Personal information

3D genome organization, single cell omics, cancer epigenetics, sequence variations

Activities

Employment (2)

Bristol-Myers Squibb: NY, NY, US

2022-08-01 to present | Senior Scientist (Informatics & Predictive Sciences)
Employment
Source: Self-asserted source
Yan Kai

Dana-Farber Cancer Institute: Boston, MA, US

2018-06-04 to 2022-07-31 | Research Fellow (Biostats and Computational Biology)
Employment
Source: Self-asserted source
Yan Kai

Education and qualifications (1)

George Washington University: Washington, DC, US

2012-09-01 to 2018-05-31 | PhD (Department of Physics)
Education
Source: Self-asserted source
Yan Kai

Works (20)

Identifying Quantitatively Differential Chromosomal Compartmentalization Changes and Their Biological Significance from Hi-C data using DARIC

2023-04-28 | Preprint
Contributors: Yan Kai; Nan Liu; Stuart H Orkin; Guo-Cheng Yuan
Source: Self-asserted source
Yan Kai

Matrin3 mediates differentiation through stabilizing chromatin accessibility and chromatin loop-domain interactions, and YY1 mediated enhancer-promoter interactions

2023-03-31 | Preprint
Contributors: Tianxin Liu; Qian Zhu; Kai Yan; Trevor Bingham; Hye Ji Cha; Stuti Mehta; Thorsten M Schlaeger; Guo-Cheng Yuan; Stuart H Orkin
Source: Self-asserted source
Yan Kai

Lysine methyltransferase Kmt2d regulates naive CD8+ T cell activation-induced survival

Frontiers in Immunology
2023-01-19 | Journal article
Part of ISSN: 1664-3224
Contributors: Jaekwan Kim; Thomas Nguyen; Jeffrey Cifello; Raheel Ahmad; Yongqing Zhang; Qian Yang; Ji-Eun Lee; Xiang Li; Yan Kai; Supriyo De et al.
Source: Self-asserted source
Yan Kai

Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells

Cell Chemical Biology
2022-08 | Journal article
Part of ISSN: 2451-9456
Contributors: Stuti Mehta; Altantsetseg Buyanbat; Yan Kai; Ozge Karayel; Seth Raphael Goldman; Davide Seruggia; Kevin Zhang; Yuko Fujiwara; Katherine A. Donovan; Qian Zhu et al.
Source: Self-asserted source
Yan Kai

MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape

Molecular Cell
2022-03 | Journal article
Part of ISSN: 1097-2765
Contributors: Sarah Naomi Olsen; Laura Godfrey; James P. Healy; Yoolim A. Choi; Yan Kai; Charles Hatton; Florian Perner; Elena L. Haarer; Behnam Nabet; Guo-Cheng Yuan et al.
Source: Self-asserted source
Yan Kai

A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

Genes & Development
2022-03-01 | Journal article
Part of ISSN: 0890-9369
Part of ISSN: 1549-5477
Contributors: Taku Harada; Yaser Heshmati; Jérémie Kalfon; Monika W. Perez; Juliana Xavier Ferrucio; Jazmin Ewers; Benjamin Hubbell Engler; Andrew Kossenkov; Jana M. Ellegast; Joanna S. Yi et al.
Source: Self-asserted source
Yan Kai

Mapping the evolving landscape of super-enhancers during cell differentiation

Genome Biology
2021-12 | Journal article
Part of ISSN: 1474-760X
Contributors: Yan Kai; Bin E. Li; Ming Zhu; Grace Y. Li; Fei Chen; Yingli Han; Hye Ji Cha; Stuart H. Orkin; Wenqing Cai; Jialiang Huang et al.
Source: Self-asserted source
Yan Kai

Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture

Nature Communications
2021-10-29 | Journal article | Author
Part of ISSN: 2041-1723
Contributors: Hye Ji Cha; Özgün Uyan; Yan Kai; Tianxin Liu; Qian Zhu; Zuzana Tothova; Giovanni A. Botten; Jian Xu; Guo-Cheng Yuan; Job Dekker et al.
Source: Self-asserted source
Yan Kai

Transcription factor competition at the γ-globin promoters controls hemoglobin switching

Nature Genetics
2021-04 | Journal article
Part of ISSN: 1061-4036
Part of ISSN: 1546-1718
Contributors: Nan Liu; Shuqian Xu; Qiuming Yao; Qian Zhu; Yan Kai; Jonathan Hsu; Phraew Sakon; Luca Pinello; Guo-Cheng Yuan; Daniel Bauer et al.
Source: Self-asserted source
Yan Kai

Multi-scale annotations of chromatin states in 127 human cell-types

2020-12-23 | Preprint
Contributors: Yan Kai; Stephanos Tsoucas; Shengbao Suo; Guo-Cheng Yuan
Source: Self-asserted source
Yan Kai

BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice

Nature Communications
2020-06-15 | Journal article
Part of ISSN: 2041-1723
Contributors: Stephanie Perkail; Jaclyn Andricovich; Yan Kai; Alexandros Tzatsos
Source: Self-asserted source
Yan Kai

Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer

JCI Insight
2019-12-19 | Journal article | Author
Part of ISSN: 2379-3708
Contributors: Ya Zhang; Xuefeng Wu; Yan Kai; Chia-Han Lee; Fengdong Cheng; Yixuan Li; Yongbao Zhuang; Javid Ghaemmaghami; Kun-Han Chuang; Zhuo Liu et al.
Source: Self-asserted source
Yan Kai

Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features

Nature Communications
2018-10-11 | Journal article
Source: Self-asserted source
Yan Kai

dbVar structural variant cluster set for data analysis and variant comparison [version 1; referees: awaiting peer review]

2016-04-13 | Journal article
Contributors: Lon Phan; Jeffrey Hsu; Le Quang Minh Tri; Michaela Willi; Tamer Mansour; Yan Kai; John Garner; John Lopez; Ben Busby
Source: check_circle
F1000

Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance

Oncogene
Journal article
Source: Self-asserted source
Yan Kai

DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR- Chk1 pathway in ovarian cancer

Cancer Letters
Journal article
Source: Self-asserted source
Yan Kai

Epigenetic regulation of lineage commitment in normal and malignant hematopoiesis by histone demethylase KDM2B

The Journal of clinical investigation
Journal article
Source: Self-asserted source
Yan Kai

Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors

Cancer Cell
Journal article
Source: Self-asserted source
Yan Kai

Lysine-specific histone demethylases in normal and malignant hematopoiesis

Experimental Hematology
Journal article
Source: Self-asserted source
Yan Kai

miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer

Oncogene
Journal article
Source: Self-asserted source
Yan Kai