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Scopus Author ID: 57195535367

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Education and qualifications (3)

University of Oxford: Oxford, Oxfordshire, GB

2017 to 2022 | DPhil in Chemical Biology (Chemistry)
Education
Source: Self-asserted source
Pauline A. Lang

Johannes Gutenberg Universität Mainz: Mainz, Rheinland-Pfalz, DE

2015 to 2017 | Master of Science in Biomedical Chemistry (Chemistry)
Education
Source: Self-asserted source
Pauline A. Lang

Johannes Gutenberg Universität Mainz: Mainz, Rheinland-Pfalz, DE

2011 to 2015 | Bachelor of Science in Chemistry and Biomedical Chemistry (Chemistry)
Education
Source: Self-asserted source
Pauline A. Lang

Funding (1)

National PhD Training Programme in Antimicrobial Resistance Research

Grant
Medical Research Foundation (London, GB)
Part of GRANT_NUMBER:

MRF-145-0004-TPG-AVISO
Source: Self-asserted source
Pauline A. Lang

Works (17)

Biochemical and crystallographic studies of l,d-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate

Communications Biology
2024-09-18 | Journal article
DOI: 10.1038/s42003-024-06785-3
Contributors: Mariska de Munnik; Pauline A. Lang; Karina Calvopiña; Patrick Rabe; Jürgen Brem; Christopher J. Schofield
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Crossref

How Clavulanic Acid Inhibits Serine β‐Lactamases

ChemBioChem
2024-07-25 | Journal article
DOI: 10.1002/cbic.202400280
Part of ISSN: 1439-4227
Part of ISSN: 1439-7633
Contributors: Pauline Lang; Mariska de Munnik; Abraham Oluwole; Timothy Claridge; Carol Robinson; Jurgen Brem; Christopher Schofield
Source: Self-asserted source
Pauline A. Lang

High-throughput screen with the l,d-transpeptidase LdtMt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors

Chemical Science
2023 | Journal article
DOI: 10.1039/D2SC06858C
Contributors: Mariska de Munnik; Pauline A. Lang; Francisco De Dios Anton; Mónica Cacho; Robert H. Bates; Jürgen Brem; Beatriz Rodríguez Miquel; Christopher J. Schofield
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Crossref

Pretargeted PET Imaging with a TCO-Conjugated Anti-CD44v6 Chimeric mAb U36 and [89Zr]Zr-DFO-PEG5-Tz

Bioconjugate Chemistry
2022-05-18 | Journal article
DOI: 10.1021/acs.bioconjchem.2c00164
Contributors: Dave Lumen; Danielle Vugts; Marion Chomet; Surachet Imlimthan; Mirkka Sarparanta; Ricardo Vos; Maxime Schreurs; Mariska Verlaan; Pauline A. Lang; Eero Hippeläinen et al.
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Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors

Proceedings of the National Academy of Sciences
2022-05-03 | Journal article
DOI: 10.1073/pnas.2117310119
Contributors: Pauline A. Lang; Ritu Raj; Anthony Tumber; Christopher T. Lohans; Patrick Rabe; Carol V. Robinson; Jürgen Brem; Christopher J. Schofield
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Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Nature Chemistry
2022-01 | Journal article
DOI: 10.1038/s41557-021-00831-x
Part of ISSN: 1755-4330
Part of ISSN: 1755-4349
Source: Self-asserted source
Pauline A. Lang

An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography

Nature Communications
2021-12 | Journal article
DOI: 10.1038/s41467-021-24757-7
Part of ISSN: 2041-1723
Source: Self-asserted source
Pauline A. Lang

X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis

Science Advances
2021-08 | Journal article
DOI: 10.1126/sciadv.abh0250
Part of ISSN: 2375-2548
Source: Self-asserted source
Pauline A. Lang

Structural Investigations of the Inhibition of Escherichia coli AmpC β-Lactamase by Diazabicyclooctanes

Antimicrobial Agents and Chemotherapy
2021-01-20 | Journal article
DOI: 10.1128/AAC.02073-20
Contributors: Pauline A. Lang; Thomas M. Leissing; Malcolm G. P. Page; Christopher J. Schofield; Jürgen Brem
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Crossref

Anaerobic fixed-target serial crystallography

IUCrJ
2020-09-01 | Journal article
DOI: 10.1107/S2052252520010374
Contributors: Patrick Rabe; John H. Beale; Agata Butryn; Pierre Aller; Anna Dirr; Pauline A. Lang; Danny N. Axford; Stephen B. Carr; Thomas M. Leissing; Michael A. McDonough et al.
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Crossref

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli

Biomolecules
2020-06-12 | Journal article
DOI: 10.3390/biom10060899
Contributors: Pauline A. Lang; Anete Parkova; Thomas M. Leissing; Karina Calvopiña; Ricky Cain; Alen Krajnc; Tharindi D. Panduwawala; Jules Philippe; Colin W. G. Fishwick; Peteris Trapencieris et al.
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Crossref

Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen

Chemical Communications
2019 | Journal article
DOI: 10.1039/C9CC04145A
Contributors: Mariska de Munnik; Christopher T. Lohans; Pauline A. Lang; Gareth W. Langley; Tika R. Malla; Anthony Tumber; Christopher J. Schofield; Jürgen Brem
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Crossref

Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

Antimicrobial Agents and Chemotherapy
2019-10 | Journal article
DOI: 10.1128/AAC.00564-19
Contributors: Catherine L. Tooke; Philip Hinchliffe; Pauline A. Lang; Adrian J. Mulholland; Jürgen Brem; Christopher J. Schofield; James Spencer
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Crossref

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases

Journal of Medicinal Chemistry
2019-09-26 | Journal article
DOI: 10.1021/acs.jmedchem.9b00911
Contributors: Alen Krajnc; Jürgen Brem; Philip Hinchliffe; Karina Calvopiña; Tharindi D. Panduwawala; Pauline A. Lang; Jos J. A. G. Kamps; Jonathan M. Tyrrell; Emma Widlake; Benjamin G. Saward et al.
Source: check_circle
Crossref

Mapping the Hydrophobic Substrate Binding Site of Phenylalanine Ammonia-Lyase from Petroselinum crispum

ACS Catalysis
2019-09-06 | Journal article
DOI: 10.1021/acscatal.9b02108
Contributors: Emma Z. A. Nagy; Souad D. Tork; Pauline A. Lang; Alina Filip; Florin D. Irimie; László Poppe; Monica I. Toşa; Christopher J. Schofield; Jürgen Brem; Csaba Paizs et al.
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Crossref

Will morphing boron-based inhibitors beat the β-lactamases?

Current Opinion in Chemical Biology
2019-06 | Journal article
DOI: 10.1016/j.cbpa.2019.03.001
Contributors: Alen Krajnc; Pauline A Lang; Tharindi D Panduwawala; Jürgen Brem; Christopher J Schofield
Source: check_circle
Crossref

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates

Journal of Molecular Biology
2017 | Journal article
DOI: 10.1016/j.jmb.2017.08.007
EID:

2-s2.0-85028659047

Part of ISSN: 10898638 00222836
Contributors: Tarhonskaya, H.; Nowak, R.P.; Johansson, C.; Szykowska, A.; Tumber, A.; Hancock, R.L.; Lang, P.; Flashman, E.; Oppermann, U.; Schofield, C.J. et al.
Source: Self-asserted source
Pauline A. Lang via Scopus - Elsevier
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