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Keywords

HGF, MET receptor, Signal Transduction, Autophagy, Heart, Brain, Antibodies

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Italy

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Employment (2)

University of Turin: Turin, Piemonte, IT

PROFESSOR of BIOCHEMISTRY (ONCOLOGY)
Employment
Source: Self-asserted source
Tiziana Crepaldi

Candiolo Cancer Institute: Candiolo, IT

Employment
Source: Self-asserted source
Tiziana Crepaldi

Works (50 of 81)

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NMDA Receptor and Its Emerging Role in Cancer

International Journal of Molecular Sciences
2023-01-28 | Journal article
DOI: 10.3390/ijms24032540
Contributors: Simona Gallo; Annapia Vitacolonna; Tiziana Crepaldi
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Crossref
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The PSI Domain of the MET Oncogene Encodes a Functional Disulfide Isomerase Essential for the Maturation of the Receptor Precursor

International Journal of Molecular Sciences
2022-10 | Journal article | Author
DOI: 10.3390/ijms232012427
Contributors: Dogus Murat Altintas; Simona Gallo; Cristina Basilico; Marina Cerqua; Alessio Bocedi; Annapia Vitacolonna; Orsola Botti; Elena Casanova; Ilaria Rancati; Chiara Milanese et al.
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Multidisciplinary Digital Publishing Institute

MET Oncogene Controls Invasive Growth by Coupling with NMDA Receptor

Cancers
2022-09-11 | Journal article
DOI: 10.3390/cancers14184408
Contributors: Simona Gallo; Annapia Vitacolonna; Paolo Comoglio; Tiziana Crepaldi
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Crossref
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Two-Chains Tissue Plasminogen Activator Unifies Met and NMDA Receptor Signalling to Control Neuronal Survival

International Journal of Molecular Sciences
2021-12 | Journal article | Author
DOI: 10.3390/ijms222413483
Contributors: Elodie Hedou; Sara Douceau; Arnaud Chevilley; Alexandre Varangot; Audrey M. Thiebaut; Hortense Triniac; Isabelle Bardou; Carine Ali; Mike Maillasson; Tiziana Crepaldi et al.
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Multidisciplinary Digital Publishing Institute
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Engineering, Characterization, and Biological Evaluation of an Antibody Targeting the HGF Receptor.

Frontiers in immunology
2021-12-03 | Journal article
DOI: 10.3389/fimmu.2021.775151
PMID: 34925346
PMC: PMC8679783
Source: Self-asserted source
Tiziana Crepaldi
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Factor XII protects neurons from apoptosis by epidermal and hepatocyte growth factor receptor-dependent mechanisms.

Journal of thrombosis and haemostasis : JTH
2021-06-29 | Journal article
DOI: 10.1111/jth.15414
PMID: 34060720
Source: Self-asserted source
Tiziana Crepaldi

HGF and MET: From Brain Development to Neurological Disorders.

Frontiers in cell and developmental biology
2021-06-09 | Journal article
DOI: 10.3389/fcell.2021.683609
PMID: 34179015
PMC: PMC8220160
Source: Self-asserted source
Tiziana Crepaldi

Identification of novel circulating microRNAs in advanced heart failure by next-generation sequencing.

ESC heart failure
2021-05-02 | Journal article
DOI: 10.1002/ehf2.13371
PMID: 33934544
PMC: PMC8318428
Source: Self-asserted source
Tiziana Crepaldi

The Long-Lasting Protective Effect of HGF in Cardiomyoblasts Exposed to Doxorubicin Requires a Positive Feed-Forward Loop Mediated by Erk1,2-Timp1-Stat3.

International journal of molecular sciences
2020-07-24 | Journal article
DOI: 10.3390/ijms21155258
PMID: 32722178
PMC: PMC7432797
Source: Self-asserted source
Tiziana Crepaldi

Activation of the MET receptor attenuates doxorubicin-induced cardiotoxicity in vivo and in vitro.

British journal of pharmacology
2020-05-29 | Journal article
DOI: 10.1111/bph.15039
PMID: 32133617
PMC: PMC7280013
Source: Self-asserted source
Tiziana Crepaldi

Molecular Engineering Strategies Tailoring the Apoptotic Response to a MET Therapeutic Antibody.

Cancers
2020-03-21 | Journal article
DOI: 10.3390/cancers12030741
PMID: 32245152
PMC: PMC7140090
Source: Self-asserted source
Tiziana Crepaldi

ERK: A Key Player in the Pathophysiology of Cardiac Hypertrophy.

International journal of molecular sciences
2019-05-01 | Journal article
DOI: 10.3390/ijms20092164
PMID: 31052420
PMC: PMC6539093
Source: Self-asserted source
Tiziana Crepaldi

A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart

BioMed Research International
2016 | Journal article
DOI: 10.1155/2016/9549036
EID:

2-s2.0-84973311497
Contributors: Sala, V.; Gatti, S.; Gallo, S.; Medico, E.; Cantarella, D.; Cimino, J.; Ponzetto, A.; Crepaldi, T.
Source: Self-asserted source
Tiziana Crepaldi via Scopus - Elsevier

Cardiac concentric hypertrophy promoted by activated Met receptor is mitigated in vivo by inhibition of Erk1,2 signalling with Pimasertib

Journal of Molecular and Cellular Cardiology
2016 | Journal article
DOI: 10.1016/j.yjmcc.2016.02.017
EID:

2-s2.0-84960384875
Contributors: Sala, V.; Gallo, S.; Gatti, S.; Medico, E.; Vigna, E.; Cantarella, D.; Fontani, L.; Natale, M.; Cimino, J.; Morello, M. et al.
Source: Self-asserted source
Tiziana Crepaldi via Scopus - Elsevier

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Autophagy
2016 | Journal article
DOI: 10.1080/15548627.2015.1100356
EID:

2-s2.0-85013763791
Contributors: Klionsky, D.J.; Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; Adams, C.M.; Adams, P.D. et al.
Source: Self-asserted source
Tiziana Crepaldi via Scopus - Elsevier

Hepatocyte growth factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes

eLife
2016 | Journal article
DOI: 10.7554/eLife.12116
EID:

2-s2.0-84961935854
Contributors: Morena, D.; Maestro, N.; Bersani, F.; Forni, P.E.; Lingua, M.F.; Foglizzo, V.; Šćepanović, P.; Miretti, S.; Morotti, A.; Shern, J.F. et al.
Source: Self-asserted source
Tiziana Crepaldi via Scopus - Elsevier

Cellular and molecular mechanisms of HGF/Met in the cardiovascular system

Clinical Science
2015 | Journal article
DOI: 10.1042/CS20150502
EID:

2-s2.0-84952001288
Contributors: Gallo, S.; Sala, V.; Gatti, S.; Crepaldi, T.
Source: Self-asserted source
Tiziana Crepaldi via Scopus - Elsevier

Anti-Differentiation Effect of Oncogenic Met Receptor in Terminally-Differentiated Myotubes.

Biomedicines
2015-02-12 | Journal article
DOI: 10.3390/biomedicines3010124
PMID: 28536403
PMC: PMC5344230
Source: Self-asserted source
Tiziana Crepaldi

Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy.

2014 | Journal article
DOI: 10.1038/cddis.2014.155
PMID: 24743740
PMC: PMC4001309
Contributors: Gallo S; Gatti S; Sala V; Albano R; Costelli P; Casanova E; Comoglio PM; Crepaldi T
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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HGF/Met Axis in Heart Function and Cardioprotection.

Biomedicines
2014-10-21 | Journal article
DOI: 10.3390/biomedicines2040247
PMID: 28548070
PMC: PMC5344277
Source: Self-asserted source
Tiziana Crepaldi

MicroRNAs in myocardial ischemia: identifying new targets and tools for treating heart disease. New frontiers for miR-medicine.

2014-04 | Journal article
DOI: 10.1007/s00018-013-1504-0
PMID: 24218009
Contributors: Sala V; Bergerone S; Gatti S; Gallo S; Ponzetto A; Ponzetto C; Crepaldi T
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Gene expression profiling of HGF/Met activation in neonatal mouse heart.

2013-06 | Journal article
DOI: 10.1007/s11248-012-9667-2
PMID: 23224784
Contributors: Gatti S; Leo C; Gallo S; Sala V; Bucci E; Natale M; Cantarella D; Medico E; Crepaldi T
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Signaling to cardiac hypertrophy: insights from human and mouse RASopathies.

2012 | Journal article
DOI: 10.2119/molmed.2011.00512
PMID: 22576369
PMC: PMC3459479
Contributors: Sala V; Gallo S; Leo C; Gatti S; Gelb BD; Crepaldi T
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes.

2012-10 | Journal article
DOI: 10.1042/BJ20120200
PMID: 22845468
Contributors: Campia I; Sala V; Kopecka J; Leo C; Mitro N; Costamagna C; Caruso D; Pescarmona G; Crepaldi T; Ghigo D et al.
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Activated Met signalling in the developing mouse heart leads to cardiac disease.

2011 | Journal article
DOI: 10.1371/journal.pone.0014675
PMID: 21347410
PMC: PMC3036588
Contributors: Leo C; Sala V; Morello M; Chiribiri A; Riess I; Mancardi D; Schiaffino S; Ponzetto C; Crepaldi T
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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A mouse model for spatial and temporal expression of HGF in the heart.

2011-12 | Journal article
DOI: 10.1007/s11248-011-9485-y
PMID: 21360304
Contributors: Riess I; Sala V; Leo C; Demaria M; Gatti S; Gallo S; Fitou A; Boero O; Levi R; Cuccovillo I et al.
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Novel therapy for myocardial infarction: can HGF/Met be beneficial?

2011-05 | Journal article
DOI: 10.1007/s00018-011-0633-6
PMID: 21327916
Contributors: Sala V; Crepaldi T
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Hepatocyte growth factor regulates migration of olfactory interneuron precursors in the rostral migratory stream through Met-Grb2 coupling.

2008-06 | Journal article
DOI: 10.1523/JNEUROSCI.1083-08.2008
PMID: 18524894
Contributors: Garzotto D; Giacobini P; Crepaldi T; Fasolo A; De Marchis S
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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An in vivo model of Met-driven lymphoma as a tool to explore the therapeutic potential of Met inhibitors.

2008-04 | Journal article
DOI: 10.1158/1078-0432.CCR-07-2064
PMID: 18381964
Contributors: Accornero P; Lattanzio G; Mangano T; Chiarle R; Taulli R; Bersani F; Forni PE; Miretti S; Scuoppo C; Dastrù W et al.
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Bortezomib-mediated proteasome inhibition as a potential strategy for the treatment of rhabdomyosarcoma.

2008-04 | Journal article
DOI: 10.1016/j.ejca.2008.02.022
PMID: 18342500
Contributors: Bersani F; Taulli R; Accornero P; Morotti A; Miretti S; Crepaldi T; Ponzetto C
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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The oncogenic transcription factor PAX3-FKHR can convert fibroblasts into contractile myotubes.

2007-07 | Journal article
DOI: 10.1016/j.yexcr.2007.02.037
PMID: 17490646
Contributors: Scuoppo C; Riess I; Schmitt-Ney M; Allegra P; Forni PE; Bersani F; Taulli R; Accornero P; Crepaldi T; Ponzetto C
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Conditional activation of MET in differentiated skeletal muscle induces atrophy.

2007-03 | Journal article
DOI: 10.1074/jbc.M610916200
PMID: 17194700
Contributors: Crepaldi T; Bersani F; Scuoppo C; Accornero P; Prunotto C; Taulli R; Forni PE; Leo C; Chiarle R; Griffiths J et al.
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Ghrelin and des-acyl ghrelin promote differentiation and fusion of C2C12 skeletal muscle cells.

2007-03 | Journal article
DOI: 10.1091/mbc.E06-05-0402
PMID: 17202410
PMC: PMC1805095
Contributors: Filigheddu N; Gnocchi VF; Coscia M; Cappelli M; Porporato PE; Taulli R; Traini S; Baldanzi G; Chianale F; Cutrupi S et al.
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migration.

2007-01 | Journal article
DOI: 10.1523/JNEUROSCI.4979-06.2007
PMID: 17215404
Contributors: Giacobini P; Messina A; Wray S; Giampietro C; Crepaldi T; Carmeliet P; Fasolo A
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Validation of met as a therapeutic target in alveolar and embryonal rhabdomyosarcoma.

2006-05 | Journal article
DOI: 10.1158/0008-5472.CAN-05-4292
PMID: 16651427
Contributors: Taulli R; Scuoppo C; Bersani F; Accornero P; Forni PE; Miretti S; Grinza A; Allegra P; Schmitt-Ney M; Crepaldi T et al.
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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RNAi technology and lentiviral delivery as a powerful tool to suppress Tpr-Met-mediated tumorigenesis.

2005-05 | Journal article
DOI: 10.1038/sj.cgt.7700815
PMID: 15719029
Contributors: Taulli R; Accornero P; Follenzi A; Mangano T; Morotti A; Scuoppo C; Forni PE; Bersani F; Crepaldi T; Chiarle R et al.
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles.

2004-11 | Journal article
DOI: 10.1002/dvdy.20177
PMID: 15376315
Contributors: Prunotto C; Crepaldi T; Forni PE; Ieraci A; Kelly RG; Tajbakhsh S; Buckingham M; Ponzetto C
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor.

2001-12 | Journal article
DOI: 10.1074/jbc.M104323200
PMID: 11571281
Contributors: Grisendi S; Chambraud B; Gout I; Comoglio PM; Crepaldi T
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Effect of hepatocyte growth factor on assembly of zonula occludens-1 protein at the plasma membrane.

1998-09 | Journal article
DOI: 10.1002/(SICI)1097-4652(199809)176:3<465::AID-JCP3>3.0.CO;2-M
PMID: 9699499
Contributors: Grisendi S; Arpin M; Crepaldi T
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central

Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF.

1998-01 | Journal article
PMID: 9405310
Contributors: Prat M; Crepaldi T; Pennacchietti S; Bussolino F; Comoglio PM
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central

Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells.

1997-07 | Journal article
DOI: 10.1083/jcb.138.2.423
PMID: 9230083
PMC: PMC2138186
Contributors: Crepaldi T; Gautreau A; Comoglio PM; Louvard D; Arpin M
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Overexpression of c-met protooncogene product and raised Ki67 index in hepatocellular carcinomas with respect to benign liver conditions.

1995-06 | Journal article
DOI: 10.1016/0270-9139(95)90457-3
PMID: 7768498
Contributors: Grigioni WF; Fiorentino M; D'Errico A; Ponzetto A; Crepaldi T; Prat M; Comoglio PM
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Generation of a truncated hepatocyte growth factor receptor in the endoplasmic reticulum

Journal of Biological Chemistry
1994 | Journal article
EID:

2-s2.0-0028040132
Contributors: Crepaldi, T.; Prat, M.; Giordano, S.; Medico, E.; Comoglio, P.M.
Source: Self-asserted source
Tiziana Crepaldi via Scopus - Elsevier

Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells

Journal of Cell Biology
1994 | Journal article
EID:

2-s2.0-0028258532
Contributors: Crepaldi, T.; Pollack, A.L.; Prat, M.; Zborek, A.; Mostov, K.; Comoglio, P.M.
Source: Self-asserted source
Tiziana Crepaldi via Scopus - Elsevier

Overexpression of the Met/HGF receptor in ovarian cancer.

1994-09 | Journal article
DOI: 10.1002/ijc.2910580507
PMID: 8077049
Contributors: Di Renzo MF; Olivero M; Katsaros D; Crepaldi T; Gaglia P; Zola P; Sismondi P; Comoglio PM
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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Selective expression of the Met/HGF receptor in human central nervous system microglia

Oncogene
1993 | Journal article
EID:

2-s2.0-0027512426
Contributors: Di Renzo, M.F.; Bertolotto, A.; Olivero, M.; Putzolu, P.; Crepaldi, T.; Schiffer, D.; Pagni, C.A.; Comoglio, P.M.
Source: Self-asserted source
Tiziana Crepaldi via Scopus - Elsevier

Quantitative expression of HLA class I molecules in acute non-lymphoblastic leukaemia cells.

1993-06 | Journal article
DOI: 10.1111/j.1744-313X.1993.tb00107.x
PMID: 8338814
Contributors: D'Alfonso S; Savoia P; Pitti G; Peruccio D; Pozzi C; Crepaldi T; Falda M; Ficara F; Resegotti L; Momigliano Richiardi P
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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C-terminal truncated forms of Met, the hepatocyte growth factor receptor

Molecular and Cellular Biology
1991 | Journal article
EID:

2-s2.0-0025932538
Contributors: Prat, M.; Crepaldi, T.; Gandino, L.; Giordano, S.; Longati, P.; Comoglio, P.
Source: Self-asserted source
Tiziana Crepaldi via Scopus - Elsevier

Chronic active hepatitis B. Interferon-activated natural killer-like cells against a hepatoma cell line transfected with the hepatitis B virus nucleic acid

Liver
1991 | Journal article
EID:

2-s2.0-0025891930
Contributors: Actis, G.C.; Ponzetto, A.; D'Urso, N.; Saracco, G.; Crepaldi, T.; Bellone, G.; Catucci, L.M.; Zarcone, D.; Verme, G.
Source: Self-asserted source
Tiziana Crepaldi via Scopus - Elsevier

The receptor encoded by the human c-MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors.

1991-09 | Journal article
DOI: 10.1002/ijc.2910490302
PMID: 1917129
Contributors: Prat M; Narsimhan RP; Crepaldi T; Nicotra MR; Natali PG; Comoglio PM
Source: Self-asserted source
Tiziana Crepaldi via Europe PubMed Central
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