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Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human MYBPC3 HCM

Circulation Research
2023-03-03 | Journal article
DOI: 10.1161/CIRCRESAHA.122.321956
Contributors: Josè Manuel Pioner; Giulia Vitale; Sonette Steczina; Marianna Langione; Francesca Margara; Lorenzo Santini; Francesco Giardini; Erica Lazzeri; Nicoletta Piroddi; Beatrice Scellini et al.
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Human iPSC-CMs and in-silico technologies define mechanisms and accelerate targeted pharmacogenetics in hypertrophic cardiomyopathy

2022-06-11 | Preprint
DOI: 10.1101/2022.06.08.495324
Contributors: Francesca Margara; Yiangos Psaras; Zhinuo Jenny Wang; Manuel Schmid; Ruben Doste; Amanda Garfinkel; Giuliana G. Repetti; Jonathan Seidman; Christine Seidman; Blanca Rodriguez et al.
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CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes

Circulation Research
2021-07-09 | Journal article
DOI: 10.1161/CIRCRESAHA.121.318868
Contributors: Yiangos Psaras; Francesca Margara; Marcelo Cicconet; Alexander J. Sparrow; Giuliana G. Repetti; Manuel Schmid; Violetta Steeples; Jonathan A.L. Wilcox; Alfonso Bueno-Orovio; Charles S. Redwood et al.
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Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post-myocardial infarction

EP Europace
2021-03-04 | Journal article
DOI: 10.1093/europace/euaa405
Part of ISSN: 1099-5129
Part of ISSN: 1532-2092
Source: Self-asserted source
Francesca Margara

In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment

Progress in Biophysics and Molecular Biology
2021-01 | Journal article
DOI: 10.1016/j.pbiomolbio.2020.06.007
Contributors: Francesca Margara; Zhinuo J. Wang; Francesc Levrero-Florencio; Alfonso Santiago; Mariano Vázquez; Alfonso Bueno-Orovio; Blanca Rodriguez
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The ‘Digital Twin’ to enable the vision of precision cardiology

European Heart Journal
2020-12-21 | Journal article
DOI: 10.1093/eurheartj/ehaa159
Contributors: Jorge Corral-Acero; Francesca Margara; Maciej Marciniak; Cristobal Rodero; Filip Loncaric; Yingjing Feng; Andrew Gilbert; Joao F Fernandes; Hassaan A Bukhari; Ali Wajdan et al.
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Sensitivity analysis of a strongly-coupled human-based electromechanical cardiac model: Effect of mechanical parameters on physiologically relevant biomarkers

Computer Methods in Applied Mechanics and Engineering
2020-04 | Journal article
DOI: 10.1016/j.cma.2019.112762
Part of ISSN: 0045-7825
Source: Self-asserted source
Francesca Margara
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