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Employment (4)

London School of Hygiene & Tropical Medicine: London, GB

2024-08-01 to present | Assistant Professor (Infection Biology)
Employment
Source: Self-asserted source
Richard J. Wall

London School of Hygiene & Tropical Medicine Faculty of Infectious and Tropical Diseases: London, London, GB

2022-10-15 to 2024-07-31 | Research Fellow (Department of Infection Biology)
Employment
Source: Self-asserted source
Richard J. Wall

University of Dundee: Dundee, Dundee, GB

2015-05-01 to 2022-10-14 | Senior Research Associate (School of Life Sciences)
Employment
Source: Self-asserted source
Richard J. Wall

University of Nottingham: Nottingham, GB

2012-12-15 to 2015-04-30 | Research Associate (Life Sciences)
Employment
Source: Self-asserted source
Richard J. Wall

Works (42)

An open-access dashboard to interrogate the genetic diversity of Mycobacterium tuberculosis clinical isolates.

Scientific reports
2024-10 | Journal article
DOI: 10.1038/s41598-024-75818-y
PMID: 39433543
PMC: PMC11494124
Contributors: Phelan J; Van den Heede K; Masyn S; Verbeeck R; Lamprecht DA; Koul A; Wall RJ
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Insights into the use of cytochrome bc1 inhibitors for future therapeutic strategies for tuberculosis

2024-10 | Preprint
DOI: 10.21203/rs.3.rs-5331796/v1
PPR: PPR933674
Contributors: Pérez CA; Lenaerts A; Villellas C; Guillemont J; Dallow J; Painter H; Ammerman N; Hassan A; Golovkine G; Brock L et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

ResMAP—a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in Plasmodium

mBio
2024-10-16 | Journal article
DOI: 10.1128/mbio.01708-24
Contributors: Richard J. Wall; Stuart A. MacGowan; Irene Hallyburton; Aisha J. Syed; Sowmya Ajay Castro; Gourav Dey; Rachel Milne; Stephen Patterson; Jody Phelan; Natalie Wiedemar et al.
Source: check_circle
Crossref

Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes.

Nature communications
2024-09 | Journal article
DOI: 10.1038/s41467-024-52432-0
PMID: 39285175
PMC: PMC11405848
Contributors: Trenaman A; Tinti M; Wall RJ; Horn D
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Targeting de novo purine biosynthesis for tuberculosis treatment

2024-09 | Preprint
DOI: 10.21203/rs.3.rs-4913610/v1
PPR: PPR906674
Contributors: Lamprecht D; Wall R; Davies C; Pearson W; Davis E; Willcocks S; Dallow J; Leemans A; Wetzel J; Daems S et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1.

PLoS pathogens
2024-07 | Journal article
DOI: 10.1371/journal.ppat.1012382
PMID: 38991025
PMC: PMC11265716
Contributors: Tulloch LB; Tinti M; Wall RJ; Weidt SK; Corpas-Lopez V; Dey G; Smith TK; Fairlamb AH; Barrett MP; Wyllie S
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Targeted protein degradation of the CPSF complex by benzoxaboroles through sumoylation

2024-03 | Preprint
DOI: 10.1101/2024.03.11.584402
PPR: PPR818702
Contributors: Zhang N; Samad A; Zahedifard F; Wall RJ; Horn D; Zoltner M; Field MC
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Non-canonical endogenous expression of voltage-gated sodium channel NaV1.7 subtype by the TE671 rhabdomyosarcoma cell line

2024-01 | Preprint
DOI: 10.22541/au.170666896.68088559/v1
PPR: PPR820742
Contributors: Ngum N; Aziz M; Wall R; Duce I; Mellor I
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc<sub>1</sub>.

Science translational medicine
2023-12 | Journal article
DOI: 10.1126/scitranslmed.adh9902
PMID: 38091406
PMC: PMC7615677
Contributors: Braillard S; Keenan M; Breese KJ; Heppell J; Abbott M; Islam R; Shackleford DM; Katneni K; Crighton E; Chen G et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Short-course combination treatment for experimental chronic Chagas disease

Science Translational Medicine
2023-12-13 | Journal article
DOI: 10.1126/scitranslmed.adg8105
Contributors: Silvia González; Richard J. Wall; John Thomas; Stephanie Braillard; Gino Brunori; Isabel Camino Díaz; Juan Cantizani; Sandra Carvalho; Pablo Castañeda Casado; Eric Chatelain et al.
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Crossref

RES-Seq-a barcoded library of drug-resistant <i>Leishmania donovani</i> allowing rapid assessment of cross-resistance and relative fitness.

mBio
2023-11 | Journal article
DOI: 10.1128/mbio.01803-23
PMID: 37929970
PMC: PMC10746238
Contributors: Tulloch LB; Carvalho S; Lima M; Wall RJ; Tinti M; Pinto EG; MacLean L; Wyllie S
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.

Journal of medicinal chemistry
2023-06 | Journal article
DOI: 10.1021/acs.jmedchem.3c00509
PMID: 37343180
PMC: PMC10350920
Contributors: Cleghorn LAT; Wall RJ; Albrecht S; MacGowan SA; Norval S; De Rycker M; Woodland A; Spinks D; Thompson S; Patterson S et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase

ACS Infectious Diseases
2022-09-09 | Journal article
DOI: 10.1021/acsinfecdis.2c00364
Contributors: Rachel Milne; Natalie Wiedemar; Victoriano Corpas-Lopez; Eoin Moynihan; Richard J. Wall; Alice Dawson; David A. Robinson; Sharon M. Shepherd; Robert J. Smith; Irene Hallyburton et al.
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Crossref

Non-canonical endogenous expression of voltage-gated sodium channel Na<sub>V</sub> 1.7 subtype by the TE671 rhabdomyosarcoma cell line.

The Journal of physiology
2022-04 | Journal article
DOI: 10.1113/jp283055
PMID: 35413129
Contributors: Ngum NM; Aziz MYA; Mohammed Latif L; Wall RJ; Duce IR; Mellor IR
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.

Journal of medicinal chemistry
2022-03 | Journal article
DOI: 10.1021/acs.jmedchem.1c02104
PMID: 35303411
PMC: PMC9014415
Contributors: Smith A; Wall RJ; Patterson S; Rowan T; Rico Vidal E; Stojanovski L; Huggett M; Hampton SE; Thomas MG; Corpas Lopez V et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis.

Journal of medicinal chemistry
2021-10 | Journal article
DOI: 10.1021/acs.jmedchem.1c01437
PMID: 34711050
PMC: PMC8591608
Contributors: Mowbray CE; Braillard S; Glossop PA; Whitlock GA; Jacobs RT; Speake J; Pandi B; Nare B; Maes L; Yardley V et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease.

Antimicrobial agents and chemotherapy
2021-10 | Journal article
DOI: 10.1128/aac.01535-21
PMID: 34606338
PMC: PMC8765320
Contributors: Lima ML; Tulloch LB; Corpas-Lopez V; Carvalho S; Wall RJ; Milne R; Rico E; Patterson S; Gilbert IH; Moniz S et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series.

Microorganisms
2021-06 | Journal article
DOI: 10.3390/microorganisms9071408
PMID: 34210040
PMC: PMC8305145
Contributors: Van den Kerkhof M; Leprohon P; Mabille D; Hendrickx S; Tulloch LB; Wall RJ; Wyllie S; Chatelain E; Mowbray CE; Braillard S et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial.

Cell chemical biology
2021-03 | Journal article
DOI: 10.1016/j.chembiol.2021.02.008
PMID: 33691122
PMC: PMC8153249
Contributors: Paradela LS; Wall RJ; Carvalho S; Chemi G; Corpas-Lopez V; Moynihan E; Bello D; Patterson S; Güther MLS; Fairlamb AH et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Plasmodium DEH is ER-localized and crucial for oocyst mitotic division during malaria transmission

Life Science Alliance
2020-12 | Journal article
DOI: 10.26508/lsa.202000879
Contributors: David S Guttery; Rajan Pandey; David JP Ferguson; Richard J Wall; Declan Brady; Dinesh Gupta; Anthony A Holder; Rita Tewari
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Crossref

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent <i>In Vitro</i> Antileishmanial Activity: Initial SAR and Assessment of <i>In Vivo</i> Activity.

Journal of medicinal chemistry
2020-08 | Journal article
DOI: 10.1021/acs.jmedchem.0c00705
PMID: 32663005
PMC: PMC7748245
Contributors: Thomas MG; De Rycker M; Wall RJ; Spinks D; Epemolu O; Manthri S; Norval S; Osuna-Cabello M; Patterson S; Riley J et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission.

Cell reports
2020-02 | Journal article
DOI: 10.1016/j.celrep.2020.01.033
PMID: 32049018
PMC: PMC7016506
Contributors: Pandey R; Abel S; Boucher M; Wall RJ; Zeeshan M; Rea E; Freville A; Lu XM; Brady D; Daniel E et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

The Q<sub>i</sub> Site of Cytochrome <i>b</i> is a Promiscuous Drug Target in <i>Trypanosoma cruzi</i> and <i>Leishmania donovani</i>.

ACS infectious diseases
2020-01 | Journal article
DOI: 10.1021/acsinfecdis.9b00426
PMID: 31967783
PMC: PMC7076694
Contributors: Wall RJ; Carvalho S; Milne R; Bueren-Calabuig JA; Moniz S; Cantizani-Perez J; MacLean L; Kessler A; Cotillo I; Sastry L et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Systematic analysis of Plasmodium myosins reveals differential expression, localisation, and function in invasive and proliferative parasite stages.

Cellular microbiology
2019-07 | Journal article
DOI: 10.1111/cmi.13082
PMID: 31283102
PMC: PMC6851706
Contributors: Wall RJ; Zeeshan M; Katris NJ; Limenitakis R; Rea E; Stock J; Brady D; Waller RF; Holder AA; Tewari R
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.

Proceedings of the National Academy of Sciences of the United States of America
2019-04 | Journal article
DOI: 10.1073/pnas.1820175116
PMID: 30962368
PMC: PMC6511062
Contributors: Wyllie S; Brand S; Thomas M; De Rycker M; Chung CW; Pena I; Bingham RP; Bueren-Calabuig JA; Cantizani J; Cebrian D et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.

ACS infectious diseases
2018-11 | Journal article
DOI: 10.1021/acsinfecdis.8b00226
PMID: 30380837
PMC: PMC6332449
Contributors: Corpas-Lopez V; Moniz S; Thomas M; Wall RJ; Torrie LS; Zander-Dinse D; Tinti M; Brand S; Stojanovski L; Manthri S et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.

Proceedings of the National Academy of Sciences of the United States of America
2018-09 | Journal article
DOI: 10.1073/pnas.1807915115
PMID: 30185555
PMC: PMC6156652
Contributors: Wall RJ; Rico E; Lukac I; Zuccotto F; Elg S; Gilbert IH; Freund Y; Alley MRK; Field MC; Wyllie S et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.

Antimicrobial agents and chemotherapy
2018-07 | Journal article
DOI: 10.1128/aac.00235-18
PMID: 29844044
PMC: PMC6105827
Contributors: Wall RJ; Moniz S; Thomas MG; Norval S; Ko EJ; Marco M; Miles TJ; Gilbert IH; Horn D; Fairlamb AH et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis.

Scientific reports
2018-04 | Journal article
DOI: 10.1038/s41598-018-23871-9
PMID: 29618731
PMC: PMC5884774
Contributors: Wall RJ; Ferguson DJP; Freville A; Franke-Fayard B; Brady D; Zeeshan M; Bottrill AR; Wheatley S; Fry AM; Janse CJ et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Compositional and expression analyses of the glideosome during the <i>Plasmodium</i> life cycle reveal an additional myosin light chain required for maximum motility.

The Journal of biological chemistry
2017-09 | Journal article
DOI: 10.1074/jbc.m117.802769
PMID: 28893907
PMC: PMC5663884
Contributors: Green JL; Wall RJ; Vahokoski J; Yusuf NA; Ridzuan MAM; Stanway RR; Stock J; Knuepfer E; Brady D; Martin SR et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.

The Journal of biological chemistry
2016-10 | Journal article
DOI: 10.1074/jbc.m116.750422
PMID: 27703008
PMC: PMC5114424
Contributors: Dewar S; Sienkiewicz N; Ong HB; Wall RJ; Horn D; Fairlamb AH
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

SAS6-like protein in Plasmodium indicates that conoid-associated apical complex proteins persist in invasive stages within the mosquito vector.

Scientific reports
2016-06 | Journal article
DOI: 10.1038/srep28604
PMID: 27339728
PMC: PMC4919640
Contributors: Wall RJ; Roques M; Katris NJ; Koreny L; Stanway RR; Brady D; Waller RF; Tewari R
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes.

PLoS pathogens
2015-11 | Journal article
DOI: 10.1371/journal.ppat.1005273
PMID: 26565797
PMC: PMC4643991
Contributors: Roques M; Wall RJ; Douglass AP; Ramaprasad A; Ferguson DJ; Kaindama ML; Brusini L; Joshi N; Rchiad Z; Brady D et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain.

The Journal of biological chemistry
2015-03 | Journal article
DOI: 10.1074/jbc.m115.637694
PMID: 25802338
PMC: PMC4424349
Contributors: Yusuf NA; Green JL; Wall RJ; Knuepfer E; Moon RW; Schulte-Huxel C; Stanway RR; Martin SR; Howell SA; Douse CH et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor.

Environment international
2014-12 | Journal article
DOI: 10.1016/j.envint.2014.12.002
PMID: 25540854
Contributors: Wall RJ; Fernandes A; Rose M; Bell DR; Mellor IR
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

The repeat region of the circumsporozoite protein is critical for sporozoite formation and maturation in Plasmodium.

PloS one
2014-12 | Journal article
DOI: 10.1371/journal.pone.0113923
PMID: 25438048
PMC: PMC4250072
Contributors: Ferguson DJ; Balaban AE; Patzewitz EM; Wall RJ; Hopp CS; Poulin B; Mohmmed A; Malhotra P; Coppi A; Sinnis P et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Mixed halogenated dioxins/furans (PXDD/Fs) and biphenyls (PXBs) in food: occurrence and toxic equivalent exposure using specific relative potencies.

Environment international
2014-08 | Journal article
DOI: 10.1016/j.envint.2014.07.007
PMID: 25108070
Contributors: Fernandes AR; Mortimer D; Wall RJ; Bell DR; Rose M; Carr M; Panton S; Smith F
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation.

Cell host & microbe
2014-07 | Journal article
DOI: 10.1016/j.chom.2014.05.020
PMID: 25011111
PMC: PMC4094981
Contributors: Guttery DS; Poulin B; Ramaprasad A; Wall RJ; Ferguson DJ; Brady D; Patzewitz EM; Whipple S; Straschil U; Wright MH et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite.

Biology open
2013-09 | Journal article
DOI: 10.1242/bio.20136163
PMID: 24244852
PMC: PMC3828762
Contributors: Poulin B; Patzewitz EM; Brady D; Silvie O; Wright MH; Ferguson DJ; Wall RJ; Whipple S; Guttery DS; Tate EW et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

An ancient protein phosphatase, SHLP1, is critical to microneme development in Plasmodium ookinetes and parasite transmission.

Cell reports
2013-02 | Journal article
DOI: 10.1016/j.celrep.2013.01.032
PMID: 23434509
PMC: PMC3617505
Contributors: Patzewitz EM; Guttery DS; Poulin B; Ramakrishnan C; Ferguson DJ; Wall RJ; Brady D; Holder AA; Szöőr B; Tewari R
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Fused mesoionic heterocyclic compounds are a new class of aryl hydrocarbon receptor (AhR) agonist of exceptional potency.

Toxicology
2012-09 | Journal article
DOI: 10.1016/j.tox.2012.09.003
PMID: 23000282
Contributors: Wall RJ; Bell DR; Bazzi R; Fernandes A; Rose M; Rowlands JC; Mellor IR
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central

Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context.

Toxicology
2012-04 | Journal article
DOI: 10.1016/j.tox.2012.03.011
PMID: 22507882
PMC: PMC3515069
Contributors: Wall RJ; He G; Denison MS; Congiu C; Onnis V; Fernandes A; Bell DR; Rose M; Rowlands JC; Balboni G et al.
Source: Self-asserted source
Richard J. Wall via Europe PubMed Central
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