Personal information

Emails & domains

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ASIH INSERM UMR U978

Other IDs

ResearcherID: N-3718-2017
Loop profile: 2415851

Keywords

Lymphoid malignancies, B cell survival, B cell receptor signaling pathway, Signalosome and Syk , Phosphorylation and activity

Countries

France

Biography

Interest: Signaling pathways and their involvement in tumorigenesis
Current: How dysfunctional regulation of signaling proteins and their complexes contribute to the development of chronic lymphocytic leukemia to identify functional biomarkers and potential therapeutic targets

Activities

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Employment (6)

Institut National de la Recherche et de la Santé Médicale: Bobigny, FR

2009-01-01 to present | Researcher at INSERM (CR1) (UFR SMBH, UMR 978 INSERM-Université Paris 13)
Employment
Source: Self-asserted source
Christine LE ROY

Prix Paris-Bio et Fondation pour la Recherche Médicale: Paris, FR

2007-04-01 to 2008-12-31 | Post-doc/ Etude des altérations de la signalisation du BCR dans les cellules des patients atteints de Leucémie Lymphoïde Chronique (Institut Cochin, INSERM U567-UMR8104)
Employment
Source: Self-asserted source
Christine LE ROY

Medical Research Council Canada: Toronto, Ontario, CA

2003-04-01 to 2007-03-31 | Post-doc/TGFb receptors and endocytosis (Samuel Lunenfeld Research Institute, Dr JL Wrana's Lab)
Employment
Source: Self-asserted source
Christine LE ROY

Medical Research Council Canada: Toronto, Ontario , CA

2000-03-01 to 2003-03-01 | Post-doc/Etude de la signalisation et du trafic des récepteurs des TGFb1 (Samuel Lunenfeld Research Institute (Dr. JL Wrana's lab))
Employment
Source: Self-asserted source
Christine LE ROY

INSERM: Toronto, CA

1999-01-13 to 2000-01-13 | Post-doc/TGFbreceptor signaling and trafficking (Samuel Lunenfeld Research Institute (Dr. JL Wrana's lab))
Employment
Source: Self-asserted source
Christine LE ROY

Ministère de l'Enseignement Supérieur et de la Recherche: Lyon, FR

1995-11-30 to 1998-11-23 | Autocrine/paracrine regulation of steroidogenic cell differentiated functions by TGFb1 (INSERM-INRA U418)
Employment
Source: Self-asserted source
Christine LE ROY

Education and qualifications (6)

Université Paris 13: Villetaneuse, Île-de-France, FR

2009-01-01 to 2013-09-23 | HDR (Habilitation à Diriger des Recherches) (UMR 978 INSERM-Univsersité Paris 13)
Education
Source: Self-asserted source
Christine LE ROY

Université Claude Bernard Lyon 1: Villeurbanne, Auvergne-Rhône-Alpes, FR

1995-11-30 to 1998-11-23 | PhD "Métabolisme, Endocrinologie et Nutrition" (INSERM-INRA U418)
Education
Source: Self-asserted source
Christine LE ROY

Université Claude Bernard Lyon 1: Lyon, FR

1994-09-01 to 1995-07-01 | DEA en Métabolisme, Endocrinologie et Nutrition
Education
Source: Self-asserted source
Christine LE ROY

Université d'Aix-Marseille II: Marseille, FR

1993-09-01 to 1994-06-01 | Maîtrise de Biochimie - option "Génétique et Biologie du Développement"
Education
Source: Self-asserted source
Christine LE ROY

Université d'Aix-Marseille II: Marseille, FR

1992-09-01 to 1993-06-01 | Licence de Biochimie
Education
Source: Self-asserted source
Christine LE ROY

Université d'Aix-Marseille II: Marseille, FR

1990-09-01 to 1991-06-01 | DEUG de Sciences Section, "Sciences de la nature et de la vie"
Education
Source: Self-asserted source
Christine LE ROY

Professional activities (6)

GROUPE FILO (French Initiative Leukemia Organization): Tours, FR

2009-01-01 to present
Membership
Source: Self-asserted source
Christine LE ROY

European Research Initiative on CLL (ERIC): Barcelona, ES

2009-01-01 to present
Membership
Source: Self-asserted source
Christine LE ROY

Becton Dickinson Biosciences: Rungis, FR

2009-09-04 to 2009-09-04 | Phosflow and Human B cells (R&D department, BD US Pr. R Balderas)
Invited position
Source: Self-asserted source
Christine LE ROY

Institut Pasteur de Lille : Lille, FR

2005-09-03 to 2005-09-05 | TGFb receptor signaling and trafficking (UMR 8117 CNRS (Pr Y Delaunoit))
Invited position
Source: Self-asserted source
Christine LE ROY

Wellcome Trust Centre: Oxford, GB

2003-02-23 to 2003-02-25 | Distinct endocytic pathways regulate TGF receptor signaling and turnover (Pr. EK Bikoff)
Invited position
Source: Self-asserted source
Christine LE ROY

Harvard University: Cambridge, MA, US

2002-08-07 to 2002-08-09 | Compartmentalization of TGF receptor into distinct pathways regulates signal transduction and receptor turnover (Molecular and Cellular Biology (Pr. EJ Robertson))
Invited position
Source: Self-asserted source
Christine LE ROY

Works (30)

The survival grip–how cell adhesion promotes tumor maintenance within the microenvironment

FEBS Letters
2024-12-20 | Journal article
DOI: 10.1002/1873-3468.15074
Part of ISSN: 0014-5793
Part of ISSN: 1873-3468
Contributors: Laura Gardano; Jordan Ferreira; Christine Le Roy; Dominique Ledoux; Nadine Varin‐Blank
Source: Self-asserted source
Christine LE ROY

Identification of the Axis β-Catenin–BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment

International Journal of Molecular Sciences
2023-12 | Journal article | Author
DOI: 10.3390/ijms242417623
Contributors: Imane Mihoub; Tareck Rharass; Souhaïl Ouriemmi; Antonin Oudar; Laure Aubard; Valérie Gratio; Gregory Lazarian; Jordan FERREIRA; Elisabetta Dondi; Florence Cymbalista et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Immuno-regulatory malignant B cells contribute to Chronic Lymphocytic Leukemia progression

Cancer Gene Therapy
2023-01 | Journal article | Author
DOI: 10.1038/s41417-023-00602-5
Part of ISSN: 0929-1903
Part of ISSN: 1476-5500
Contributors: Arsène Mékinian; Anne Quinquenel; Koceïla Ait Belkacem; Feriel Kanoun; Elisabetta Dondi; Emilie Franck; Marouane Boubaya; Maïssa Mhibik; Fanny Baran-Marszak; Rémi Letestu et al.
Source: Self-asserted source
Christine LE ROY

Regulatory interplay between Vav1, Syk and β-catenin occurs in lung cancer cells

Cellular Signalling
2021-10 | Journal article
DOI: 10.1016/j.cellsig.2021.110079
Part of ISSN: 0898-6568
Contributors: Christine LE ROY
Source: Self-asserted source
Christine LE ROY

Differential morphological and functional features of fibroblasts explanted from Solar Lentigo.

The British journal of dermatology
2017 | Journal article
DOI: 10.1111/bjd.15386
WOSUID:

MEDLINE:28211565
Contributors: Goorochurn, R; Viennet, C; Tissot, M; Locatelli, F; Granger, C; Varin-Blank, N; Humbert, P; Le Roy, C
Source: Self-asserted source
Christine LE ROY via ResearcherID

Phosphorylation impact on Spleen Tyrosine kinase conformation by Surface Enhanced Raman Spectroscopy

Scientific Reports
2017 | Journal article
DOI: 10.1038/srep39766
WOSUID:

WOS:000391182400001
Contributors: Cottat, Maximilien; Yasukuni, Ryohei; Homma, Yo; Lidgi-Guigui, Nathalie; Varin-Blank, Nadine; de la Chapelle, Marc Lamy; Le Roy, Christine
Source: Self-asserted source
Christine LE ROY via ResearcherID

Biological processes in solar lentigo: insights brought by experimental models

Experimental Dermatology
2016 | Journal article
DOI: 10.1111/exd.12937
WOSUID:

WOS:000373072800277
Contributors: Goorochurn, Ranesha; Viennet, Cecline; Granger, Corinne; Fanian, Ferial; Varin-Blank, Nadine; Le Roy, Christine; Humbert, Philippe
Source: Self-asserted source
Christine LE ROY via ResearcherID

Protein kinase D-dependent CXCR4 down-regulation upon BCR triggering is linked to lymphadenopathy in chronic lymphocytic leukaemia

Oncotarget
2016 | Journal article
DOI: 10.18632/oncotarget.9031
WOSUID:

WOS:000380942600010
Contributors: Saint-Georges, Stephane; Quettier, Maude; Bouyaba, Marouane; Le Coquil, Stephanie; Lauriente, Vanessa; Guittat, Lionel; Levy, Vincent; Ajchenbaum-Cymbalista, Florence; Varin-Blank, Nadine; Le Roy, Christine et al.
Source: Self-asserted source
Christine LE ROY via ResearcherID

CD9, a key actor in the dissemination of lymphoblastic leukemia, modulating CXCR4-mediated migration via RAC1 signaling

Blood
2015 | Journal article
DOI: 10.1182/blood-2015-02-628560
WOSUID:

WOS:000365451500014
Contributors: Arnaud, M. P.; Vallee, A.; Robert, G.; Bonneau, J.; Leroy, C.; Varin-Blank, N.; Rio, A. G.; Troadec, M. B.; Galibert, M. D.; Gandemer, V.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Mechanisms of the BCR-Mediated CXCR4 Down-Regulation and Its Clinical Relevance in Chronic Lymphocytic Leukemia Progression

Blood
2015 | Journal article
WOSUID:

WOS:000368021801089
Contributors: Le Roy, Christine; Ledoux, Dominique; Saint Georges, Stephane; Quettier, Maud; Boubaya, Marouane; Le Coquil, Stephanie; Lauriente, Vanessa; Guittat, Lionel; Levy, Vincent; Cymbalista, Florence et al.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Old DAT and new data: Positive direct antiglobulin test identifies a subgroup with poor outcome among chronic lymphocytic leukemia stage A patients

American Journal of Hematology
2015 | Journal article
DOI: 10.1002/ajh.23861
WOSUID:

WOS:000346771400002
Contributors: Quinquenel, Anne; Al Nawakil, Chadi; Baran-Marszak, Fanny; Eclache, Virginie; Letestu, Remi; Khalloufi, Mohammed; Boubaya, Marouane; Le Roy, Christine; Varin-Blank, Nadine; Delmer, Alain et al.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Disruption of CD9 Expression Affects Adhesion, Migration, and Actin Polymerization through RAC1 Signalling Pathway in ETV6/RUNX1 Pre-B Lymphocytes

Blood
2014 | Journal article
WOSUID:

WOS:000349233804032
Contributors: Arnaud, Marie-Pierre; Vallee, Audrey; Robert, Guillaume; Bonneau, Jacinthe; Dondi, Elisabetta; Le Roy, Christine; Varin-Blank, Nadine; Galibert, Marie-Dominique; Troadec, Marie-Berengere; Gandemer, Virginie
Source: Self-asserted source
Christine LE ROY via ResearcherID

AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments

Haematologica-the Hematology Journal
2012 | Journal article
DOI: 10.3324/haematol.2011.052779
WOSUID:

WOS:000303241600024
Contributors: Stamatopoulos, Basile; Meuleman, Nathalie; De Bruyn, Cecile; Pieters, Karlien; Mineur, Philippe; Le Roy, Christine; Saint-Georges, Stephane; Varin-Blank, Nadine; Cymbalista, Florence; Bron, Dominique et al.
Source: Self-asserted source
Christine LE ROY via ResearcherID

The degree of BCR and NFAT activation predicts clinical outcomes in chronic lymphocytic leukemia

Blood
2012 | Journal article
DOI: 10.1182/blood-2011-12-397158
WOSUID:

WOS:000307412400020
Contributors: Le Roy, Christine; Deglesne, Pierre-Antoine; Chevallier, Nathalie; Beitar, Taoufik; Eclache, Virginie; Quettier, Maude; Boubaya, Marouane; Letestu, Remi; Levy, Vincent; Ajchenbaum-Cymbalista, Florence et al.
Source: Self-asserted source
Christine LE ROY via ResearcherID

AMD3100 DISRUPTS THE CROSS-TALK BETWEEN CHRONIC LYMPHOCYTIC LEUKEMIA CELLS AND THEIR MICROENVIRONMENT: PRECLINICAL EVIDENCE FOR ITS COMBINATION WITH CLL TREATMENTS

Annals of Oncology
2011 | Journal article
WOSUID:

WOS:000291996300031
Contributors: Stamatopoulos, B.; Le Roy, C.; Meuleman, N.; De Bruyn, C.; Pieters, K.; Mineur, P.; Ledoux, D.; Varin-Blank, N.; Cymbalista, F.; Bron, D. et al.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Flow Cytometry APC-Tandem Dyes Are Degraded Through a Cell-Dependent Mechanism

Cytometry Part A
2009 | Journal article
DOI: 10.1002/cyto.a.20774
WOSUID:

WOS:000270419700011
Contributors: Le Roy, Christine; Varin-Blank, Nadine; Ajchenbaum-Cymbalista, Florence; Letestu, Remi
Source: Self-asserted source
Christine LE ROY via ResearcherID

The extracellular domain of the TGF beta type II receptor regulates membrane raft partitioning

Biochemical Journal
2009 | Journal article
DOI: 10.1042/bj20081131
WOSUID:

WOS:000267612200012
Contributors: Luga, Valbona; McLean, Sarah; Le Roy, Christine; O'Connor-McCourt, Maureen; Wrana, Jeffrey L.; Di Guglielmo, Gianni M.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

Nature Reviews Molecular Cell Biology
2005 | Journal article
DOI: 10.1038/nrm1571
WOSUID:

WOS:000226720500011
Contributors: Le Roy, C.; Wrana, J. L.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

Molecular Cell
2005 | Journal article
DOI: 10.1016/j.molcel.2005.06.028
WOSUID:

WOS:000231079600005
Contributors: Ogunjimi, A. A.; Briant, D. J.; Pece-Barbara, N.; Le Roy, C.; Di Guglielmo, G. M.; Kavsak, P.; Rasmussen, R. K.; Seet, B. T.; Sicheri, F.; Wrana, J. L.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Signaling and endocytosis: A team effort for cell migration

Developmental Cell
2005 | Journal article
DOI: 10.1016/j.devcel.2005.07.007
WOSUID:

WOS:000231280100001
Contributors: Le Roy, C.; Wrana, J. L.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Cell biology - An unexpected social servant

Nature
2004 | Journal article
DOI: 10.1038/431142a
WOSUID:

WOS:000223746000025
Contributors: Le Roy, C.; Wrana, J. L.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis

Science
2004 | Journal article
DOI: 10.1126/science.1102109
WOSUID:

WOS:000224304000051
Contributors: Partridge, E. A.; Le Roy, C.; Di Guglielmo, G. M.; Pawling, J.; Cheung, P.; Granovsky, M.; Nabi, I. R.; Wrana, J. L.; Dennis, J. W.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover

Nature Cell Biology
2003 | Journal article
DOI: 10.1038/ncb975
WOSUID:

WOS:000182691400014
Contributors: Di Guglielmo, G. M.; Le Roy, C.; Goodfellow, A. F.; Wrana, J. L.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Regulation by adrenocorticotropin (ACTH), angiotensin II, transforming growth factor-beta, and insulin-like growth factor I of bovine adrenal cell steroidogenic capacity and expression of ACTH receptor, steroidogenic acute regulatory protein, cytochrome P450c17, and 3 beta-hydroxysteroid dehydrogenase

Endocrinology
2000 | Journal article
DOI: 10.1210/en.141.5.1599
WOSUID:

WOS:000088386000004
Contributors: Le Roy, C.; Li, J. Y.; Stocco, D. M.; Langlois, D.; Saez, J. M.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Autocrine regulation of Leydig cell differentiated functions by insulin-like growth factor I and transforming growth factor beta

Journal of Steroid Biochemistry and Molecular Biology
1999 | Journal article
DOI: 10.1016/s0960-0760(99)00075-8
WOSUID:

WOS:000081196600042
Contributors: Le Roy, C.; Lejeune, H.; Chuzel, F.; Saez, J. M.; Langlois, D.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Overexpression of a dominant-negative type II TGF beta receptor tagged with green fluorescent protein inhibits the effects of TGF beta on cell growth and gene expression of mouse adrenal tumor cell line Y-1 and enhances cell tumorigenicity

Molecular and Cellular Endocrinology
1999 | Journal article
DOI: 10.1016/s0303-7207(99)00176-8
WOSUID:

WOS:000084146200012
Contributors: Le Roy, C.; Maisnier-Patin, K.; Leduque, P.; Li, J. Y.; Saez, J. M.; Langlois, D.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Antisense oligonucleotide targeting the transforming growth factor beta 1 increases expression of specific genes and functions of Leydig cells

European Journal of Biochemistry
1998 | Journal article
DOI: 10.1046/j.1432-1327.1998.2570506.x
WOSUID:

WOS:000076653400028
Contributors: Le Roy, C.; Leduque, P.; Li, J. Y.; Saez, J. M.; Langlois, D.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Autocrine role of TGF beta 1 in adrenal

Hormone and Metabolic Research
1998 | Journal article
DOI: 10.1055/s-2007-978906
WOSUID:

WOS:000074552400021
Contributors: Langlois, D.; Le Roy, C.; Penhoat, A.; Lebrethon, M. C.; Saez, J. M.
Source: Self-asserted source
Christine LE ROY via ResearcherID

GIF-DB, a WWW database on gene interactions involved in Drosophila melanogaster development

Nucleic Acids Research
1997 | Journal article
DOI: 10.1093/nar/25.1.67
WOSUID:

WOS:A1997WD44300015
Contributors: Jacq, B.; Horn, F.; Janody, F.; Gompel, N.; Serralbo, O.; Mohr, E.; Leroy, C.; Bellon, B.; Fasano, L.; Laurenti, P. et al.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Repression of transforming growth factor beta 1 protein by antisense oligonucleotide-induced increase of adrenal cell differentiated functions

Journal of Biological Chemistry
1996 | Journal article
WOSUID:

WOS:A1996UJ34200093
Contributors: LeRoy, C.; Leduque, P.; Dubois, P. M.; Saez, J. M.; Langlois, D.
Source: Self-asserted source
Christine LE ROY via ResearcherID

Peer review (1 review for 1 publication/grant)

Review activity for International journal of molecular sciences. (1)
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