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Loop profile: 252624
Scopus Author ID: 56121786600

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Employment (1)

Aarhus University: Aarhus C, DK

2022-03-02
Employment
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Aarhus University

Education and qualifications (1)

Aarhus University: Aarhus, DK

2014 to 2019-01 | PhD (iNANO)
Education
Source: Self-asserted source
Lucy Kate Ladefoged

Works (21)

Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT3 receptors

Nature Structural and Molecular Biology
2024-08 | Journal article | Author
DOI: 10.1038/s41594-024-01282-x
SOURCE-WORK-ID:

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EID:

2-s2.0-85191981558

PMID: 38698207
Contributors: Uriel López-Sánchez; Lachlan Jake Munro; Lucy Kate Ladefoged; Anders Juel Pedersen; Christian Colding Brun; Signe Meisner Lyngby; Delphine Baud; Céline Juillan-Binard; Miriam Grønborg Pedersen; Sarah C.R. Lummis et al.
Source: check_circle
Aarhus University

Inhibitory effects of fluorinated benzenesulfonamides on insulin fibrillation

International Journal of Biological Macromolecules
2023-02 | Journal article | Author
DOI: 10.1016/j.ijbiomac.2022.12.105
SOURCE-WORK-ID:

5f0fb9da-19f3-4d73-a7c6-e7524ac10c25

PMID: 36529223
EID:

2-s2.0-85144547638
Contributors: Saeid Hadi Alijanvand; Lucy Kate Ladefoged; Asta Zubrienė; Andrius Sakalauskas; Gunna Christiansen; Virginija Dudutiene; Birgit Schiøtt; Daumantas Matulis; Vytautas Smirnovas; Daniel E Otzen
Source: check_circle
Aarhus University

Potentiation of Drug Toxicity through Virus Latency Reversal Promotes Preferential Elimination of HIV Infected Cells

Advanced Therapeutics
2022-11 | Journal article | Author
DOI: 10.1002/adtp.202200113
SOURCE-WORK-ID:

323f54da-3321-4e75-890f-728061c7bbe7

EID:

2-s2.0-85137344580
Contributors: Truong Thanh Tung; Manuel Hayn; Camilla Frich Riber; Lia-Raluca Olari; Lucy Kate Ladefoged; Morten T. Jarlstad Olesen; Josefine H. Jakobsen; Cherie K. Lunabjerg-Vestergaard; Birgit Schiøtt; Jan Münch et al.
Source: check_circle
Aarhus University

Binding and Activation of Serotonergic G-Protein Coupled Receptors by the Multimodal Antidepressant Vortioxetine

ACS Chemical Neuroscience
2022-04 | Journal article | Author
DOI: 10.1021/acschemneuro.1c00029
SOURCE-WORK-ID:

f01b51c7-cba9-47c9-a4ee-20a5b9583329

EID:

2-s2.0-85127869497

PMID: 35348335
WOSUID:

000794206200004
Contributors: Lucy Kate Ladefoged; Rebekka Koch; Philip C. Biggin; Birgit Schiøtt
Source: check_circle
Aarhus University

Geometry and water accessibility of the inhibitor binding site of Na+-pump

Biophysical Journal
2021-07 | Journal article | Author
DOI: 10.1016/j.bpj.2021.05.018
SOURCE-WORK-ID:

62a38489-ca08-4e8b-a50b-3569b2d1d1a6

EID:

2-s2.0-85108799463

PMID: 34087213
Contributors: Erika Aloi; Jin Hua Guo; Rita Guzzi; Ren Wang Jiang; Lucy Kate Ladefoged; Derek Marsh; Mikael Esmann; Rosa Bartucci; Natalya Fedosova
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Aarhus University

Beneficent and Maleficent Effects of Cations on Bufadienolide Binding to Na+,K+-ATPase

Journal of Chemical Information and Modeling
2021-02 | Journal article | Author
DOI: 10.1021/acs.jcim.0c01396
SOURCE-WORK-ID:

1ab67a37-8b31-416b-ac09-81614a520710

EID:

2-s2.0-85100620624
Contributors: Lucy Kate Ladefoged; Birgit Schiøtt; Natalya Fedosova
Source: check_circle
Aarhus University

A Photoswitchable Inhibitor of the Human Serotonin Transporter

ACS Chemical Neuroscience
2020-05 | Journal article | Author
DOI: 10.1021/acschemneuro.9b00521
SOURCE-WORK-ID:

06c184d1-338d-4999-8b3c-d2246336f99d

EID:

2-s2.0-85084270924

PMID: 32275382
Contributors: Bichu Cheng; Johannes Morstein; Lucy Kate Ladefoged; Jannick Bang Maesen; Birgit Schiøtt; Steffen Sinning; Dirk Trauner
Source: check_circle
Aarhus University

Computational modeling of the serotonergic synapse

2019 | Dissertation or Thesis | Author
SOURCE-WORK-ID:

d4965f86-6a3c-4ff6-9b98-bfbb0f1208a7
Contributors: Lucy Kate Ladefoged
Source: check_circle
Aarhus University

Molecular Insight into the Agonist Properties of the Multimodal Antidepressant Vortioxetine in Human 5-HT3A Receptors

2019 | Conference abstract | Author
SOURCE-WORK-ID:

7fb644c7-5846-430e-84e9-3cd9abf3991d
Contributors: Lucy Kate Ladefoged; Birgit Schiøtt; Lachlan Jake Munro; Anders Skov Kristensen
Source: check_circle
Aarhus University

Conformational changes in the 5-HT3A receptor extracellular domain measured by voltage-clamp fluorometry

Molecular Pharmacology
2019-12 | Journal article | Author
DOI: 10.1124/mol.119.116657
SOURCE-WORK-ID:

3978728f-cb4f-4b2f-bf0c-bc7074a2fb94

EID:

2-s2.0-85076848890

PMID: 31582575
Contributors: Lachlan Munro; Lucy Kate Ladefoged; Vithushan Padmanathan; Signe Andersen; Birgit Schiøtt; Anders S. Kristensen
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Aarhus University

Substrate and inhibitor binding to the serotonin transporter

Neuropharmacology
2019-12-15 | Journal article | Author
DOI: 10.1016/j.neuropharm.2019.02.030
SOURCE-WORK-ID:

170d151a-a2d7-46c0-9ee9-d8245a8c16b0

PMID: 30807752
EID:

2-s2.0-85076110909
Contributors: Talia Zeppelin; Lucy Kate Ladefoged; Steffen Sinning; Birgit Schiøtt
Source: check_circle
Aarhus University

Molecular modeling of neurological membrane proteins − from binding sites to synapses

Neuroscience Letters
2019-05 | Journal article | Author
DOI: 10.1016/j.neulet.2018.05.034
SOURCE-WORK-ID:

f84ec85a-aa5e-4a7d-9e5d-e2fa2222d725

EID:

2-s2.0-85047900123

PMID: 29802917
WOSUID:

000469151300007
Contributors: Lucy Kate Ladefoged; Talia Zeppelin; Birgit Schiøtt
Source: check_circle
Aarhus University

Modeling and mutational analysis of the binding mode for the multimodal antidepressant drug vortioxetine to the human 5-HT3A receptor

Molecular Pharmacology
2018-12-01 | Journal article | Author
DOI: 10.1124/mol.118.113530
SOURCE-WORK-ID:

d088da9c-7987-4260-95fb-6024161e431e

EID:

2-s2.0-85056549408

PMID: 30257860
Contributors: Lucy Kate Ladefoged; Lachlan Jake Munro; Anders Juel Pedersen; Sarah C. R. Lummis; Benny Bang-Andersen; Thomas Balle; Birgit Schiøtt; Anders Skov Kristensen
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Aarhus University

Divergent synthesis of new α-glucosidase inhibitors obtained through a vinyl Grignard-mediated carbocyclisation

Organic & Biomolecular Chemistry
2018-08-07 | Journal article | Author
DOI: 10.1039/c8ob01433g
SOURCE-WORK-ID:

a02e5257-9084-4567-94bf-6d1755a4556a

PMID: 30110037
EID:

2-s2.0-85052685562
Contributors: Ida M B Knudsen; Christinne Hedberg; Lucy Kate Ladefoged; Daisuke Ide; Anne Brinkø; Espen Z Eikeland; Atsushi Kato; Henrik Helligsø Jensen
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Aarhus University

A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition

PLOS Computational Biology
2018-01-01 | Journal article | Author
DOI: 10.1371/journal.pcbi.1005907
SOURCE-WORK-ID:

e7957839-ae16-406b-bee1-32867e010114

EID:

2-s2.0-85041402165

PMID: 29329285
Contributors: Talia Zeppelin; Lucy Kate Ladefoged; Steffen Sinning; Xavier Periole; Birgit Schiøtt
Source: check_circle
Aarhus University

Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands

ACS Chemical Neuroscience
2016-10-19 | Journal article | Author
DOI: 10.1021/acschemneuro.6b00164
SOURCE-WORK-ID:

95954741-6838-4271-9d10-2ceef3acdbcb

WOSUID:

000385994000013

PMID: 27425420
EID:

2-s2.0-84992212849
Contributors: Jacob Andersen; Lucy Kate Ladefoged; Trine N. Bjerre Kristensen; Lachlan Munro; Julie Grouleff; Nicolai Stuhr-Hansen; Anders S. Kristensen; Birgit Schiøtt; Kristian Strømgaard
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Aarhus University

Binding of the Multimodal Antidepressant Drug Vortioxetine to the Human Serotonin Transporter

ACS Chemical Neuroscience
2015 | Journal article | Author
DOI: 10.1021/acschemneuro.5b00225
SOURCE-WORK-ID:

bde4cc84-4649-4383-a439-74386c50d192

WOSUID:

000365146900012

EID:

2-s2.0-84947720884

PMID: 26389667
Contributors: Jacob Andersen; Lucy Kate Ladefoged; Danyang Wang; Trine N. Bjerre Kristensen; Benny Bang-Andersen; Anders S. Kristensen; Birgit Schiøtt; Kristian Stromgaard
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Aarhus University

Monoamine transporters

Frontiers in Pharmacology
2015-10-16 | Journal article | Author
DOI: 10.3389/fphar.2015.00235
SOURCE-WORK-ID:

24a46466-6d08-4861-bca3-52e5e6afc425

WOSUID:

000366050000001

EID:

2-s2.0-84944806286

PMID: 26528185
Contributors: Julie Grouleff; Lucy Kate Ladefoged; Heidi Koldso; Birgit Schiøtt
Source: check_circle
Aarhus University

Binding-Induced Fluorescence of Serotonin Transporter Ligands

ACS Chemical Neuroscience
2014-01 | Journal article | Author
DOI: 10.1021/cn400230x
SOURCE-WORK-ID:

f48548ce-b408-4372-acfa-1bf465a2d376

EID:

2-s2.0-84898983109

PMID: 24460204
Contributors: James Wilson; Lucy Kate Ladefoged; Michael Babinchak; Birgit Schiøtt
Source: check_circle
Aarhus University

Binding modes of a novel antidepressant to the human serotonin transporter

12th iNANO annual meeting, Aarhus, Denmark, 17/01/2014
2014-01-16 | Conference poster | Author
SOURCE-WORK-ID:

909587d5-e242-42e2-ba2e-0fe8c9bf5e71
Contributors: Lucy Kate Ladefoged; Birgit Schiøtt
Source: check_circle
Aarhus University

Binding of fluorescent neurotransmitter analogs to the human serotonin transporter explored using molecular mechanics

Biology & chemistry computational research, San Diego, CA, United States, 17/06/2013
2013-08-09 | Conference poster | Author
SOURCE-WORK-ID:

6eb02ba8-0a72-475d-ac13-50353f69c56a
Contributors: Lucy Kate Ladefoged; Birgit Schiøtt; James Wilson; Rommie Amaro
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Aarhus University
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