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Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections

Journal of Antimicrobial Chemotherapy
2025-01-03 | Journal article
Contributors: Irene Hernández-Lozano; Vincent Aranzana-Climent; Sha Cao; Carina Matias; Jon Ulf Hansen; Edgars Liepinsh; Diarmaid Hughes; Sven N Hobbie; Carina Vingsbo Lundberg; Lena E Friberg
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Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity–reducing agent uridine

Journal of Antimicrobial Chemotherapy
2024-12-17 | Journal article
Contributors: Jolanta J Levenfors; Joakim Bjerketorp; Bengt Guss; Christina Nord; Sha Cao; Diarmaid Hughes; Anders Broberg; Bo Öberg
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Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria

Molecular Biology and Evolution
2022-04-10 | Journal article
Contributors: Sha Cao; Gerrit Brandis; Douglas L. Huseby; Diarmaid Hughes; Heather Hendrickson
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Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella

mBio
2021-06-29 | Journal article
Contributors: Eva Garmendia; Gerrit Brandis; Lionel Guy; Sha Cao; Diarmaid Hughes; Kelly T. Hughes
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