Personal information

Other IDs

Scopus Author ID: 56454407800
ResearcherID: P-5858-2018
Loop profile: 676671

Keywords

Diabetes, Epigenetics, Cardiovascular and renal Complications

Countries

India, United States

Activities

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Employment (4)

City of Hope: Duarte, CA, US

2021-09 to present | Postdoctoral Fellow (Diabetes Complications and Metabolism)
Employment
Source: Self-asserted source
Vajir Malek

Syngene International Ltd: Bangalore, Karnataka, IN

2021-03 to 2021-08 | Research Investigator (Drug Metabolism and Pharmacokinetics (DMPK))
Employment
Source: Self-asserted source
Vajir Malek

Kashiv Biosciences LLC: Ahmedabad, Gujarat, IN

2019-08 to 2021-03 | Associate Scientist (New Chemical Entity (NCE) Development)
Employment
Source: Self-asserted source
Vajir Malek

Birla Institute of Technology and Science: Pilani, Rajasthan, IN

2014-09-28 to 2015-01-11 | Junior Research Fellow
Employment
Source: Self-asserted source
Vajir Malek

Education and qualifications (3)

Birla Institute of Technology and Science: Pilani, Rajasthan, IN

2015-01-12 to present | Ph.D. (Pharmacy)
Education
Source: Self-asserted source
Vajir Malek

National Institute of Pharmaceutical Education and Research: Sas Nagar, Punjab, IN

2012-07-15 to 2014-06-30 | M.S. (Pharm.) (Pharmacology and Toxicology)
Education
Source: Self-asserted source
Vajir Malek

L. M. College of Pharmacy: Ahmedabad, Gujarat , IN

2008-07-01 to 2012-05-01 | B.Pharm (Pharmacy)
Education
Source: Self-asserted source
Vajir Malek

Funding (1)

ICMR-SRF

2018-04 to present | Salary award
Indian Council of Medical Research (Delhi, IN)
GRANT_NUMBER:

45/10/2018-PHA/BMS/OL
Source: Self-asserted source
Vajir Malek

Works (24)

Palmitic Acid–Induced Long Noncoding RNA <i>PARAIL</i> Regulates Inflammation via Interaction With RNA-Binding Protein ELAVL1 (ELAV Like RNA-Binding Protein 1) in Monocytes and Macrophages

Arteriosclerosis, Thrombosis, and Vascular Biology
2023-04-27 | Journal article | Author
DOI: 10.1161/atvbaha.122.318536
Part of ISSN: 1079-5642
Part of ISSN: 1524-4636
Contributors: Vinay Tanwar; Marpadga A Reddy; Sadhan Das; Vishnu Amaram Samara; Maryam Abdollahi; Suchismita Dey; Vajir Malek; Rituparna Ganguly; Kenneth Stapleton; Linda Lanting et al.
Source: Self-asserted source
Vajir Malek
grade
Preferred source (of 2)‎

Potential of Renin-Angiotensin-Aldosterone System Modulations in Diabetic Kidney Disease: Old Players to New Hope!

Reviews of Physiology, Biochemistry and Pharmacology
2020-09-27 | Book chapter
DOI: 10.1007/112_2020_50
Part of ISSN: 0303-4240
Part of ISSN: 1617-5786
Source: Self-asserted source
Vajir Malek

Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy

Life Sciences
2019 | Journal article
DOI: 10.1016/j.lfs.2019.02.027
EID:

2-s2.0-85061543842
Contributors: Malek, V.; Sharma, N.; Sankrityayan, H.; Gaikwad, A.B.
Source: Self-asserted source
Vajir Malek via Scopus - Elsevier

Angiotensin II type 2 receptor and angiotensin-converting enzyme 2 mediate ischemic renal injury in diabetic and non-diabetic rats.

Life sciences
2019-08-27 | Journal article
DOI: 10.1016/j.lfs.2019.116796
PMID: 31470003
Source: Self-asserted source
Vajir Malek

Simultaneous Inhibition of Neprilysin and Activation of ACE2 Prevented Diabetic Cardiomyopathy

Pharmacological Reports
2019-05-15 | Journal article
DOI: 10.1016/j.pharep.2019.05.008
Part of ISSN: 1734-1140
Source: Self-asserted source
Vajir Malek

Histone acetylation regulates natriuretic peptides and neprilysin gene expressions in diabetic cardiomyopathy and nephropathy.

Current molecular pharmacology
2018-11 | Journal article
DOI: 10.2174/1874467212666181122092300
PMID: 30465518
Contributors: Malek V; Sharma N; Gaikwad AB
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 2)‎

Telmisartan and thiorphan combination treatment attenuates fibrosis and apoptosis in preventing diabetic cardiomyopathy.

Cardiovascular research
2018-09 | Journal article
DOI: 10.1093/cvr/cvy226
PMID: 30184174
Contributors: Malek V; Bhanudas Gaikwad A
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 2)‎

Esculetin ameliorates insulin resistance and type 2 diabetic nephropathy through reversal of histone H3 acetylation and H2A lysine 119 monoubiquitination

Journal of Functional Foods
2017 | Journal article
DOI: 10.1016/j.jff.2017.05.051
EID:

2-s2.0-85020033727
Contributors: Kadakol, A.; Malek, V.; Goru, S.K.; Pandey, A.; Sharma, N.; Gaikwad, A.B.
Source: Self-asserted source
Vajir Malek via Scopus - Elsevier
grade
Preferred source (of 2)‎

Esculetin ameliorates vascular perturbation by intervening in the occupancy of H2BK120Ub at At1, At2, Tgfβ1 and Mcp1 promoter gene in thoracic aorta of IR and T2D rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2017-09 | Journal article
DOI: 10.1016/j.biopha.2017.09.067
PMID: 28946194
Contributors: Kadakol A; Goru SK; Malek V; Gaikwad AB
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 3)‎

Telmisartan and esculetin combination ameliorates type 2 diabetic cardiomyopathy by reversal of H3, H2A, and H2B histone modifications.

Indian journal of pharmacology
2017-09 | Journal article
DOI: 10.4103/ijp.IJP_710_16
PMID: 29515275
PMC: PMC5830845
Contributors: Kadakol A; Malek V; Goru SK; Pandey A; Gaikwad AB
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 3)‎

Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT2 receptor expression in a rat model of type1 diabetes.

British Journal of Pharmacology
2017-08 | Journal article
DOI: 10.1111/bph.13946
PMID: 28688122
Contributors: Goru SK; Kadakol A; Malek V; Pandey A; Sharma N; Gaikwad AB
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 3)‎

Neprilysin inhibitors: A new hope to halt the diabetic cardiovascular and renal complications?

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2017-04 | Journal article
DOI: 10.1016/j.biopha.2017.04.024
PMID: 28419972
Contributors: Malek V; Gaikwad AB
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 3)‎

Esculetin ameliorates hepatic fibrosis in high fat diet induced non-alcoholic fatty liver disease by regulation of FoxO1 mediated pathway.

Pharmacological reports : PR
2017-02 | Journal article
DOI: 10.1016/j.pharep.2017.02.005
PMID: 28527877
Contributors: Pandey A; Raj P; Goru SK; Kadakol A; Malek V; Sharma N; Gaikwad AB
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 3)‎

H2AK119 monoubiquitination regulates Angiotensin II receptor mediated macrophage infiltration and renal fibrosis in type 2 diabetic rats.

Biochimie
2016-10 | Journal article
DOI: 10.1016/j.biochi.2016.09.016
PMID: 27693081
Contributors: Pandey A; Goru SK; Kadakol A; Malek V; Sharma N; Gaikwad AB
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 3)‎

Histone H2AK119 and H2BK120 mono-ubiquitination modulate SET7/9 and SUV39H1 in type 1 diabetes-induced renal fibrosis.

The Biochemical journal
2016-08 | Journal article
DOI: 10.1042/bcj20160595
PMID: 27582499
Contributors: Goru SK; Kadakol A; Pandey A; Malek V; Sharma N; Gaikwad AB
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 3)‎

Activation of angiotensin-converting enzyme 2 (ACE2) attenuates allergic airway inflammation in rat asthma model.

Toxicology and applied pharmacology
2016-06 | Journal article
DOI: 10.1016/j.taap.2016.06.026
PMID: 27343405
Contributors: Dhawale VS; Amara VR; Karpe PA; Malek V; Patel D; Tikoo K
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 3)‎

FoxO1 Inhibitors: The Future Medicine for Metabolic Disorders?

Current diabetes reviews
2016-01 | Journal article
DOI: 10.2174/1573399811666150804104858
PMID: 26239835
Contributors: Pandey A; Kumar GS; Kadakol A; Malek V; Gaikwad AB
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 2)‎

Esculetin reverses histone H2A/H2B ubiquitination, H3 dimethylation, acetylation and phosphorylation in preventing type 2 diabetic cardiomyopathy

Journal of Functional Foods
2015 | Journal article
DOI: 10.1016/j.jff.2015.05.017
EID:

2-s2.0-84938864455
Contributors: Kadakol, A.; Malek, V.; Goru, S.K.; Pandey, A.; Gaikwad, A.B.
Source: Self-asserted source
Vajir Malek via Scopus - Elsevier
grade
Preferred source (of 2)‎

Insulin sensitizing and cardioprotective effects of Esculetin and Telmisartan combination by attenuating Ang II mediated vascular reactivity and cardiac fibrosis.

European journal of pharmacology
2015-09 | Journal article
DOI: 10.1016/j.ejphar.2015.09.035
PMID: 26409041
Contributors: Kadakol A; Pandey A; Goru SK; Malek V; Gaikwad AB
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 3)‎

NFAT inhibitor tributylhexadecylphosphoniumbromide, ameliorates high fructose induced insulin resistance and nephropathy.

Chemico-biological interactions
2015-09 | Journal article
DOI: 10.1016/j.cbi.2015.09.002
PMID: 26358169
Contributors: Sanghavi M; Vajir M; Kumar S; Tikoo K
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 2)‎

Differential regulation of angiotensin converting enzyme 2 and nuclear factor-κB by angiotensin II receptor subtypes in type 2 diabetic kidney.

Biochimie
2015-08 | Journal article
DOI: 10.1016/j.biochi.2015.08.005
PMID: 26271886
Contributors: Pandey A; Goru SK; Kadakol A; Malek V; Gaikwad AB
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 3)‎

Esculetin attenuates alterations in Ang II and acetylcholine mediated vascular reactivity associated with hyperinsulinemia and hyperglycemia.

Biochemical and biophysical research communications
2015-04 | Journal article
DOI: 10.1016/j.bbrc.2015.04.036
PMID: 25887801
Contributors: Kadakol A; Malek V; Goru SK; Pandey A; Bagal S; Gaikwad AB
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 3)‎

Nanoparticles: A Neurotoxicological Perspective.

CNS & neurological disorders drug targets
2015-01 | Journal article
DOI: 10.2174/1871527314666150821112411
PMID: 26295811
Contributors: Pandey A; Malek V; Prabhakar V; Kulkarni YA; Gaikwad AB
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 3)‎

Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: role of epigenetic histone modifications.

Biochemical pharmacology
2014-12 | Journal article
DOI: 10.1016/j.bcp.2014.11.013
PMID: 25482567
Contributors: Tikoo K; Patel G; Kumar S; Karpe PA; Sanghavi M; Malek V; Srinivasan K
Source: Self-asserted source
Vajir Malek via Europe PubMed Central
grade
Preferred source (of 3)‎

Peer review (28 reviews for 7 publications/grants)

Review activity for Biochemical and biophysical research communications. (1)
Review activity for Biomedicine & pharmacotherapy. (2)
Review activity for Drug discovery today. (1)
Review activity for European journal of pharmacology. (13)
Review activity for Life sciences. (4)
Review activity for Pathology, research and practice. (1)
Review activity for Vascular pharmacology. (6)
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