Personal information

Germany

Biography

Andreas studied chemistry at the Ludwig-Maximilians-University of Munich (LMU, Germany), studied chemistry at the Ludwig-Maximilians University of Munich, Germany, and received his M.Sc. degree in 2010.

In 2010 Andreas joined the research group of Frank M. Boeckler (Laboratory for Molecular Design and Pharmaceutical Biophysics, at the University of Tuebingen, Germany) for his Ph.D. thesis where he studied the applicability of halogen bonds for molecular drug design. He characterised (theoretical and experimental) possible binding patterns to address the amino acids Methionine, Histidine, protein backbone, and Aspartate & Glutamate. Furthermore he could find a bivalent halogen-chalcogen binding mechanism through halogen bonding in the kinase JNK3. Such a binding mechanism can only happen to a few classes of kinases which might help to identifiy new ligands inducing such a binding pattern. His Ph.D. work has led to 11 publications (two first author publications).

In 2016 Andreas joined the research group of Prof. Bornberg-Bauer at the Institute of Evolution and Biodiversity at the University of Muenster, where he studies the structure and function of de novo proteins from mouse, drosophila, and homo sapiens. Since September 2018 he is Project manager according to the gene technology act (§ 15 GenTSV) and since January 2020 Safety manager for laboratories at IEB.

From August 2019 until October 2019 he joined the Lab of Prof. Ylva Ivarsson, BMC, Uppsala, Sweden, to learn and measure his de novo proteins via phage display in order to identify possible binding patterns through an EMBO Short-term scholarship.

Activities

Employment (5)

Westfalische Wilhelms-Universität Munster: Munster, Nordrhein-Westfalen, DE

2018-10-01 to present | Project manager according to the gene technology act ( §15 GenTSV)
Employment
Source: Self-asserted source
Andreas Lange

Westfalische Wilhelms-Universität Munster: Munster, Nordrhein-Westfalen, DE

2016-10-01 to present | Research Associate (Institute for Evolution and Biodiversity)
Employment
Source: Self-asserted source
Andreas Lange

Uppsala biomedicinska centrum: Uppsala, SE

2019-08-01 to 2019-10-31 | Visiting PostDoc - Performing Peptide Phage Display on de novo genes
Employment
Source: Self-asserted source
Andreas Lange

Eberhard Karls Universität Tübingen: Tubingen, Baden-Württemberg, DE

2015-10-01 to 2016-09-30 | Postdoctoral Research Associate (Molec. Design & Pharm. Biophysics)
Employment
Source: Self-asserted source
Andreas Lange

Eberhard Karls Universität Tübingen: Tubingen, Baden-Württemberg, DE

2010-07-01 to 2015-09-30 | PhD student (Molec. Design & Pharm. Biophysics)
Employment
Source: Self-asserted source
Andreas Lange

Education and qualifications (3)

Eberhard Karls Universität Tübingen: Tubingen, Baden-Württemberg, DE

2010-07-01 to 2015-09-30 | PhD (Molec. Design & Pharm. Biophysics)
Education
Source: Self-asserted source
Andreas Lange

Ludwig Maximilian University of Munich: Munich, DE

2008-04-01 to 2010-05-31 | MSc in Chemistry
Education
Source: Self-asserted source
Andreas Lange

Ludwig Maximilian University of Munich: Munich, DE

2004-10-01 to 2008-03-31 | BSc in Chemistry and Biochemistry
Education
Source: Self-asserted source
Andreas Lange

Professional activities (2)

Society for Molecular Biology and Evolution: Lawrence, KS, US

Membership
Source: Self-asserted source
Andreas Lange

Faculty Opinions: London, GB

2020-11-05 to present | Associate Faculty Member
Invited position
Source: check_circle
Faculty Opinions

Funding (1)

Characterization of de novo proteins using peptide phage display

2019-08 to 2019-10 | Award
European Molecular Biology Organization (Heidelberg, DE)
GRANT_NUMBER:

8268

Source: Self-asserted source
Andreas Lange

Works (23)

Structure-function analysis of Factor Seven Activating Protease (FSAP) by in-silico methods and its expression in insect cells.

2025-01-08 | Preprint
Contributors: Sai Priya Kandanur; Abdulbaki Coban; Andreas Lange; Carsten Kemena; Aumkar Logendran; Bjorn Dalhus; Jonas Emsley; Sandip M Kanse
Source: check_circle
Crossref

Ancestral aryl sulfatases in the alkaline phosphatase family allow for greater increases in catalytic efficiency than extant variants

2024-12-11 | Preprint
Contributors: Bernard Eenink; Magdalena Heberlein; Josephin M. Holstein; Andreas Lange; Carina Dilkaute; Tomasz S. Kaminski; Erich Bornberg-Bauer; Joachim Jose; Florian Hollfelder; Bert van Loo
Source: check_circle
Crossref

Heterologous expression of naturally evolved putative de novo proteins with chaperones

Protein Science
2022-08 | Journal article
Contributors: Lars A. Eicholt; Margaux Aubel; Katrin Berk; Erich Bornberg‐Bauer; Andreas Lange
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Chaperones facilitate heterologous expression of naturally evolved putative de novo proteins

2022-03-02 | Preprint
Contributors: Lars A. Eicholt; Margaux Aubel; Katrin Berk; Erich Bornberg-Bauer; Andreas Lange
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Experimental characterisation of de novo proteins and their unevolved random-sequence counterparts

2022-01-17 | Preprint
Contributors: Brennen Heames; Filip Buchel; Margaux Aubel; Vyacheslav Tretyachenko; Andreas Lange; Erich Bornberg-Bauer; Klara Hlouchova
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Structure and function of naturally evolved de novo proteins

Current Opinion in Structural Biology
2021-06 | Journal article
Contributors: Erich Bornberg-Bauer; Klara Hlouchova; Andreas Lange
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Structural and functional characterization of a putative de novo gene in Drosophila

Nature Communications
2021-03-12 | Journal article
Contributors: Andreas Lange; Prajal H. Patel; Brennen Heames; Adam M. Damry; Thorsten Saenger; Colin J. Jackson; Geoffrey D. Findlay; Erich Bornberg-Bauer
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Structural and functional characterization of a putativede novogene inDrosophila

2021-01-19 | Preprint
Contributors: Andreas Lange; Prajal H. Patel; Brennen Heames; Adam M. Damry; Thorsten Saenger; Colin J. Jackson; Geoffrey D. Findlay; Erich Bornberg-Bauer
Source: check_circle
Crossref

Small-Molecule Intervention At The Dimerization Interface Of Survivin By Novel Rigidized Scaffolds

Drug Design, Development and Therapy
2019-12 | Journal article
Source: Self-asserted source
Andreas Lange
grade
Preferred source (of 3)‎

Scaffold Effects on Halogen Bonding Strength.

Journal of chemical information and modeling
2019-01 | Journal article
Contributors: Lange A; Heidrich J; Zimmermann MO; Exner TE; Boeckler FM
Source: Self-asserted source
Andreas Lange via Europe PubMed Central
grade
Preferred source (of 2)‎

Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3.

Journal of medicinal chemistry
2017-01 | Journal article
Contributors: Muth F; El-Gokha A; Ansideri F; Eitel M; Döring E; Sievers-Engler A; Lange A; Boeckler FM; Lämmerhofer M; Koch P et al.
Source: Self-asserted source
Andreas Lange via Europe PubMed Central
grade
Preferred source (of 2)‎

Using Surface Scans for the Evaluation of Halogen Bonds toward the Side Chains of Aspartate, Asparagine, Glutamate, and Glutamine.

Journal of chemical information and modeling
2016-07 | Journal article
Contributors: Zimmermann MO; Lange A; Zahn S; Exner TE; Boeckler FM
Source: Self-asserted source
Andreas Lange via Europe PubMed Central
grade
Preferred source (of 2)‎

11th German Conference on Chemoinformatics (GCC 2015) : Fulda, Germany. 8-10 November 2015.

Journal of cheminformatics
2016-04 | Journal article
Contributors: Fechner U; de Graaf C; Torda AE; Güssregen S; Evers A; Matter H; Hessler G; Richmond NJ; Schmidtke P; Segler MHS et al.
Source: Self-asserted source
Andreas Lange via Europe PubMed Central

Fluorescence polarization-based assays for detecting compounds binding to inactive c-Jun N-terminal kinase 3 and p38α mitogen-activated protein kinase.

Analytical biochemistry
2016-03 | Journal article
Contributors: Ansideri F; Lange A; El-Gokha A; Boeckler FM; Koch P
Source: Self-asserted source
Andreas Lange via Europe PubMed Central
grade
Preferred source (of 2)‎

Targeting the Gatekeeper MET146 of C-Jun N-Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond.

Journal of the American Chemical Society
2015-11 | Journal article
Contributors: Lange A; Günther M; Büttner FM; Zimmermann MO; Heidrich J; Hennig S; Zahn S; Schall C; Sievers-Engler A; Ansideri F et al.
Source: Self-asserted source
Andreas Lange via Europe PubMed Central
grade
Preferred source (of 2)‎

Evaluating the potential of halogen bonding in molecular design: automated scaffold decoration using the new scoring function XBScore.

Journal of chemical information and modeling
2015-02 | Journal article
Contributors: Zimmermann MO; Lange A; Boeckler FM
Source: Self-asserted source
Andreas Lange via Europe PubMed Central
grade
Preferred source (of 2)‎

Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery.

Future medicinal chemistry
2014-04 | Journal article
Contributors: Zimmermann MO; Lange A; Wilcken R; Cieslik MB; Exner TE; Joerger AC; Koch P; Boeckler FM
Source: Self-asserted source
Andreas Lange via Europe PubMed Central
grade
Preferred source (of 2)‎

Scaffold dependencies for halogen bonding: quantum mechanical investigation of nitrogen-bearing heterocycles.

Journal of cheminformatics
2014-03 | Journal article
Contributors: Lange A; Zimmermann M; Boeckler M
Source: Self-asserted source
Andreas Lange via Europe PubMed Central

Machine learning estimates of natural product conformational energies.

PLoS computational biology
2014-01 | Journal article
Contributors: Rupp M; Bauer MR; Wilcken R; Lange A; Reutlinger M; Boeckler FM; Schneider G
Source: Self-asserted source
Andreas Lange via Europe PubMed Central
grade
Preferred source (of 2)‎

Targeting histidine side chains in molecular design through nitrogen-halogen bonds.

Journal of chemical information and modeling
2013-11 | Journal article
Contributors: Lange A; Zimmermann MO; Wilcken R; Zahn S; Boeckler FM
Source: Self-asserted source
Andreas Lange via Europe PubMed Central
grade
Preferred source (of 2)‎

Principles and applications of halogen bonding in medicinal chemistry and chemical biology.

Journal of medicinal chemistry
2013-01 | Journal article
Contributors: Wilcken R; Zimmermann MO; Lange A; Joerger AC; Boeckler FM
Source: Self-asserted source
Andreas Lange via Europe PubMed Central
grade
Preferred source (of 2)‎

Using halogen bonds to address the protein backbone: a systematic evaluation.

Journal of computer-aided molecular design
2012-08 | Journal article
Contributors: Wilcken R; Zimmermann MO; Lange A; Zahn S; Boeckler FM
Source: Self-asserted source
Andreas Lange via Europe PubMed Central
grade
Preferred source (of 2)‎

Addressing Methionine in Molecular Design through Directed Sulfur-Halogen Bonds.

Journal of chemical theory and computation
2011-06 | Journal article
Contributors: Wilcken R; Zimmermann MO; Lange A; Zahn S; Kirchner B; Boeckler FM
Source: Self-asserted source
Andreas Lange via Europe PubMed Central
grade
Preferred source (of 2)‎

Peer review (2 reviews for 2 publications/grants)

Review activity for Faculty Opinions (1)
Review activity for Genome biology. (1)