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Employment (3)

East Carolina University Brody School of Medicine: Greenville, NC, US

2019-07-01 to present | PROFESSOR (MICROBIOLOGY AND IMMUNOLOGY)
Employment
Source: Self-asserted source
MD A. MOTALEB

East Carolina University Brody School of Medicine: Greenville, NC, US

2014-07-01 to 2019-06-30 | Associate Professor (Microbiology & Immunology)
Employment
Source: Self-asserted source
MD A. MOTALEB

East Carolina University Brody School of Medicine: Greenville, NC, US

2008-07-02 to 2014-06-30 | Assistant Professor (Microbiology & Immunology)
Employment
Source: Self-asserted source
MD A. MOTALEB

Education and qualifications (2)

Osaka University: Suita, Osaka, JP

1998 | Ph.D. (Molecular & Cellular Biology)
Education
Source: Self-asserted source
MD A. MOTALEB

Dhaka University: Dhaka, Dhaka District, BD

1992 | M.S. (Biochemistry)
Education
Source: Self-asserted source
MD A. MOTALEB

Professional activities (1)

American Society for Microbiology: Washington, DC, US

Membership
Source: Self-asserted source
MD A. MOTALEB

Funding (11)

Delineation of Unique Flagellar Proteins in Spirochetes

2024-02 to 2028-12 | Grant
National Institute of Allergy and Infectious Diseases (Md., Md., US)
GRANT_NUMBER: 2R01AI132818
Source: Self-asserted source
MD A. MOTALEB

SpoVG and PlzA Regulation of Lyme Disease Spirochete Infection Processes

2020-04-01 to 2024-03-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R01AI144126
Source: Self-asserted source
MD A. MOTALEB via DimensionsWizard

Delineation of unique flagellar proteins in spirochetes

2018-05-01 to 2022-04-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R01AI132818
Source: Self-asserted source
MD A. MOTALEB via DimensionsWizard

Discovery and characterization of novel flagellar proteins in Borrelia burgdorferi

2015-02-01 to 2017-01-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 5R21AI113014-02
Source: Self-asserted source
MD A. MOTALEB via DimensionsWizard

Intravital assessment of Borrelia burgdorferi-immune cell interactions in skin

2014-08 to 2015-07 | Grant
National Institute of Allergy and Infectious Diseases (MD, MD, US)
Source: Self-asserted source
MD A. MOTALEB

Delineation of Borrelia burgdorferi motility and chemotaxis in the development of

2011-09-15 to 2016-08-31 | Grant
National Institute of Arthritis and Musculoskeletal and Skin Diseases (Bethesda, US)
GRANT_NUMBER: 5R01AR060834-05
Source: Self-asserted source
MD A. MOTALEB via DimensionsWizard

Structure-Function Relationships in the Spirochetal Flagellar Motor

2010-02 to 2025-05 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R01AI087946
Part of GRANT_NUMBER:

R01AI087946

Source: Self-asserted source
MD A. MOTALEB
grade
Preferred source (of 2)‎

The Role of Borrelia Burgdorferi Chemotoxis in the Pathogenesis of Lyme Disease

2007-08-01 to 2010-07-31 | Grant
National Institute of Arthritis and Musculoskeletal and Skin Diseases (Bethesda, US)
GRANT_NUMBER: 5R03AR054582-03
Source: Self-asserted source
MD A. MOTALEB via DimensionsWizard

A unique chemotaxis system: the Lyme disease spirochete B. burgdorferi

2004-12 to 2005-12 | Grant
RDG-West Virginia University (Morgantown, WV, US)
Source: Self-asserted source
MD A. MOTALEB

Function of the Borrelia burgdorferi motility gene cheX in chemotaxis and virulence

2003 to 2005 | Grant
American Heart Association (TX, TX, US)
GRANT_NUMBER:

0365225B

Source: Self-asserted source
MD A. MOTALEB

Role of CheX in Chemotaxis and Asymmetric Flagellar Rotation in Borrelia Burgdorferi

2003 to 2004 | Grant
RDG-West Virginia University (Morgantown, WV, US)
Source: Self-asserted source
MD A. MOTALEB

Works (50)

FlbB forms a distinctive ring essential for periplasmic flagellar assembly and motility in Borrelia burgdorferi

PLOS Pathogens
2025-01-08 | Journal article
Contributors: Jack M. Botting; Jenifer Coburn; Md Khalesur Rahman; Hui Xu; Jian Yue; Wangbiao Guo; Joshua T. Del Mundo; Michal Hammel; Md A. Motaleb; Jun Liu
Source: check_circle
Crossref

Borrelia burgdorferiPlzA is a cyclic‐di‐GMP dependent DNA and RNA binding protein

Molecular Microbiology
2024-05 | Journal article
Contributors: Nerina Jusufovic; Andrew C. Krusenstjerna; Christina R. Savage; Timothy C. Saylor; Catherine A. Brissette; Wolfram R. Zückert; Paula J. Schlax; Md A. Motaleb; Brian Stevenson
Source: check_circle
Crossref

FliL ring enhances the function of periplasmic flagella

Proceedings of the National Academy of Sciences
2022-03-15 | Journal article
Contributors: Shuaiqi Guo; Hui Xu; Yunjie Chang; Md A. Motaleb; Jun Liu
Source: check_circle
Crossref

BB0259 Encompasses a Peptidoglycan Lytic Enzyme Function for Proper Assembly of Periplasmic Flagella in Borrelia burgdorferi.

Frontiers in microbiology
2021-10 | Journal article
Contributors: Xu H; Hu B; Flesher DA; Liu J; Motaleb MA
Source: Self-asserted source
MD A. MOTALEB via Europe PubMed Central

Molecular mechanism for rotational switching of the bacterial flagellar motor

Nature Structural & Molecular Biology
2020-11 | Journal article
Contributors: Yunjie Chang; Kai Zhang; Brittany L. Carroll; Xiaowei Zhao; Nyles W. Charon; Steven J. Norris; Md A. Motaleb; Chunhao Li; Jun Liu
Source: check_circle
Crossref

BB0326 is responsible for the formation of periplasmic flagellar collar and assembly of the stator complex in Borrelia burgdorferi.

Molecular microbiology
2019-11-19 | Journal article
Source: Self-asserted source
MD A. MOTALEB
grade
Preferred source (of 2)‎

Structural insights into flagellar stator-rotor interactions.

eLife
2019-07-17 | Journal article
Source: Self-asserted source
MD A. MOTALEB

Cryo-electron tomography of periplasmic flagella in Borrelia burgdorferi reveals a distinct cytoplasmic ATPase complex.

PLoS biology
2018-11-09 | Journal article
Source: Self-asserted source
MD A. MOTALEB

A tetratricopeptide repeat domain protein has profound effects on assembly of periplasmic flagella, morphology and motility of the lyme disease spirochete Borrelia burgdorferi.

Molecular microbiology
2018-10-15 | Journal article
Source: Self-asserted source
MD A. MOTALEB

In situ structures of periplasmic flagella reveal a distinct cytoplasmic ATPase complex in Borrelia burgdorferi

2018-04 | Preprint
Contributors: Qin Z; Manne A; Tu J; Yu Z; Lees K; Yerke A; Lin T; Li C; Norris SJ; Motaleb MA et al.
Source: Self-asserted source
MD A. MOTALEB via Europe PubMed Central

Borrelia burgdorferi CheD promotes various functions in chemotaxis and the pathogenic life cycle of the spirochete

Infection and Immunity
2016 | Journal article
EID:

2-s2.0-84971524653

Contributors: Moon, K.H.; Hobbs, G.; Motaleb, M.A.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Spirochetes flagellar collar protein FlbB has astounding effects in orientation of periplasmic flagella, bacterial shape, motility, and assembly of motors in Borrelia burgdorferi

Molecular Microbiology
2016 | Journal article
EID:

2-s2.0-84982899123

Contributors: Moon, K.H.; Zhao, X.; Manne, A.; Wang, J.; Yu, Z.; Liu, J.; Motaleb, M.A.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Borrelia burgdorferi CheY2 Is Dispensable for Chemotaxis or Motility but Crucial for the Infectious Life Cycle of the Spirochete.

Infection and immunity
2016-12-29 | Journal article
Source: Self-asserted source
MD A. MOTALEB

The Borrelia burgdorferi CheY3 response regulator is essential for chemotaxis and completion of its natural infection cycle.

Cellular microbiology
2016-07-11 | Journal article
Source: Self-asserted source
MD A. MOTALEB
grade
Preferred source (of 2)‎

Motor rotation is essential for the formation of the periplasmic flagellar ribbon, cellular morphology, and Borrelia burgdorferi persistence within Ixodes scapularis tick and murine hosts

Infection and Immunity
2015 | Journal article
EID:

2-s2.0-84928184720

Contributors: Sultan, S.Z.; Sekar, P.; Zhao, X.; Manne, A.; Liu, J.; Wooten, R.M.; Motaleb, M.A.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Spirochetal motility and chemotaxis in the natural enzootic cycle and development of Lyme disease

Current Opinion in Microbiology
2015 | Journal article
EID:

2-s2.0-84945949541

Contributors: Motaleb, M.D.A.; Liu, J.; Mark Wooten, R.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Initial characterization of the FlgE hook high molecular weight complex of Borrelia burgdorferi

PLoS ONE
2014 | Journal article
EID:

2-s2.0-84901455536

Contributors: Miller, K.A.; Motaleb, M.A.; Liu, J.; Hu, B.; Caimano, M.J.; Miller, M.R.; Charon, N.W.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi

Frontiers in cellular and infection microbiology
2014 | Journal article
EID:

2-s2.0-84923271143

Contributors: Novak, E.A.; Sultan, S.Z.; Motaleb, M.A.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Three dimensional visualization of bacterial type III export apparatus in the lyme disease spirochete Borrelia burgdorferi

Microscopy and Microanalysis
2014 | Journal article
EID:

2-s2.0-84927948771

Contributors: Tu, J.; Zhao, X.; Manne, A.; Lees, K.; Zhang, K.; Li, C.; Nortis, S.J.; Motaleb, Md.A.; Liu, J.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Cryoelectron tomography reveals the sequential assembly of bacterial flagella in Borrelia burgdorferi

Proceedings of the National Academy of Sciences of the United States of America
2013 | Journal article
EID:

2-s2.0-84883311301

Contributors: Zhao, X.; Zhang, K.; Boquoi, T.; Hu, B.; Motaleb, M.A.; Miller, K.A.; James, M.E.; Charon, N.W.; Manson, M.D.; Norris, S.J. et al.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Motility is crucial for the infectious life cycle of Borrelia burgdorferi.

Infection and immunity
2013-03 | Journal article
Contributors: Sultan SZ; Manne A; Stewart PE; Bestor A; Rosa PA; Charon NW; Motaleb MA
Source: Self-asserted source
MD A. MOTALEB via Europe PubMed Central

The unique paradigm of spirochete motility and chemotaxis

Annual Review of Microbiology
2012 | Book
EID:

2-s2.0-84871275433

Contributors: Charon, N.W.; Cockburn, A.; Li, C.; Liu, J.; Miller, K.A.; Miller, M.R.; Motaleb, M.A.; Wolgemuth, C.W.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

A novel gene inactivation system reveals altered periplasmic flagellar orientation in a Borrelia burgdorferi flil mutant

Journal of Bacteriology
2011 | Journal article
EID:

2-s2.0-79959326635

Contributors: Motaleb, M.A.; Pitzer, J.E.; Sultan, S.Z.; Liu, J.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Analysis of the Borrelia burgdorferi cyclic-di-GMP-binding protein PlzA reveals a role in motility and virulence

Infection and Immunity
2011 | Journal article
EID:

2-s2.0-79955642814

Contributors: Pitzer, J.E.; Sultan, S.Z.; Hayakawa, Y.; Hobbs, G.; Miller, M.R.; Motaleb, M.A.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Analysis of the Borrelia burgdorferi cyclic-di-GMP-binding protein PlzA reveals a role in motility and virulence

Infection and Immunity
2011 | Journal article
EID:

2-s2.0-79959410913

Contributors: Pitzer, J.E.; Sultan, S.Z.; Hayakawa, Y.; Hobbs, G.; Miller, M.R.; Motaleb, M.A.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Analysis of the HD-GYP domain cyclic dimeric gmp phosphodiesterase reveals a role in motility and the enzootic life cycle of Borrelia burgdorferi

Infection and Immunity
2011 | Journal article
EID:

2-s2.0-79961113805

Contributors: Sultan, S.Z.; Pitzer, J.E.; Boquoi, T.; Hobbs, G.; Miller, M.R.; Motaleb, M.A.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

CheY3 of Borrelia burgdorferi is the key response regulator essential for chemotaxis and forms a long-lived phosphorylated intermediate

Journal of Bacteriology
2011 | Journal article
EID:

2-s2.0-79959326874

Contributors: Motaleb, M.A.; Sultan, S.Z.; Miller, M.R.; Li, C.; Charon, N.W.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclic-di-guanosine monophosphate in motility and virulence

Molecular Microbiology
2010 | Journal article
EID:

2-s2.0-77953988576

Contributors: Sultan, S.Z.; Pitzer, J.E.; Miller, M.R.; Motaleb, M.A.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Identical phosphatase mechanisms achieved through distinct modes of binding phosphoprotein substrate

Proceedings of the National Academy of Sciences of the United States of America
2010 | Journal article
EID:

2-s2.0-76649097688

Contributors: Pazy, Y.; Motaleb, M.A.; Guarnieri, M.T.; Charon, N.W.; Zhao, R.; Silversmith, R.E.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

The chic motility and chemotaxis of Borrelia burgdorferi

Borrelia: Molecular and Cellular Biology
2009 | Book chapter
Source: Self-asserted source
MD A. MOTALEB
grade
Preferred source (of 2)‎

The elastic basis for the shape of Borrelia burgdorferi

Biophysical Journal
2009 | Journal article
EID:

2-s2.0-68949119913

Contributors: Dombrowski, C.; Kan, W.; Motaleb, Md.A.; Charon, N.W.; Goldstein, R.E.; Wolgemuth, C.W.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

The flat-ribbon configuration of the periplasmic flagella of Borrelia burgdorferi and its relationship to motility and morphology

Journal of Bacteriology
2009 | Journal article
EID:

2-s2.0-58649114723

Contributors: Charon, N.W.; Goldstein, S.F.; Marko, M.; Hsieh, C.; Gebhardt, L.L.; Motaleb, M.A.; Wolgemuth, C.W.; Limberger, R.J.; Rowe, N.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Borrelia burgdorferi uniquely regulates its motility genes and has an intricate flagellar hook basal body structure.

Journal of Bacteriology
2008 | Journal article
Source: Self-asserted source
MD A. MOTALEB

Spent culture medium from virulent Borrelia burgdorferi increases permeability of individually perfused microvessels of rat mesentery

PLoS ONE
2008 | Journal article
EID:

2-s2.0-58149350102

Contributors: Zhou, X.; Miller, M.R.; Motaleb, Md.; Charon, N.W.; He, P.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Isolation and Characterization of Chemotaxis Mutants of the Lyme Disease Spirochete Borrelia burgdorferi Using Allelic Exchange Mutagenesis, Flow Cytometry, and Cell Tracking

Methods in Enzymology
2007 | Book
EID:

2-s2.0-34447107335

Contributors: Motaleb, Md.A.; Miller, M.R.; Bakker, R.G.; Li, C.; Charon, N.W.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Phosphorylation Assays of Chemotaxis Two-Component System Proteins in Borrelia burgdorferi

Methods in Enzymology
2007 | Book
EID:

2-s2.0-34447107130

Contributors: Motaleb, Md.A.; Miller, M.R.; Li, C.; Charon, N.W.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Motility gene regulation and chemotaxis in Borrelia burgdorferi

Molecular Biology of Spirochetes
2006 | Book chapter
Source: Self-asserted source
MD A. MOTALEB

CheX is a phosphorylated CheY phosphatase essential for Borrelia burgdorferi chemotaxis

Journal of Bacteriology
2005 | Journal article
EID:

2-s2.0-28044460791

Contributors: Motaleb, M.A.; Miller, M.R.; Li, C.; Bakker, R.G.; Goldstein, S.F.; Silversmith, R.E.; Bourret, R.B.; Charon, N.W.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

The decrease in FlaA observed in a flaB mutant of Borrelia burgdorferi occurs posttranscriptionally

Journal of Bacteriology
2004 | Journal article
EID:

2-s2.0-2942605826

Contributors: Motaleb, M.A.; Sal, M.S.; Charon, N.W.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Asymmetrical flagellar rotation in Borrelia burgdorferi nonchemotactic mutants

Proceedings of the National Academy of Sciences of the United States of America
2002 | Journal article
EID:

2-s2.0-0037197987

Contributors: Li, C.; Bakker, R.G.; Motaleb, Md.A.; Sartakova, M.L.; Cabello, F.C.; Charon, N.W.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Complementation of a nonmotile flaB mutant of Borrelia burgdorferi by chromosomal integration of a plasmid containing a wild-type flaB allele

Journal of Bacteriology
2001 | Journal article
EID:

2-s2.0-0034751688

Contributors: Sartakova, M.L.; Dobrikova, E.Y.; Motaleb, M.A.; Godfrey, H.P.; Charon, N.W.; Cabello, F.C.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Gyrations, Rotations, Periplasmic Flagella: The biology of Spirochete motility

The Spirochete: Molecular and Cellular Biology
2001 | Book chapter
Source: Self-asserted source
MD A. MOTALEB

Spirochete piroplasmic flagella and motility

Journal of Molecular Microbiology and Biotechnology
2000 | Journal article
EID:

2-s2.0-0034304515

Contributors: Li, C.; Motaleb, Md.A.; Sal, M.; Goldstein, S.F.; Charon, N.W.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Spirochete periplasmic flagella and motility.

Journal of molecular microbiology and biotechnology
2000-10 | Journal article
Contributors: Li C; Motaleb A; Sal M; Goldstein SF; Charon NW
Source: Self-asserted source
MD A. MOTALEB via Europe PubMed Central

Borrelia burgdorferi periplasmic flagella have both skeletal and motility functions.

Proceedings of the National Academy of Sciences of the United States of America
2000-09 | Journal article
Contributors: Motaleb MA; Corum L; Bono JL; Elias AF; Rosa P; Samuels DS; Charon NW
Source: Self-asserted source
MD A. MOTALEB via Europe PubMed Central

Characterization of cis-elements required for the transcriptional activation of the rae28/mph1 gene in F9 cells

Biochemical and Biophysical Research Communications
1999 | Journal article
EID:

2-s2.0-0033609965

Contributors: Motaleb, M.A.; Takihara, Y.; Ohta, H.; Shimada, K.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Sequence-specific DNA binding activity in the rae28 protein, a mouse homologue of the Drosophila polyhomeotic protein

Biochemistry and Molecular Biology International
1998 | Journal article
EID:

2-s2.0-0032438183

Contributors: Nomura, M.; Takihara, Y.; Motaleb, Md.A.; Horie, K.; Higashinakagawa, T.; Shimada, K.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

A survey of genes expressed in mouse embryonal carcinoma F9 cells: Characterization of expressed sequence tags matching no known genes

Journal of Biochemistry
1997 | Journal article
EID:

2-s2.0-0030789001

Contributors: Nomura, M.; Nishiguchi, S.; Motaleb, Md.A.; Takihara, Y.; Takagi, T.; Yasunaga, T.; Shimada, K.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects

Development
1997 | Journal article
EID:

2-s2.0-0030729636

Contributors: Takihara, Y.; Tomotsune, D.; Shirai, M.; Katoh-Fukui, Y.; Nishii, K.; Motaleb, A.; Nomura, M.; Tsuchiya, R.; Fujita, Y.; Shibata, Y. et al.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier

Structural organization of the rae28 gene, a putative murine homologue of the Drosophila polyhomeotic gene

Journal of Biochemistry
1996 | Journal article
EID:

2-s2.0-0029809253

Contributors: Motaleb, Md.A.; Takihara, Y.; Nomura, M.; Matsuda, Y.; Higashinakagawa, T.; Shimada, K.
Source: Self-asserted source
MD A. MOTALEB via Scopus - Elsevier