Personal information

Epilepsy, Alzheimer's disease, High frequency oscillations
United States

Biography

Christos Lisgaras is Research Assistant Professor at New York University Grossman School of Medicine, Department of Psychiatry. He also is Research Scientist at the Nathan S. Kline Institute for Psychiatric Research, Center for Dementia Research where his laboratory is located.

My work is primarily focused on developing novel approaches and biomarkers to help treat psychiatric comorbidities and memory deficits for a range of brain disorders including epilepsy, Alzheimer’s disease (AD), and seizure disorders. More specifically, I use electroencephalography (EEG) as a vehicle to better understand the circuits and mechanisms involved in brain disease with a focus on abnormal oscillations such as high frequency oscillations (HFOs>250Hz).

A major arm of my research program investigates the overlap between AD and epilepsy with a focus on common EEG disturbances. In three mouse lines with AD features, I found that HFOs were a new abnormal electrical activity that emerged very early in life and well before neuropathology developed. Notably, HFOs were previously considered a promising epilepsy biomarker but their occurrence in AD was unknown. I also tackled an outstanding question in AD that relates to where abnormal electrical activity originates in the brain. To that end, I employed large-scale electrophysiological recordings in three animal models of AD and found a dominant role of the dentate gyrus in generating abnormal electrical activity.

The second arm of my research program is focused on developing novel neurostimulation protocols to precisely disrupt abnormal electrical activity in both AD and epilepsy. These advanced tools have the potential to uncover circuit mechanisms underlying comorbidities with unprecedented selectivity which may contribute to less side-effects of prolonged treatments.

Last, I am interested in developing new and improved animal models of neurologic disease. To that end, I modified a widely used animal model of epilepsy (intrahippocampal kainic acid model) to show robust chronic convulsive seizures with human seizure onset patterns to better simulate human temporal lobe epilepsy in laboratory mice.

Activities

Employment (4)

New York University: New York, US

2024-05 to present | Research Assistant Professor (Psychiatry)
Employment
Source: Self-asserted source
Christos Panagiotis Lisgaras

NYU Langone Medical Center: NY, NY, US

2019-07 to 2024 | Postdoctoral Fellow (Child and Adolescent Psychiatry, Neuroscience and Physiology and the Neuroscience Institute)
Employment
Source: Self-asserted source
Christos Panagiotis Lisgaras

Nathan Kline Institute for Psychiatric Research: Orangeburg, New York, US

2019-07 to 2024 | Assistant Research Scientist (Center for Dementia Research)
Employment
Source: Self-asserted source
Christos Panagiotis Lisgaras

Albert Einstein College of Medicine: New York, New York, US

2017-08 to 2019-07 | Research Fellow (Neurology)
Employment
Source: Self-asserted source
Christos Panagiotis Lisgaras

Education and qualifications (2)

University of Ioannina: Ioannina, GR

2013-12 to 2017-07 | PhD (Biological Applications and Technology)
Education
Source: Self-asserted source
Christos Panagiotis Lisgaras

University of Ioannina: Ioannina, GR

2008 to 2013 | BS (Biological Applications & Technology)
Education
Source: Self-asserted source
Christos Panagiotis Lisgaras

Professional activities (2)

International League Against Epilepsy: West Hartford, Connecticut, US

Invited position
Source: Self-asserted source
Christos Panagiotis Lisgaras

American Epilepsy Society: Chicago, Illinois, US

Invited position
Source: Self-asserted source
Christos Panagiotis Lisgaras

Funding (3)

High frequency oscillations in Alzheimer's disease

2024-09 to present | Grant
National Institute on Aging (Baltimore, US)
GRANT_NUMBER:

R21AG086880

Source: Self-asserted source
Christos Panagiotis Lisgaras

3rd International Workshop on High Frequency Oscillations in Epilepsy

2024-05-23 to 2025-05-22 | Grant
American Epilepsy Society (Chicago, US)
GRANT_NUMBER:

1259845

Source: Self-asserted source
Christos Panagiotis Lisgaras via DimensionsWizard

Closed-loop strategies in experimental epilepsy

2022-09 to present | Grant
NYU Langone Medical Center (NY, NY, US)
Source: Self-asserted source
Christos Panagiotis Lisgaras

Works (10)

The role of electroencephalography in epilepsy research—From seizures to interictal activity and comorbidities

Epilepsia
2025-02-06 | Journal article
Contributors: Christos Panagiotis Lisgaras; Liset M. de la Prida; Edward Bertram; Mark Cunningham; David Henshall; Anli A. Liu; Vadym Gnatkovsky; Simona Balestrini; Marco de Curtis; Aristea S. Galanopoulou et al.
Source: check_circle
Crossref

High Frequency Oscillations (>250Hz) Outnumber Interictal Spikes in Preclinical Studies of Alzheimer’s Disease

2023-11-02 | Preprint
Contributors: Christos Panagiotis Lisgaras; Helen E. Scharfman
Source: check_circle
Crossref

Interictal spikes in Alzheimer's disease: Preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum

Neurobiology of Disease
2023-10 | Journal article
Part of ISSN: 0969-9961
Contributors: Christos Panagiotis Lisgaras; Helen E. Scharfman
Source: Self-asserted source
Christos Panagiotis Lisgaras

Hippocampal area CA2 controls seizure dynamics, interictal EEG abnormalities and social comorbidity in mouse models of temporal lobe epilepsy

2023-01-19 | Preprint
Contributors: Christos Panagiotis Lisgaras; Azahara Oliva; Sam Mckenzie; John LaFrancois; Steven A. Siegelbaum; Helen E. Scharman
Source: check_circle
Crossref

High Frequency Oscillations ( 250‐500Hz ) in Animal Models of Alzheimer's Disease and Two Animal Models of Epilepsy

Epilepsia
2022-11-08 | Journal article
Source: Self-asserted source
Christos Panagiotis Lisgaras
grade
Preferred source (of 3)‎

Robust chronic convulsive seizures, high frequency oscillations, and human seizure onset patterns in an intrahippocampal kainic acid model in mice.

Neurobiology of disease
2022-01-26 | Journal article
Contributors: Christos Panagiotis Lisgaras; Lisgaras CP; Scharfman HE
Source: Self-asserted source
Christos Panagiotis Lisgaras

Region-specific Effects of Early-life Status Epilepticus on the Adult Hippocampal CA3 – Medial Entorhinal Cortex Circuitry In vitro: Focus on Interictal Spikes and Concurrent High-frequency Oscillations

Neuroscience
2021-07 | Journal article
Contributors: Christos Panagiotis Lisgaras; Apostolos Mikroulis; Caterina Psarropoulou
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Climate change and epilepsy: Insights from clinical and basic science studies.

Epilepsy & behavior : E&B
2021-02-10 | Journal article
Contributors: Christos Panagiotis Lisgaras; Gulcebi MI; Emanuele Bartolini; Lee O; Lisgaras CP; Onat F; Mifsud J; Striano P; Vezzani A; Michael Hildebrand et al.
Source: Self-asserted source
Christos Panagiotis Lisgaras

In search of antiepileptogenic treatments for post-traumatic epilepsy

Neurobiology of Disease
2018-06 | Journal article
Part of ISSN: 0969-9961
Contributors: Patricia G. Saletti; Idrish Ali; Pablo M. Casillas-Espinosa; Bridgette D. Semple; Christos Lisgaras; Solomon L. Moshé; Aristea S. Galanopoulou
Source: Self-asserted source
Christos Panagiotis Lisgaras via Crossref Metadata Search

Immature Status Epilepticus: In Vitro Models Reveal Differences In Cholinergic Control and Hfo Properties of Adult Ca3 Interictal Discharges In Temporal Vs Septal Hippocampus

Neuroscience
2017-11 | Journal article
Part of ISSN: 0306-4522
Contributors: Apostolos Mikroulis; Christos Panagiotis Lisgaras; Caterina Psarropoulou
Source: Self-asserted source
Christos Panagiotis Lisgaras via Crossref Metadata Search
grade
Preferred source (of 2)‎

Peer review (7 reviews for 3 publications/grants)

Review activity for Communications biology. (1)
Review activity for Neurobiology of disease. (4)
Review activity for Progress in neurobiology. (2)