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ResearcherID: D-6652-2017

Keywords

Machine intelligence, AI for science, AI for biomedicine

Biography

PhD pharmacologist leading AI for biomedicine.
Track-recorded by academic funding for advanced computing, by translating that into deliverables in the drug-tech industry, and facilitating startup fundraising with timely milestone achievements.

Activities

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Employment (7)

INF Tech: Shanghai, CN

2022-04-20 to 2023-03-31 | Product Director (AIDD)
Employment
Source: Self-asserted source
Nan-Lan Huang

GenHouse Pharma: SuZhou, CN

2021-09-01 to 2022-03-10 | Associate Director (AIDD)
Employment
Source: Self-asserted source
Nan-Lan Huang

Insilico Medicine: Taipei, TW

2019-10-01 to 2021-03-10 | Team Lead (Computational Chemistry)
Employment
Source: Self-asserted source
Nan-Lan Huang

National Taiwan University: Taipei, TW

2018-04-01 to 2018-06-30 | Contract Research Scientist (Institute of Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Nan-Lan Huang

Academia Sinica: Taipei, Taipei, TW

2013-05-01 to 2017-12-15 | Postdoctoral Fellow (Research Center for Applied Sciences)
Employment
Source: Self-asserted source
Nan-Lan Huang

University of California San Diego: La Jolla, CA, US

2016-08-01 to 2017-07-31 | Visiting Assistant Project Scientist (Skaggs School of Pharmacy and Pharmaceutical Sciences)
Employment
Source: Self-asserted source
Nan-Lan Huang

Academia Sinica: Taipei, Taipei, TW

2010-08-24 to 2013-04-30 | Postdoctoral Fellow (Institute of Plant and Microbial Biology)
Employment
Source: Self-asserted source
Nan-Lan Huang

Education and qualifications (2)

National Taiwan University: Taipei, TW

2004-06-01 to 2010-08-01 | PhD Pharmacology (Department and Graduate Institute of Pharmacology)
Education
Source: Self-asserted source
Nan-Lan Huang

National Taiwan University: Taipei, TW

2000-08-01 to 2004-06-01 | BS Pharmacy (School of Pharmacy)
Education
Source: Self-asserted source
Nan-Lan Huang

Funding (2)

Coordinated Dynamics Orchestrating the DNA Re-Ligation by De-Poisoned Topoisomerase II

2017-03 to 2017-03 | Award
Ministry of Science and Technology, Taiwan (Taipei, TW)
Source: Self-asserted source
Nan-Lan Huang

Mechanistic basis of DNA rejoining in the cleavage complex of topoisomerase II

2016-08 to 2017-08 | Salary award
Academia Sinica (Taipei, TW)
Source: Self-asserted source
Nan-Lan Huang

Works (10)

A bioactivity foundation model using pairwise meta-learning

Nature Machine Intelligence
2024-08-14 | Journal article
DOI: 10.1038/s42256-024-00876-w
Contributors: Bin Feng; Zequn Liu; Nanlan Huang; Zhiping Xiao; Haomiao Zhang; Srbuhi Mirzoyan; Hanwen Xu; Jiaran Hao; Yinghui Xu; Ming Zhang et al.
Source: check_circle
Crossref

Toward Drug-Target Interaction Prediction via Ensemble Modeling and Transfer Learning

2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
2021-12-09 | Journal article
DOI: 10.1109/bibm52615.2021.9669729
Contributors: Po-Yu Kao; Shu-Min Kao; Nan-Lan Huang; Yen-Chu Lin
Source: Self-asserted source
Nan-Lan Huang

Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate

Nature Communications
2018-08-06 | Journal article
DOI: 10.1038/s41467-018-05406-y
Contributors: Shin-Fu Chen; Nan-Lan Huang; Jung-Hsin Lin; Chyuan-Chuan Wu; Ying-Ren Wang; Yu-Jen Yu; Michael K. Gilson; Nei-Li Chan
Source: check_circle
Crossref

Recovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation

Nucleic Acids Research
2015 | Journal article
DOI: 10.1093/nar/gkv672
WOSUID:

WOS:000360588200018
Contributors: Huang, Nan-Lan; Lin, Jung-Hsin
Source: Self-asserted source
Nan-Lan Huang via ResearcherID

Drug-Induced Conformational Population Shifts in Topoisomerase-DNA Ternary Complexes

Molecules
2014 | Journal article
DOI: 10.3390/molecules19067415
WOSUID:

WOS:000338586700031
Contributors: Huang, Nan-Lan; Lin, Jung-Hsin
Source: Self-asserted source
Nan-Lan Huang via ResearcherID

Oleosin of Subcellular Lipid Droplets Evolved in Green Algae

Plant Physiology
2013 | Journal article
DOI: 10.1104/pp.112.212514
WOSUID:

WOS:000316987900022
Contributors: Huang, Nan-Lan; Huang, Ming-Der; Chen, Tung-Ling L.; Huang, Anthony H. C.
Source: Self-asserted source
Nan-Lan Huang via ResearcherID

Rimonabant inhibits TNF-alpha-induced endothelial IL-6 secretion via CB1 receptor and cAMP-dependent protein kinase pathway

Acta Pharmacologica Sinica
2010 | Journal article
DOI: 10.1038/aps.2010.126
WOSUID:

WOS:000284055500006
Contributors: Huang, Nan-lan; Juang, Jyh-ming; Wang, Yi-ho; Hsueh, Chia-hsiang; Liang, Yao-jen; Lin, Jiunn-lee; Tsai, Chia-ti; Lai, Ling-ping
Source: Self-asserted source
Nan-Lan Huang via ResearcherID

Metformin inhibits TNF-alpha-induced I kappa B kinase phosphorylation, I kappa B-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation

International Journal of Cardiology
2009 | Journal article
DOI: 10.1016/j.ijcard.2008.04.010
WOSUID:

WOS:000266264500004
Contributors: Huang, Nan-Lan; Chiang, Shu-Hui; Hsueh, Chia-Hsiang; Liang, Yao-Jen; Chen, Yi-Jung; Lai, Ling-Ping
Source: Self-asserted source
Nan-Lan Huang via ResearcherID

Coordinated Dynamics Orchestrating the DNA Re-Ligation by De-Poisoned Topoisomerase II

Biophysical Journal
Journal article
DOI: 10.1016/j.bpj.2015.11.1949
WOSUID:

WOS:000375142200253
Contributors: Huang, Nan-Lan; Lin, Jung-Hsin
Source: Self-asserted source
Nan-Lan Huang via ResearcherID

Topoisomerase Poison Disturbs Relaxation of Mechanical Stresses During Gating Motion of DNA-Binding Core

Biophysical Journal
Journal article
DOI: 10.1016/j.bpj.2016.11.2022
WOSUID:

WOS:000402375600847
Contributors: Huang, Nan-Lan; Gilson, Michael K.
Source: Self-asserted source
Nan-Lan Huang via ResearcherID
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