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Employment (1)

University of Cambridge: Cambridge, Cambridgeshire, GB

2018 to present | Principal Research Associate (Cambridge Institute for Medical Research)
Employment
Source: Self-asserted source
Bernard Kelly

Education and qualifications (2)

University of Cambridge: Cambridge, Cambridgeshire, GB

MA(Hons) Natural Sciences
Education
Source: Self-asserted source
Bernard Kelly

MRC Laboratory of Molecular Biology: Cambridge, Cambridgeshire, GB

PhD
Education
Source: Self-asserted source
Bernard Kelly

Works (22)

Untangling structural molecular details of the endocytic adaptor protein CALM upon binding with phosphatidylinositol 4,5-bisphosphate-containing model membranes

2024-12-28 | Preprint
DOI: 10.1101/2024.12.28.630489
Contributors: Andreas Santamaria; Daniel Pereira; Nisha Pawar; Bernard T. Kelly; Javier Carrascosa-Tejedor; Mariana Sardo; Luís Mafra; Giovanna Fragneto; David J. Owen; Ildefonso Marín-Montesinos et al.
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Crossref

Virus-Specific Nanobody-Chimeras Degrade the Human Cytomegalovirus US28 Protein in CD34+ Cells

Pathogens
2024-09-24 | Journal article
DOI: 10.3390/pathogens13100821
Contributors: Emma Poole; Janika Schmitt; Stephen C. Graham; Bernard T. Kelly; John Sinclair
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Crossref
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Repurposing an endogenous degradation domain for antibody-mediated disposal of cell-surface proteins

EMBO Reports
2024-01-29 | Journal article
DOI: 10.1038/s44319-024-00063-3
Contributors: Janika Schmitt; Emma Poole; Ian Groves; David J Owen; Stephen C Graham; John Sinclair; Bernard T Kelly
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Crossref

FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P<sub>2</sub>-dependent switch.

Science advances
2022-04 | Journal article
DOI: 10.1126/sciadv.abn2018
PMID: 35486718
PMC: PMC9054013
Contributors: Zaccai NR; Kadlecova Z; Dickson VK; Korobchevskaya K; Kamenicky J; Kovtun O; Umasankar PK; Wrobel AG; Kaufman JGG; Gray SR et al.
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

FCHO controls AP2’s critical endocytic roles through a PtdIns4,5P<sub>2</sub> membrane-dependent switch

2022-04 | Preprint
DOI: 10.1101/2022.04.02.486817
PPR: PPR476904
Contributors: Zaccai NR; Kadlecova Z; Dickson VK; Korobchevskaya K; Kamenicky J; Kovtun O; Umasankar PK; Wrobel AG; Kaufman JG; Gray S et al.
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles

Science Advances
2020-07-24 | Journal article
DOI: 10.1126/sciadv.aba8381
Contributors: Oleksiy Kovtun; Veronica Kane Dickson; Bernard T. Kelly; David J. Owen; John A. G. Briggs
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Crossref

Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.

Developmental cell
2020-03 | Journal article
DOI: 10.1016/j.devcel.2020.02.010
PMID: 32155440
PMC: PMC7063567
Contributors: Wrobel AG; Kadlecova Z; Kamenicky J; Yang JC; Herrmann T; Kelly BT; McCoy AJ; Evans PR; Martin S; Müller S et al.
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

Architecture of the AP2:clathrin coat on the membranes of clathrin-coated vesicles

2020-01-28 | Preprint
DOI: 10.1101/2020.01.28.922591
Contributors: Oleksiy Kovtun; Veronica Kane Dickson; Bernard T. Kelly; David. J. Owen; John A. G. Briggs
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Crossref

Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.

Developmental cell
2019-08 | Journal article
DOI: 10.1016/j.devcel.2019.07.017
PMID: 31430451
PMC: PMC6706699
Contributors: Wrobel AG; Kadlecova Z; Kamenicky J; Yang JC; Herrmann T; Kelly BT; McCoy AJ; Evans PR; Martin S; Müller S et al.
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

Cellular and viral peptides bind multiple sites on the N-terminal domain of clathrin.

Traffic (Copenhagen, Denmark)
2016-12 | Journal article
DOI: 10.1111/tra.12457
PMID: 27813245
PMC: PMC5182127
Contributors: Muenzner J; Traub LM; Kelly BT; Graham SC
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

Using selenomethionyl derivatives to assign sequence in low-resolution structures of the AP2 clathrin adaptor.

Acta crystallographica. Section D, Structural biology
2016-03 | Journal article
DOI: 10.1107/s2059798315021580
PMID: 26960121
PMC: PMC4784665
Contributors: Kelly BT; Graham SC; Owen DJ
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.

Developmental cell
2015-04 | Journal article
DOI: 10.1016/j.devcel.2015.03.002
PMID: 25898166
PMC: PMC4406947
Contributors: Miller SE; Mathiasen S; Bright NA; Pierre F; Kelly BT; Kladt N; Schauss A; Merrifield CJ; Stamou D; Höning S et al.
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

Clathrin adaptors. AP2 controls clathrin polymerization with a membrane-activated switch.

Science (New York, N.Y.)
2014-07 | Journal article
DOI: 10.1126/science.1254836
PMID: 25061211
PMC: PMC4333214
Contributors: Kelly BT; Graham SC; Liska N; Dannhauser PN; Höning S; Ungewickell EJ; Owen DJ
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

Endocytic sorting of transmembrane protein cargo.

Current opinion in cell biology
2011-03 | Journal article
DOI: 10.1016/j.ceb.2011.03.004
PMID: 21450449
Contributors: Kelly BT; Owen DJ
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex.

Cell
2010-06 | Journal article
DOI: 10.1016/j.cell.2010.05.006
PMID: 20603002
PMC: PMC3655264
Contributors: Jackson LP; Kelly BT; McCoy AJ; Gaffry T; James LC; Collins BM; Höning S; Evans PR; Owen DJ
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex.

Nature
2008-12 | Journal article
DOI: 10.1038/nature07422
PMID: 19140243
PMC: PMC4340503
Contributors: Kelly BT; McCoy AJ; Späte K; Miller SE; Evans PR; Höning S; Owen DJ
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

Selective gene amplification.

Protein engineering, design & selection : PEDS
2007-11 | Journal article
DOI: 10.1093/protein/gzm060
PMID: 18055506
Contributors: Kelly BT; Griffiths AD
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

Droplets as microreactors for high-throughput biology.

Chembiochem : a European journal of chemical biology
2007-02 | Journal article
DOI: 10.1002/cbic.200600425
PMID: 17226878
Contributors: Taly V; Kelly BT; Griffiths AD
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

Miniaturizing chemistry and biology in microdroplets.

Chemical communications (Cambridge, England)
2007-02 | Journal article
DOI: 10.1039/b616252e
PMID: 17476389
Contributors: Kelly BT; Baret JC; Taly V; Griffiths AD
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

Directed evolution by in vitro compartmentalization.

Nature methods
2006-07 | Journal article
DOI: 10.1038/nmeth897
PMID: 16791215
Contributors: Miller OJ; Bernath K; Agresti JJ; Amitai G; Kelly BT; Mastrobattista E; Taly V; Magdassi S; Tawfik DS; Griffiths AD
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

High-throughput screening of enzyme libraries: in vitro evolution of a beta-galactosidase by fluorescence-activated sorting of double emulsions.

Chemistry & biology
2005-12 | Journal article
DOI: 10.1016/j.chembiol.2005.09.016
PMID: 16356846
Contributors: Mastrobattista E; Taly V; Chanudet E; Treacy P; Kelly BT; Griffiths AD
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central

Selection of ribozymes that catalyse multiple-turnover Diels-Alder cycloadditions by using in vitro compartmentalization.

Proceedings of the National Academy of Sciences of the United States of America
2005-10 | Journal article
DOI: 10.1073/pnas.0503733102
PMID: 16260754
PMC: PMC1283419
Contributors: Agresti JJ; Kelly BT; Jäschke A; Griffiths AD
Source: Self-asserted source
Bernard Kelly via Europe PubMed Central
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