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Scopus Author ID: 7201812121

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Employment (5)

Massaryk University: Brno, CZ

2014-11-10 to present | ERA Chair (CEITEC)
Employment
Source: Self-asserted source
Mary Anne O'Connell

Stockholms Universitet: Stockholm, SE

2013 to 2014 | Visiting Professor
Employment
Source: Self-asserted source
Mary Anne O'Connell

Medical Research Council: Edinburgh, GB

1997-09-01 to 2013-01-31 | Group Leader (Huma Genetics Unit)
Employment
Source: Self-asserted source
Mary Anne O'Connell

Universität Basel Department Biozentrum: Basel, BS, CH

1990-11-15 to 1997-06-31 | Postdoctoral Fellow (cell Biology)
Employment
Source: Self-asserted source
Mary Anne O'Connell

Massachusetts Institute of Technology: Cambridge, MA, US

1987-01-01 to 1990-11-14 | Postdoctoral Fellow (Cancer Center)
Employment
Source: Self-asserted source
Mary Anne O'Connell

Education and qualifications (2)

Yeshiva University Albert Einstein College of Medicine: Bronx, NY, US

1981-09-01 to 1986-10-04 | PhD (Molecular Biology)
Education
Source: Self-asserted source
Mary Anne O'Connell

University College Galway: Galway, IE

1977-10 to 1981-06 | B.Sc(Hons) (Microbiology)
Education
Source: Self-asserted source
Mary Anne O'Connell

Professional activities (1)

European Molecular Biology Organization: Heidelberg, DE

2017
Distinction
Source: Self-asserted source
Mary Anne O'Connell

Works (50 of 80)

Items per page:
Page 1 of 2

Distinct interactomes of ADAR1 nuclear and cytoplasmic protein isoforms and their responses to interferon induction

Nucleic Acids Research
2024-12-11 | Journal article
DOI: 10.1093/nar/gkae1106
Contributors: Dragana Vukić; Anna Cherian; Salla Keskitalo; Yih Tyng Bong; Martin Marônek; Leena Yadav; Liam P Keegan; Markku Varjosalo; Mary A O’Connell
Source: check_circle
Crossref

An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

Cell Reports
2024-08 | Journal article
DOI: 10.1016/j.celrep.2024.114618
Part of ISSN: 2211-1247
Contributors: Ketty Sinigaglia; Anna Cherian; Qiupei Du; Valentina Lacovich; Dragana Vukić; Janka Melicherová; Pavla Linhartova; Lisa Zerad; Stanislav Stejskal; Radek Malik et al.
Source: Self-asserted source
Mary Anne O'Connell

Amyloid precursor protein induces reactive astrogliosis

Acta Physiologica
2024-06 | Journal article
DOI: 10.1111/apha.14142
Part of ISSN: 1748-1708
Part of ISSN: 1748-1716
Contributors: Gretsen Velezmoro Jáuregui; Dragana Vukić; Isaac G. Onyango; Carlos Arias; Jan S. Novotný; Kateřina Texlová; Shanshan Wang; Kristina Locker Kovačovicova; Natalie Polakova; Jana Zelinkova et al.
Source: Self-asserted source
Mary Anne O'Connell

Adenosine Deaminase Acting on RNA (ADAR) Enzymes: A Journey from Weird to Wondrous

Accounts of Chemical Research
2023-11-21 | Journal article
DOI: 10.1021/acs.accounts.3c00433
Contributors: Liam P. Keegan; Khadija Hajji; Mary A. O’Connell
Source: check_circle
Crossref

The mechanical regulation of RNA binding protein hnRNPC in the failing heart

Science Translational Medicine
2022-11-23 | Journal article | Author
DOI: 10.1126/scitranslmed.abo5715
Part of ISSN: 1946-6234
Part of ISSN: 1946-6242
Contributors: Fabiana Martino; Nandan Mysore Varadarajan; Ana Rubina Perestrelo; Vaclav Hejret; Helena Durikova; Dragana Vukic; Vladimir Horvath; Francesca Cavalieri; Frank Caruso; Waleed S. Albihlal et al.
Source: Self-asserted source
Mary Anne O'Connell

ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations

RNA
2022-10 | Journal article
DOI: 10.1261/rna.079266.122
Contributors: Khadija Hajji; Jiří Sedmík; Anna Cherian; Damiano Amoruso; Liam P. Keegan; Mary A. O'Connell
Source: check_circle
Crossref

ADAR1 entraps sinister cellular dsRNAs, thresholding antiviral responses

Trends in Immunology
2021-11 | Journal article
DOI: 10.1016/j.it.2021.09.013
Contributors: Liam P. Keegan; Dragana Vukić; Mary A. O’Connell
Source: check_circle
Crossref

The effects of RNA editing in cancer tissue at different stages in carcinogenesis

RNA Biology
2021-11-02 | Journal article
DOI: 10.1080/15476286.2021.1877024
Contributors: Małgorzata Kurkowiak; Łukasz Arcimowicz; Elżbieta Chruściel; Zuzanna Urban-Wójciuk; Ines Papak; Liam Keegan; Mary O’Connell; Jacek Kowalski; Ted Hupp; Natalia Marek-Trzonkowska
Source: check_circle
Crossref

Interplays of different types of epitranscriptomic mRNA modifications

RNA Biology
2021-10-15 | Journal article
DOI: 10.1080/15476286.2021.1969113
Contributors: Praveenkumar Rengaraj; Aleš Obrdlík; Dragana Vukić; Nandan Mysore Varadarajan; Liam P. Keegan; Štěpánka Vaňáčová; Mary A. O’Connell
Source: check_circle
Crossref

ADAR RNA Modifications, the Epitranscriptome and Innate Immunity

Trends in Biochemical Sciences
2021-09 | Journal article
DOI: 10.1016/j.tibs.2021.02.002
Part of ISSN: 0968-0004
Source: Self-asserted source
Mary Anne O'Connell

European COST action CA16120 EPITRAN: the first four years and beyond

RNA Biology
2021-09-28 | Journal article
DOI: 10.1080/15476286.2021.1982121
Part of ISSN: 1547-6286
Part of ISSN: 1555-8584
Source: Self-asserted source
Mary Anne O'Connell

Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

Nature Communications
2020-12 | Journal article
DOI: 10.1038/s41467-020-15435-1
Part of ISSN: 2041-1723
Source: Self-asserted source
Mary Anne O'Connell

Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

BMC Biology
2020-12 | Journal article
DOI: 10.1186/s12915-020-0747-0
Part of ISSN: 1741-7007
Source: Self-asserted source
Mary Anne O'Connell
grade
Preferred source (of 4)‎

Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy

Journal of Medical Genetics
2020-07-27 | Journal article
DOI: 10.1136/jmedgenet-2020-107048
Part of ISSN: 0022-2593
Part of ISSN: 1468-6244
Source: Self-asserted source
Mary Anne O'Connell

Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures

The American Journal of Human Genetics
2020-04 | Journal article
DOI: 10.1016/j.ajhg.2020.02.015
Part of ISSN: 0002-9297
Source: Self-asserted source
Mary Anne O'Connell
grade
Preferred source (of 2)‎

A celebration of the life of Marie Öhman (1964-2019)

RNA (New York, N.Y.)
2019 | Journal article
DOI: 10.1261/rna.072645.119
EID:

2-s2.0-85072294294

Part of ISBN:

14699001
Contributors: Bass, B.L.; O'Connell, M.A.; Wagner, E.G.H.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep

Biochim Biophys Acta Gene Regul Mech
2019 | Journal article
DOI: 10.1016/j.bbagrm.2018.10.011
Contributors: Sinigaglia, K.; Wiatrek, D.; Khan, A.; Michalik, D.; Sambrani, N.; Sedmík, J.; Vukić, D.; O'Connell, M. A.; Keegan, L. P.
Source: Self-asserted source
Mary Anne O'Connell via ResearcherID
grade
Preferred source (of 2)‎

Activation of innate immunity by mitochondrial dsRNA in mouse cells lacking p53 protein

RNA
2019-06 | Journal article
DOI: 10.1261/rna.069625.118
Part of ISSN: 1355-8382
Part of ISSN: 1469-9001
Source: Self-asserted source
Mary Anne O'Connell

Positioning Europe for the EPITRANSCRIPTOMICS challenge.

RNA biology
2018 | Journal article
DOI: 10.1080/15476286.2018.1460996
WOSUID:

MEDLINE:29671387
Contributors: Jantsch, Michael F; Quattrone, Alessandro; O'Connell, Mary; Helm, Mark; Frye, Michaela; Macias-Gonzales, Manuel; Ohman, Marie; Ameres, Stefan; Willems, Luc; Fuks, Francois et al.
Source: Self-asserted source
Mary Anne O'Connell via ResearcherID
grade
Preferred source (of 2)‎

A to I editing in disease is not fake news

RNA Biol
2017 | Journal article
DOI: 10.1080/15476286.2017.1306173
Contributors: Bajad, P.; Jantsch, M. F.; Keegan, L.; O'Connell, M.
Source: Self-asserted source
Mary Anne O'Connell via ResearcherID
grade
Preferred source (of 2)‎

ADAR RNA editing below the backbone

RNA
2017 | Journal article
DOI: 10.1261/rna.060921.117
EID:

2-s2.0-85027574125

Part of ISBN:

14699001 13558382
Contributors: Keegan, L.; Khan, A.; Vukic, D.; O'Connell, M.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

ADAR RNA editing in human disease; more to it than meets the I

Human Genetics
2017 | Journal article
DOI: 10.1007/s00439-017-1837-0
WOSUID:

WOS:000410757000016
Contributors: Gallo, Angela; Vukic, Dragana; Michalik, David; O'Connell, Mary A.; Keegan, Liam P.
Source: Self-asserted source
Mary Anne O'Connell via ResearcherID

Dynamic landscape and regulation of RNA editing in mammals

Nature
2017 | Journal article
DOI: 10.1038/nature24041
WOSUID:

WOS:000412829500047
Contributors: Tan, Meng How; Li, Qin; Shanmugam, Raghuvaran; Piskol, Robert; Kohler, Jennefer; Young, Amy N.; Liu, Kaiwen Ivy; Zhang, Rui; Amaswami, Gokul R.; Ariyoshi, Kentaro et al.
Source: Self-asserted source
Mary Anne O'Connell via ResearcherID
grade
Preferred source (of 2)‎

Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria

Elife
2017 | Journal article
DOI: 10.7554/eLife.29156
WOSUID:

WOS:000412360800001
Contributors: Quin, Jaclyn E.; Bujila, Ioana; Cherif, Mariama; Sanou, Guillaume S.; Qu, Ying; Homann, Manijeh Vafa; Rolicka, Anna; Sirima, Sodiomon B.; O'Connell, Mary A.; Lennartsson, Andreas et al.
Source: Self-asserted source
Mary Anne O'Connell via ResearcherID

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins

Biomolecules
2015 | Journal article
DOI: 10.3390/biom5042338
WOSUID:

WOS:000367537500007
Contributors: Mannion, Niamh; Arieti, Fabiana; Gallo, Angela; Keegan, Liam P.; O'Connell, Mary A.
Source: Self-asserted source
Mary Anne O'Connell via ResearcherID

The Epitranscriptome and Innate Immunity

PLOS Genetics
2015-12-10 | Journal article
DOI: 10.1371/journal.pgen.1005687
Part of ISSN: 1553-7404
Source: Self-asserted source
Mary Anne O'Connell

RNA modification and the epitranscriptome; the next frontier.

2015-04 | Journal article
DOI:

10.1261/rna.050260.115

PMID:

25780199

PMC:

PMC4371341
Contributors: O'Connell M
Source: Self-asserted source
Mary Anne O'Connell via Europe PubMed Central
grade
Preferred source (of 3)‎

The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster

Nucleic Acids Research
2014 | Journal article
DOI:

10.1093/nar/gkt909

EID:

2-s2.0-84893306964
Contributors: Li, X.; Overton, I.M.; Baines, R.A.; Keegan, L.P.; O'Connell, M.A.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

Cell Reports
2014-11 | Journal article
DOI: 10.1016/j.celrep.2014.10.041
Part of ISSN: 2211-1247
Source: Self-asserted source
Mary Anne O'Connell

Identifying RNA editing sites using RNA sequencing data alone

Nature Methods
2013 | Journal article
DOI:

10.1038/nmeth.2330

EID:

2-s2.0-84873414540
Contributors: Ramaswami, G.; Zhang, R.; Piskol, R.; Keegan, L.P.; Deng, P.; O'Connell, M.A.; Li, J.B.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type i interferon signature

Nature Genetics
2012 | Journal article
DOI:

10.1038/ng.2414

EID:

2-s2.0-84868207785
Contributors: Rice, G.I.; Kasher, P.R.; Forte, G.M.A.; Mannion, N.M.; Greenwood, S.M.; Szynkiewicz, M.; Dickerson, J.E.; Bhaskar, S.S.; Zampini, M.; Briggs, T.A. et al.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

Regulation and functions of ADAR in Drosophila

Current Topics in Microbiology and Immunology
2012 | Book
DOI:

10.1007/82_2011_152

EID:

2-s2.0-81855172227
Contributors: Paro, S.; Li, X.; O'Connell, M.A.; Keegan, L.P.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

Solution structure of the N-terminal dsRBD of Drosophila ADAR and interaction studies with RNA

Biochimie
2012 | Journal article
DOI:

10.1016/j.biochi.2011.12.017

EID:

2-s2.0-84861599510
Contributors: Barraud, P.; Heale, B.S.E.; O'Connell, M.A.; Allain, F.H.-T.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: Loss of ADAR1 in insects

Nucleic Acids Research
2011 | Journal article
DOI:

10.1093/nar/gkr423

EID:

2-s2.0-80052460364
Contributors: Keegan, L.P.; McGurk, L.; Palavicini, J.P.; Brindle, J.; Paro, S.; Li, X.; Rosenthal, J.J.C.; O'Connell, M.A.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects

EMBO Journal
2011 | Journal article
DOI:

10.1038/emboj.2011.303

EID:

2-s2.0-80054895180
Contributors: Marcucci, R.; Brindle, J.; Paro, S.; Casadio, A.; Hempel, S.; Morrice, N.; Bisso, A.; Keegan, L.P.; Del Sal, G.; O'Connell, M.A.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

RNA Editing by Mammalian ADARs

Advances in Genetics
2011 | Book
DOI:

10.1016/B978-0-12-380860-8.00003-3

EID:

2-s2.0-79551648715
Contributors: Hogg, M.; Paro, S.; Keegan, L.P.; O'Connell, M.A.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

Analysis of a to I editing of miRNA in macrophages exposed to salmonella

RNA Biology
2010 | Journal article
DOI:

10.4161.rna.7.5.13269

EID:

2-s2.0-78649385610
Contributors: Heale, B.S.E.; Eulalio, A.; Schulte, L.; Vogel, J.; O'Connell, M.A.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

Human BLCAP transcript: New editing events in normal and cancerous tissues

International Journal of Cancer
2010 | Journal article
DOI:

10.1002/ijc.25022

EID:

2-s2.0-77953412786
Contributors: Galeano, F.; Leroy, A.; Rossetti, C.; Gromova, I.; Gautier, P.; Keegan, L.P.; Massimi, L.; Di Rocco, C.; O'Connell, M.A.; Gallo, A.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

The effect of RNA editing and ADARs on miRNA biogenesis and function

Advances in Experimental Medicine and Biology
2010 | Book
DOI:

10.1007/978-1-4419-7823-3_8

EID:

2-s2.0-79958287315
Contributors: Heale, B.S.E.; Keegan, L.P.; O'Connell, M.A.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

ADARs have effects beyond RNA editing

Cell Cycle
2009 | Journal article
EID:

2-s2.0-74849101768
Contributors: Heale, B.S.E.; Keegan, L.P.; O'Connell, M.A.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

An extra double-stranded RNA binding domain confers high activity to a squid RNA editing enzyme

RNA
2009 | Journal article
DOI:

10.1261/rna.1471209

EID:

2-s2.0-66449109164
Contributors: Palavicini, J.P.; O'Connell, M.A.; Rosenthal, J.J.C.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

Biological roles of ADARs

DNA and RNA Modification Enzymes: Structure, Mechanism, Function and Evolution
2009 | Book chapter
Source: Self-asserted source
Mary Anne O'Connell

Editing independent effects of ADARs on the miRNA/siRNA pathways

EMBO Journal
2009 | Journal article
DOI:

10.1038/emboj.2009.244

EID:

2-s2.0-70350336432
Contributors: Heale, B.S.E.; Keegan, L.P.; McGurk, L.; Michlewski, G.; Brindle, J.; Stanton, C.M.; Caceres, J.F.; O'Connell, M.A.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

Evidence for ADAR-induced hypermutation of the Drosophila sigma virus (Rhabdoviridae)

BMC Genetics
2009 | Journal article
DOI:

10.1186/1471-2156-10-75

EID:

2-s2.0-71949124275
Contributors: Carpenter, J.A.; Keegan, L.P.; Wilfert, L.; O'Connell, M.A.; Jiggins, F.M.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR.

2009-04 | Journal article
DOI:

10.1093/nar/gkn1080

PMID:

19153139

PMC:

PMC2655694
Contributors: Marcucci R; Romano M; Feiguin F; O'Connell MA; Baralle FE
Source: Self-asserted source
Mary Anne O'Connell via Europe PubMed Central
grade
Preferred source (of 2)‎

Down-regulation of RNA Editing in Pediatric Astrocytomas

Journal of Biological Chemistry
2008-03-14 | Journal article
DOI: 10.1074/jbc.m708316200
Part of ISSN: 0021-9258
Part of ISSN: 1083-351X
Source: Self-asserted source
Mary Anne O'Connell

Purification and Assay of ADAR Activity

Methods in Enzymology
2007 | Book
DOI:

10.1016/S0076-6879(07)24014-5

EID:

2-s2.0-34548562454
Contributors: Keegan, L.P.; Rosenthal, J.J.; Roberson, L.M.; O'Connell, M.A.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

Three-dimensional imaging of Drosophila melanogaster

PLoS ONE
2007 | Journal article
DOI:

10.1371/journal.pone.0000834

EID:

2-s2.0-41049093625
Contributors: McGurk, L.; Morrison, H.; Keegan, L.P.; Sharpe, J.; O'Connell, M.A.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

Drosha versus ADAR: Wrangling over pri-miRNA

Nature Structural and Molecular Biology
2006 | Journal article
DOI:

10.1038/nsmb0106-3

EID:

2-s2.0-30044434746
Contributors: O'Connell, M.A.; Keegan, L.P.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier

A bioinformatic screen for novel A-I RNA editing sites reveals recoding editing in BC10

Bioinformatics
2005 | Journal article
DOI:

10.1093/bioinformatics/bti411

EID:

2-s2.0-20744459167
Contributors: Clutterbuck, D.R.; Leroy, A.; O'Connell, M.A.; Semple, C.A.M.
Source: Self-asserted source
Mary Anne O'Connell via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (3 reviews for 3 publications/grants)

Review activity for EMBO journal. (1)
Review activity for Genome biology. (1)
Review activity for Trends in genetics. (1)
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