
Review activity for Scientific reports. (10)
Review activity for Seminars in cell & developmental biology. (1)
Review activity for Small science. (2)
Review activity for Stem cells. (1)
Review activity for The EMBO journal. (1)
Review activity for The journal of clinical investigation. (2)
Review activity for The Journal of pathology. (3)
Review activity for The journal of physiology. (1)
Review activity for Theranostics (1)
Review activity for Thrombosis and haemostasis. (2)
Review activity for Trends in endocrinology and metabolism. (1)