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Keywords

Optics and Photonics, Optical Imaging, Optical Diagnostics

Countries

United States

Biography

Paul Kumar Upputuri, M.Sc., Ph.D. – Biomedical Optics Researcher

Dr. Paul Kumar Upputuri is a researcher in biomedical optics, with over a decade of experience developing innovative optical technologies for advanced medical diagnostics. His work focuses on creating cutting-edge solutions for the early detection of cancers, particularly in pancreatic and bile duct tissues.

Dr. Paul holds a Ph.D. in Physics (Optics) from the Indian Institute of Technology (IIT) Madras, where he laid the foundation for his impactful contributions to optical science. Over the years, he has published extensively in internationally renowned journals, including Nature Communications, Science Advances, Nano Letters, ACS Nano, and Biomedical Optics Express. His research has earned thousands of citations globally, reflecting its significant influence in the field.

In addition to his publications, Dr. Paul is the author of the SPIE Spotlights eBook RGB Interferometry for Optical Metrology, a valuable resource for professionals in optics and metrology. He has presented his work at numerous international conferences and actively contributes to the optics and photonics community as a Senior Member of SPIE – The International Society for Optics and Photonics.

Dr. Paul’s research combines innovation and real-world impact, with his recent work focusing on advancing clinical optical diagnostic tools to improve early disease detection. His dedication and expertise continue to drive progress in biomedical optics, helping bridge the gap between research and improved patient outcomes.

Activities

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Employment (3)

Harvard University: Cambridge, MA, US

2019-11-10 to present | Researcher (Medicine)
Employment
Source: Self-asserted source
Paul Kumar Upputuri

Nanyang Technological University: Singapore, Singapore, SG

2014-04-15 to 2019-11-03 | Research Fellow (Biomedical Engineering )
Employment
Source: Self-asserted source
Paul Kumar Upputuri

National University of Singapore: Singapore, SG

2011-05-15 to 2013-12-31 | Research Fellow (Optics and Photonics)
Employment
Source: Self-asserted source
Paul Kumar Upputuri

Education and qualifications (1)

Indian Institute of Technology Madras: Chennai, Tamil Nadu, IN

2005-10-10 to 2010-06-30 | PhD (Physics)
Education
Source: Self-asserted source
Paul Kumar Upputuri

Professional activities (3)

SPIE: Bellingham, WA, US

2021-04-01 to present | Senior member
Membership
Source: Self-asserted source
Paul Kumar Upputuri

Optical Society of America: Washington, DC, US

2010-10-01 to present
Membership
Source: Self-asserted source
Paul Kumar Upputuri

SPIE: Bellingham, WA, US

2006-01-01 to present
Membership
Source: Self-asserted source
Paul Kumar Upputuri

Works (50)

Dual-angle light scattering spectroscopy for calibration-free measurements of scatterer suspensions

Optics Letters
2025-01-01 | Journal article
DOI: 10.1364/OL.543614
Contributors: Xuejun Zhang; Paul K. Upputuri; Mark F. Coughlan; David J. Kemble; Umar Khan; Yuri N. Zakharov; Lei Zhang; Lev T Perelman; Le Qiu
Source: check_circle
Crossref

Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids

Science Advances
2021-08-20 | Journal article
DOI: 10.1126/sciadv.abj2800
Contributors: Giuseppe Pettinato; Mark F. Coughlan; Xuejun Zhang; Liming Chen; Umar Khan; Maria Glyavina; Conor J. Sheil; Paul K. Upputuri; Yuri N. Zakharov; Edward Vitkin et al.
Source: check_circle
Crossref

Recent advances in photoacoustic contrast agents for in vivo imaging

WIREs Nanomedicine and Nanobiotechnology
2020-07 | Journal article
DOI: 10.1002/wnan.1618
Contributors: Paul Kumar Upputuri; Manojit Pramanik
Source: check_circle
Crossref

Real-time monitoring of temperature using a pulsed laser-diode-based photoacoustic system

Optics Letters
2020-02-01 | Journal article
DOI: 10.1364/OL.386173
Contributors: Paul Kumar Upputuri; Dhiman Das; Muneesh Maheshwari; Yang Yaowen; Manojit Pramanik
Source: check_circle
Crossref

Contrast-enhanced photoacoustic imaging in the second near-infrared window using semiconducting polymer nanoparticles

Journal of Biomedical Optics
2019 | Journal article
SOURCE-WORK-ID:

101418004350-104
Contributors: Upputuri, P. K.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Super-resolution photoacoustic microscopy using near-field localization by a plasmonic metal nanoaperture: a simulation study

IEEE Journal of Selected Topics in Quantum Electronics
2019 | Journal article
DOI: 10.1109/JSTQE.2018.2796132
WOSUID:

WOS:000435223800001
Contributors: Park, B.; Lee, H.; Upputuri, P. K.; Pramanik, M.; Kim, D.; Kim, C.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

RGB Interferometry for Optical Metrology

SPIE
2019-12 | Book
Source: Self-asserted source
Paul Kumar Upputuri

High-speed, low-cost, pulsed-laser-diode-based second-generation desktop photoacoustic tomography system

Optics Letters
2019-01-01 | Journal article
DOI: 10.1364/OL.44.000081
Contributors: Sandeep Kumar Kalva; Paul Kumar Upputuri; Manojit Pramanik
Source: check_circle
Crossref

Compact Plasmonic Blackbody for Cancer Theranosis in Near-Infrared II Window

Acs Nano
2018 | Journal article
DOI: 10.1021/acsnano.7b08725
WOSUID:

WOS:000428972600058
Contributors: Zhou, J.; Jiang, Y.; Hou, S.; Upputuri, P. K.; Wu, D.; Li, J.; Wang, P.; Zhen, X.; Pramanik, M.; Pu, K. et al.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Fast photoacoustic imaging systems using pulsed laser diodes: a review

Biomedical Engineering Letters
2018 | Journal article
DOI: 10.1007/s13534-018-0060-9
WOSUID:

WOS:000440668500004
Contributors: Upputuri, P. K.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

High-speed, low-cost, pulsed laser diode based second generation desktop photoacoustic tomography system (PLD-PAT-G2)

Optics Letters
2018 | Journal article
SOURCE-WORK-ID:

101418004351-86
Contributors: Kalva, S. K.; Upputuri, P. K.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging

Nano Research
2018 | Journal article
DOI: https://doi.org/10.1007/s12274-018-2175-9
Contributors: Wang, Z.; Upputuri, P. K.; Zhen, X.; Zhang, R.; Jiang, Y.; Ai, X.; Zhang, Z.; Hu, M.; Meng, Z.; Lu, Y. F. et al.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Phase shifting white light interferometry using colour CCD for optical metrology and bio-imaging applications

Proc SPIE
2018 | Conference paper
DOI: http://dx.doi.org/10.1117/12.2287090
Contributors: Upputuri, P. K.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Photoacoustic imaging at 1064 nm wavelength with exogenous contrast agents

Proc SPIE
2018 | Conference paper
DOI: http://dx.doi.org/10.1117/12.2287084
Contributors: Upputuri, P. K.; Jiang, Y.; Pu, K.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Super-resolution photoacoustic microscopy using a localized near-field of a plasmonic nanoaperture: A three-dimensional simulation study

Proc SPIE
2018 | Conference paper
DOI: http://dx.doi.org/10.1117/12.2289418
Contributors: Park, B.; Lee, H.; Upputuri, P. K.; Pramanik, M.; Kim, D.; Kim, C.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

A High-performance compact photoacoustic tomography system for in vivo small-animal brain imaging

Journal of Visualized Experiments
2017 | Journal article
DOI: 10.3791/55811
WOSUID:

WOS:000407448100054
Contributors: Upputuri, P. K.; Periyasamy, Vijitha; Kalva, S. K.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Activatable photoacoustic nanoprobes for in vivo ratiometric imaging of peroxynitrite

Advanced Materials
2017 | Journal article
DOI: 10.1002/adma.201604764
WOSUID:

WOS:000396143000023
Contributors: Zhang, J.; Zhen, X.; Upputuri, P. K.; Pramanik, M.; Chen, P.; Pu, K.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Amphiphilic semiconducting polymer as multifunctional nanocarrier for fluorescence/photoacoustic imaging guided chemo-photothermal therapy

Biomaterials
2017 | Journal article
DOI: 10.1016/j.biomaterials.2017.08.037
WOSUID:

WOS:000413135200014
Contributors: Jiang, Y.; Cui, D.; Fang, Y.; Upputuri, P. K.; Pramanik, M.; Ding, D.; Pu, K.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window

Nano Letters
2017 | Journal article
DOI: 10.1021/acs.nanolett.7b02106
WOSUID:

WOS:000407540300061
Contributors: Jiang, Y.; Upputuri, P. K.; Xie, C.; Lyu, Y.; Zhang, L.; Xiong, Q.; Pramanik, M.; Pu, K.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Dynamic in vivo imaging of small animal brain using pulsed laser diode-based photoacoustic tomography system

Journal of Biomedical Optics
2017 | Journal article
DOI: 10.1117/1.JBO.22.9.090501
WOSUID:

WOS:000413570000001
Contributors: Upputuri, P. K.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Microsphere-aided optical microscopy and its applications for super-resolution imaging

Optics Communications
2017 | Journal article
DOI: 10.1016/j.optcom.2017.05.049
WOSUID:

WOS:000412617900006
Contributors: Upputuri, P. K.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Near Infrared light-responsive liposomal contrast agent for photoacoustic imaging and drug release applications

Journal of Biomedical Optics
2017 | Journal article
DOI: 10.1117/1.JBO.22.4.041007
WOSUID:

WOS:000400896100010
Contributors: Sivasubramanian, K.; Mathiyazhakan, M.; Wiraja, C.; Upputuri, P. K.; Xu, C.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Photonic nanojet engineering to achieve super-resolution in photo-acoustic microscopy – a simulation study

Proc SPIE
2017 | Conference paper
DOI: 10.1117/12.2250483
WOSUID:

WOS:000405954800131
Contributors: Upputuri, P. K.; Krisnan, M.; Moothanchery, M.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Pulsed laser diode photoacoustic tomography (PLD-PAT) system for fast in vivo imaging of small animal brain

Proc SPIE
2017 | Conference paper
DOI: 10.1117/12.2250481
WOSUID:

WOS:000405954800152
Contributors: Upputuri, P. K.; Kalva, S. K.; Moothanchery, M.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Recent advances toward preclinical and clinical translation of photoacoustic tomography: a review

Journal of Biomedical Optics
2017 | Journal article
DOI: 10.1117/1.JBO.22.4.041006
WOSUID:

WOS:000400896100009
Contributors: Upputuri, P. K.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Self-Quenched semiconducting polymer nanoparticles for amplified in vivo photoacoustic imaging

Biomaterials
2017 | Journal article
DOI: 10.1016/j.biomaterials.2016.12.004
WOSUID:

WOS:000393244600001
Contributors: Xie, C.; Upputuri, P. K.; Zhen, X.; Pramanik, M.; Pu, K.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

A dual function theranostic agent for near-infrared photoacoustic imaging and photothermal therapy

Proc SPIE
2016 | Conference paper
DOI: 10.1117/12.2211947
WOSUID:

WOS:000383224800010
Contributors: Upputuri, P. K.; Huang, S.; Wang, M.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

A dual-functional benzobisthiadiazole derivative as an effective theranostic agent for near-infrared photoacoustic imaging and photothermal therapy

Journal of Materials Chemistry B
2016 | Journal article
DOI: 10.1039/c5tb02367j
WOSUID:

WOS:000371062000013
Contributors: Huang, S.; Upputuri, P. K.; Liu, H.; Pramanik, M.; Wang, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

High-speed pre-clinical brain imaging using pulsed laser diode based photoacoustic tomography (PLD-PAT) system

Proc SPIE
2016 | Conference paper
DOI: 10.1117/12.2211891
WOSUID:

WOS:000378437000138
Contributors: Upputuri, Paul Kumar; Pramanik, Manojit
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

In situ synthesis of gold nanostars within liposomes for controlled drug release and photoacoustic imaging

Science China Materials
2016 | Journal article
DOI: 10.1007/s40843-016-5101-3
WOSUID:

WOS:000391274100002
Contributors: Mathiyazhakan, Malathi; Upputuri, Paul Kumar; Sivasubramanian, Kathyayini; Dhayani, Ashish; Vemula, Praveen Kumar; Zou, Peichao; Pu, Kanyi; Yang, Cheng; Pramanik, Manojit; Xu, Chenjie
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Multi-colour microscopic interferometry for optical metrology and imaging applications

Optics and Lasers in Engineering
2016 | Journal article
DOI: 10.1016/j.optlaseng.2016.03.020
WOSUID:

WOS:000376713300002
Contributors: Upputuri, Paul Kumar; Pramanik, Manojit; Nandigana, Krishna Mohan; Kothiyal, Mahendra Prasad
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Near-infrared light-sensitive liposomes for enhanced plasmid DNA transfection

Bioengineering & Translational Medicine
2016 | Journal article
DOI: 10.1002/btm2.10020
Contributors: Wiraja, C.; Mathiyazhakan, M.; Movahedi, F.; Upputuri, P. K.; Cheng, Y.; Pramanik, M.; Yang, L.; David, B.; Xu, C.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Quantitative measurement of displacement in photopolymer layers during holographic recording using phase shifting electronic speckle pattern interferometry

Proc SPIE
2016 | Conference paper
DOI: 10.1117/12.2211577
WOSUID:

WOS:000380605300039
Contributors: Moothanchery, M.; Bavigadda, V.; Upputuri, P. K.; Pramanik, M.; Toal, V.; Naydenova, I.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

High speed photoacoustic tomography system with low cost portable pulsed diode laser

Proc SPIE
2015 | Conference paper
DOI: 10.1117/12.2186136
WOSUID:

WOS:000359674600016
Contributors: Upputuri, P. K.; Sivasubramanian, K.; Pramanik, M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Interferometry with broadband light: Applications in Metrology

Asian Journal of Physics
2015 | Journal article
SOURCE-WORK-ID:

1014180129114-124
Contributors: Kothiyal, Mahendra P.; Upputuri, Paul Kumar
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Performance characterization of low-cost, high-speed, portable pulsed laser diode photoacoustic tomography (PLD-PAT) system

Biomedical Optics Express
2015 | Journal article
DOI: 10.1364/BOE.6.004118
WOSUID:

WOS:000362236600041
Contributors: Upputuri, Paul Kumar; Pramanik, Manojit
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Pulsed laser diode based optoacoustic imaging of biological tissues

Biomedical Physics & Engineering Express
2015 | Journal article
DOI: 10.1088/2057-1976/1/4/045010
WOSUID:

WOS:000422560200010
Contributors: Upputuri, Paul Kumar; Pramanik, Manojit
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Recent developments in vascular imaging techniques in tissue engineering and regenerative medicine

BioMed Research International
2015 | Journal article
DOI: 10.1155/2015/783983
WOSUID:

WOS:000351384700001
Contributors: Upputuri, Paul Kumar; Sivasubramanian, Kathyayini; Mark, Chong Seow Khoon; Pramanik, Manojit
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Single-shot interferometry techniques for optical testing

Asian Journal of Physics
2015 | Journal article
SOURCE-WORK-ID:

1014180129115-137
Contributors: Upputuri, Paul Kumar; Nandigana, Krishna Mohan; Kothiyal, Mahendra P.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

White light single-shot interferometry with colour CCD camera for optical inspection of microsystems

Proc SPIE
2015 | Conference paper
DOI: 10.1117/12.2185802
WOSUID:

WOS:000359674600012
Contributors: Upputuri, Paul Kumar; Pramanik, Manojit; Nandigana, Krishna Mohan; Kothiyal, Mahendra Prasad
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Chirped time-resolved CARS microscopy with square-pulse excitation

Optics Express
2014 | Journal article
DOI: 10.1364/OE.22.009611 10.1364/OE.22.009611.
Contributors: Upputuri, P. K.; Gong, L.; Wang, H.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Measurement of large discontinuities using single white light interferogram

Optics Express
2014 | Journal article
DOI: 10.1364/OE.22.027373
WOSUID:

WOS:000344004900090
Contributors: Upputuri, Paul Kumar; Gong, Li; Wang, Haifeng; Pramanik, Manojit; Nandigana, Krishna Mohan; Kothiyal, Mahendra Prasad
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Microscopic TV holo-shearography for microsystems metrology

Journal of Instrumentation Society of India
2014 | Journal article
SOURCE-WORK-ID:

1014180129115-130
Contributors: Kumar, U. Paul; Somasundaram, U.; Mohan, N. Krishna; Kothiyal, M. P.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Super-resolution coherent anti-Stokes Raman scattering microscopy with photonic nanojets

Optics Express
2014 | Journal article
DOI: 10.1364/OE.22.012890
WOSUID:

WOS:000337501600019
Contributors: Upputuri, P. K.; Wu, Zhe; Gong, Li; Ong, C. K.; Wang, H.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Super-resolution photoacoustic microscopy using photonic nanojets: a simulation study

Journal of Biomedical Optics
2014 | Journal article
DOI: 10.1117/1.JBO.19.11.116003
WOSUID:

WOS:000347442000026
Contributors: Upputuri, Paul Kumar; Wen, Zhuo-Bin; Wu, Zhe; Pramanik, Manojit
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Two-wavelength microscopic speckle interferometry using colour CCD camera

Proc SPIE
2014 | Conference paper
DOI: 10.1117/12.2081122
WOSUID:

WOS:000353122200072
Contributors: Upputuri, P. K.; Pramanik, M.; Kothiyal, Mahendra P.; Nandigana, Krishna M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Use of two wavelengths in microscopic TV holography for nondestructive testing

Optical Engineering
2014 | Journal article
DOI: 10.1117/1.OE.53.11.110501
WOSUID:

WOS:000347723600002
Contributors: Upputuri, Paul Kumar; Umapathy, Somasundaram; Pramanik, Manojit; Kothiyal, Mahendra Prasad; Nandigana, Krishna Mohan
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

White light interferometer with color CCD for 3D-surface profiling of microsystems

Proc SPIE
2014 | Conference paper
DOI: 10.1117/12.2081117
WOSUID:

WOS:000353122200078
Contributors: Upputuri, P. K.; Pramanik, M.; Kothiyal, Mahendra P.; Nandigana, Krishna M.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

A picosecond near-infrared laser source based on a self-seeded optical parametric generator

Applied Physics B
2013 | Journal article
DOI: 10.1007/s00340-013-5434-1
WOSUID:

WOS:000325099400012
Contributors: Upputuri, Paul Kumar; Wang, Haifeng
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Circularly polarized coherent anti-Stokes Raman scattering microscopy

Optics Letters
2013 | Journal article
DOI: 10.1364/OL.38.001262
WOSUID:

WOS:000317580200027
Contributors: Upputuri, P. K.; Lin, J.; Gong, L.; Liu, X.; Wang, H.; Huang, Z.
Source: Self-asserted source
Paul Kumar Upputuri via ResearcherID

Peer review (1 review for 1 publication/grant)

Review activity for Biomedical engineering letters. (1)
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