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Prions, Creutzfeldt Jakob Disease, Gerstmann Straüssler Scheinker, Fatal Familial Insomnia, GSS, FFI, CJD
Spain

Activities

Employment (2)

ATLAS Molecular Pharma: Derio, ES

2018-11 to present | Postdoctoral Researcher
Employment
Source: Self-asserted source
Jorge M. Charco

CIC bioGUNE: Derio, Basque Country, ES

2015-01 to 2018-10 | PhD student (Proteomics)
Employment
Source: Self-asserted source
Jorge M. Charco

Education and qualifications (5)

Dirección General de Agricultura, Ganadería y Alimentación. Comunidad de Madrid: Madrid, ES

2022 to present | Qualification for design of Projects and Procedures for Laboratory Animal Sciences (Category D)
Qualification
Source: Self-asserted source
Jorge M. Charco

Instituto de Estudios de Ciencias de la Salud de Castilla y León: Soria, Castile and Leon, ES

2014 to present | XII Training Course for Experimenters in Laboratory Animal Sciences (Category B and C)
Qualification
Source: Self-asserted source
Jorge M. Charco

CIC bioGUNE: Derio, Basque Country, ES

2015-01 to 2018-10 | PhD in Neuroscience (Proteomics)
Education
Source: Self-asserted source
Jorge M. Charco

University of Salamanca: Salamanca, Castile and Leon, ES

2013 to 2014 | Masters degree in Neuroscience (Instituto de Neurociencias de Castilla y León (INCYL))
Education
Source: Self-asserted source
Jorge M. Charco

University of Salamanca: Salamanca, Castile and Leon, ES

2008 to 2013 | Biology Degree
Education
Source: Self-asserted source
Jorge M. Charco

Works (23)

Cofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity of recombinant murine prions

PLOS Pathogens
2025-01-22 | Journal article
Part of ISSN: 1553-7374
Contributors: Miguel A. Pérez-Castro; Hasier Eraña; Enric Vidal; Jorge M. Charco; Nuria L. Lorenzo; Nuno Gonçalves-Anjo; Josu Galarza-Ahumada; Carlos M. Díaz-Domínguez; Patricia Piñeiro; Ezequiel González-Miranda et al.
Source: Self-asserted source
Jorge M. Charco

A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions

Nature Communications
2024-03-08 | Journal article
Contributors: Hasier Eraña; Cristina Sampedro-Torres-Quevedo; Jorge M. Charco; Carlos M. Díaz-Domínguez; Francesca Peccati; Maitena San-Juan-Ansoleaga; Enric Vidal; Nuno Gonçalves-Anjo; Miguel A. Pérez-Castro; Ezequiel González-Miranda et al.
Source: check_circle
Crossref

Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation.

Acta neuropathologica communications
2023-09 | Journal article
Contributors: Eraña H; Díaz-Domínguez CM; Charco JM; Vidal E; González-Miranda E; Pérez-Castro MA; Piñeiro P; López-Moreno R; Sampedro-Torres-Quevedo C; Castilla J
Source: Self-asserted source
Jorge M. Charco via Europe PubMed Central

Analysis of a large case series of fatal familial insomnia to determine tests with the highest diagnostic value

Journal of Neuropathology & Experimental Neurology
2023-01-20 | Journal article
Contributors: Izaro Kortazar-Zubizarreta; Hasier Eraña; Arrate Pereda; Jorge M Charco; Africa Manero-Azua; Rebeca Ruiz-Onandi; Urko Aguirre; Gonzalo Gonzalez-Chinchon; R Prieto-Tedejo; J H Somme et al.
Source: check_circle
Crossref

Glycans are not necessary to maintain the pathobiological features of bovine spongiform encephalopathy.

PLoS pathogens
2022-10 | Journal article
Contributors: Otero A; Barrio T; Eraña H; Charco JM; Betancor M; Díaz-Domínguez CM; Marín B; Andréoletti O; Torres JM; Kong Q et al.
Source: Self-asserted source
Jorge M. Charco via Europe PubMed Central

Description of the first Spanish case of Gerstmann–Sträussler–Scheinker disease with A117V variant: clinical, histopathological and biochemical characterization

Journal of Neurology
2022-08 | Journal article
Contributors: Hasier Eraña; Beatriz San Millán; Carlos M. Díaz-Domínguez; Jorge M. Charco; Rosa Rodríguez; Irene Viéitez; Arrate Pereda; Rosa Yañez; Mariví Geijo; Carmen Navarro et al.
Source: check_circle
Crossref

Homozygous R136S mutation in PRNP gene causes inherited early onset prion disease.

Alzheimer's research & therapy
2021-10 | Journal article
Contributors: Ximelis T; Marín-Moreno A; Espinosa JC; Eraña H; Charco JM; Hernández I; Riveira C; Alcolea D; González-Roca E; Aldecoa I et al.
Source: Self-asserted source
Jorge M. Charco via Europe PubMed Central

Improving the Pharmacological Properties of Ciclopirox for Its Use in Congenital Erythropoietic Porphyria

Journal of Personalized Medicine
2021-05-28 | Journal article
Contributors: Ganeko Bernardo-Seisdedos; Jorge M. Charco; Itxaso SanJuan; Sandra García-Martínez; Pedro Urquiza; Hasier Eraña; Joaquín Castilla; Oscar Millet
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear.

Scientific reports
2021-04-08 | Journal article
Source: Self-asserted source
Jorge M. Charco

A Novel, Reliable and Highly Versatile Method to Evaluate Different Prion Decontamination Procedures.

Frontiers in bioengineering and biotechnology
2020-10 | Journal article
Contributors: Eraña H; Pérez-Castro MÁ; García-Martínez S; Charco JM; López-Moreno R; Díaz-Dominguez CM; Barrio T; González-Miranda E; Castilla J
Source: Self-asserted source
Jorge M. Charco via Europe PubMed Central

Detection of Pathognomonic Biomarker PrPSc and the Contribution of Cell Free-Amplification Techniques to the Diagnosis of Prion Diseases.

Biomolecules
2020-03 | Journal article
Contributors: Eraña H; Charco JM; González-Miranda E; García-Martínez S; López-Moreno R; Pérez-Castro MA; Díaz-Domínguez CM; García-Salvador A; Castilla J
Source: Self-asserted source
Jorge M. Charco via Europe PubMed Central

Dogs are resistant to prion infection, due to the presence of aspartic or glutamic acid at position 163 of their prion protein.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2020-01-15 | Journal article
Source: Self-asserted source
Jorge M. Charco

The amino acid residue in position 163 of canine PrP<sup>C</sup> is critical to the exceptional resistance of dogs to prion infections: evidence from transgenic mouse models

2019-10 | Preprint
Contributors: Vidal E; Fernández-Borges N; Eraña H; Parra B; Pintado B; Sánchez-Martín MA; Charco JM; Ordoñez M; Pérez-Castro MA; Pumarola M et al.
Source: Self-asserted source
Jorge M. Charco via Europe PubMed Central

Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies

PLOS Pathogens
2019-10-23 | Journal article
Contributors: Hasier Eraña; David Westaway; Jorge M. Charco; Michele A. Di Bari; Carlos M. Díaz-Domínguez; Rafael López-Moreno; Enric Vidal; Ezequiel González-Miranda; Miguel A. Pérez-Castro; Sandra García-Martínez et al.
Source: check_circle
Crossref

Insights into the Bidirectional Properties of the Sheep-Deer Prion Transmission Barrier.

Molecular neurobiology
2018-12-27 | Journal article
Source: Self-asserted source
Jorge M. Charco

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria.

Science translational medicine
2018-09 | Journal article
Contributors: Urquiza P; Laín A; Sanz-Parra A; Moreno J; Bernardo-Seisdedos G; Dubus P; González E; Gutiérrez-de-Juan V; García S; Eraña H et al.
Source: Self-asserted source
Jorge M. Charco via Europe PubMed Central

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

PloS one
2017 | Journal article
Source: Self-asserted source
Jorge M. Charco via Europe PubMed Central

Recombinant PrP and Its Contribution to Research on Transmissible Spongiform Encephalopathies

Pathogens
2017-12 | Journal article
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Cofactors influence the biological properties of infectious recombinant prions.

Acta neuropathologica
2017-11 | Journal article
Source: Self-asserted source
Jorge M. Charco via Europe PubMed Central

An in vitro approach to identify the key amino acids in the low susceptibility of rabbit PrP to misfolding.

Journal of virology
2017-10 | Journal article
Source: Self-asserted source
Jorge M. Charco via Europe PubMed Central

Generation of a new infectious recombinant prion: a model to understand Gerstmann-Sträussler-Scheinker syndrome.

Scientific reports
2017-08 | Journal article
Source: Self-asserted source
Jorge M. Charco via Europe PubMed Central
grade
Preferred source (of 2)‎

Prion-like disorders and Transmissible Spongiform Encephalopathies: An overview of the mechanistic features that are shared by the various disease-related misfolded proteins.

Biochemical and biophysical research communications
2017-02 | Journal article
Source: Self-asserted source
Jorge M. Charco via Europe PubMed Central

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.

Scientific reports
2016-03 | Journal article
Source: Self-asserted source
Jorge M. Charco via Europe PubMed Central

Peer review (3 reviews for 2 publications/grants)

Review activity for PloS one. (2)
Review activity for Veterinary research. (1)