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Loop profile: 1885966

Keywords

Structural biochemistry, cell biology, small GTPases, small molecules, membranes, cancer

Countries

France

Activities

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Employment (5)

CNRS / ENS Paris-Saclay: Gif-sur-Yvette, FR

2023 to present | Senior scientist (LBPA Agata Nawrotek's lab)
Employment
Source: Self-asserted source
Mahel Zeghouf

CNRS Délégation Ile-de-France Sud: Gif-sur-Yvette, Île-de-France, FR

2015 to 2023 | Senior scientist (ENS Paris-Saclay Jacqueline Cherfils lab)
Employment
Source: Self-asserted source
Mahel Zeghouf

CNRS Délégation Ile-de-France Sud: Gif-sur-Yvette, Île-de-France, FR

2004 to 2014 | Senior scientist (LEBS Jacqueline Cherfils lab)
Employment
Source: Self-asserted source
Mahel Zeghouf

CNRS Délégation Ile-de-France Sud: Gif-sur-Yvette, Île-de-France, FR

2003-01-01 to 2004 | Research associate (LEBS Florence Lederer's lab)
Employment
Source: Self-asserted source
Mahel Zeghouf

University of Toronto: Toronto, ON, CA

1999-11 to 2002-12 | Post-doc (Banting and Best Department of Medical Research Jack Greenblatt's lab)
Employment
Source: Self-asserted source
Mahel Zeghouf

Education and qualifications (1)

Joseph Fourier University: Grenoble, FR

1996-09 to 1999-09-21 | PhD (CBCRB Marc Fontecave's lab)
Education
Source: Self-asserted source
Mahel Zeghouf

Works (40)

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

Nature Communications
2023-07-12 | Journal article
DOI: 10.1038/s41467-023-39894-4
Contributors: Candice Sartre; François Peurois; Marie Ley; Marie-Hélène Kryszke; Wenhua Zhang; Delphine Courilleau; Rodolphe Fischmeister; Yves Ambroise; Mahel Zeghouf; Sarah Cianferani et al.
Source: check_circle
Crossref

Molecular principles of bidirectional signalling between membranes and small GTPases

FEBS Letters
2023-03 | Journal article
DOI: 10.1002/1873-3468.14585
Contributors: Agata Nawrotek; Pavlina Dubois; Mahel Zeghouf; Jacqueline Cherfils
Source: check_circle
Crossref

Protein–membrane interactions in small GTPase signalling and pharmacology: perspectives from Arf GTPases studies

Biochemical Society Transactions
2020-12-18 | Journal article
DOI: 10.1042/BST20200482
Contributors: Agata Nawrotek; Mahel Zeghouf; Jacqueline Cherfils
Source: check_circle
Crossref

Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes

Structure
2019 | Journal article
DOI: 10.1016/j.str.2019.09.007
Part of ISSN: 0969-2126
Contributors: Sanchaita Das; Andrew W. Malaby; Agata Nawrotek; Wenhua Zhang; Mahel Zeghouf; Sarah Maslen; Mark Skehel; Srinivas Chakravarthy; Thomas C. Irving; Osman Bilsel et al.
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Publisher Correction: PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling

Nature Chemical Biology
2019-03-04 | Journal article
DOI: 10.1038/s41589-019-0255-0
Part of ISSN: 1552-4450
Contributors: Agata Nawrotek; Sarah Benabdi; Supaporn Niyomchon; Marie-Hélène Kryszke; Christophe Ginestier; Tatiana Cañeque; Livia Tepshi; Angelica Mariani; Robert P. St. Onge; Guri Giaever et al.
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule

Scientific Reports
2017-10 | Journal article
DOI: 10.1038/s41598-017-13619-2
Part of ISSN: 2045-2322
Contributors: Yann Ferrandez; Wenhua Zhang; François Peurois; Lurlène Akendengué; Anne Blangy; Mahel Zeghouf; Jacqueline Cherfils
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles

Biochemistry
2017-09 | Journal article
DOI: 10.1021/acs.biochem.7b00706
Part of ISSN: 0006-2960
Contributors: Sarah Benabdi; François Peurois; Agata Nawrotek; Jahnavi Chikireddy; Tatiana Cañeque; Takao Yamori; Isamu Shiina; Yoshimi Ohashi; Shingo Dan; Raphaël Rodriguez et al.
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering

Biochemical Journal
2017-03 | Journal article
DOI: 10.1042/bcj20170015
Part of ISSN: 0264-6021
Contributors: François Peurois; Simon Veyron; Yann Ferrandez; Ilham Ladid; Sarah Benabdi; Mahel Zeghouf; Gérald Peyroche; Jacqueline Cherfils
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Allosteric regulation of Arf GTPases and their GEFs at the membrane interface

Small GTPases
2016-07 | Journal article
DOI: 10.1080/21541248.2016.1215778
Part of ISSN: 2154-1248
Contributors: Agata Nawrotek; Mahel Zeghouf; Jacqueline Cherfils
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation

Nature Communications
2015-02-03 | Journal article
DOI: 10.1038/ncomms7218
Part of ISSN: 2041-1723
Contributors: Virginie Vives; Gaëlle Cres; Christian Richard; Muriel Busson; Yann Ferrandez; Anne-Gaelle Planson; Mahel Zeghouf; Jacqueline Cherfils; Luc Malaval; Anne Blangy
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

High yield production of myristoylated Arf6 small GTPase by recombinant N-myristoyl transferase

Small GTPases
2014-10 | Journal article
DOI: 10.4161/sgtp.22895
Part of ISSN: 2154-1248
Contributors: Dominique Padovani; Mahel Zeghouf; José A. Traverso; Carmela Giglione; Jacqueline Cherfils
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

EFA6 controls Arf1 and Arf6 activation through a negative feedback loop

Proceedings of the National Academy of Sciences
2014-08-11 | Journal article
DOI: 10.1073/pnas.1409832111
Part of ISSN: 0027-8424
Contributors: D. Padovani; M. Folly-Klan; A. Labarde; S. Boulakirba; V. Campanacci; M. Franco; M. Zeghouf; J. Cherfils
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

Science
2014-04-10 | Journal article
DOI: 10.1126/science.1250217
Part of ISSN: 0036-8075
Contributors: A. Y. Lee; R. P. St.Onge; M. J. Proctor; I. M. Wallace; A. H. Nile; P. A. Spagnuolo; Y. Jitkova; M. Gronda; Y. Wu; M. K. Kim et al.
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

A Novel Membrane Sensor Controls the Localization and ArfGEF Activity of Bacterial RalF

PLoS Pathogens
2013-11 | Journal article
DOI: 10.1371/journal.ppat.1003747
Part of ISSN: 1553-7374
Contributors: Marcia Folly-Klan; Eric Alix; Danièle Stalder; Pampa Ray; Lionel V. Duarte; Anna Delprato; Mahel Zeghouf; Bruno Antonny; Valérie Campanacci; Craig R. Roy et al.
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Integrated Conformational and Lipid-Sensing Regulation of Endosomal ArfGEF BRAG2

PLoS Biology
2013-09-10 | Journal article
DOI: 10.1371/journal.pbio.1001652
Part of ISSN: 1545-7885
Contributors: Kaheina Aizel; Valérie Biou; Jorge Navaza; Lionel V. Duarte; Valérie Campanacci; Jacqueline Cherfils; Mahel Zeghouf; Frederick Hughson
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Regulation of Small GTPases by GEFs, GAPs, and GDIs

Physiological Reviews
2013-01 | Journal article
DOI: 10.1152/physrev.00003.2012
Part of ISSN: 0031-9333
Contributors: Jacqueline Cherfils; Mahel Zeghouf
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Fam65b Is a New Transcriptional Target of FOXO1 That Regulates RhoA Signaling for T Lymphocyte Migration

The Journal of Immunology
2012 | Journal article
DOI: 10.4049/jimmunol.1201174
Part of ISSN: 0022-1767
Contributors: Pablo Rougerie; Quitterie Largeteau; Laura Megrelis; Florent Carrette; Thomas Lejeune; Lara Toffali; Barbara Rossi; Mahel Zeghouf; Jacqueline Cherfils; Gabriela Constantin et al.
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Structure of the GDP-bound G domain of the RGK protein Rem2

Acta Crystallographica Section F Structural Biology and Crystallization Communications
2012-05 | Journal article
DOI: 10.1107/s1744309112013541
Part of ISSN: 1744-3091
Contributors: Philippe Reymond; Aline Coquard; Mélanie Chenon; Mahel Zeghouf; Ahmed El Marjou; Andrew Thompson; Julie Ménétrey
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

An unfolding model for the GDP/GTP conformational switch of the GTPase Arf6

Acta Crystallographica Section A Foundations of Crystallography
2011-08 | Journal article
DOI: 10.1107/s0108767311091276
Part of ISSN: 0108-7673
Contributors: K. Aizel; V. Biou; P. Roblin; A. Thureau; E. Jacquet; E. Guittet; C. V. Heijenoort; M. Zeghouf; V. Buosi; J. Perez et al.
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Chronicles of the GTPase switch

Nature Chemical Biology
2011-07 | Journal article
DOI: 10.1038/nchembio.608
Part of ISSN: 1552-4450
Contributors: Jacqueline Cherfils; Mahel Zeghouf
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

LG186: An Inhibitor of GBF1 Function that Causes Golgi Disassembly in Human and Canine Cells

Traffic
2010-10 | Journal article
DOI: 10.1111/j.1600-0854.2010.01122.x
Part of ISSN: 1398-9219
Contributors: Frédéric Boal; Lucie Guetzoyan; Richard B. Sessions; Mahel Zeghouf; Robert A. Spooner; J. Michael Lord; Jacqueline Cherfils; Guy J. Clarkson; Lynne M. Roberts; David J. Stephens
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

SAXS and X-ray Crystallography Suggest an Unfolding Model for the GDP/GTP Conformational Switch of the Small GTPase Arf6

Journal of Molecular Biology
2010-10 | Journal article
DOI: 10.1016/j.jmb.2010.08.002
Part of ISSN: 0022-2836
Contributors: Valérie Biou; Kaheina Aizel; Pierre Roblin; Aurélien Thureau; Eric Jacquet; Sebastian Hansson; Bernard Guibert; Eric Guittet; Carine van Heijenoort; Mahel Zeghouf et al.
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function

Virology
2009-05 | Journal article
DOI: 10.1016/j.virol.2009.03.005
Part of ISSN: 0042-6822
Contributors: Alan Cochrane; Laura Lea Murley; Mian Gao; Raymond Wong; Kiera Clayton; Nicole Brufatto; Veronica Canadien; Daniel Mamelak; Tricia Chen; Dawn Richards et al.
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Aptamer-Derived Peptides as Potent Inhibitors of the Oncogenic RhoGEF Tgat

Chemistry & Biology
2009-04 | Journal article
DOI: 10.1016/j.chembiol.2009.02.006
Part of ISSN: 1074-5521
Contributors: Nathalie Bouquier; Sylvie Fromont; Jean-Christophe Zeeh; Camille Auziol; Pauline Larrousse; Bruno Robert; Mahel Zeghouf; Jacqueline Cherfils; Anne Debant; Susanne Schmidt
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

An Arf1 GTPase mutant with different responses to GEF inhibitors

Biochemical and Biophysical Research Communications
2008 | Journal article
DOI: 10.1016/j.bbrc.2008.09.107
Part of ISSN: 0006-291X
Contributors: Sebastian Flisiak; Jean-Christophe Zeeh; Bernard Guibert; Jacqueline Cherfils; Mahel Zeghouf
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

In Vitro Assays to Characterize Inhibitors of the Activation of Small G Proteins by Their Guanine Nucleotide Exchange Factors

Methods in Enzymology
2008 | Other
DOI: 10.1016/s0076-6879(07)38004-x
Part of ISSN: 0076-6879
Contributors: Jean‐Christophe Zeeh; Bruno Antonny; Jacqueline Cherfils; Mahel Zeghouf
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Structure and inhibition of Arf GTPases

Acta Crystallographica Section A Foundations of Crystallography
2008-08 | Journal article
DOI: 10.1107/s0108767308089356
Part of ISSN: 0108-7673
Contributors: J. Cherfils; J.-C. Zeeh; M. Zeghouf; V. Biou; V. Buosi; A. Thureau; C. van Heijenoort; E. Guittet
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes

Proceedings of the National Academy of Sciences
2007-06-11 | Journal article
DOI: 10.1073/pnas.0700773104
Part of ISSN: 0027-8424
Contributors: J. Viaud; M. Zeghouf; H. Barelli; J.-C. Zeeh; A. Padilla; B. Guibert; P. Chardin; C. A. Royer; J. Cherfils; A. Chavanieu
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Dual Specificity of the Interfacial Inhibitor Brefeldin A for Arf Proteins and Sec7 Domains

Journal of Biological Chemistry
2006-02 | Journal article
DOI: 10.1074/jbc.m600149200
Part of ISSN: 0021-9258
Contributors: Jean-Christophe Zeeh; Mahel Zeghouf; Cedric Grauffel; Bernard Guibert; Elyette Martin; Annick Dejaegere; Jacqueline Cherfils
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Arf, Sec7 and Brefeldin A: a model towards the therapeutic inhibition of guanine nucleotide-exchange factors

Biochemical Society Transactions
2005 | Journal article
DOI: 10.1042/bst20051265
Part of ISSN: 0300-5127
Contributors: B. Guibert; M. Zeghouf; J.-C. Zeeh; J. Cherfils
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

RPAP1, a Novel Human RNA Polymerase II-Associated Protein Affinity Purified with Recombinant Wild-Type and Mutated Polymerase Subunits

Molecular and Cellular Biology
2004-07 | Journal article
DOI: 10.1128/mcb.24.16.7043-7058.2004
Part of ISSN: 0270-7306
Contributors: C. Jeronimo; M.-F. Langelier; M. Zeghouf; M. Cojocaru; D. Bergeron; D. Baali; D. Forget; S. Mnaimneh; A. P. Davierwala; J. Pootoolal et al.
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Sequential Peptide Affinity (SPA) System for the Identification of Mammalian and Bacterial Protein Complexes

Journal of Proteome Research
2004-06 | Journal article
DOI: 10.1021/pr034084x
Part of ISSN: 1535-3893
Contributors: Mahel Zeghouf; Joyce Li; Gareth Butland; Anna Borkowska; Veronica Canadien; Dawn Richards; Bryan Beattie; Andrew Emili; Jack F. Greenblatt
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Protein Profiling with Epstein-Barr Nuclear Antigen-1 Reveals an Interaction with the Herpesvirus-associated Ubiquitin-specific Protease HAUSP/USP7

Journal of Biological Chemistry
2003-06-03 | Journal article
DOI: 10.1074/jbc.m303977200
Part of ISSN: 0021-9258
Contributors: Melissa N. Holowaty; Mahel Zeghouf; Hong Wu; Judy Tellam; Vicki Athanasopoulos; Jack Greenblatt; Lori Frappier
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

A Simplifed Functional Version of theEscherichia coliSulfite Reductase

Journal of Biological Chemistry
2000-09 | Journal article
DOI: 10.1074/jbc.m005619200
Part of ISSN: 0021-9258
Contributors: Mahel Zeghouf; Marc Fontecave; Jacques Covès
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module 1 1Edited by R. Huber

Journal of Molecular Biology
2000-05 | Journal article
DOI: 10.1006/jmbi.2000.3748
Part of ISSN: 0022-2836
Contributors: Arnaud Gruez; David Pignol; Mahel Zeghouf; Jacques Covès; Marc Fontecave; Jean-Luc Ferrer; Juan Carlos Fontecilla-Camps
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

31P Nuclear magnetic resonance study of the flavoprotein component of the Escherichia coli sulfite reductase

European Journal of Biochemistry
1999-04 | Journal article
DOI: 10.1046/j.1432-1327.1999.00274.x
Part of ISSN: 0014-2956
Contributors: Adeline Evrard; Mahel Zeghouf; Marc Fontecave; Claude Roby; Jacques Coves
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

The Flavoprotein Component of theEscherichia coliSulfite Reductase Can Act as a Cytochrome P450c17 Reductase

Biochemical and Biophysical Research Communications
1998-05 | Journal article
DOI: 10.1006/bbrc.1998.8671
Part of ISSN: 0006-291X
Contributors: Mahel Zeghouf; Geneviève Defaye; Marc Fontecave; Jacques Coves
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

The Flavoprotein Component of theEscherichia coliSulfite Reductase: Expression, Purification, and Spectral and Catalytic Properties of a Monomeric Form Containing both the Flavin Adenine Dinucleotide and the Flavin Mononucleotide Cofactors

Biochemistry
1998-04 | Journal article
DOI: 10.1021/bi9728699
Part of ISSN: 0006-2960
Contributors: Mahel Zeghouf; Marc Fontecave; David Macherel; Jacques Covès
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

The FNR-like domain of the Escherichia coli sulfite reductase flavoprotein component: crystallization and preliminary X-ray analysis

Acta Crystallographica Section D Biological Crystallography
1998-01-01 | Journal article
DOI: 10.1107/s090744499701069x
Part of ISSN: 0907-4449
Contributors: Arnaud Gruez; Mahel Zeghouf; Jay Bertrand; Michel Eschenbrenner; Jacques Covès; Marc Fontecave; David Pignol; Juan-Carlos Fontecilla-Camps
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Flavin Mononucleotide-Binding Domain of the Flavoprotein Component of the Sulfite Reductase fromEscherichia coli

Biochemistry
1997-05 | Journal article
DOI: 10.1021/bi9623744
Part of ISSN: 0006-2960
Contributors: Jacques Covès; Mahel Zeghouf; David Macherel; Bruno Guigliarelli; Marcel Asso; Marc Fontecave
Source: Self-asserted source
Mahel Zeghouf via Crossref Metadata Search

Peer review (1 review for 1 publication/grant)

Review activity for Journal of medicinal chemistry. (1)
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